Laboratory of Bioinorganic Immunology & Drug Discovery
We are a dynamic and multinational team working in the Institute of Pharmaceutical Sciences at King's College London
Our multidisciplinary research crosses the boundaries of bioinorganic chemistry and immunology/virology. We use a combination of molecular biology and cell biological methods, biophysical techniques, biochemical assays, and computational biochemistry.
The research in our group is broadly divided into two themes: (i) Protein engineering to design and develop new therapeutics and (ii) Elucidating the function of iron-sulfur clusters, one of the oldest bioinorganic cofactors of life, at the crossroads of the immune response and cancer.
News & Events
PhD Scholarship success for the group
A-ProX, a spinout based on the group discoveries and supported by King's Spinout Accelerator Program
MRC Gap Fund to Design and Develop Novel Multifunctional Antivirals.
M.Sc. Student Theo Situmorag Wins Best Thesis Prize
PhD student Thao Nghi Hoang's Review Article Published in Current Opinion in Chemical Biology
PhD Student Yujie Sheng Wins Best Poster Prize in COST Yong Investigator Meeting, TU Delft, the Netherlands
Latest Publications
A Versatile Virus-Mimetic Engineering Approach for Concurrent Protein Nanocage Surface-Functionalization and Cargo Encapsulation
We mimic the HIV-1 Gag polypeptide precursors and create precursors of nanocages (PRECs). We show that in the presence of a protease, the precursors are cleaved to form subunits that are spontaneously self-assembled to generate PINCs (Protein-induced nanocages). The PINC formation is used to encapsulate a cargo and concurrently decorate the nanocages’ surface with a protein.
Immunology & Microbial Sciences
- King's College London
- Life Sciences & Medicine
Research output
- 880930 Citations
- 7740 Article
- 1497 Meeting abstract
- 544 Review article
- 414 Literature review
- 331 Editorial
- 219 Chapter
- 172 Conference paper
- 139 Meeting Abstract
- 99 Comment/debate
- 80 Poster abstract
- 17 Other contribution
- 14 Short survey
- 10 Preprint
- 5 Book/Film/Article review
- 2 Other chapter contribution
- 1 Conference contribution
- 1 Entry in encyclopedia/dictionary
- 1 Foreword/postscript
Research output per year
- 1 - 50 out of 11,686 results
- Publication Year, Title (ascending)
Search results
Lovit: long video transformer for surgical phase recognition.
Research output : Contribution to journal › Article › peer-review
- Temporal Information 100%
- Art Performance 50%
- Global Feature 50%
- local feature 50%
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial
- Rheumatoid Arthritis 100%
- Clinical Trial 100%
- Inflammatory Arthritis 100%
- Abatacept 100%
- Therapeutic Procedure 25%
Accelarated immune ageing is associated with COVID-19 disease severity
- COVID-19 100%
- Cytotoxic T-Cell 57%
- T-Helper Cell 28%
Acceptability of 'as needed' biologic therapy in psoriasis: insights from a multi-stakeholder mixed methods study
- Patient 100%
- Psoriasis 100%
- Biological Therapy 100%
- Clinician 85%
- Drug Therapy 21%
A Formal Approach For Modelling And Analysing Surgical Procedures
Research output : Chapter in Book/Report/Conference proceeding › Conference paper › peer-review
- Modeling 100%
- Automated Analysis 16%
- Surgery Planning 16%
Amyloid-β peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer’s disease with APPdup and Down syndrome
- Familial Alzheimer's Disease 100%
- Cerebral Amyloid Angiopathy 100%
- Tau Protein 11%
- Brain Imaging 11%
An algorithm for the diagnosis and management of IgE-mediated food allergy, 2024 update
Research output : Contribution to journal › Comment/debate › peer-review
A new mutation of Sgms1 causes gradual hearing loss associated with a reduced endocochlear potential
- Sensation of Hearing 100%
- Hearing Loss 100%
- Cell Signaling 50%
- Enzymes 50%
- Expression Analysis 50%
Approaches to the identification and management of depression in people living with chronic kidney disease: a scoping review of 860 papers
Research output : Contribution to journal › Review article › peer-review
- Kidney Disease 100%
- Scoping Review 100%
- Chronic Kidney Disease 100%
- Care Pathway 18%
- Screening 18%
A randomised controlled trial of the effect of intra-articular lidocaine on pain scores in inflammatory arthritis
- Randomized Controlled Trial 100%
- Lidocaine 100%
- Patient 57%
- Numeric Rating Scale 57%
A randomized controlled trial of a digital cognitive-behavioral therapy program (COMPASS) for managing depression and anxiety related to living with a long-term physical health condition
- Anxiety 100%
- Health 100%
- Cognitive Behavioral Therapy 100%
A real-world longitudinal study implementing digital screening and treatment for distress in inflammatory bowel disease (IBD): The COMPASS-IBD study protocol
- Therapeutic Procedure 100%
- Screening 100%
- Mental Health 23%
- Patient 23%
- Mass Screening 23%
A set of circulating microRNAs belonging to the 14q32 chromosome locus identifies two subgroups of individuals with recent-onset type 1 diabetes
- MicroRNA 100%
- Sequencing 16%
Associations between social determinants of health and co- and multi-morbidity in people of Black ethnicities with HIV
A subpopulation of tissue remodeling monocytes stimulates revascularization of the ischemic limb.
- Revascularization 100%
- Patient 42%
A Turning point in Hepatology? EASL Reflects on the First Approved Drug for MASH
Author correction:: the ideal framework for surgical robotics: development, comparative evaluation and long-term monitoring (nature medicine, (2024), 30, 1, (61-75), 10.1038/s41591-023-02732-7): the ideal framework for surgical robotics: development, comparative evaluation and long-term monitoring.
- Robotics 100%
- Nature Medicine 100%
- Medicine 100%
Autotaxin upregulation in liver failure and the effect on monocyte phenotype and function is a pan-aetiology phenomenon
Bacterial vaccines for the management of recurrent urinary tract infections: a systematic review and meta-analysis.
- Meta-Analysis 100%
- Systematic Review 100%
- Urinary Tract Infection 100%
- Patient 40%
- Randomized Controlled Trial 30%
Basophil activation test in the food allergy clinic: its current use and future applications
- Immunoglobulin E 100%
- Hypersensitive Response 33%
- Allergy 33%
BAT and MAT for diagnosis of peanut allergy: A systematic review and meta-analysis
- Mast Cell 100%
- Peanut Extract 60%
Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of oesophageal varices: study protocol for a randomised controlled trial
- Prophylaxis 100%
- Beta Adrenergic Receptor Blocking Agent 100%
- Esophageal Varices 100%
- Liver Cirrhosis 83%
Biomarkers of peanut allergy in children over time
- Biological Marker 100%
- Peanut Allergy 100%
- Groundnut 100%
Biomechanical activation of keloid fibroblasts promotes lysosomal remodelling and exocytosis
- Exocytosis 100%
- Keloid 100%
- Muscle Contractility 30%
- Extracellular Matrix 30%
- Autophagy 20%
BiTE therapy for rheumatoid arthritis
Breaking down barriers between liver, addiction, and mental health services for people with alcohol-related liver disease, cardiovascular comorbidities in psoriatic arthritis: state of the art.
- Cardiovascular System 100%
- Psoriatic Arthritis 100%
- Patient 50%
- Cardiovascular Risk 20%
- Cardiovascular Disease 20%
CD1 MOLECULES: BEYOND ANTIGEN PRESENTATION
Cellular uptake and in vivo distribution of mesenchymal-stem-cell-derived extracellular vesicles are protein corona dependent.
- Protein 100%
- Mesenchymal Stem Cell 100%
- Albumin 75%
Characterisation and correction of polarisation effects in fluorescently labelled fibres
- Microscopy 100%
- Quantitative Technique 100%
- Collagen Gel 100%
Characteristics of emerging new autoimmune diseases after COVID-19 vaccination: A sub-study by the COVAD group
- Systemic Autoimmune Disease 100%
- Analysis 28%
Chondroitin Sulfate Proteoglycan 4 (CSPG4) as an Emerging Target for Immunotherapy to Treat Melanoma
- Proteochondroitin Sulfate 100%
- Melanoma 100%
- Therapeutic Procedure 37%
- Patient 25%
- Mimotope 16%
Chondroitin Sulfate Proteoglycan 4 (CSPG4) as an Emerging Target for Immunotherapy To Treat Melanoma
Cis-interaction between cd52 and t cell receptor complex interferes with cd4 + t cell activation in acute decompensation of cirrhosis.
- T Cell Receptor 100%
- T-Helper Cell 100%
- T Cell Activation 100%
- Immune System Disorders 40%
- Peripheral Blood Lymphocyte 20%
Cis-interaction between CD52 and T cell receptor complex interferes with CD4 + T cell activation in acute decompensation of cirrhosis.
Clinical and experimental immunology: highlights of 2023.
Research output : Contribution to journal › Editorial › peer-review
Clinical implications of inflammation in patients with cirrhosis
- Liver Cirrhosis 100%
- Inflammation 100%
- Systemic Inflammation 100%
Clinician and patient views on janus kinase inhibitors in the treatment of inflammatory arthritis: a mixed methods study
- Clinician 100%
- Janus Kinase Inhibitor 100%
Coalition for Health and Gender Equity (CHANGE)-a protocol for a global cross-sectional survey of health and gender equity in rheumatology
- Gender 100%
- Descriptive Analysis 100%
- Healthcare Professional 28%
- Physician 20%
- Health Care Personnel 20%
Comment on: Antibody predictors of mortality and lung function trends in myositis spectrum interstitial lung disease: reply
Comparative analysis of centrally mediated and inflammatory pain experiences amongst patients diagnosed with rheumatoid arthritis: a multimethods study.
- Analysis 100%
- Experience 100%
- Inflammatory Pain 100%
- Visual Analog Scale 40%
Coordinated nasal mucosa-mediated immunity accelerates recovery from COVID-19
- Immunity 100%
- Nose Mucosa 100%
- Mediator 50%
- Symptom 50%
Correlates and Predictors of Symptom Severity Over Time in People Under Investigation for Postural Orthostatic Tachycardia Syndrome
- Chronic Disorder 100%
- Social Support 100%
- Multiple Linear Regression 100%
- Longitudinal Analysis 100%
Correlates of breakthrough COVID-19 in vaccinated patients with systemic sclerosis: survival analysis from a multicentre international patient-reported survey
- Survival Analysis 100%
- Systemic Scleroderma 100%
- Control 100%
Courage in decision-making: A mixed-methods study of COVID-19 vaccine uptake in women of reproductive age in the UK
- COVID-19 Vaccine 100%
- COVID-19 25%
- Analysis 16%
COVID-19 breakthrough infections in type 1 diabetes mellitus: a cross-sectional study by the COVID-19 Vaccination in Autoimmune Diseases (COVAD) Group
- Insulin Dependent Diabetes Mellitus 100%
- Infection 100%
- Cross Sectional Study 100%
COVID-19 vaccination-related delayed adverse events among people with rheumatoid arthritis: Results from the international COVAD survey
- Adverse Event 100%
- Autoimmune Disease 100%
- Patient 41%
- Control 41%
- Hospitalization 16%
CTLA-4 expressing innate lymphoid cells modulate mucosal homeostasis in a microbiota dependent manner
- Lymphoid Cell 100%
- Inflammatory Bowel Disease 40%
- Therapeutic Procedure 20%
- Pathogen 20%
- Organism 20%
Defining predictors of responsiveness to advanced therapies in Crohn's disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine
- Personalized Medicine 100%
- Ulcerative Colitis 100%
- Crohn's Disease 100%
- Cohort Study 100%
Derivation and simulation of a computational model of active cell populations: How overlap avoidance, deformability, cell-cell junctions and cytoskeletal forces affect alignment
Research output : Working paper/Preprint › Preprint
- Cell Population 100%
- Cell Junction 100%
- Scar Tissue 20%