difference of concept paper and research paper

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• Charlesworth Author Services
• 08 March, 2022

Concept Paper vs. Research Proposal – and when to use each

On the surface, concept papers sound like they do the same job as a research proposal – and essentially, they do. Both are designed to communicate the rationale, methodology and outcomes of a proposed piece of work. The difference between the two lies mostly in the level of detail and the potential audience, based on which your approach towards writing each will vary. In this article, we dig deeper into these and recommend when to use which.

Concept paper: Putting your idea to paper

• What : A concept paper verbalises an idea and puts it to paper for the first time. Here, an overall rationale is presented, with a focus on the essential idea and potential impact of the expected outcome(s). However, what you would not include here is much in-depth detail.
• When : Writing a concept paper is most useful when an initial expression of interest is made to either a collaborator or funder – provided the funder has mechanisms for you to do this, like an open call.
• Why : The aim of your concept paper will be to win your audience over with your idea and its potential ramifications. 

(For more on concept papers, read: Understanding and developing a concept paper )

Research proposal: Showing how things will get done

Let’s say that through your concept paper, you find funding and collaborators for your proposed research project. You will now get into the nitty gritty of the project with a research proposal, while still keeping it “consumable” enough for a broader audience.

• What : A research proposal builds on a concept paper by now including aspects like key deliverables, milestones and specific outcomes, as well as how you plan to achieve these. 
• When : You will typically send a research proposal to sources of funding of an open nature, i.e. those that do not require a standardised form to be filled in, as is often the case with institutional internal funding or private investors.
• Why : It is not necessary for you to first send someone a concept paper and follow it up with a proposal. However, you may often need to follow this sequence in order to provide only ‘need to know’ material depending on the stage of your relationship with potential partners.

( For more on research proposals, read: Writing a successful research proposal )

When both are needed, a concept paper precedes a research proposal

Deciding between a concept paper and a research proposal

Whether you send someone a concept paper or a research proposal depends entirely on two things: 

• Your existing relationship with whomever you are reaching out to
• What you are trying to achieve

If you are emailing an organisation or individual for the first time, you are more likely to receive a response by attaching a brief, snappy concept paper that is easily read by a multitude of people. On the other hand, some larger organisations, such as pharmaceutical companies, are very used to seeing full-fledged research proposals and may have a portal on their website where you would need to upload one, enabling them to skip the preliminary step of vetting your work through a concept paper.

Our recommendation : Given how pressed many people are for time these days, it would be prudent to send concept papers more frequently than research proposals. If more information is required, you will be asked for it.

Concept papers and research proposals do very similar things, but set out and achieve very different aims. They are often sent in sequence – the concept paper first, followed by the research proposal. The need for a research proposal arises when the concept paper has achieved its mark – when, for example, more information is required for a funding decision to be reached, or due diligence is to be performed, as a result of your concept paper gaining preliminary acceptance. Following up with a research proposal fills in the gaps and will aid in answering questions arising from the concept paper.

Read previous (second) in series: Writing a successful Research Proposal

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What is a Concept Paper and How do You Write One?

• By DiscoverPhDs
• August 26, 2020

What is a Concept Paper?

A concept paper is a short document written by a researcher before starting their research project, with the purpose of explaining what the study is about, why it is important and the methods that will be used.

The concept paper will include your proposed research title, a brief introduction to the subject, the aim of the study, the research questions you intend to answer, the type of data you will collect and how you will collect it. A concept paper can also be referred to as a research proposal.

What is the Purpose of a Concept Paper?

The primary aim of a research concept paper is to convince the reader that the proposed research project is worth doing. This means that the reader should first agree that the research study is novel and interesting. They should be convinced that there is a need for this research and that the research aims and questions are appropriate.

Finally, they should be satisfied that the methods for data collection proposed are feasible, are likely to work and can be performed within the specific time period allocated for this project.

The three main scenarios in which you may need to write a concept paper are if you are:

• A final year undergraduate or master’s student preparing to start a research project with a supervisor.
• A student submitting a research proposal to pursue a PhD project under the supervision of a professor.
• A principal investigator submitting a proposal to a funding body to secure financial support for a research project.

How Long is a Concept Paper?

The concept paper format is usually between 2 and 3 pages in length for students writing proposals for undergraduate, master’s or PhD projects. Concept papers written as part of funding applications may be over 20 pages in length.

How do you Write a Concept Paper?

There are 6 important aspects to consider when writing a concept paper or research proposal:

• 1. The wording of the title page, which is best presented as a question for this type of document. At this study concept stage, you can write the title a bit catchier, for example “Are 3D Printed Engine Parts Safe for Use in Aircraft?”.
• A brief introduction and review of relevant existing literature published within the subject area and identification of where the gaps in knowledge are. This last bit is particularly important as it guides you in defining the statement of the problem. The concept paper should provide a succinct summary of ‘the problem’, which is usually related to what is unknown or poorly understood about your research topic . By the end of the concept paper, the reader should be clear on how your research idea will provide a ‘solution’ to this problem.
• The overarching research aim of your proposed study and the objectives and/or questions you will address to achieve this aim. Align all of these with the problem statement; i.e. write each research question as a clear response to addressing the limitations and gaps identified from previous literature. Also give a clear description of your primary hypothesis.
• The specific data outputs that you plan to capture. For example, will this be qualitative or quantitative data? Do you plan to capture data at specific time points or at other defined intervals? Do you need to repeat data capture to asses any repeatability and reproducibility questions?
• The research methodology you will use to capture this data, including any specific measurement or analysis equipment and software you will use, and a consideration of statistical tests to help interpret the data. If your research requires the use of questionnaires, how will these be prepared and validated? In what sort of time frame would you plan to collect this data?
• Finally, include a statement of the significance of the study , explaining why your research is important and impactful. This can be in the form of a concluding paragraph that reiterate the statement of the problem, clarifies how your research will address this and explains who will benefit from your research and how.

You may need to include a short summary of the timeline for completing the research project. Defining milestones of the time points at which you intend to complete certain tasks can help to show that you’ve considered the practicalities of running this study. It also shows that what you have proposed is feasible in order to achieve your research goal.

If you’re pitching your proposed project to a funder, they may allocate a proportion of the money based on the satisfactory outcome of each milestone. These stakeholders may also be motivated by knowing that you intend to convert your dissertation into an article for journal publication; this level of dissemination is of high importance to them.

Additionally, you may be asked to provide a brief summary of the projected costs of running the study. For a PhD project this could be the bench fees associated with consumables and the cost of any travel if required.

Make sure to include references and cite all other literature and previous research that you discuss in your concept paper.

This guide gave you an overview of the key elements you need to know about when writing concept papers. The purpose of these are first to convey to the reader what your project’s purpose is and why your research topic is important; this is based on the development of a problem statement using evidence from your literature review.

Explain how it may positively impact your research field and if your proposed research design is appropriate and your planned research method achievable.

The scope of the study is defined at the start of the study. It is used by researchers to set the boundaries and limitations within which the research study will be performed.

Find out the differences between a Literature Review and an Annotated Bibliography, whey they should be used and how to write them.

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A concept paper is a short document written by a researcher before starting their research project, explaining what the study is about, why it is needed and the methods that will be used.

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Rakhi is a PhD student at the Institute of Chemical Technology, Mumbai, India. Her research is on the production of Borneol and Menthol and development of separation process from the reaction mixture.

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What exactly is a Concept Paper, and how do you write one?

Learn why a concept paper is important, what the main elements of a research concept paper are, and how to create an excellent one.

Prior to submitting a formal proposal (business proposal, product, or research proposal), many private organizations have historically asked for the submission of a concept paper for review. 

Recently, organizations have begun to advocate for the usage of concept papers as a way for applicants to obtain informal input on their ideas and projects before submitting a proposal. Several of these organizations now demand a concept paper as part of the official application process. 

Simply described, a concept paper is a preliminary document that explains the purpose of research, why it is being conducted, and how it will be performed. It examines a concept or idea and offers an outline of the topic that a researcher wants to pursue. Continue reading to learn more about concept papers and how to create a good one. 

What a concept paper is and its purpose

A concept paper is a brief paper that outlines the important components of a research or project before it is carried out. Its purpose is to offer an overview. Entrepreneurs working on a business idea or product, as well as students and researchers, frequently write concept papers .  

Researchers may be required to prepare a concept paper when submitting a project proposal to a funding authority to acquire the required grants.

As a consequence, the importance is based on the fact that it should help the examiner determine whether the research is relevant, practicable, and useful . 

If not, they may suggest looking into a different research area. It also allows the examiner to assess your comprehension of the research and, as a result, if you are likely to require assistance in completing the research.

Illustrate your Concept Paper with infographics 

Infographics are very useful to explain complex subjects in a very short time. Use Mind the Graph to create beautiful infographics for your Concept Paper with scientifically accurate illustrations, icons, arrows and many other design tools.

Concept paper’s elements for an academic research 

To produce an effective concept paper, you must first comprehend the essential elements of academic research:

• Title page: Mention the applicant’s name, institution, project title, and submission date.
• Background for the research: The second section should be the purpose section, which should be able to clear out what has already been stated about the subject, any gaps in information that need to be filled or problems to be solved, as well as the reason why you wish to examine the issue.
• Literature review: In this section, you should provide a theoretical basis and supporting material for your chosen subject.
• State the problem and your goals: Describe the overall problems, including the research questions and objectives. State your research’s unique and original aspects, concentrate on providing and clearly discussing your goals towards the problem.
• Methodology: Provide the data analysis system to be utilized, data collecting method, tools to be used, and research participants in this section.
• Timeline: Include a realistic timeline estimate that is defined in months and years.
• References: Add a list of all sources cited in your concept paper , such as books, journals, and other resources.

Tips on writing an effective concept paper

A concept paper is extremely crucial for a project or research, especially if it requires funding. Check out these simple tips to ensure your concept paper is successful and simple.

• Choose a research topic that truly piques your curiosity
• Create a list of research questions. The more, the merrier.
• When describing the project’s reasoning, use data and numbers. 
• Use no more than 5 single-spaced pages. 
• Tailor your speech to the appropriate audience.
• Make certain that the basic format elements, such as page numbers, are included. 
• Spend additional time on your timeline as this section is critical for funding.
• Give specific examples of how you plan to measure your progress toward your goals.
• Provide an initial budget when seeking funds. Sponsors will want to obtain an idea of how much funds are required.

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How To Write a Concept Paper for Academic Research: An Ultimate Guide

A concept paper is one of the first steps in helping you fully realize your research project. Because of this, some schools opt to teach students how to write concept papers as early as high school. In college, professors sometimes require their students to submit concept papers before suggesting their research projects to serve as the foundations for their theses.

If you’re reading this right now, you’ve probably been assigned by your teacher or professor to write a concept paper. To help you get started, we’ve prepared a comprehensive guide on how to write a proper concept paper.

Related: How to Write Significance of the Study (with Examples)

Table of Contents

What is the concept paper, 1. academic research concept papers, 2. advertising concept papers, 3. research grant concept papers, concept paper vs. research proposal, tips for finding your research topic, 2. think of research questions that you want to answer in your project, 3. formulate your research hypothesis, 4. plan out how you will achieve, analyze, and present your data, 2. introduction, 3. purpose of the study, 4. preliminary literature review, 5. objectives of the study, 6. research questions and hypotheses, 7. proposed methodology, 8. proposed research timeline, 9. references, sample concept paper for research proposal (pdf), tips for writing your concept paper.

Generally, a concept paper is a summary of everything related to your proposed project or topic. A concept paper indicates what the project is all about, why it’s important, and how and when you plan to conduct your project.

Different Types of the Concept Paper and Their Uses

This type of concept paper is the most common type and the one most people are familiar with. Concept papers for academic research are used by students to provide an outline for their prospective research topics.

These concept papers are used to help students flesh out all the information and ideas related to their topic so that they may arrive at a more specific research hypothesis.

Since this is the most common type of concept paper, it will be the main focus of this article.

Advertising concept papers are usually written by the creative and concept teams in advertising and marketing agencies.

Through a concept paper, the foundation or theme for an advertising campaign or strategy is formed. The concept paper can also serve as a bulletin board for ideas that the creative and concept teams can add to or develop. 

This type of concept paper usually discusses who the target audience of the campaign is, what approach of the campaign will be, how the campaign will be implemented, and the projected benefits and impact of the campaign to the company’s sales, consumer base, and other aspects of the company.

This type of concept paper is most common in the academe and business world. Alongside proving why your research project should be conducted, a research grant concept paper must also appeal to the company or funding agency on why they should be granted funds.

The paper should indicate a proposed timeline and budget for the entire project. It should also be able to persuade the company or funding agency on the benefits of your research project– whether it be an increase in sales or productivity or for the benefit of the general public.

It’s important to discuss the differences between the two because a lot of people often use these terms interchangeably.

A concept paper is one of the first steps in conducting a research project. It is during this process that ideas and relevant information to the research topic are gathered to produce the research hypothesis. Thus, a concept paper should always precede the research proposal. 

A research proposal is a more in-depth outline of a more fleshed-out research project. This is the final step before a researcher can conduct their research project. Although both have similar elements and structures, a research proposal is more specific when it comes to how the entire research project will be conducted.

Getting Started on Your Concept Paper

1. find a research topic you are interested in.

When choosing a research topic, make sure that it is something you are passionate about or want to learn more about. If you are writing one for school, make sure it is still relevant to the subject of your class. Choosing a topic you aren’t invested in may cause you to lose interest in your project later on, which may lower the quality of the research you’ll produce.

A research project may last for months and even years, so it’s important that you will never lose interest in your topic.

• Look for inspiration everywhere. Take a walk outside, read books, or go on your computer. Look around you and try to brainstorm ideas about everything you see. Try to remember any questions you might have asked yourself before like why something is the way it is or why can’t this be done instead of that . 
• Think big. If you’re having trouble thinking up a specific topic to base your research project on, choosing a broad topic and then working your way down should help.
• Is it achievable? A lot of students make the mistake of choosing a topic that is hard to achieve in terms of materials, data, and/or funding available. Before you decide on a research topic, make sure you consider these aspects. Doing so will save you time, money, and effort later on.
• Be as specific as can be. Another common mistake that students make is that they sometimes choose a research topic that is too broad. This results in extra effort and wasted time while conducting their research project. For example: Instead of “The Effects of Bananas on Hungry Monkeys” , you could specify it to “The Effects of Cavendish Bananas on Potassium-deficiency in Hungry Philippine Long-tailed Macaques in Palawan, Philippines”.

Now that you have a general idea of the topic of your research project, you now need to formulate research questions based on your project. These questions will serve as the basis for what your project aims to answer. Like your research topic, make sure these are specific and answerable.

Following the earlier example, possible research questions could be:

• Do Cavendish bananas produce more visible effects on K-deficiency than other bananas?
• How susceptible are Philippine long-tailed macaques to K-deficiency?
• What are the effects of K-deficiency in Philippine long-tailed macaques?

After formulating the research questions, you should also provide your hypothesis for each question. A research hypothesis is a tentative answer to the research problem. You must provide educated answers to the questions based on your existing knowledge of the topic before you conduct your research project.

After conducting research and collecting all of the data into the final research paper, you will then have to approve or disprove these hypotheses based on the outcome of the project.

Prepare a plan on how to acquire the data you will need for your research project. Take note of the different types of analysis you will need to perform on your data to get the desired results. Determine the nature of the relationship between different variables in your research.

Also, make sure that you are able to present your data in a clear and readable manner for those who will read your concept paper. You can achieve this by using tables, charts, graphs, and other visual aids.

Related: How to Make Conceptual Framework (with Examples and Templates)

Generalized Structure of a Concept Paper

Since concept papers are just summaries of your research project, they are usually short and  no longer than 5 pages. However, for big research projects, concept papers can reach up to more than 20 pages.

Your teacher or professor may give you a certain format for your concept papers. Generally, most concept papers are double-spaced and are less than 500 words in length. 

Even though there are different types of concept papers, we’ve provided you with a generalized structure that contains elements that can be found in any type of concept paper.

The title for your paper must be able to effectively summarize what your research is all about. Use simple words so that people who read the title of your research will know what it’s all about even without reading the entire paper. 

The introduction should give the reader a brief background of the research topic and state the main objective that your project aims to achieve. This section should also include a short overview of the benefits of the research project to persuade the reader to acknowledge the need for the project.

The Purpose of the Study should be written in a way that convinces the reader of the need to address the existing problem or gap in knowledge that the research project aims to resolve. In this section, you have to go into more detail about the benefits and value of your project for the target audience/s. 

This section features related studies and papers that will support your research topic. Use this section to analyze the results and methodologies of previous studies and address any gaps in knowledge or questions that your research project aims to answer. You may also use the data to assert the importance of conducting your research.

When choosing which papers and studies you should include in the Preliminary Literature Review, make sure to choose relevant and reliable sources. Reliable sources include academic journals, credible news outlets, government websites, and others. Also, take note of the authors for the papers as you will need to cite them in the References section.

Simply state the main objectives that your research is trying to achieve. The objectives should be able to indicate the direction of the study for both the reader and the researcher. As with other elements in the paper, the objectives should be specific and clearly defined.

Gather the research questions and equivalent research hypotheses you formulated in the earlier step and list them down in this section.

In this section, you should be able to guide the reader through the process of how you will conduct the research project. Make sure to state the purpose for each step of the process, as well as the type of data to be collected and the target population.

Depending on the nature of your research project, the length of the entire process can vary significantly. What’s important is that you are able to provide a reasonable and achievable timeline for your project.

Make sure the time you will allot for each component of your research won’t be too excessive or too insufficient so that the quality of your research won’t suffer.

Ensure that you will give credit to all the authors of the sources you used in your paper. Depending on your area of study or the instructions of your professor, you may need to use a certain style of citation.

There are three main citation styles: the American Psychological Association (APA), Modern Language Association (MLA), and the Chicago style.

The APA style is mostly used for papers related to education, psychology, and the sciences. The APA citation style usually follows this format:

The MLA citation style is the format used by papers and manuscripts in disciplines related to the arts and humanities. The MLA citation style follows this format:

The Chicago citation style is usually used for papers related to business, history, and the fine arts. It follows this citation format:

This is a concept paper sample provided by Dr. Bernard Lango from the Jomo Kenyatta University of Agriculture and Technology (modified for use in this article). Simply click the link above the download the PDF file.

• Use simple, concise language. Minimize the use of flowery language and always try to use simple and easy-to-understand language. Too many technical or difficult words in your paper may alienate your readers and make your paper hard to read. 
• Choose your sources wisely. When scouring the Internet for sources to use, you should always be wary and double-check the authenticity of your source. Doing this will increase the authenticity of your research project’s claims and ensure better data gathered during the process.
• Follow the specified format, if any. Make sure to follow any specified format when writing your concept paper. This is very important, especially if you’re writing your concept paper for class. Failure to follow the format will usually result in point deductions and delays because of multiple revisions needed.
• Proofread often. Make it a point to reread different sections of your concept paper after you write them. Another way you can do this is by taking a break for a few days and then coming back to proofread your writing. You may notice certain areas you’d like to revise or mistakes you’d like to fix. Make proofreading a habit to increase the quality of your paper.

Written by Ruth Raganit

in Career and Education , Juander How

Ruth Raganit

Ruth Raganit obtained her Bachelor of Science degree in Geology from the University of the Philippines – Diliman. Her love affair with Earth sciences began when she saw a pretty rock and wondered how it came to be. She also likes playing video games, doing digital art, and reading manga.

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How to Write a Concept Paper in 7 Steps

Before you can write a research paper, or begin your research, you may have to write a concept paper.

A concept paper is a short academic paper that explains the research you plan to conduct. It covers your research goals, how you’ll carry out the research, how you’ll collect data, and the questions you aim to answer through your research.

What is a concept paper?

A concept paper is typically a two- to three-page paper that concisely explains a proposed research project. If the paper is for a funding application, it may be twenty pages or longer.

In the paper, they demonstrate why their proposed project is worthwhile. The paper covers:

• Research goals
• Questions the research aims to answer
• The research methods the author will use
• The types of data that will be collected

A concept paper is also known as a research proposal. They may be submitted to investors to secure funding, or a student may submit one to their supervisor before starting a research project. Through reading a student’s concept paper, an academic supervisor can assess their project’s feasibility and, if necessary, suggest adjustments the student can make to improve their project so it’s more realistic or valuable. Similarly, prospective investors can decide whether a project is something they’d like to support. Undeveloped or unrealistic projects can end at the concept paper stage

7 steps for writing a concept paper

A concept paper’s title should directly express the paper’s content. Think of it as a preview for the reader. The title can be the question the proposed project aims to answer, or it can be a short statement that summarizes the paper.

2 Introduction outlining problem and gaps in knowledge

In the introduction section, provide an overview of your research project. This should include a short overview of the current state of your research area and existing gaps in this area. After explaining these, state which of these knowledge gaps you aim to fill with your research. This section should also mention any contradictory theories regarding the questions you aim to answer.

3 Mission statement

Your concept paper’s introduction should also include a mission statement . This is a sentence or two that concisely states your research purpose in an engaging way. Remember, the goal is to get your project approved—so your mission statement should communicate why the reader’s approval will benefit your field.

4 Research aim

Your concept paper also needs to address the reason why you’re conducting the specific research you’ve planned. This part, along with the following two sections, are sometimes grouped together as a concept paper’s project description.

In this section, cover the following:

• The reason why your research is important
• The questions you aim to answer through your research

5 Methodology

A concept paper also needs to discuss the methodology you plan to use while conducting your research. This is the strategy or strategies you will use to collect data, such as:

• Experiments
• Case studies
• Observations

This section should also include any ethical concerns that could arise during the research period.

6 Outline of proposed methods and potential impact

After describing your proposed methodology, write a section that discusses exactly how you’ll conduct your research using these methods. Be as specific as possible—if you plan to utilize resources like specialized equipment or collaborate with an expert in your field, include this information in this section. In this section, outline how long you expect the research to take and note the specific milestones you plan to hit during that time frame.

This section should also discuss your research’s potential impact. Discuss who your research and results will impact and how it will impact them. For example, you might conduct a study on undergraduate sleep schedules and publish a paper that supports campus-wide policy changes that promote healthy sleep cycles for students who live on campus.

A concept paper also needs to include a section that addresses the project’s budget. The section should explain the overall cost and break it down into individual expenses so readers can see exactly how the money will be spent.

Tips for writing a concept paper

Write to your audience.

A concept paper is a piece of academic writing, so use a professional tone . Avoid colloquialisms, slang, and other conversational language. Your concept paper should use the same tone and style as your accompanying research paper.

Write according to your reader’s familiarity with the subject of your concept paper. For example, if you’re proposing an IT project and your intended reader is the head of your university’s IT department, you can use technical jargon they will understand. If the intended reader is somebody in a non-technical role, avoid jargon and make sure you define every vocabulary word that might not be familiar to them. By ensuring your reader understands your concept paper, you increase the likelihood of them approving your project.

Use an engaging, accurate title

Just like a clear, intriguing subject line increases the likelihood of a recipient reading an email, an engaging title increases the likelihood of your reader not only reading your concept paper but understanding it. Choose a title that’s concise (fewer than 15 words or so) and accurately reflects your paper’s content. After reading your paper’s title, your reader should not be surprised by your proposed research.

Keep it to an appropriate length

If you’re a student writing a concept paper for an undergraduate, master’s, or doctoral project, two to three pages is generally the right length for your paper. Don’t worry about getting too detailed about the specifics of your research; a high-level overview is sufficient.

Concept papers meant to secure funding from investors can be longer than academic concept papers.

How is a concept paper different from a research paper?

The main difference between a concept paper and a research paper is when they’re written in relation to a research project. A concept paper is written before its author begins their research, and a research paper is written after they’ve completed it. In other words, a concept paper introduces readers to its author’s academic project, and a research paper explains the outcome of the project.

Concept paper FAQs

A concept paper is often a two- to three-page paper that concisely explains a proposed research project.

When do you need a concept paper?

You need a concept paper to outline a proposed research project. Often, they are part of undergraduate, graduate, and doctoral research proposals. It’s also common for entrepreneurs and individuals conducting scientific and public-service-related research to write concept papers to garner support for their work.

What are the main steps of writing a concept paper?

Write an engaging, accurate title

• Outline the problem you aim to solve
• Write a mission statement
• Explain your research aim
• Explain your research methodology
• Explain your research methods and the potential impact of your work
• Discuss your project’s budget and how it will be allocated

While a concept paper introduces a proposed research project by outlining its purpose, process, and goals, a research paper discusses a completed project in detail.

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How to Write a Concept Paper for a PhD: A 10-Step Guide

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You’re ready to enroll for your Ph.D. studies but feeling anxious. You don’t know whether your application will be accepted or what it would take to be accepted.

Aside from your academic qualifications, a concept paper is one of the most critical determinants. If you’re planning to pursue a Ph.D., you need to learn how to write an effective concept paper to convince your professors.

Writing a concept paper requires strong analytical skills, advanced research knowledge, and excellent writing skills.

This blog post will give you a step-by-step guide on how to write a concept paper for a Ph.D. to get you a step closer to becoming a doctor of philosophy.

What is a concept paper for Ph.D.?

A concept paper for a Ph.D. is a written statement outlining the objectives and concepts of a proposed research study. It acts as an introduction to your dissertation or full thesis.

It is also an important part of the application process for Ph.D. programs and helps the admissions committee evaluate a student's research potential.

It typically includes background information on the topic to be studied, an overview of existing research, and the proposed research design. It also highlights potential results from the proposed study and their practical applications.

Ultimately, concept papers for Ph.D. programs help determine whether a student is qualified to pursue doctoral-level work in their chosen field.

How long is a Ph.D. concept paper?

The length of your concept paper will depend on your field of study and the requirements set by your university. Generally speaking, most universities expect concept papers to be between 3-5 pages long. Some papers may be longer or shorter depending on how much detail your project entails.

Key takeaways

A concept paper for Ph.D. includes:

• Background information on the topic;
• Overview of existing research;
• Proposed research design;
• Potential results from the study;
• Practical applications of the study.

How to Write a Concept Paper for Ph.D.?

An effective concept paper will help you get approval from your professor or adviser to begin your doctoral work.

What are the characteristics of a good concept paper?

A good concept paper should present an idea or topic in a clear and concise manner. It should provide an overview of what the research project will cover and explain why it’s important.

Additionally, it should highlight any potential implications of the research study and how they can be addressed or minimized. The goal of the paper is to convince the reader that your proposed project is worth pursuing and that it contributes new knowledge to your field of study.

What are the 5 elements of a concept paper?

The five elements of a concept paper are:

• Background;
• Purpose statement;
• Problem statement;
• Research questions or hypotheses;
• Significance or implications for practice.

These elements work together to provide a comprehensive overview of your proposed research project and show why it’s worth pursuing.

Here are the steps to write an outstanding concept paper that stands no chance of being rejected.

1. Define the title and purpose of your study

The first step in writing a concept paper is defining the title and purpose of your study. What will your research be about? And what are you trying to accomplish through it?

The title and purpose of your study will set the foundation for your concept paper. This part should be concise and clear so that readers understand the basis and significance of your research. When formulating the title, ensure it accurately reflects the main focus of your entire research study.

2. Describe the background and scope of your study

The next step is to provide an overview of the background information of your study topic and explain how it relates to your proposed project.

When describing the background of your study, you need to provide some context about why this topic is important enough to warrant academic inquiry.

Highlight any existing studies or theories related to your topic so that readers understand why you have chosen it as part of your dissertation research.

3. Identify the problem statement

Next, identify a problem statement that outlines what issue or gap in the knowledge you are attempting to address through your research project. Every good concept paper should include a well thought problem statement.

Your problem statement should be precise and concise so readers can easily understand what they can expect from reading further.

Here, you should make it clear why there’s a need for further investigation in your chosen field and how your research will contribute new insights into existing knowledge.

4. List your goals and objectives

Now that you’ve established your problem statement, you need to outline the specific goals and objectives that will guide you through your research.

Here, you outline what steps you’ll take and what specifically you hope to achieve in every stage of the study. This could mean anything from creating new theories, testing existing theories or models, exploring the techniques used in other studies, etc.

Your goals and objectives will give the readers a heads-up about what outcomes they can expect from the project.

Ensure whatever goals and objectives you list are measurable and achievable within the scope of your research study.

5. Formulate research questions

Next, formulate detailed research questions (and accompanying hypotheses) based on the topic you plan to explore.

These questions should include the variables you plan to manipulate or measure during data collection. Ensure the questions are clear and written in simple language so readers can understand what you’ll address through the study.

Also, don’t forget to create hypotheses for every research question you write. These are specific claims that will act as the starting points for further inquiry and potential conclusions for the study.

6. Explain the theoretical framework of the study

Once you’ve formulated your research questions, the next step is to explain the theoretical framework or foundational concept of the study.

Identify and briefly explain the theories that inspired you and connect them back to your intended study.

This will set out the context of your project and show that you’ve read and understood existing knowledge on the subject. This theoretical knowledge will come in handy if your application is accepted.

7. Write the literature review

The next step is to write the literature review. Here, you identify information and existing knowledge from previous studies and other published articles.

Your literature review should also include summaries or reviews of key texts related to your topic. You can get information for this section from peer-reviewed articles and online journals like OpenDOAR and CORE.

Remember, all the facts, statistics, and other relevant information must be accompanied by appropriate citations and references.

8. Describe the proposed research methodology

After writing the literature review, go ahead and describe the research design and methodology you’ll be employing.

Some of the critical details to include in this section include:

• What data collection methods you’ll use? (e.g., surveys, interviews, or questionnaires).
• How many participants will form your sample size?
• What data analysis methods will you use? (e.g., qualitative versus quantitative).

Be sure to highlight any ethical considerations involved in your research methodology. For instance, explain the informed consent procedures you’ll use if your research involves human participation.

Also, explain how you’ll minimize the potential risks associated with participating in your research activities.

9. Explain the significance of the study (and its implications)

Now that you’ve explained the methodology, it’s time to let the readers understand why this study is important and why it makes a significant contribution to existing research.

Additionally, explain how this study will impact theory development and its significance for policymakers or practitioners in your field of study.

You should also discuss any potential implications of conducting this research (e.g., ethical considerations or political ramifications).

10. Include references/bibliography

Finally, include references or a bibliography at the end of your concept paper to build credibility for your research paper.

A bibliography enables you to give credit where it belongs by recognizing the owners of your reference materials.

Ensure you format references properly according to the style specified by the institution you’re applying to. This could be, for example, APA, MLA, or Harvard referencing style.

What is the difference between a concept paper and a research paper?

A concept paper outlines what you plan to do (in future tense), while a research paper explains what you did (in past tense) after completing your research project. In other words, a concept paper serves as an introduction to your research, while a research paper provides evidence-based results from experiments conducted during your study.

Final thoughts

The thought of writing a concept paper for your Ph.D. can be intimidating at first. However, once you know the right approach to take and invest enough time, the writing process becomes hassle-free.

Start by brainstorming your ideas, researching related topics, and creating an outline. Also, ensure you clearly define your concept and know the exact approach you’ll be taking. This way, you won’t find yourself stuck when your concept paper has been approved for further research.

After completing the paper, revise it to ensure everything is clear and accurate with no typos. In the end, you’ll have an excellent concept paper that will pave the way for you to pursue your doctoral studies.

If you need help writing a concept paper for your Ph.D., turn to Writers Per Hour for assistance. With expert Doctoral writers on the team, we can draft a compelling concept paper that is 100% original and written from scratch as per your requirements.

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Cultural Relativity and Acceptance of Embryonic Stem Cell Research

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There is a debate about the ethical implications of using human embryos in stem cell research, which can be influenced by cultural, moral, and social values. This paper argues for an adaptable framework to accommodate diverse cultural and religious perspectives. By using an adaptive ethics model, research protections can reflect various populations and foster growth in stem cell research possibilities.

INTRODUCTION

Stem cell research combines biology, medicine, and technology, promising to alter health care and the understanding of human development. Yet, ethical contention exists because of individuals’ perceptions of using human embryos based on their various cultural, moral, and social values. While these disagreements concerning policy, use, and general acceptance have prompted the development of an international ethics policy, such a uniform approach can overlook the nuanced ethical landscapes between cultures. With diverse viewpoints in public health, a single global policy, especially one reflecting Western ethics or the ethics prevalent in high-income countries, is impractical. This paper argues for a culturally sensitive, adaptable framework for the use of embryonic stem cells. Stem cell policy should accommodate varying ethical viewpoints and promote an effective global dialogue. With an extension of an ethics model that can adapt to various cultures, we recommend localized guidelines that reflect the moral views of the people those guidelines serve.

Stem cells, characterized by their unique ability to differentiate into various cell types, enable the repair or replacement of damaged tissues. Two primary types of stem cells are somatic stem cells (adult stem cells) and embryonic stem cells. Adult stem cells exist in developed tissues and maintain the body’s repair processes. [1] Embryonic stem cells (ESC) are remarkably pluripotent or versatile, making them valuable in research. [2] However, the use of ESCs has sparked ethics debates. Considering the potential of embryonic stem cells, research guidelines are essential. The International Society for Stem Cell Research (ISSCR) provides international stem cell research guidelines. They call for “public conversations touching on the scientific significance as well as the societal and ethical issues raised by ESC research.” [3] The ISSCR also publishes updates about culturing human embryos 14 days post fertilization, suggesting local policies and regulations should continue to evolve as ESC research develops. [4]  Like the ISSCR, which calls for local law and policy to adapt to developing stem cell research given cultural acceptance, this paper highlights the importance of local social factors such as religion and culture.

I.     Global Cultural Perspective of Embryonic Stem Cells

Views on ESCs vary throughout the world. Some countries readily embrace stem cell research and therapies, while others have stricter regulations due to ethical concerns surrounding embryonic stem cells and when an embryo becomes entitled to moral consideration. The philosophical issue of when the “someone” begins to be a human after fertilization, in the morally relevant sense, [5] impacts when an embryo becomes not just worthy of protection but morally entitled to it. The process of creating embryonic stem cell lines involves the destruction of the embryos for research. [6] Consequently, global engagement in ESC research depends on social-cultural acceptability.

a.     US and Rights-Based Cultures

In the United States, attitudes toward stem cell therapies are diverse. The ethics and social approaches, which value individualism, [7] trigger debates regarding the destruction of human embryos, creating a complex regulatory environment. For example, the 1996 Dickey-Wicker Amendment prohibited federal funding for the creation of embryos for research and the destruction of embryos for “more than allowed for research on fetuses in utero.” [8] Following suit, in 2001, the Bush Administration heavily restricted stem cell lines for research. However, the Stem Cell Research Enhancement Act of 2005 was proposed to help develop ESC research but was ultimately vetoed. [9] Under the Obama administration, in 2009, an executive order lifted restrictions allowing for more development in this field. [10] The flux of research capacity and funding parallels the different cultural perceptions of human dignity of the embryo and how it is socially presented within the country’s research culture. [11]

b.     Ubuntu and Collective Cultures

African bioethics differs from Western individualism because of the different traditions and values. African traditions, as described by individuals from South Africa and supported by some studies in other African countries, including Ghana and Kenya, follow the African moral philosophies of Ubuntu or Botho and Ukama , which “advocates for a form of wholeness that comes through one’s relationship and connectedness with other people in the society,” [12] making autonomy a socially collective concept. In this context, for the community to act autonomously, individuals would come together to decide what is best for the collective. Thus, stem cell research would require examining the value of the research to society as a whole and the use of the embryos as a collective societal resource. If society views the source as part of the collective whole, and opposes using stem cells, compromising the cultural values to pursue research may cause social detachment and stunt research growth. [13] Based on local culture and moral philosophy, the permissibility of stem cell research depends on how embryo, stem cell, and cell line therapies relate to the community as a whole. Ubuntu is the expression of humanness, with the person’s identity drawn from the “’I am because we are’” value. [14] The decision in a collectivistic culture becomes one born of cultural context, and individual decisions give deference to others in the society.

Consent differs in cultures where thought and moral philosophy are based on a collective paradigm. So, applying Western bioethical concepts is unrealistic. For one, Africa is a diverse continent with many countries with different belief systems, access to health care, and reliance on traditional or Western medicines. Where traditional medicine is the primary treatment, the “’restrictive focus on biomedically-related bioethics’” [is] problematic in African contexts because it neglects bioethical issues raised by traditional systems.” [15] No single approach applies in all areas or contexts. Rather than evaluating the permissibility of ESC research according to Western concepts such as the four principles approach, different ethics approaches should prevail.

Another consideration is the socio-economic standing of countries. In parts of South Africa, researchers have not focused heavily on contributing to the stem cell discourse, either because it is not considered health care or a health science priority or because resources are unavailable. [16] Each country’s priorities differ given different social, political, and economic factors. In South Africa, for instance, areas such as maternal mortality, non-communicable diseases, telemedicine, and the strength of health systems need improvement and require more focus. [17] Stem cell research could benefit the population, but it also could divert resources from basic medical care. Researchers in South Africa adhere to the National Health Act and Medicines Control Act in South Africa and international guidelines; however, the Act is not strictly enforced, and there is no clear legislation for research conduct or ethical guidelines. [18]

Some parts of Africa condemn stem cell research. For example, 98.2 percent of the Tunisian population is Muslim. [19] Tunisia does not permit stem cell research because of moral conflict with a Fatwa. Religion heavily saturates the regulation and direction of research. [20] Stem cell use became permissible for reproductive purposes only recently, with tight restrictions preventing cells from being used in any research other than procedures concerning ART/IVF.  Their use is conditioned on consent, and available only to married couples. [21] The community's receptiveness to stem cell research depends on including communitarian African ethics.

c.     Asia

Some Asian countries also have a collective model of ethics and decision making. [22] In China, the ethics model promotes a sincere respect for life or human dignity, [23] based on protective medicine. This model, influenced by Traditional Chinese Medicine (TCM), [24] recognizes Qi as the vital energy delivered via the meridians of the body; it connects illness to body systems, the body’s entire constitution, and the universe for a holistic bond of nature, health, and quality of life. [25] Following a protective ethics model, and traditional customs of wholeness, investment in stem cell research is heavily desired for its applications in regenerative therapies, disease modeling, and protective medicines. In a survey of medical students and healthcare practitioners, 30.8 percent considered stem cell research morally unacceptable while 63.5 percent accepted medical research using human embryonic stem cells. Of these individuals, 89.9 percent supported increased funding for stem cell research. [26] The scientific community might not reflect the overall population. From 1997 to 2019, China spent a total of $576 million (USD) on stem cell research at 8,050 stem cell programs, increased published presence from 0.6 percent to 14.01 percent of total global stem cell publications as of 2014, and made significant strides in cell-based therapies for various medical conditions. [27] However, while China has made substantial investments in stem cell research and achieved notable progress in clinical applications, concerns linger regarding ethical oversight and transparency. [28] For example, the China Biosecurity Law, promoted by the National Health Commission and China Hospital Association, attempted to mitigate risks by introducing an institutional review board (IRB) in the regulatory bodies. 5800 IRBs registered with the Chinese Clinical Trial Registry since 2021. [29] However, issues still need to be addressed in implementing effective IRB review and approval procedures.

The substantial government funding and focus on scientific advancement have sometimes overshadowed considerations of regional cultures, ethnic minorities, and individual perspectives, particularly evident during the one-child policy era. As government policy adapts to promote public stability, such as the change from the one-child to the two-child policy, [30] research ethics should also adapt to ensure respect for the values of its represented peoples.

Japan is also relatively supportive of stem cell research and therapies. Japan has a more transparent regulatory framework, allowing for faster approval of regenerative medicine products, which has led to several advanced clinical trials and therapies. [31] South Korea is also actively engaged in stem cell research and has a history of breakthroughs in cloning and embryonic stem cells. [32] However, the field is controversial, and there are issues of scientific integrity. For example, the Korean FDA fast-tracked products for approval, [33] and in another instance, the oocyte source was unclear and possibly violated ethical standards. [34] Trust is important in research, as it builds collaborative foundations between colleagues, trial participant comfort, open-mindedness for complicated and sensitive discussions, and supports regulatory procedures for stakeholders. There is a need to respect the culture’s interest, engagement, and for research and clinical trials to be transparent and have ethical oversight to promote global research discourse and trust.

d.     Middle East

Countries in the Middle East have varying degrees of acceptance of or restrictions to policies related to using embryonic stem cells due to cultural and religious influences. Saudi Arabia has made significant contributions to stem cell research, and conducts research based on international guidelines for ethical conduct and under strict adherence to guidelines in accordance with Islamic principles. Specifically, the Saudi government and people require ESC research to adhere to Sharia law. In addition to umbilical and placental stem cells, [35] Saudi Arabia permits the use of embryonic stem cells as long as they come from miscarriages, therapeutic abortions permissible by Sharia law, or are left over from in vitro fertilization and donated to research. [36] Laws and ethical guidelines for stem cell research allow the development of research institutions such as the King Abdullah International Medical Research Center, which has a cord blood bank and a stem cell registry with nearly 10,000 donors. [37] Such volume and acceptance are due to the ethical ‘permissibility’ of the donor sources, which do not conflict with religious pillars. However, some researchers err on the side of caution, choosing not to use embryos or fetal tissue as they feel it is unethical to do so. [38]

Jordan has a positive research ethics culture. [39] However, there is a significant issue of lack of trust in researchers, with 45.23 percent (38.66 percent agreeing and 6.57 percent strongly agreeing) of Jordanians holding a low level of trust in researchers, compared to 81.34 percent of Jordanians agreeing that they feel safe to participate in a research trial. [40] Safety testifies to the feeling of confidence that adequate measures are in place to protect participants from harm, whereas trust in researchers could represent the confidence in researchers to act in the participants’ best interests, adhere to ethical guidelines, provide accurate information, and respect participants’ rights and dignity. One method to improve trust would be to address communication issues relevant to ESC. Legislation surrounding stem cell research has adopted specific language, especially concerning clarification “between ‘stem cells’ and ‘embryonic stem cells’” in translation. [41] Furthermore, legislation “mandates the creation of a national committee… laying out specific regulations for stem-cell banking in accordance with international standards.” [42] This broad regulation opens the door for future global engagement and maintains transparency. However, these regulations may also constrain the influence of research direction, pace, and accessibility of research outcomes.

e.     Europe

In the European Union (EU), ethics is also principle-based, but the principles of autonomy, dignity, integrity, and vulnerability are interconnected. [43] As such, the opportunity for cohesion and concessions between individuals’ thoughts and ideals allows for a more adaptable ethics model due to the flexible principles that relate to the human experience The EU has put forth a framework in its Convention for the Protection of Human Rights and Dignity of the Human Being allowing member states to take different approaches. Each European state applies these principles to its specific conventions, leading to or reflecting different acceptance levels of stem cell research. [44]

For example, in Germany, Lebenzusammenhang , or the coherence of life, references integrity in the unity of human culture. Namely, the personal sphere “should not be subject to external intervention.” [45]  Stem cell interventions could affect this concept of bodily completeness, leading to heavy restrictions. Under the Grundgesetz, human dignity and the right to life with physical integrity are paramount. [46] The Embryo Protection Act of 1991 made producing cell lines illegal. Cell lines can be imported if approved by the Central Ethics Commission for Stem Cell Research only if they were derived before May 2007. [47] Stem cell research respects the integrity of life for the embryo with heavy specifications and intense oversight. This is vastly different in Finland, where the regulatory bodies find research more permissible in IVF excess, but only up to 14 days after fertilization. [48] Spain’s approach differs still, with a comprehensive regulatory framework. [49] Thus, research regulation can be culture-specific due to variations in applied principles. Diverse cultures call for various approaches to ethical permissibility. [50] Only an adaptive-deliberative model can address the cultural constructions of self and achieve positive, culturally sensitive stem cell research practices. [51]

II.     Religious Perspectives on ESC

Embryonic stem cell sources are the main consideration within religious contexts. While individuals may not regard their own religious texts as authoritative or factual, religion can shape their foundations or perspectives.

The Qur'an states:

“And indeed We created man from a quintessence of clay. Then We placed within him a small quantity of nutfa (sperm to fertilize) in a safe place. Then We have fashioned the nutfa into an ‘alaqa (clinging clot or cell cluster), then We developed the ‘alaqa into mudgha (a lump of flesh), and We made mudgha into bones, and clothed the bones with flesh, then We brought it into being as a new creation. So Blessed is Allah, the Best of Creators.” [52]

Many scholars of Islam estimate the time of soul installment, marked by the angel breathing in the soul to bring the individual into creation, as 120 days from conception. [53] Personhood begins at this point, and the value of life would prohibit research or experimentation that could harm the individual. If the fetus is more than 120 days old, the time ensoulment is interpreted to occur according to Islamic law, abortion is no longer permissible. [54] There are a few opposing opinions about early embryos in Islamic traditions. According to some Islamic theologians, there is no ensoulment of the early embryo, which is the source of stem cells for ESC research. [55]

In Buddhism, the stance on stem cell research is not settled. The main tenets, the prohibition against harming or destroying others (ahimsa) and the pursuit of knowledge (prajña) and compassion (karuna), leave Buddhist scholars and communities divided. [56] Some scholars argue stem cell research is in accordance with the Buddhist tenet of seeking knowledge and ending human suffering. Others feel it violates the principle of not harming others. Finding the balance between these two points relies on the karmic burden of Buddhist morality. In trying to prevent ahimsa towards the embryo, Buddhist scholars suggest that to comply with Buddhist tenets, research cannot be done as the embryo has personhood at the moment of conception and would reincarnate immediately, harming the individual's ability to build their karmic burden. [57] On the other hand, the Bodhisattvas, those considered to be on the path to enlightenment or Nirvana, have given organs and flesh to others to help alleviate grieving and to benefit all. [58] Acceptance varies on applied beliefs and interpretations.

Catholicism does not support embryonic stem cell research, as it entails creation or destruction of human embryos. This destruction conflicts with the belief in the sanctity of life. For example, in the Old Testament, Genesis describes humanity as being created in God’s image and multiplying on the Earth, referencing the sacred rights to human conception and the purpose of development and life. In the Ten Commandments, the tenet that one should not kill has numerous interpretations where killing could mean murder or shedding of the sanctity of life, demonstrating the high value of human personhood. In other books, the theological conception of when life begins is interpreted as in utero, [59] highlighting the inviolability of life and its formation in vivo to make a religious point for accepting such research as relatively limited, if at all. [60] The Vatican has released ethical directives to help apply a theological basis to modern-day conflicts. The Magisterium of the Church states that “unless there is a moral certainty of not causing harm,” experimentation on fetuses, fertilized cells, stem cells, or embryos constitutes a crime. [61] Such procedures would not respect the human person who exists at these stages, according to Catholicism. Damages to the embryo are considered gravely immoral and illicit. [62] Although the Catholic Church officially opposes abortion, surveys demonstrate that many Catholic people hold pro-choice views, whether due to the context of conception, stage of pregnancy, threat to the mother’s life, or for other reasons, demonstrating that practicing members can also accept some but not all tenets. [63]

Some major Jewish denominations, such as the Reform, Conservative, and Reconstructionist movements, are open to supporting ESC use or research as long as it is for saving a life. [64] Within Judaism, the Talmud, or study, gives personhood to the child at birth and emphasizes that life does not begin at conception: [65]

“If she is found pregnant, until the fortieth day it is mere fluid,” [66]

Whereas most religions prioritize the status of human embryos, the Halakah (Jewish religious law) states that to save one life, most other religious laws can be ignored because it is in pursuit of preservation. [67] Stem cell research is accepted due to application of these religious laws.

We recognize that all religions contain subsets and sects. The variety of environmental and cultural differences within religious groups requires further analysis to respect the flexibility of religious thoughts and practices. We make no presumptions that all cultures require notions of autonomy or morality as under the common morality theory , which asserts a set of universal moral norms that all individuals share provides moral reasoning and guides ethical decisions. [68] We only wish to show that the interaction with morality varies between cultures and countries.

III.     A Flexible Ethical Approach

The plurality of different moral approaches described above demonstrates that there can be no universally acceptable uniform law for ESC on a global scale. Instead of developing one standard, flexible ethical applications must be continued. We recommend local guidelines that incorporate important cultural and ethical priorities.

While the Declaration of Helsinki is more relevant to people in clinical trials receiving ESC products, in keeping with the tradition of protections for research subjects, consent of the donor is an ethical requirement for ESC donation in many jurisdictions including the US, Canada, and Europe. [69] The Declaration of Helsinki provides a reference point for regulatory standards and could potentially be used as a universal baseline for obtaining consent prior to gamete or embryo donation.

For instance, in Columbia University’s egg donor program for stem cell research, donors followed standard screening protocols and “underwent counseling sessions that included information as to the purpose of oocyte donation for research, what the oocytes would be used for, the risks and benefits of donation, and process of oocyte stimulation” to ensure transparency for consent. [70] The program helped advance stem cell research and provided clear and safe research methods with paid participants. Though paid participation or covering costs of incidental expenses may not be socially acceptable in every culture or context, [71] and creating embryos for ESC research is illegal in many jurisdictions, Columbia’s program was effective because of the clear and honest communications with donors, IRBs, and related stakeholders.  This example demonstrates that cultural acceptance of scientific research and of the idea that an egg or embryo does not have personhood is likely behind societal acceptance of donating eggs for ESC research. As noted, many countries do not permit the creation of embryos for research.

Proper communication and education regarding the process and purpose of stem cell research may bolster comprehension and garner more acceptance. “Given the sensitive subject material, a complete consent process can support voluntary participation through trust, understanding, and ethical norms from the cultures and morals participants value. This can be hard for researchers entering countries of different socioeconomic stability, with different languages and different societal values. [72]

An adequate moral foundation in medical ethics is derived from the cultural and religious basis that informs knowledge and actions. [73] Understanding local cultural and religious values and their impact on research could help researchers develop humility and promote inclusion.

IV.     Concerns

Some may argue that if researchers all adhere to one ethics standard, protection will be satisfied across all borders, and the global public will trust researchers. However, defining what needs to be protected and how to define such research standards is very specific to the people to which standards are applied. We suggest that applying one uniform guide cannot accurately protect each individual because we all possess our own perceptions and interpretations of social values. [74] Therefore, the issue of not adjusting to the moral pluralism between peoples in applying one standard of ethics can be resolved by building out ethics models that can be adapted to different cultures and religions.

Other concerns include medical tourism, which may promote health inequities. [75] Some countries may develop and approve products derived from ESC research before others, compromising research ethics or drug approval processes. There are also concerns about the sale of unauthorized stem cell treatments, for example, those without FDA approval in the United States. Countries with robust research infrastructures may be tempted to attract medical tourists, and some customers will have false hopes based on aggressive publicity of unproven treatments. [76]

For example, in China, stem cell clinics can market to foreign clients who are not protected under the regulatory regimes. Companies employ a marketing strategy of “ethically friendly” therapies. Specifically, in the case of Beike, China’s leading stem cell tourism company and sprouting network, ethical oversight of administrators or health bureaus at one site has “the unintended consequence of shifting questionable activities to another node in Beike's diffuse network.” [77] In contrast, Jordan is aware of stem cell research’s potential abuse and its own status as a “health-care hub.” Jordan’s expanded regulations include preserving the interests of individuals in clinical trials and banning private companies from ESC research to preserve transparency and the integrity of research practices. [78]

The social priorities of the community are also a concern. The ISSCR explicitly states that guidelines “should be periodically revised to accommodate scientific advances, new challenges, and evolving social priorities.” [79] The adaptable ethics model extends this consideration further by addressing whether research is warranted given the varying degrees of socioeconomic conditions, political stability, and healthcare accessibilities and limitations. An ethical approach would require discussion about resource allocation and appropriate distribution of funds. [80]

While some religions emphasize the sanctity of life from conception, which may lead to public opposition to ESC research, others encourage ESC research due to its potential for healing and alleviating human pain. Many countries have special regulations that balance local views on embryonic personhood, the benefits of research as individual or societal goods, and the protection of human research subjects. To foster understanding and constructive dialogue, global policy frameworks should prioritize the protection of universal human rights, transparency, and informed consent. In addition to these foundational global policies, we recommend tailoring local guidelines to reflect the diverse cultural and religious perspectives of the populations they govern. Ethics models should be adapted to local populations to effectively establish research protections, growth, and possibilities of stem cell research.

For example, in countries with strong beliefs in the moral sanctity of embryos or heavy religious restrictions, an adaptive model can allow for discussion instead of immediate rejection. In countries with limited individual rights and voice in science policy, an adaptive model ensures cultural, moral, and religious views are taken into consideration, thereby building social inclusion. While this ethical consideration by the government may not give a complete voice to every individual, it will help balance policies and maintain the diverse perspectives of those it affects. Embracing an adaptive ethics model of ESC research promotes open-minded dialogue and respect for the importance of human belief and tradition. By actively engaging with cultural and religious values, researchers can better handle disagreements and promote ethical research practices that benefit each society.

This brief exploration of the religious and cultural differences that impact ESC research reveals the nuances of relative ethics and highlights a need for local policymakers to apply a more intense adaptive model.

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[5] Concerning the moral philosophies of stem cell research, our paper does not posit a personal moral stance nor delve into the “when” of human life begins. To read further about the philosophical debate, consider the following sources:

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[7] Socially, at its core, the Western approach to ethics is widely principle-based, autonomy being one of the key factors to ensure a fundamental respect for persons within research. For information regarding autonomy in research, see: Department of Health, Education, and Welfare, & National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research (1978). The Belmont Report. Ethical principles and guidelines for the protection of human subjects of research.; For a more in-depth review of autonomy within the US, see: Beauchamp, T. L., & Childress, J. F. (1994). Principles of Biomedical Ethics . Oxford University Press.

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[9] Stem Cell Research Enhancement Act of 2005, H. R. 810, 109 th Cong. (2001). https://www.govtrack.us/congress/bills/109/hr810/text ; Bush, G. W. (2006, July 19). Message to the House of Representatives . National Archives and Records Administration. https://georgewbush-whitehouse.archives.gov/news/releases/2006/07/20060719-5.html

[10] National Archives and Records Administration. (2009, March 9). Executive order 13505 -- removing barriers to responsible scientific research involving human stem cells . National Archives and Records Administration. https://obamawhitehouse.archives.gov/the-press-office/removing-barriers-responsible-scientific-research-involving-human-stem-cells

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[13] Source for further reading: Tangwa G. B. (2007). Moral status of embryonic stem cells: perspective of an African villager. Bioethics , 21(8), 449–457. https://doi.org/10.1111/j.1467-8519.2007.00582.x , see also Mnisi, F. M. (2020). An African analysis based on ethics of Ubuntu - are human embryonic stem cell patents morally justifiable? African Insight , 49 (4).

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[17] Department of Health Republic of South Africa. (2021). Health Research Priorities (revised) for South Africa 2021-2024 . National Health Research Strategy. https://www.health.gov.za/wp-content/uploads/2022/05/National-Health-Research-Priorities-2021-2024.pdf

[18] Oosthuizen, H. (2013). Legal and Ethical Issues in Stem Cell Research in South Africa. In: Beran, R. (eds) Legal and Forensic Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-32338-6_80 , see also: Gaobotse G (2018) Stem Cell Research in Africa: Legislation and Challenges. J Regen Med 7:1. doi: 10.4172/2325-9620.1000142

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[21] Kooli, C. Review of assisted reproduction techniques, laws, and regulations in Muslim countries.  Middle East Fertil Soc J   24 , 8 (2020). https://doi.org/10.1186/s43043-019-0011-0 ; Gaobotse, G. (2018) Stem Cell Research in Africa: Legislation and Challenges. J Regen Med 7:1. doi: 10.4172/2325-9620.1000142

[22] Pang M. C. (1999). Protective truthfulness: the Chinese way of safeguarding patients in informed treatment decisions. Journal of medical ethics , 25(3), 247–253. https://doi.org/10.1136/jme.25.3.247

[23] Wang, L., Wang, F., & Zhang, W. (2021). Bioethics in China’s biosecurity law: Forms, effects, and unsettled issues. Journal of law and the biosciences , 8(1).  https://doi.org/10.1093/jlb/lsab019 https://academic.oup.com/jlb/article/8/1/lsab019/6299199

[24] Wang, Y., Xue, Y., & Guo, H. D. (2022). Intervention effects of traditional Chinese medicine on stem cell therapy of myocardial infarction.  Frontiers in pharmacology ,  13 , 1013740. https://doi.org/10.3389/fphar.2022.1013740

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[30] Chen, H., Wei, T., Wang, H.  et al.  Association of China’s two-child policy with changes in number of births and birth defects rate, 2008–2017.  BMC Public Health   22 , 434 (2022). https://doi.org/10.1186/s12889-022-12839-0

[31] Azuma, K. Regulatory Landscape of Regenerative Medicine in Japan.  Curr Stem Cell Rep   1 , 118–128 (2015). https://doi.org/10.1007/s40778-015-0012-6

[32] Harris, R. (2005, May 19). Researchers Report Advance in Stem Cell Production . NPR. https://www.npr.org/2005/05/19/4658967/researchers-report-advance-in-stem-cell-production

[33] Park, S. (2012). South Korea steps up stem-cell work.  Nature . https://doi.org/10.1038/nature.2012.10565

[34] Resnik, D. B., Shamoo, A. E., & Krimsky, S. (2006). Fraudulent human embryonic stem cell research in South Korea: lessons learned.  Accountability in research ,  13 (1), 101–109. https://doi.org/10.1080/08989620600634193 .

[35] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: interviews with researchers from Saudi Arabia. BMC medical ethics, 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6

[36] Association for the Advancement of Blood and Biotherapies.  https://www.aabb.org/regulatory-and-advocacy/regulatory-affairs/regulatory-for-cellular-therapies/international-competent-authorities/saudi-arabia

[37] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: Interviews with researchers from Saudi Arabia.  BMC medical ethics ,  21 (1), 35. https://doi.org/10.1186/s12910-020-00482-6

[38] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: Interviews with researchers from Saudi Arabia. BMC medical ethics , 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6

Culturally, autonomy practices follow a relational autonomy approach based on a paternalistic deontological health care model. The adherence to strict international research policies and religious pillars within the regulatory environment is a great foundation for research ethics. However, there is a need to develop locally targeted ethics approaches for research (as called for in Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: interviews with researchers from Saudi Arabia. BMC medical ethics, 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6), this decision-making approach may help advise a research decision model. For more on the clinical cultural autonomy approaches, see: Alabdullah, Y. Y., Alzaid, E., Alsaad, S., Alamri, T., Alolayan, S. W., Bah, S., & Aljoudi, A. S. (2022). Autonomy and paternalism in Shared decision‐making in a Saudi Arabian tertiary hospital: A cross‐sectional study. Developing World Bioethics , 23 (3), 260–268. https://doi.org/10.1111/dewb.12355 ; Bukhari, A. A. (2017). Universal Principles of Bioethics and Patient Rights in Saudi Arabia (Doctoral dissertation, Duquesne University). https://dsc.duq.edu/etd/124; Ladha, S., Nakshawani, S. A., Alzaidy, A., & Tarab, B. (2023, October 26). Islam and Bioethics: What We All Need to Know . Columbia University School of Professional Studies. https://sps.columbia.edu/events/islam-and-bioethics-what-we-all-need-know

[39] Ababneh, M. A., Al-Azzam, S. I., Alzoubi, K., Rababa’h, A., & Al Demour, S. (2021). Understanding and attitudes of the Jordanian public about clinical research ethics.  Research Ethics ,  17 (2), 228-241.  https://doi.org/10.1177/1747016120966779

[40] Ababneh, M. A., Al-Azzam, S. I., Alzoubi, K., Rababa’h, A., & Al Demour, S. (2021). Understanding and attitudes of the Jordanian public about clinical research ethics.  Research Ethics ,  17 (2), 228-241.  https://doi.org/10.1177/1747016120966779

[41] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[42] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[43] The EU’s definition of autonomy relates to the capacity for creating ideas, moral insight, decisions, and actions without constraint, personal responsibility, and informed consent. However, the EU views autonomy as not completely able to protect individuals and depends on other principles, such as dignity, which “expresses the intrinsic worth and fundamental equality of all human beings.” Rendtorff, J.D., Kemp, P. (2019). Four Ethical Principles in European Bioethics and Biolaw: Autonomy, Dignity, Integrity and Vulnerability. In: Valdés, E., Lecaros, J. (eds) Biolaw and Policy in the Twenty-First Century. International Library of Ethics, Law, and the New Medicine, vol 78. Springer, Cham. https://doi.org/10.1007/978-3-030-05903-3_3

[44] Council of Europe. Convention for the protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine: Convention on Human Rights and Biomedicine (ETS No. 164) https://www.coe.int/en/web/conventions/full-list?module=treaty-detail&treatynum=164 (forbidding the creation of embryos for research purposes only, and suggests embryos in vitro have protections.); Also see Drabiak-Syed B. K. (2013). New President, New Human Embryonic Stem Cell Research Policy: Comparative International Perspectives and Embryonic Stem Cell Research Laws in France.  Biotechnology Law Report ,  32 (6), 349–356. https://doi.org/10.1089/blr.2013.9865

[45] Rendtorff, J.D., Kemp, P. (2019). Four Ethical Principles in European Bioethics and Biolaw: Autonomy, Dignity, Integrity and Vulnerability. In: Valdés, E., Lecaros, J. (eds) Biolaw and Policy in the Twenty-First Century. International Library of Ethics, Law, and the New Medicine, vol 78. Springer, Cham. https://doi.org/10.1007/978-3-030-05903-3_3

[46] Tomuschat, C., Currie, D. P., Kommers, D. P., & Kerr, R. (Trans.). (1949, May 23). Basic law for the Federal Republic of Germany. https://www.btg-bestellservice.de/pdf/80201000.pdf

[47] Regulation of Stem Cell Research in Germany . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-germany

[48] Regulation of Stem Cell Research in Finland . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-finland

[49] Regulation of Stem Cell Research in Spain . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-spain

[50] Some sources to consider regarding ethics models or regulatory oversights of other cultures not covered:

Kara MA. Applicability of the principle of respect for autonomy: the perspective of Turkey. J Med Ethics. 2007 Nov;33(11):627-30. doi: 10.1136/jme.2006.017400. PMID: 17971462; PMCID: PMC2598110.

Ugarte, O. N., & Acioly, M. A. (2014). The principle of autonomy in Brazil: one needs to discuss it ...  Revista do Colegio Brasileiro de Cirurgioes ,  41 (5), 374–377. https://doi.org/10.1590/0100-69912014005013

Bharadwaj, A., & Glasner, P. E. (2012). Local cells, global science: The rise of embryonic stem cell research in India . Routledge.

For further research on specific European countries regarding ethical and regulatory framework, we recommend this database: Regulation of Stem Cell Research in Europe . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-europe   

[51] Klitzman, R. (2006). Complications of culture in obtaining informed consent. The American Journal of Bioethics, 6(1), 20–21. https://doi.org/10.1080/15265160500394671 see also: Ekmekci, P. E., & Arda, B. (2017). Interculturalism and Informed Consent: Respecting Cultural Differences without Breaching Human Rights.  Cultura (Iasi, Romania) ,  14 (2), 159–172.; For why trust is important in research, see also: Gray, B., Hilder, J., Macdonald, L., Tester, R., Dowell, A., & Stubbe, M. (2017). Are research ethics guidelines culturally competent?  Research Ethics ,  13 (1), 23-41.  https://doi.org/10.1177/1747016116650235

[52] The Qur'an  (M. Khattab, Trans.). (1965). Al-Mu’minun, 23: 12-14. https://quran.com/23

[53] Lenfest, Y. (2017, December 8). Islam and the beginning of human life . Bill of Health. https://blog.petrieflom.law.harvard.edu/2017/12/08/islam-and-the-beginning-of-human-life/

[54] Aksoy, S. (2005). Making regulations and drawing up legislation in Islamic countries under conditions of uncertainty, with special reference to embryonic stem cell research. Journal of Medical Ethics , 31: 399-403.; see also: Mahmoud, Azza. "Islamic Bioethics: National Regulations and Guidelines of Human Stem Cell Research in the Muslim World." Master's thesis, Chapman University, 2022. https://doi.org/10.36837/ chapman.000386

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[57] Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

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[59] There is no explicit religious reference to when life begins or how to conduct research that interacts with the concept of life. However, these are relevant verses pertaining to how the fetus is viewed. (( King James Bible . (1999). Oxford University Press. (original work published 1769))

Jerimiah 1: 5 “Before I formed thee in the belly I knew thee; and before thou camest forth out of the womb I sanctified thee…”

In prophet Jerimiah’s insight, God set him apart as a person known before childbirth, a theme carried within the Psalm of David.

Psalm 139: 13-14 “…Thou hast covered me in my mother's womb. I will praise thee; for I am fearfully and wonderfully made…”

These verses demonstrate David’s respect for God as an entity that would know of all man’s thoughts and doings even before birth.

[60] It should be noted that abortion is not supported as well.

[61] The Vatican. (1987, February 22). Instruction on Respect for Human Life in Its Origin and on the Dignity of Procreation Replies to Certain Questions of the Day . Congregation For the Doctrine of the Faith. https://www.vatican.va/roman_curia/congregations/cfaith/documents/rc_con_cfaith_doc_19870222_respect-for-human-life_en.html

[62] The Vatican. (2000, August 25). Declaration On the Production and the Scientific and Therapeutic Use of Human Embryonic Stem Cells . Pontifical Academy for Life. https://www.vatican.va/roman_curia/pontifical_academies/acdlife/documents/rc_pa_acdlife_doc_20000824_cellule-staminali_en.html ; Ohara, N. (2003). Ethical Consideration of Experimentation Using Living Human Embryos: The Catholic Church’s Position on Human Embryonic Stem Cell Research and Human Cloning. Department of Obstetrics and Gynecology . Retrieved from https://article.imrpress.com/journal/CEOG/30/2-3/pii/2003018/77-81.pdf.

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Can the greening of the tax system improve enterprises’ ESG performance? Evidence from China

• Published: 15 May 2024
• Volume 57 , article number  127 , ( 2024 )

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• Caiyun Lin 1 ,
• Shibao Lu 2 ,
• Xuyang Su 1 &
• Chuanhao Wen 1  

Can the greening of the tax system truly drive high-quality development of enterprises? ESG, as an investment concept and evaluation criterion focusing on corporate sustainable development, is an essential tool for enterprises to practice high-quality economic development. Based on this, using China’s environmental protection tax reform in 2018 as a natural experiment, this paper examines the impact and transmission paths of environmental protection tax on enterprises’ ESG performance from the unique dual perspectives of external attention and internal decision-making, adopting a diference-in-differences (DID) approach. The study finds that, firstly, environmental protection tax significantly improves enterprises’ ESG levels through the internal level of green innovation and external public environmental concerns. Moreover, the level of internal governance and external analyst attention play a positive moderating role in this process. Secondly, the improvement effect of environmental protection tax on enterprises’ ESG performance is more significant for manufacturing enterprises, non-state-owned enterprises, financially resource-rich enterprises, and enterprises located in regions with higher economic growth, lower government-market linkage, and better legal environment. This research responds to the fundamental question of whether the greening of the tax system can truly promote high-quality development of enterprises, and provides valuable insight into how to further enhance the promoting role of environmental protection tax on enterprises’ ESG performance.

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The environmental protection tax reform implemented since 2018 generally refers to the original pollution discharge fee system. However, local governments are allowed to independently increase the collection standards for taxable pollutants within 10 times the minimum collection standard set by the central government for major pollutants. After the official implementation of the environmental protection tax, some provinces and cities have increased the collection standards for taxable pollutants, which means an increase in the environmental protection tax rate. Meanwhile, other provinces and cities have kept the environmental protection tax rate unchanged from the previous pollutant discharge fee standards, following the principle of “tax burden remains the same”.

Environmental regulations in China can be categorized into three types: command and control regulations, market-based environmental regulations, and public participation regulations.

In order to address the challenges of cross-regional environmental governance and strengthen the national ecological environment supervision capacity, China has established a regional environmental inspection system. This system began with the establishment of the “Regional Environmental supervision Center”. With the adoption of the “Environmental Protection Inspection Plan (Trial)” in 2015, the “Regional Environmental supervision Center” was adjusted to the “Regional Environmental Inspection Bureau”, thus clearly establishing an environmental inspection mechanism.

The definition of heavily-polluting industries is based on the criteria provided by the China Securities Regulatory Commission's revised “Guidelines for Industry Classification of listed companies” in 2012 and the Ministry of Environmental Protection's published “List of Classification and Management of Environmental Protection Inspection Industries for listed companies”.

The marketization index constructed by Fan Gang and Wang Xiaolu et al. consists of five components: government-market relationship, non-state economic development, degree of product market development, degree of factor market development, and degree of development of market intermediary organizations and legal system environment.

Shareholder aspect includes the proportion of shares held by the largest shareholder, the ownership balance index, property rights nature, and institutional investor shareholding. The board of directors aspect includes board independence, board size, and whether the chairman and CEO positions are combined. The incentive mechanism aspect includes the proportion of management's equity holdings, and the compensation of the top three management members.

Analysts' attention reflects the number of analysts (or teams) that have tracked and analyzed the company within a year. One team is considered as one unit, and its individual members are not counted separately.

Research reports' attention refers to the number of research reports that have tracked and analyzed the company within a year.

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Acknowledgements

This research was supported by the Major Project of the National Social Science Fund of China (20&ZD095), the Yunnan Provincial Workstation of Philosophy and Social Sciences Experts (2021GZZH01) , Humanities and Social Science Project of the Ministry of Education—Tracking and Evaluation of Green Development Performance of Ecological Products on the Improvement Path in the Middle and Lower reaches of the Yangtze River (23A10673002), Sichuan Province philosophy and social science key project (SCJJ23ND46) and the Innovation Team for Green Development in the Upper Yangtze River at Yunnan University. The authors sincerely thank the reviewers and editors.

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Lin, C., Lu, S., Su, X. et al. Can the greening of the tax system improve enterprises’ ESG performance? Evidence from China. Econ Change Restruct 57 , 127 (2024). https://doi.org/10.1007/s10644-024-09687-w

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EDITORIAL article

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The Future of the Homology Concept under Novel Evolutionary Paradigms

Editorial: The Future of the Homology Concept under Novel Evolutionary Paradigms Provisionally Accepted

• 1 Federal University of Pernambuco, Brazil
• 2 University of Brasilia, Brazil
• 3 Colombian Corporation for Agricultural Research (AGROSAVIA), Colombia

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understanding organismal form and its evolutionary implications. Göpel argues that morphology has historically been undervalued as merely descriptive. Traditionally linked with the concept of homology, morphology has evolved from being perceived merely as an auxiliary discipline to being recognized as an explanatory science capable of providing insights into the evolutionary processes. The paper argues against reducing morphology to descriptive, non-explanatory endeavors, illustrating its role in understanding biological diversity through evolutionary perspectives. It highlights the challenges faced in defining and using the concept of homology-essential for understanding biological similarities and differences-due to its diverse interpretations across different studies. The manuscript further explores the integration of modern technological approaches such as 3D digital data and computational methods like ontologies. These cutting-edge tools have not only expanded the scope and accuracy of morphological studies but also opened up new avenues for research. Using ontologies-structured knowledge bases that define terms and their relationships-holds immense potential to enhance conceptual clarity and foster better communication within the scientific community. This approach is seen as a promising solution to the challenge of diverse interpretations associated with critical morphological concepts, especially homology. The manuscript underscores the thrill of these advancements and the importance of maintaining conceptual clarity, especially in the use of terms like 'homology,' which have varied interpretations across different studies. It advocates for conceptual explicitness to facilitate clearer communication and understanding within the scientific community.In the opinion article "Homologous vs. homocratic neurons: revisiting complex evolutionary trajectories , Leonid L. Moroz and Daria Y. Romanova provides a brief historical overview of the homology concept and discusses its applications to diverse nervous systems of invertebrates targeting the level of individual functionally characterized neurons. They make an argument against a single origin of neurons, which they claim is not supported by existing data. These authors then bring two cases: First, Daria Y. Romanova and Leonid L. Moroz discusses the "Parallel evolution of gravity sensing" . In this article, they highlight the evolution of gravity sensing and the comparative biology of gravity reception, by tracing the parallel evolution of gravity sensing. Early diverging metazoans evolved alternative solutions toward spatial orientation. Gravitational sensitivity and locomotory integrative systems studies should target the understanding of convergent evolution at all levels of biological organization. Secondly, in the opinion article on "Syncytial nets and chemical signaling: emerging properties of alternative integrative systems", Leonid L. Moroz presents the Ctenophora chemical language for intercellular communications as a unique and mostly unknown subset of signal molecules for neural architecture. The molecular deciphering of neural toolkits in ctenophores includes a reduced representation of canonical bilaterian neurogenic and synaptic gene complement, with an apparent lack of classical low molecular weight transmitters (Moroz et al., 2014;Moroz et al., 2020). Moroz introduces these comb jellies with unique neural organizations of enigmatic origins; and lacking recognized homologies to any other animal phylum.Overall, the papers presented in this Research Topic make strong cases for the renewed recognition of morphology as a vital scientific discipline that contributes significantly to our understanding of biological forms and their functional, developmental, and evolutionary contexts. Definitions of homologous features should extend beyond similarity in appearance and shared position to encompass shared genetic arrangements, integrating developmental approaches alongside phylogenetic methods. Therefore, we advocate for the advance of a dynamic conceptual framework of homology will certainly revitalize morphology as a discipline and its role in explaining evolutionary processes at the same level as molecular biology.

Keywords: Biodiversity, Evo-Devo, development, Synthesis, morphology

Received: 05 May 2024; Accepted: 16 May 2024.

Copyright: © 2024 Almeida, André and Yockteng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Thiago André, University of Brasilia, Brasilia, Brazil

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• Published: 06 May 2024

APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease

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• Alzheimer's disease
• Predictive markers

This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer’s disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, genetically determined form of AD. Data from the National Alzheimer’s Coordinating Center and five large cohorts with AD biomarkers were analyzed. The analysis included 3,297 individuals for the pathological study and 10,039 for the clinical study. Findings revealed that almost all APOE4 homozygotes exhibited AD pathology and had significantly higher levels of AD biomarkers from age 55 compared to APOE3 homozygotes. By age 65, nearly all had abnormal amyloid levels in cerebrospinal fluid, and 75% had positive amyloid scans, with the prevalence of these markers increasing with age, indicating near-full penetrance of AD biology in APOE4 homozygotes. The age of symptom onset was earlier in APOE4 homozygotes at 65.1, with a narrower 95% prediction interval than APOE3 homozygotes. The predictability of symptom onset and the sequence of biomarker changes in APOE4 homozygotes mirrored those in autosomal dominant AD and Down syndrome. However, in the dementia stage, there were no differences in amyloid or tau positron emission tomography across haplotypes, despite earlier clinical and biomarker changes. The study concludes that APOE4 homozygotes represent a genetic form of AD, suggesting the need for individualized prevention strategies, clinical trials and treatments.

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Data availability.

Access to tabular data from ADNI ( https://adni.loni.usc.edu/ ), OASIS ( https://oasis-brains.org/ ), A4 ( https://ida.loni.usc.edu/collaboration/access/appLicense.jsp ) and NACC ( https://naccdata.org/ ) can be requested online, as publicly available databases. All requests will be reviewed by each studyʼs scientific board. Concrete inquiries to access the WRAP ( https://wrap.wisc.edu/data-requests-2/ ) and ALFA + ( https://www.barcelonabeta.org/en/alfa-study/about-the-alfa-study ) cohort data can be directed to each study team for concept approval and feasibility consultation. Requests will be reviewed to verify whether the request is subject to any intellectual property.

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All statistical analyses and raw figures were generated using R (v.4.2.2). We used the open-sourced R packages of ggplot2 (v.3.4.3), dplyr (v.1.1.3), ggstream (v.0.1.0), ggpubr (v.0.6), ggstatsplot (v.0.12), Rmisc (v.1.5.1), survival (v.3.5), survminer (v.0.4.9), gtsummary (v.1.7), epitools (v.0.5) and statsExpression (v.1.5.1). Rscripts to replicate our findings can be found at https://gitlab.com/vmontalb/apoe4-asdad (ref. 32 ). For neuroimaging analyses, we used Free Surfer (v.6.0) and ANTs (v.2.4.0).

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Acknowledgements

We acknowledge the contributions of several consortia that provided data for this study. We extend our appreciation to the NACC, the Alzheimer’s Disease Neuroimaging Initiative, The A4 Study, the ALFA Study, the Wisconsin Register for Alzheimer’s Prevention and the OASIS3 Project. Without their dedication to advancing Alzheimer’s disease research and their commitment to data sharing, this study would not have been possible. We also thank all the participants and investigators involved in these consortia for their tireless efforts and invaluable contributions to the field. We also thank the institutions that funded this study, the Fondo de Investigaciones Sanitario, Carlos III Health Institute, the Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas and the Generalitat de Catalunya and La Caixa Foundation, as well as the NIH, Horizon 2020 and the Alzheimer’s Association, which was crucial for this research. Funding: National Institute on Aging. This study was supported by the Fondo de Investigaciones Sanitario, Carlos III Health Institute (INT21/00073, PI20/01473 and PI23/01786 to J.F., CP20/00038, PI22/00307 to A.B., PI22/00456 to M.S.-C., PI18/00435 to D.A., PI20/01330 to A.L.) and the Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas Program 1, partly jointly funded by Fondo Europeo de Desarrollo Regional, Unión Europea, Una Manera de Hacer Europa. This work was also supported by the National Institutes of Health grants (R01 AG056850; R21 AG056974, R01 AG061566, R01 AG081394 and R61AG066543 to J.F., S10 OD025245, P30 AG062715, U54 HD090256, UL1 TR002373, P01 AG036694 and P50 AG005134 to R.S.; R01 AG027161, R01 AG021155, R01 AG037639, R01 AG054059; P50 AG033514 and P30 AG062715 to S.J.) and ADNI (U01 AG024904), the Department de Salut de la Generalitat de Catalunya, Pla Estratègic de Recerca I Innovació en Salut (SLT006/17/00119 to J.F.; SLT002/16/00408 to A.L.) and the A4 Study (R01 AG063689, U24 AG057437 to R.A.S). It was also supported by Fundación Tatiana Pérez de Guzmán el Bueno (IIBSP-DOW-2020-151 o J.F.) and Horizon 2020–Research and Innovation Framework Programme from the European Union (H2020-SC1-BHC-2018-2020 to J.F.; 948677 and 847648 to M.S.-C.). La Caixa Foundation (LCF/PR/GN17/50300004 to M.S.-C.) and EIT Digital (Grant 2021 to J.D.G.) also supported this work. The Alzheimer Association also participated in the funding of this work (AARG-22-923680 to A.B.) and A4/LEARN Study AA15-338729 to R.A.S.). O.D.-I. receives funding from the Alzheimer’s Association (AARF-22-924456) and the Jerome Lejeune Foundation postdoctoral fellowship.

Author information

These authors contributed equally: Juan Fortea, Víctor Montal.

Authors and Affiliations

Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau - Biomedical Research Institute Sant Pau, Barcelona, Spain

Juan Fortea, Jordi Pegueroles, Daniel Alcolea, Olivia Belbin, Oriol Dols-Icardo, Lídia Vaqué-Alcázar, Laura Videla, Alexandre Bejanin, Alberto Lleó & Víctor Montal

Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas. CIBERNED, Barcelona, Spain

Juan Fortea, Jordi Pegueroles, Daniel Alcolea, Olivia Belbin, Oriol Dols-Icardo, Laura Videla, Alexandre Bejanin, Alberto Lleó & Víctor Montal

Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain

Juan Fortea & Laura Videla

Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain

Lídia Vaqué-Alcázar

Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain

Juan Domingo Gispert & Marc Suárez-Calvet

Neurosciences Programme, IMIM - Hospital del Mar Medical Research Institute, Barcelona, Spain

Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain

Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina. Instituto de Salud carlos III, Madrid, Spain

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain

Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA

Sterling C. Johnson

Brigham and Women’s Hospital Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

Reisa Sperling

Barcelona Supercomputing Center, Barcelona, Spain

Víctor Montal

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Contributions

J.F. and V.M. conceptualized the research project and drafted the initial manuscript. V.M., J.P. and J.F. conducted data analysis, interpreted statistical findings and created visual representations of the data. O.B. and O.D.-I. provided valuable insights into the genetics of APOE. L.V., A.B. and L.V.-A. meticulously reviewed and edited the manuscript for clarity, accuracy and coherence. J.D.G., M.S.-C., S.J. and R.S. played pivotal roles in data acquisition and securing funding. A.L. and D.A. contributed to the study design, offering guidance and feedback on statistical analyses, and provided critical review of the paper. All authors carefully reviewed the manuscript, offering pertinent feedback that enhanced the study’s quality, and ultimately approved the final version.

Corresponding authors

Correspondence to Juan Fortea or Víctor Montal .

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Competing interests.

S.C.J. has served at scientific advisory boards for ALZPath, Enigma and Roche Diagnostics. M.S.-C. has given lectures in symposia sponsored by Almirall, Eli Lilly, Novo Nordisk, Roche Diagnostics and Roche Farma, received consultancy fees (paid to the institution) from Roche Diagnostics and served on advisory boards of Roche Diagnostics and Grifols. He was granted a project and is a site investigator of a clinical trial (funded to the institution) by Roche Diagnostics. In-kind support for research (to the institution) was received from ADx Neurosciences, Alamar Biosciences, Avid Radiopharmaceuticals, Eli Lilly, Fujirebio, Janssen Research & Development and Roche Diagnostics. J.D.G. has served as consultant for Roche Diagnostics, receives research funding from Hoffmann–La Roche, Roche Diagnostics and GE Healthcare, has given lectures in symposia sponsored by Biogen, Philips Nederlands, Esteve and Life Molecular Imaging and serves on an advisory board for Prothena Biosciences. R.S. has received personal consulting fees from Abbvie, AC Immune, Acumen, Alector, Bristol Myers Squibb, Janssen, Genentech, Ionis and Vaxxinity outside the submitted work. O.B. reported receiving personal fees from Adx NeuroSciences outside the submitted work. D.A. reported receiving personal fees for advisory board services and/or speaker honoraria from Fujirebio-Europe, Roche, Nutricia, Krka Farmacéutica and Esteve, outside the submitted work. A.L. has served as a consultant or on advisory boards for Almirall, Fujirebio-Europe, Grifols, Eisai, Lilly, Novartis, Roche, Biogen and Nutricia, outside the submitted work. J.F. reported receiving personal fees for service on the advisory boards, adjudication committees or speaker honoraria from AC Immune, Adamed, Alzheon, Biogen, Eisai, Esteve, Fujirebio, Ionis, Laboratorios Carnot, Life Molecular Imaging, Lilly, Lundbeck, Perha, Roche and outside the submitted work. O.B., D.A., A.L. and J.F. report holding a patent for markers of synaptopathy in neurodegenerative disease (licensed to Adx, EPI8382175.0). The remaining authors declare no competing interests.

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Fortea, J., Pegueroles, J., Alcolea, D. et al. APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease. Nat Med (2024). https://doi.org/10.1038/s41591-024-02931-w

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Received : 03 November 2023

Accepted : 19 March 2024

Published : 06 May 2024

DOI : https://doi.org/10.1038/s41591-024-02931-w

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