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A systematic literature review of burden of illness in adults with
We conducted a systematic literature review to better understand the impact of moderate-to-severe asthma in the US, the UK, Germany, France, Italy, Spain, Canada, Japan, and Australia in terms of prevalence, clinical measures, health-related quality of life (HRQoL) and economic burden, for patients whose asthma is uncontrolled despite inhaled ...
Asthma
Asthma is a common pathology, affecting around 15% to 20% of people in developed countries and around 2% to 4% in less developed countries. It is significantly more common in children. Up to 40% of children will have a wheeze at some point, which, if reversible by beta-2 agonists, is termed asthma, regardless of lung function tests.
Acute Severe Asthma in Adolescent and Adult Patients: Current
A review of the literature, however failed to provide robust evidence of the effectiveness of this medication category on lung function or on the outcomes of the patients . ... Severe asthma exacerbations are a major cause of disease morbidity, functional impairment, increased healthcare costs, and increased risk of mortality. ...
Mechanisms and Management of Asthma Exacerbations
In this review, we assess the epidemiology of acute asthma, the triggers of acute exacerbations, and the mechanisms that underlie these exacerbations. We also assess current treatments that prevent exacerbations, with an emphasis on the role of type 2 airway inflammation in the context of acute exacerbations and the novel treatments that ...
Acid-Base Disturbances in Patients with Asthma: A Literature Review and
Acute severe asthma is characterized by hypoxemia [3,56] and may be accompanied by functional cardiac disorders (heart-lung interaction); increased right ventricular (RV) afterload during acute severe asthma, with increased impedance to RV ejection, and reduction of left ventricular (LV) preload and LV compliance due to leftward septal shift ...
Diagnosis and Management of Asthma in Adults : A Review
The diagnosis of asthma requires these symptoms and demonstration of reversible airway obstruction using spirometry. Identifying clinically important allergen sensitivities is useful. Inhaled short-acting β2-agonists provide rapid relief of acute symptoms, but maintenance with daily inhaled corticosteroids is the standard of care for ...
A systematic review of psychological, physical health factors, and
QoL in asthma was found to be influenced by affect and a predisposition to negative states, as found by four studies. 28,39,41,51 For instance, a model of age, gender, negative affect, and medical ...
Systematic Literature Review of Systemic Corticosteroid Use for Asthma
This systematic literature review identified a large body of evidence from observational studies documenting real-world clinical practice regarding the use of OCS/SCS therapy for the general asthma population and especially for patients with more severe disease.
Asthma
Asthma is one of the most common chronic non-communicable diseases worldwide and is characterised by variable airflow obstruction, causing dyspnoea and wheezing. Highly effective therapies are available; asthma morbidity and mortality have vastly improved in the past 15 years, and most patients can attain good asthma control. However, undertreatment is still common, and improving patient and ...
Diagnosis and Management of Asthma in Adults: A Review
Abstract. Importance: Asthma affects about 7.5% of the adult population. Evidence-based diagnosis, monitoring, and treatment can improve functioning and quality of life in adult patients with asthma. Observations: Asthma is a heterogeneous clinical syndrome primarily affecting the lower respiratory tract, characterized by episodic or persistent ...
Assessment and management of adults with asthma during the ...
We focus on the features differentiating acute asthma from covid-19, the challenges of remote assessment, and the importance of corticosteroids in patients with an asthma exacerbation. ... and TS carried out the literature review and wrote the initial drafts. All four authors contributed to editing and revision, and VM provided expert advice as ...
Full article: Systematic literature review of the clinical, humanistic
Abstract. Objective: This study sought to characterize the epidemiologic, clinical, humanistic, and economic burden of patients with asthma uncontrolled by GINA Steps 4 or 5 treatment (severe, uncontrolled asthma [SUA]). Methods: A systematic literature review adhering to PRISMA guidelines was performed. Relevant publications were searched for in MEDLINE and EMBASE from January 2004 to ...
Targeted Literature Review: Burden of Disease Associated With Severe
PURPOSE: In the USA, an estimated 19 million adults have asthma, of whom 5-10% have severe asthma (GINA steps 4-5). Of patients with severe asthma, 20-50% have uncontrolled asthma. We examined peer-reviewed literature reporting the clinical, humanistic and economic burden associated with moderate or severe, uncontrolled asthma in the USA.
A systematic literature review of burden of illness in adults with
We conducted a systematic literature review to better understand the impact of moderate-to-severe asthma in the US, the UK, Germany, France, Italy, Spain, Canada, Japan, and Australia in terms of prevalence, clinical measures, health-related quality of life (HRQoL) and economic burden, for patients whose asthma is uncontrolled despite inhaled ...
A systematic literature review of burden of illness in adults with
Background: There are limited published data on the burden of moderate/severe uncontrolled asthma. Methods: We conducted a systematic literature review to better understand the impact of moderate-to-severe asthma in the US, the UK, Germany, France, Italy, Spain, Canada, Japan, and Australia in terms of prevalence,
Acid-Base Disturbances in Patients with Asthma: A Literature Review and
Asthma is a common illness throughout the world that affects the respiratory system function, i.e., a system whose operational adequacy determines the respiratory gases exchange. It is therefore expected that acute severe asthma will be associated with respiratory acid-base disorders. In addition, t …
Barriers to clinical remission in severe asthma
Severe asthma is associated with an increased risk for exacerbations, reduced lung function, fixed airflow obstruction, and substantial morbidity and mortality. The concept of remission in severe asthma as a new treatment goal has recently gained attention due to the growing use of monoclonal antibody therapies, which target specific pathologic pathways of inflammation. This review evaluates ...
Full article: An update on asthma diagnosis
The aim of the present mini-review is to update the current international literature on topics related to asthma diagnosis with a focus on: 1) the epidemiology-burden of disease, 2) the transition of the traditional asthma diagnosis to a more "refined" asthma classification, 3) the published literature on asthma misdiagnosis, and 4) a ...
Asthma Exacerbations: Pathogenesis, Prevention, and Treatment
In 2 replicate trials with a total of 912 adult patients with severe asthma and using ICS/LABA, adding tiotropium, 5 mcg, increased the time to first exacerbation by 56 days over placebo, and reduced exacerbations by 21% (Figure 5). 86 In a systematic review of 13 randomized placebo-controlled trials, 87 tiotropium decreased rates of ...
Systematic Literature Review of Systemic Corticosteroid Use for Asthma
This review provides a comprehensive overview of oral/systemic corticosteroid use and associated adverse events for patients with all degrees of asthma severity and exposure duration. We report that oral/systemic corticosteroid use is prevalent in asthma management, and the risks of acute and chronic complications increase with the cumulative ...
Epidemiology, Healthcare Resource Utilization, and Mortality of Asthma
The effect of medications such as inhaled corticosteroids (ICS) and biologics on COVID-19 is unclear. This systematic literature review analyzed the published evidence on epidemiology and the burden of illness of asthma and COPD, and the use of baseline medicines among COVID-19 populations. ... More severe asthma may require biologic agents ...
A systematic literature review of burden of illness in adults with
Background: There are limited published data on the burden of moderate/severe uncontrolled asthma. Methods: We conducted a systematic literature review to better understand the impact of moderate-to-severe asthma in the US, the UK, Germany, France, Italy, Spain, Canada, Japan, and Australia in terms of prevalence, clinical measures, health-related quality of life (HRQoL) and economic burden ...
PDF Acid-Base Disturbances in Patients with Asthma: A Literature Review and
Journal of Clinical Medicine Review Acid-Base Disturbances in Patients with Asthma: A Literature Review and Comments on Their Pathophysiology Ioannis Vasileiadis 1,*, Emmanouil Alevrakis 2, Sevasti Ampelioti 3, Dimitrios Vagionas 1, Nikoletta Rovina 1 and Antonia Koutsoukou 1 1 Intensive Care Unit, 1st Department of Respiratory Medicine, National and Kapodistrian University of
JCM
Traumatic pain is frequently encountered in emergency care and requires immediate analgesia. Unfortunately, most trauma patients report sustained pain upon arrival at and discharge from the Emergency Department. Obtaining intravenous access to administer analgesics can be time-consuming, leading to treatment delay. This review provides an overview of analgesics with both fast onset and ...
Severe asthma in South Africa: A literature review and management
Severe asthma in South Africa (SA) is underappreciated, especially in the primary care setting. This study highlights the epidemiological context of severe asthma as a phenotypic variant. Primary care practitioners, as first-contact medical providers, need grounding in the management of severe asthma based on the precision of diagnosis and ...
IMAGES
VIDEO
COMMENTS
We conducted a systematic literature review to better understand the impact of moderate-to-severe asthma in the US, the UK, Germany, France, Italy, Spain, Canada, Japan, and Australia in terms of prevalence, clinical measures, health-related quality of life (HRQoL) and economic burden, for patients whose asthma is uncontrolled despite inhaled ...
Asthma is a common pathology, affecting around 15% to 20% of people in developed countries and around 2% to 4% in less developed countries. It is significantly more common in children. Up to 40% of children will have a wheeze at some point, which, if reversible by beta-2 agonists, is termed asthma, regardless of lung function tests.
A review of the literature, however failed to provide robust evidence of the effectiveness of this medication category on lung function or on the outcomes of the patients . ... Severe asthma exacerbations are a major cause of disease morbidity, functional impairment, increased healthcare costs, and increased risk of mortality. ...
In this review, we assess the epidemiology of acute asthma, the triggers of acute exacerbations, and the mechanisms that underlie these exacerbations. We also assess current treatments that prevent exacerbations, with an emphasis on the role of type 2 airway inflammation in the context of acute exacerbations and the novel treatments that ...
Acute severe asthma is characterized by hypoxemia [3,56] and may be accompanied by functional cardiac disorders (heart-lung interaction); increased right ventricular (RV) afterload during acute severe asthma, with increased impedance to RV ejection, and reduction of left ventricular (LV) preload and LV compliance due to leftward septal shift ...
The diagnosis of asthma requires these symptoms and demonstration of reversible airway obstruction using spirometry. Identifying clinically important allergen sensitivities is useful. Inhaled short-acting β2-agonists provide rapid relief of acute symptoms, but maintenance with daily inhaled corticosteroids is the standard of care for ...
QoL in asthma was found to be influenced by affect and a predisposition to negative states, as found by four studies. 28,39,41,51 For instance, a model of age, gender, negative affect, and medical ...
This systematic literature review identified a large body of evidence from observational studies documenting real-world clinical practice regarding the use of OCS/SCS therapy for the general asthma population and especially for patients with more severe disease.
Asthma is one of the most common chronic non-communicable diseases worldwide and is characterised by variable airflow obstruction, causing dyspnoea and wheezing. Highly effective therapies are available; asthma morbidity and mortality have vastly improved in the past 15 years, and most patients can attain good asthma control. However, undertreatment is still common, and improving patient and ...
Abstract. Importance: Asthma affects about 7.5% of the adult population. Evidence-based diagnosis, monitoring, and treatment can improve functioning and quality of life in adult patients with asthma. Observations: Asthma is a heterogeneous clinical syndrome primarily affecting the lower respiratory tract, characterized by episodic or persistent ...
We focus on the features differentiating acute asthma from covid-19, the challenges of remote assessment, and the importance of corticosteroids in patients with an asthma exacerbation. ... and TS carried out the literature review and wrote the initial drafts. All four authors contributed to editing and revision, and VM provided expert advice as ...
Abstract. Objective: This study sought to characterize the epidemiologic, clinical, humanistic, and economic burden of patients with asthma uncontrolled by GINA Steps 4 or 5 treatment (severe, uncontrolled asthma [SUA]). Methods: A systematic literature review adhering to PRISMA guidelines was performed. Relevant publications were searched for in MEDLINE and EMBASE from January 2004 to ...
PURPOSE: In the USA, an estimated 19 million adults have asthma, of whom 5-10% have severe asthma (GINA steps 4-5). Of patients with severe asthma, 20-50% have uncontrolled asthma. We examined peer-reviewed literature reporting the clinical, humanistic and economic burden associated with moderate or severe, uncontrolled asthma in the USA.
We conducted a systematic literature review to better understand the impact of moderate-to-severe asthma in the US, the UK, Germany, France, Italy, Spain, Canada, Japan, and Australia in terms of prevalence, clinical measures, health-related quality of life (HRQoL) and economic burden, for patients whose asthma is uncontrolled despite inhaled ...
Background: There are limited published data on the burden of moderate/severe uncontrolled asthma. Methods: We conducted a systematic literature review to better understand the impact of moderate-to-severe asthma in the US, the UK, Germany, France, Italy, Spain, Canada, Japan, and Australia in terms of prevalence,
Asthma is a common illness throughout the world that affects the respiratory system function, i.e., a system whose operational adequacy determines the respiratory gases exchange. It is therefore expected that acute severe asthma will be associated with respiratory acid-base disorders. In addition, t …
Severe asthma is associated with an increased risk for exacerbations, reduced lung function, fixed airflow obstruction, and substantial morbidity and mortality. The concept of remission in severe asthma as a new treatment goal has recently gained attention due to the growing use of monoclonal antibody therapies, which target specific pathologic pathways of inflammation. This review evaluates ...
The aim of the present mini-review is to update the current international literature on topics related to asthma diagnosis with a focus on: 1) the epidemiology-burden of disease, 2) the transition of the traditional asthma diagnosis to a more "refined" asthma classification, 3) the published literature on asthma misdiagnosis, and 4) a ...
In 2 replicate trials with a total of 912 adult patients with severe asthma and using ICS/LABA, adding tiotropium, 5 mcg, increased the time to first exacerbation by 56 days over placebo, and reduced exacerbations by 21% (Figure 5). 86 In a systematic review of 13 randomized placebo-controlled trials, 87 tiotropium decreased rates of ...
This review provides a comprehensive overview of oral/systemic corticosteroid use and associated adverse events for patients with all degrees of asthma severity and exposure duration. We report that oral/systemic corticosteroid use is prevalent in asthma management, and the risks of acute and chronic complications increase with the cumulative ...
The effect of medications such as inhaled corticosteroids (ICS) and biologics on COVID-19 is unclear. This systematic literature review analyzed the published evidence on epidemiology and the burden of illness of asthma and COPD, and the use of baseline medicines among COVID-19 populations. ... More severe asthma may require biologic agents ...
Background: There are limited published data on the burden of moderate/severe uncontrolled asthma. Methods: We conducted a systematic literature review to better understand the impact of moderate-to-severe asthma in the US, the UK, Germany, France, Italy, Spain, Canada, Japan, and Australia in terms of prevalence, clinical measures, health-related quality of life (HRQoL) and economic burden ...
Journal of Clinical Medicine Review Acid-Base Disturbances in Patients with Asthma: A Literature Review and Comments on Their Pathophysiology Ioannis Vasileiadis 1,*, Emmanouil Alevrakis 2, Sevasti Ampelioti 3, Dimitrios Vagionas 1, Nikoletta Rovina 1 and Antonia Koutsoukou 1 1 Intensive Care Unit, 1st Department of Respiratory Medicine, National and Kapodistrian University of
Traumatic pain is frequently encountered in emergency care and requires immediate analgesia. Unfortunately, most trauma patients report sustained pain upon arrival at and discharge from the Emergency Department. Obtaining intravenous access to administer analgesics can be time-consuming, leading to treatment delay. This review provides an overview of analgesics with both fast onset and ...
Severe asthma in South Africa (SA) is underappreciated, especially in the primary care setting. This study highlights the epidemiological context of severe asthma as a phenotypic variant. Primary care practitioners, as first-contact medical providers, need grounding in the management of severe asthma based on the precision of diagnosis and ...