medical research thesis topics

77 interesting medical research topics for 2024

Last updated

25 November 2023

Reviewed by

Brittany Ferri, PhD, OTR/L

Short on time? Get an AI generated summary of this article instead

Medical research is the gateway to improved patient care and expanding our available treatment options. However, finding a relevant and compelling research topic can be challenging.

Use this article as a jumping-off point to select an interesting medical research topic for your next paper or clinical study.

• How to choose a medical research topic

When choosing a research topic , it’s essential to consider a couple of things. What topics interest you? What unanswered questions do you want to address? 

During the decision-making and brainstorming process, here are a few helpful tips to help you pick the right medical research topic:

Focus on a particular field of study

The best medical research is specific to a particular area. Generalized studies are often too broad to produce meaningful results, so we advise picking a specific niche early in the process. 

Maybe a certain topic interests you, or your industry knowledge reveals areas of need.

Look into commonly researched topics

Once you’ve chosen your research field, do some preliminary research. What have other academics done in their papers and projects? 

From this list, you can focus on specific topics that interest you without accidentally creating a copycat project. This groundwork will also help you uncover any literature gaps—those may be beneficial areas for research.

Get curious and ask questions

Now you can get curious. Ask questions that start with why, how, or what. These questions are the starting point of your project design and will act as your guiding light throughout the process. 

For example: 

What impact does pollution have on children’s lung function in inner-city neighborhoods? 

Why is pollution-based asthma on the rise? 

How can we address pollution-induced asthma in young children? 

• 77 medical research topics worth exploring in 2023

Need some research inspiration for your upcoming paper or clinical study? We’ve compiled a list of 77 topical and in-demand medical research ideas. Let’s take a look. 

• Exciting new medical research topics

If you want to study cutting-edge topics, here are some exciting options:

COVID-19 and long COVID symptoms

Since 2020, COVID-19 has been a hot-button topic in medicine, along with the long-term symptoms in those with a history of COVID-19. 

Examples of COVID-19-related research topics worth exploring include:

The long-term impact of COVID-19 on cardiac and respiratory health

COVID-19 vaccination rates

The evolution of COVID-19 symptoms over time

New variants and strains of the COVID-19 virus

Changes in social behavior and public health regulations amid COVID-19

Vaccinations

Finding ways to cure or reduce the disease burden of chronic infectious diseases is a crucial research area. Vaccination is a powerful option and a great topic to research. 

Examples of vaccination-related research topics include:

mRNA vaccines for viral infections

Biomaterial vaccination capabilities

Vaccination rates based on location, ethnicity, or age

Public opinion about vaccination safety 

Artificial tissues fabrication

With the need for donor organs increasing, finding ways to fabricate artificial bioactive tissues (and possibly organs) is a popular research area. 

Examples of artificial tissue-related research topics you can study include:

The viability of artificially printed tissues

Tissue substrate and building block material studies

The ethics and efficacy of artificial tissue creation

• Medical research topics for medical students

For many medical students, research is a big driver for entering healthcare. If you’re a medical student looking for a research topic, here are some great ideas to work from:

Sleep disorders

Poor sleep quality is a growing problem, and it can significantly impact a person’s overall health. 

Examples of sleep disorder-related research topics include:

How stress affects sleep quality

The prevalence and impact of insomnia on patients with mental health conditions

Possible triggers for sleep disorder development

The impact of poor sleep quality on psychological and physical health

How melatonin supplements impact sleep quality

Alzheimer’s and dementia 

Cognitive conditions like dementia and Alzheimer’s disease are on the rise worldwide. They currently have no cure. As a result, research about these topics is in high demand. 

Examples of dementia-related research topics you could explore include:

The prevalence of Alzheimer’s disease in a chosen population

Early onset symptoms of dementia

Possible triggers or causes of cognitive decline with age

Treatment options for dementia-like conditions

The mental and physical burden of caregiving for patients with dementia

• Lifestyle habits and public health

Modern lifestyles have profoundly impacted the average person’s daily habits, and plenty of interesting topics explore its effects. 

Examples of lifestyle and public health-related research topics include:

The nutritional intake of college students

The impact of chronic work stress on overall health

The rise of upper back and neck pain from laptop use

Prevalence and cause of repetitive strain injuries (RSI)

• Controversial medical research paper topics

Medical research is a hotbed of controversial topics, content, and areas of study. 

If you want to explore a more niche (and attention-grabbing) concept, here are some controversial medical research topics worth looking into:

The benefits and risks of medical cannabis

Depending on where you live, the legalization and use of cannabis for medical conditions is controversial for the general public and healthcare providers.

Examples of medical cannabis-related research topics that might grab your attention include:

The legalization process of medical cannabis

The impact of cannabis use on developmental milestones in youth users

Cannabis and mental health diagnoses

CBD’s impact on chronic pain

Prevalence of cannabis use in young people

The impact of maternal cannabis use on fetal development 

Understanding how THC impacts cognitive function

Human genetics

The Human Genome Project identified, mapped, and sequenced all human DNA genes. Its completion in 2003 opened up a world of exciting and controversial studies in human genetics.

Examples of human genetics-related research topics worth delving into include:

Medical genetics and the incidence of genetic-based health disorders

Behavioral genetics differences between identical twins

Genetic risk factors for neurodegenerative disorders

Machine learning technologies for genetic research

Sexual health studies

Human sexuality and sexual health are important (yet often stigmatized) medical topics that need new research and analysis.

As a diverse field ranging from sexual orientation studies to sexual pathophysiology, examples of sexual health-related research topics include:

The incidence of sexually transmitted infections within a chosen population

Mental health conditions within the LGBTQIA+ community

The impact of untreated sexually transmitted infections

Access to safe sex resources (condoms, dental dams, etc.) in rural areas

• Health and wellness research topics

Human wellness and health are trendy topics in modern medicine as more people are interested in finding natural ways to live healthier lifestyles. 

If this field of study interests you, here are some big topics in the wellness space:

Gluten sensitivity

Gluten allergies and intolerances have risen over the past few decades. If you’re interested in exploring this topic, your options range in severity from mild gastrointestinal symptoms to full-blown anaphylaxis. 

Some examples of gluten sensitivity-related research topics include:

The pathophysiology and incidence of Celiac disease

Early onset symptoms of gluten intolerance

The prevalence of gluten allergies within a set population

Gluten allergies and the incidence of other gastrointestinal health conditions

Pollution and lung health

Living in large urban cities means regular exposure to high levels of pollutants. 

As more people become interested in protecting their lung health, examples of impactful lung health and pollution-related research topics include:

The extent of pollution in densely packed urban areas

The prevalence of pollution-based asthma in a set population

Lung capacity and function in young people

The benefits and risks of steroid therapy for asthma

Pollution risks based on geographical location

Plant-based diets

Plant-based diets like vegan and paleo diets are emerging trends in healthcare due to their limited supporting research. 

If you’re interested in learning more about the potential benefits or risks of holistic, diet-based medicine, examples of plant-based diet research topics to explore include:

Vegan and plant-based diets as part of disease management

Potential risks and benefits of specific plant-based diets

Plant-based diets and their impact on body mass index

The effect of diet and lifestyle on chronic disease management

Health supplements

Supplements are a multi-billion dollar industry. Many health-conscious people take supplements, including vitamins, minerals, herbal medicine, and more. 

Examples of health supplement-related research topics worth investigating include:

Omega-3 fish oil safety and efficacy for cardiac patients

The benefits and risks of regular vitamin D supplementation

Health supplementation regulation and product quality

The impact of social influencer marketing on consumer supplement practices

Analyzing added ingredients in protein powders

• Healthcare research topics

Working within the healthcare industry means you have insider knowledge and opportunity. Maybe you’d like to research the overall system, administration, and inherent biases that disrupt access to quality care. 

While these topics are essential to explore, it is important to note that these studies usually require approval and oversight from an Institutional Review Board (IRB). This ensures the study is ethical and does not harm any subjects. 

For this reason, the IRB sets protocols that require additional planning, so consider this when mapping out your study’s timeline. 

Here are some examples of trending healthcare research areas worth pursuing:

The pros and cons of electronic health records

The rise of electronic healthcare charting and records has forever changed how medical professionals and patients interact with their health data. 

Examples of electronic health record-related research topics include:

The number of medication errors reported during a software switch

Nurse sentiment analysis of electronic charting practices

Ethical and legal studies into encrypting and storing personal health data

Inequities within healthcare access

Many barriers inhibit people from accessing the quality medical care they need. These issues result in health disparities and injustices. 

Examples of research topics about health inequities include:

The impact of social determinants of health in a set population

Early and late-stage cancer stage diagnosis in urban vs. rural populations

Affordability of life-saving medications

Health insurance limitations and their impact on overall health

Diagnostic and treatment rates across ethnicities

People who belong to an ethnic minority are more likely to experience barriers and restrictions when trying to receive quality medical care. This is due to systemic healthcare racism and bias. 

As a result, diagnostic and treatment rates in minority populations are a hot-button field of research. Examples of ethnicity-based research topics include:

Cancer biopsy rates in BIPOC women

The prevalence of diabetes in Indigenous communities

Access inequalities in women’s health preventative screenings

The prevalence of undiagnosed hypertension in Black populations

• Pharmaceutical research topics

Large pharmaceutical companies are incredibly interested in investing in research to learn more about potential cures and treatments for diseases. 

If you’re interested in building a career in pharmaceutical research, here are a few examples of in-demand research topics:

Cancer treatment options

Clinical research is in high demand as pharmaceutical companies explore novel cancer treatment options outside of chemotherapy and radiation. 

Examples of cancer treatment-related research topics include:

Stem cell therapy for cancer

Oncogenic gene dysregulation and its impact on disease

Cancer-causing viral agents and their risks

Treatment efficacy based on early vs. late-stage cancer diagnosis

Cancer vaccines and targeted therapies

Immunotherapy for cancer

Pain medication alternatives

Historically, opioid medications were the primary treatment for short- and long-term pain. But, with the opioid epidemic getting worse, the need for alternative pain medications has never been more urgent. 

Examples of pain medication-related research topics include:

Opioid withdrawal symptoms and risks

Early signs of pain medication misuse

Anti-inflammatory medications for pain control

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Explore the Best Medical and Health Research Topics Ideas

Table of contents

• 1 How to Choose Medical Research Paper Topics
• 2 New Medical Research Paper Topics
• 3 Medical Research Topics for College Students
• 4 Controversial Medical Topics for Research Paper
• 5 Health Research Topics
• 6 Medicine Research Topics
• 7 Healthcare Research Topics
• 8 Public Health Research Topics
• 9 Mental Health Research Paper Topics
• 10 Anatomy Research Topics
• 11 Biomedical Research Topics
• 12 Bioethics Research Topics
• 13 Cancer Research Topics
• 14 Clinical Research Topics
• 15 Critical Care Research Topics
• 16 Pediatric Research Topics
• 17 Dental Research Topics Ideas
• 18 Dermatology Research Topics
• 19 Primary Care Research Topics
• 20 Pharmaceutical Research Topics
• 21 Medical Anthropology Research Topics
• 22 Paramedic Research Paper Topics
• 23 Surgery Research Topics
• 24 Radiology Research Paper Topics
• 25 Anatomy and Physiology Research Paper Topics
• 26 Healthcare Management Research Paper Topics
• 27 Medical Ethics Research Paper Topics
• 28 Environmental Health and Pollution Research Paper Topics
• 29 Conclusion

Writing an original and compelling research paper is a daunting task in such a complex and broad field as medicine. Each student decides where his interests lie, from investigating public care concerns to cancer treatment studies. We aim to help students find new angles to study and focus on relevant topics. With our resources, you can write an engaging and rigorous paper.

How to Choose Medical Research Paper Topics

Choosing good research paper topics is often more challenging than the writing process itself. You need to select a captivating subject matter that will grab the reader’s attention, showcase your knowledge of a specific field, help you progress in your studies, and perhaps even inspire future research.

To accomplish that, you need to start with brainstorming, followed by thorough research. Here are some great tips to follow:

• Pick an interesting topic – The key is to pick something that you find interesting, and yet make sure it’s not too general or too narrow. It should allow you to delve deep into the subject matter and show that you’re a professional who is ready to take on a challenge when it comes to your chosen field of medicine.
• Narrow down your focus – Once you have a list of potential topics, sift through recent medical research papers to get up-to-date with the latest trends, developments, and issues in medicine and healthcare. Check out textbooks, news articles, and other relevant sources for more information related to your potential topics. If a particular condition or disease interests you (perhaps something that drew you to a career in medicine), there’s your cue for narrowing down your topic.
• Pinpoint the “why,” “how,” and “what” – Whether you are looking into nutrition research paper topics , controversial medical topics, nursing research topics, or anything in-between, ask yourself why each of them is important. How could they contribute to the available medical studies, if any? What new information could they bring to improve the future of medicine? Asking these questions will help you pick the right medical research paper topic that suits you and helps you move forward and reach your aspirations.

To help you on that quest, we’ve compiled a list of topics that you could use or that might inspire you to come up with something unique. Let’s dive in.

New Medical Research Paper Topics

Are you interested in the newest and most interesting developments in medicine? We put hours of effort into identifying the current trends in health research so we could provide you with these examples of topics. Whether you hire a research paper writing service for students or write a paper by yourself, you need an appealing topic to focus on.

• Epidemics versus pandemics
• Child health care
• Medical humanitarian missions in the developing world
• Effectiveness of mobile health clinics in rural Africa
• Homeopathic medicines – the placebo effect
• Comparative study of the efficacy of homeopathic treatments and conventional medicine in managing chronic pain
• Virus infections – causes and treatment
• Trends in COVID-19 vaccine uptake
• Advancements in the treatment of influenza
• Is medical research on animals ethical
• Vaccination – dangers versus benefits
• Artificial tissues and organs
• Rare genetic diseases
• Brain injuries
• Long-Term Effects of COVID-19
• Social behavior shifts due to COVID-19

Medical Research Topics for College Students

You don’t know where to start with your medical research paper? There are so many things you could write about that the greatest challenge is to narrow them down. This is why we decided to help.

• Antibiotics treatments
• Efficacy of mRNA vaccines against viral diseases
• Viability and function of 3D printed tissues
• Chronic diseases
• Palliative treatment
• Battling Alzheimer’s disease
• How modern lifestyle affects public health
• Professional diseases
• Sleep disorders
• Changes in physical and mental health due to aging
• Eating disorders
• Terminal diseases

Controversial Medical Topics for Research Paper

In healthcare, new discoveries can change people’s lives in the blink of an eye. This is also the reason why there are so many controversial topics in medicine, which involve anything from religion to ethics or social responsibility. Read on to discover our top controversial research topics.

• Ethical debates on artificial tissue engineering
• Public opinions on vaccination safety
• Implementing food standards
• Telehealth’s Role in Chronic Illness Management
• Gluten allergy
• Assisted suicide for terminal patients
• Testing vaccines on animals – ethical concerns
• Moral responsibilities regarding cloning
• Marijuana legalization for medical purposes
• Abortion – medical approaches
• Vegan diets – benefits and dangers
• Increased life expectancy: a burden on the healthcare system?
• Circumcision effects

Health Research Topics

Students conducting health research struggle with finding good ideas related to their medical interests. If you want to write interesting college papers, you can select a good topic for our list.

• Impact of location, ethnicity, or age on vaccination rates
• Uses of biomaterials in vaccination technology
• Deafness: communication disorders
• Household air pollution
• Diabetes – a public danger
• Coronaviruses
• Oral health assessment
• Tobacco and alcohol control
• Diseases caused by lack of physical exercise
• How urban pollution affects respiratory diseases
• Healthy diets

Medicine Research Topics

Regardless of the requirements in your research assignment, you can write about something that is both engaging and useful in your future career. Choose a topic from below.

• Causes for the increasing cancer cases
• Insulin resistance
• How terrorism affects mental health
• AIDS/HIV – latest developments
• Treating pregnant women versus non-pregnant women
• Latest innovations in medical instruments
• Genetic engineering
• Successful treatment of mental diseases
• Is autism a disease
• Natural coma versus artificial coma
• Treatments for sleep disorders and their effectiveness
• Role of melatonin supplements in sleep quality

Healthcare Research Topics

Healthcare research includes political and social aspects, besides medical. For college students who want to explore how medicine is affected by society’s values or principles, we provide examples of topics for papers. Select yours from the list below.

• Government investment in healthcare services in the EU versus the USA
• Inequalities in healthcare assistance and services
• Electronic health records systems – pros and cons
• Can asylums treat mental issues
• Health care for prison inmates
• Equipment for improving the treatment of AIDS
• Correlation between economic development and health care services across countries
• Impact of smoking on organs
• Heart attacks – causes and effects
• Breast cancer – recent developments
• Materials used in artificial tissue and their impacts

Public Health Research Topics

For current examples of public health topics, browse our list. We provide only original, researchable examples for which you can easily find supporting data and evidence.

• Public versus private hospitals
• Health Disparities in Diabetes Management Across Different Socioeconomic Groups
• Health care professionals – management principles
• Surgery failures – who is responsible
• What legal responsibilities has the hospital administration
• Patient service quality in public versus private hospitals
• What benefits do national health care systems have
• Estimated costs of cancer treatments
• Public health in developing countries
• Banning tobacco ads – importance for public health
• Government solutions to the anti-vaccine’s movement
• How the COVID-19 pandemic has changed public health regulations

Mental Health Research Paper Topics

Mental health is one of the most complex areas of medicine, where things are never as clear as with other medical issues. This increases the research potential of the field with plenty of topics left for debate.

• Mental Health Impact of Social Media on American Teenagers
• Causes of anxiety disorders
• Bulimia versus anorexia
• Childhood trauma
• Mental health public policies
• Impact of Lifestyle Factors on the Progression of Dementia in the Elderly Population
• Postpartum Depression
• Posttraumatic Stress Disorder
• Seasonal Affective Disorder
• Schizophrenia
• Stress and its effects on sleep quality
• Insomnia and its relation to mental health disorders

Anatomy Research Topics

Anatomy covers everything about the human body and how it works. If you find that intriguing and want to pay for medical research paper, start by selecting a topic.

• Causes and treatments of virus infections
• Chemotherapy: how it affects the body
• Thyroid glands – functions in the body
• Human endocrine system
• Preventative Measures and Treatments for Common Liver Diseases
• Heart diseases
• How does the human muscular system develop
• Lymphatic system – importance
• Investigating genetic diseases
• Digestive system
• Role of the Spleen in the Human Immune System and Related Disorders

Biomedical Research Topics

Biology and medicine often work together. For the newest changes in the biomedical field, check our topics.

• Comparative Efficacy of Alternative Medicine Practices in Chronic Pain Management
• Alzheimer’s disease – paths for treatment
• Vaccines and drug development in the treatment of Ebola
• Antibiotic resistance
• Biological effects caused by aging
• Air pollution effects on health
• Infectious disease past versus present
• Regenerative medicine
• Biomedical diagnostics
• Biomedical technology
• Advanced biomaterials for vaccine delivery

Bioethics Research Topics

A controversial area of medicine, bioethics is where you get the chance to add personal input to a research topic and come up with new insights. You could consider these subjects.

• Organ donation
• Alternative or complementary medicine
• Assisted suicide or the right to die
• Artificial insemination or surrogacy
• Chemical and biological warfare
• Contraception
• Environmental bioethics
• In Vitro Fertilization
• Ethical considerations in medical research on animals

Cancer Research Topics

Are you writing a paper related to cancer causes, diagnosis, treatment or effects? Look below for a hot topic that it’s easy to research and important for medical advance.

• The ability of immune system cells to fight cancer
• Computational oncology
• Metastasis affected by drug resistance
• Stem cells – applications for cancer treatment
• Tumor microenvironment
• Obesity and age in cancer occurrence
• Early cancer detection – benefits
• Artificial intelligence predicting cancer
• Hematologic malignancies
• Pathogen-related cancers
• Impact of COVID-19 on cancer treatment studies

Clinical Research Topics

Learn more about clinical medicine by conducting more in-depth research. We prepared for you a list of relevant issues to touch upon.

• Ethical concerns regarding research on human subjects
• Subject recruitment
• Budget preparation
• Human subject protection
• Clinical trials – financial support
• Clinical practices for health professionals
• Using vulnerable populations in clinical research
• Quality assurance in clinical research
• Academic clinical trials versus clinical trials units
• Data collection and management
• Evolution of clinical symptoms in COVID-19 patients

Critical Care Research Topics

Critical care is a key area in medical studies. Explore these topics in your research paper to gain more valuable knowledge in this field. You can also get in contact with nursing research paper writers .

• Obesity and asthma – clinical manifestations
• Chronic obstructive pulmonary disease
• Rhythm analysis for cardiac arrest
• Traumatic brain injury – fluid resuscitation
• Hydrocortisone for multiple trauma patients
• Care and nutrition for critically ill adults
• Diagnosis of hypersensitivity pneumonitis
• Coma and sedation scales
• Artificial airways suctioning
• Arterial puncture and arterial line
• Long-term cardiac and respiratory effects of COVID-19

Pediatric Research Topics

Any topic that refers to health care for children, pregnant women, mothers, and adolescents goes under pediatric care.

• Early Intervention Methods for Children Diagnosed with Autism Spectrum Disorder
• Preventive healthcare strategies for children
• Impact of early childhood nutrition on long-term health
• Attention deficit hyperactivity disorder (ADHD)
• Congenital heart disease in newborns
• Adolescent medicine
• Neonatal medicine
• Rare diseases in children and teenagers
• Obesity and weight fluctuations
• Behavioral sleep problems in children
• Children with anemia
• Child healthcare enhancements and innovations

Dental Research Topics Ideas

Choose a topic on oral health or dental care from this list of the most interesting topics in the field.

• How smoking affects oral health
• Children’s risk for dental caries
• Causes of Dental Anxiety and Effective Interventions for Reducing Fear in Patients
• Types of dental materials – new advances
• Bad breath bacteria
• How diabetes affects oral health
• Oral cancer
• Dental pain – types, causes
• Dental implants
• Oral health-related quality of life
• Advancements in treatments for virus infections

Dermatology Research Topics

Find the best research topic for your dermatology paper among our examples.

• Atopic dermatitis
• Contact dermatitis
• Epidemiology behind uncommon skin disorders
• Cutaneous aging
• Risk factors of melanoma skin cancer
• Acne versus rosacea
• Genetic testing for skin conditions
• Effects of cosmetic agents on skin health
• Improving skin barrier with pharmaceutical agents
• Skin manifestations of autoimmune disorders
• Study of virus effects on skin health

Primary Care Research Topics

Write a primary care paper that can demonstrate your research skills and interest in powerful scientific findings.

• Primary care for vulnerable/uninsured populations
• Interpersonal continuity in care treatment
• How primary care contributes to health systems
• Primary care delivery models
• Developments in family medicine
• Occupational/environmental health
• Pharmacotherapy approaches
• Formal allergy testing
• Oral contraception side effects
• Dietary or behavioral interventions for obesity management

Pharmaceutical Research Topics

Pharma students who need paper topics can use one from our list. We include all things related to pharmacy life.

• Drugs that can treat cancer
• Drug excretion
• Elimination rate constant
• Inflammatory stress drug treatment
• Aspirin poising
• Ibuprofen – dangers versus benefits
• Toxicodynamics
• Opioid use disorder
• Pharmacotherapy for schizophrenia
• Ketamine in depression treatment

Medical Anthropology Research Topics

Medical anthropology unites different areas of human knowledge. Find powerful ideas for a paper below.

• Cultural contexts regarding reproductive health
• Women sexuality
• Anthropological aspects of health care
• Contributions of social sciences to public health
• Euthanasia and medical ethics across cultures
• Health-related behavior in adults across cultures
• Transcultural nursing
• Forensic psychiatry
• Symptoms of Celiac Disease – a disease with no symptoms
• Nursing ethics

Paramedic Research Paper Topics

Topics for paramedic research must be based on evidence, data, statistics, or practical experience. Just like ours.

• Trends and statistics in EMS
• Disaster medicine
• Mass casualties
• Pandemics and epidemics
• Infection control
• Basic versus advanced life support
• Scene safety in EMS
• Shock management
• Motor vehicle accidents
• Challenges in medical humanitarian missions during pandemics

Surgery Research Topics

Discover all the intricacies of surgeries that save lives by writing about our topics.

• Medical malpractice and legal issues
• Methicillin-resistant Staphylococcus aureus
• Early Detection and Management Strategies for Sepsis in Hospital Settings
• Pain management
• Perioperative nursing
• Wound management
• Colorectal cancer surgery
• Breast cancer surgery
• Minimally invasive surgeries
• Vascular disease
• Changes in surgical practices during pandemics

Radiology Research Paper Topics

Find a radiology topic related to your academic interests to write a successful paper.

• Using MRI to diagnose hepatic focal lesions
• Multidetector computer tomography
• Ultrasound elastography in breast cancer
• Assessing traumatic spinal cord injuries with MRI diffusion tensor imaging
• Sonographic imaging to detect male infertility
• Role of tomography in diagnosing cancer
• Brain tumor surgery with magnetic resonance imaging
• Bacterial meningitis imaging
• Advanced imaging techniques for virus infection detection

Anatomy and Physiology Research Paper Topics

Any ideas for a medical research paper? We have included the most important topics for an anatomy and physiology paper.

• What role has the endocrine system
• Staphylococcus aureus
• Environmental factors that affect development of human muscular system
• What role has the lymphatic system
• An investigation of genetic diseases
• Explaining the aging process
• The digestive tract
• Effects of stress on cells and muscles
• Evolution of the human nervous system
• What role has the cardiovascular system
• Impact of viruses on respiratory health in urban settings

Healthcare Management Research Paper Topics

There are numerous topics you could write about when it comes to healthcare management. There’s a wide range of options to pick, from infrastructure, staff, and financial management to HR and patient management. Here are some of the top healthcare management research paper options.

Medical Ethics Research Paper Topics

Medical ethics is a field that opens the door to numerous compelling topics for research papers. Here are some of the most appealing ones you could tackle.

• Clinical research on humans
• Vaccines and immunization
• Religious beliefs in healthcare
• Euthanasia and physician-assisted suicide
• Ethical issues across cultures
• Amniocentesis or prenatal birth defect testing
• Medical malpractice and going back to work
• Racial and ethnic preferences and perceptions in organ donations
• Racial and ethnic disparities in healthcare
• Ethical concerns of AI in healthcare
• Debates on animal ethics in medical research
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Environmental Health and Pollution Research Paper Topics

• Environmental Pollutants and Respiratory Health in Urban Areas of the USA
• How environmental changes affect human health
• Long-Term Impact of PM2.5 Exposure on Lung, Heart, and Brain Function
• Health Risks of Air Pollution Across Different Life Stages
• Hospital Admissions and Air Quality in the USA
• Risk Reduction Strategies for Indoor Air Pollution from Gas Stoves
• Impact of Air Pollution on Cognitive Development and Socioeconomic Achievements
• Long-Term Health Effects of Early Childhood Exposure to Air Pollution
• Impact of Traffic Noise on Cardiovascular Health

Selecting the right medical research topic is essential, but the writing process can be equally challenging. If you’re seeking expert help, professional research paper writing services can assist in crafting a well-researched and meticulously written paper.

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500+ Medical Research Topic Ideas

Table of Contents

Medical research plays a crucial role in advancing healthcare and improving human health. It involves the scientific study of various aspects of medicine and health, including the causes, prevention, diagnosis, and treatment of diseases. Medical research is a dynamic and ever-evolving field, with new discoveries and breakthroughs happening all the time. It encompasses a wide range of disciplines, from basic science to clinical research, and involves collaboration between scientists, doctors, and other healthcare professionals. In this article, we will explore some exciting new and latest medical research topic ideas that are currently trending in the field. These Research Topics cover a variety of areas, including genetics, infectious diseases, mental health, and more.

Medical Research Topic Ideas

Medical Research Topic Ideas are as follows:

• The efficacy of mindfulness meditation in reducing symptoms of depression and anxiety
• The effects of vitamin D supplementation on bone health in postmenopausal women
• The impact of social media on body image and eating disorders in adolescents
• The effectiveness of telemedicine in improving access to healthcare in rural communities
• The benefits and risks of long-term use of statins for cholesterol management
• The role of gut microbiota in the development of autoimmune diseases
• The potential of gene therapy for the treatment of genetic disorders
• The relationship between sleep disorders and cardiovascular disease
• The use of artificial intelligence in diagnosing and treating cancer
• The effect of exercise on cognitive function in older adults
• The impact of environmental factors on the development of asthma in children
• The effectiveness of cognitive-behavioral therapy for the treatment of PTSD in veterans
• The potential benefits of psychedelic-assisted therapy for the treatment of mental illness
• The relationship between diet and risk of developing type 2 diabetes
• The role of epigenetics in the development of psychiatric disorders
• The impact of COVID-19 on mental health and well-being
• The effectiveness of mindfulness-based stress reduction in improving quality of life in cancer patients
• The impact of childhood trauma on the development of mental illness in adulthood
• The benefits and risks of hormone replacement therapy for menopausal women
• The effect of music therapy on reducing symptoms of dementia in older adults
• The relationship between gut microbiota and obesity
• The impact of socioeconomic status on health outcomes
• The effectiveness of acupuncture in treating chronic pain
• The use of stem cells in regenerative medicine
• The impact of air pollution on respiratory health
• The potential of nanotechnology in drug delivery
• The relationship between social support and mental health
• The effectiveness of mindfulness-based interventions for addiction treatment
• The role of inflammation in the development of Alzheimer’s disease
• The use of virtual reality in pain management
• The impact of exercise on mental health in adolescents
• The effectiveness of group therapy for the treatment of substance abuse
• The relationship between sleep and weight management
• The benefits and risks of using medical marijuana for chronic pain management
• The role of the immune system in the development of autoimmune diseases
• The effectiveness of cognitive rehabilitation therapy for traumatic brain injury patients
• The impact of maternal stress on fetal development
• The relationship between physical activity and cardiovascular health
• The potential of gene editing for the treatment of genetic disorders
• The effectiveness of mindfulness-based interventions for reducing symptoms of postpartum depression.
• The impact of social media on mental health
• Investigating the use of virtual reality in pain management
• The effectiveness of mindfulness-based interventions for depression
• Exploring the relationship between sleep and anxiety
• Examining the efficacy of telemedicine in delivering mental health care
• Investigating the impact of environmental factors on the development of cancer
• The effect of exercise on cognitive function in elderly individuals
• Examining the potential benefits of psychedelic-assisted therapy for PTSD
• The relationship between diet and cardiovascular disease
• Investigating the impact of air pollution on respiratory health
• Examining the effects of social isolation on mental and physical health
• The use of machine learning in diagnosing medical conditions
• Investigating the effectiveness of acupuncture in pain management
• The impact of childhood trauma on mental and physical health outcomes in adulthood
• Examining the relationship between stress and autoimmune diseases
• The effect of music therapy on mental health outcomes
• Investigating the impact of gender on healthcare outcomes
• Examining the relationship between sleep apnea and cardiovascular disease
• The effectiveness of mindfulness-based interventions for chronic pain
• Investigating the potential benefits of medical marijuana for chronic pain management
• Examining the impact of climate change on infectious disease transmission
• The use of robotics in surgery
• Investigating the relationship between alcohol consumption and cancer risk
• The effect of meditation on blood pressure control
• Examining the impact of social determinants of health on healthcare outcomes
• The role of genetics in the development of mental health conditions
• Investigating the efficacy of cognitive-behavioral therapy for anxiety disorders
• Examining the relationship between inflammation and depression
• The impact of shift work on sleep and circadian rhythms
• Investigating the potential benefits of probiotics in gut health
• Examining the relationship between diet and mental health outcomes
• The effectiveness of art therapy for individuals with dementia
• Investigating the relationship between chronic pain and mental health outcomes
• The impact of artificial intelligence on medical diagnosis and treatment
• Examining the effectiveness of exercise in treating depression
• Investigating the relationship between inflammation and cardiovascular disease
• The effect of aromatherapy on anxiety and stress
• Examining the impact of social support on mental health outcomes
• The effectiveness of hypnotherapy in pain management.
• The role of gut microbiota in immune system modulation
• Effects of intermittent fasting on insulin sensitivity in obese individuals
• Impact of smartphone usage on sleep quality and quantity
• The potential therapeutic effects of CBD on anxiety disorders
• Association between shift work and cardiovascular disease
• Efficacy and safety of psychedelic-assisted psychotherapy in treating depression
• The relationship between stress and autoimmune diseases
• Novel therapies for Alzheimer’s disease
• The effects of high-intensity interval training on metabolic syndrome
• The role of epigenetics in the development of cancer
• The effectiveness of virtual reality in pain management
• The effects of social media on body image and eating disorders
• The association between air pollution and respiratory diseases
• Effects of mindfulness meditation on stress and anxiety in healthcare workers
• The potential benefits of ketogenic diet in treating epilepsy
• The relationship between sleep apnea and cardiovascular disease
• The impact of climate change on infectious disease outbreaks
• The effectiveness of exercise in preventing falls in the elderly
• The effects of blue light exposure on circadian rhythm and sleep quality
• The association between alcohol consumption and liver disease
• The effectiveness of cognitive-behavioral therapy in treating obsessive-compulsive disorder
• The role of gut-brain axis in mental health disorders
• The association between chronic inflammation and cancer
• The efficacy and safety of probiotics in treating irritable bowel syndrome
• The effects of social isolation on mental health in the elderly
• The impact of exercise on cognitive function in Parkinson’s disease patients
• The association between vitamin D deficiency and autoimmune diseases
• The potential therapeutic effects of music therapy in dementia patients
• The effects of second-hand smoke on cardiovascular health
• The association between maternal smoking and infant health outcomes
• The role of microbiome in the development of allergies
• The association between sleep duration and obesity
• The effects of blue light-blocking glasses on sleep quality and quantity
• The potential therapeutic effects of ketamine in treating depression
• The association between gut dysbiosis and inflammatory bowel disease
• The effectiveness of cognitive rehabilitation therapy in traumatic brain injury patients
• The impact of early childhood stress on adult mental health
• The role of inflammation in the development of type 2 diabetes
• The potential benefits of plant-based diets in preventing chronic diseases.
• The effects of exercise on cognitive function in aging adults
• The association between sleep disorders and cardiovascular disease
• The potential therapeutic effects of psilocybin in treating addiction
• The role of gut microbiota in the development of autism spectrum disorder
• The effectiveness of mindfulness-based interventions in treating depression
• The effects of air pollution on cognitive function
• The association between maternal mental health and child development
• The potential therapeutic effects of cannabis in treating chronic pain
• The role of diet in the prevention and management of diabetes
• The effects of social support on mental health in cancer patients
• The association between shift work and mental health disorders
• The efficacy of antiviral therapies in treating COVID-19
• The effects of exercise on bone health in postmenopausal women
• The association between sleep disorders and obesity
• The potential therapeutic effects of mindfulness meditation in treating anxiety disorders
• The role of gut microbiota in the development of metabolic disorders
• The effectiveness of virtual reality therapy in treating phobias
• The association between social support and immune system function
• The impact of early life stress on adult cardiovascular health
• The potential benefits of intermittent fasting in cancer prevention
• The effects of air pollution on pregnancy outcomes
• The association between maternal obesity and child health outcomes
• The efficacy of cognitive-behavioral therapy in treating post-traumatic stress disorder
• The effects of sedentary behavior on metabolic health
• The potential therapeutic effects of omega-3 fatty acids in treating depression
• The role of microbiome in the development of obesity
• The association between social isolation and cognitive decline in older adults
• The impact of environmental toxins on child development
• The potential benefits of plant-based diets in treating metabolic disorders
• The effects of sleep deprivation on cognitive function
• The association between maternal stress and fetal development
• The efficacy of pharmacological interventions in treating anxiety disorders
• The effects of air pollution on respiratory health in children
• The association between social support and cardiovascular health
• The potential therapeutic effects of mindfulness meditation in treating chronic pain
• The role of diet in the prevention and management of cardiovascular disease
• The effects of exercise on mental health in children and adolescents
• The association between social support and cancer survival rates
• The impact of environmental factors on epigenetic modifications and disease susceptibility.
• The effects of exercise on immune function
• The association between maternal obesity and infant health outcomes
• The impact of air pollution on cognitive function in children
• The association between sleep deprivation and mental health disorders
• The effectiveness of virtual reality in rehabilitation after stroke
• The role of the microbiome in the development of obesity
• The impact of noise pollution on cardiovascular health
• The association between depression and cardiovascular disease
• The association between periodontal disease and cardiovascular health
• The impact of social support on mental health outcomes in cancer patients
• The potential therapeutic effects of melatonin in treating sleep disorders
• The association between air pollution and cognitive decline in older adults
• The effectiveness of group therapy in treating social anxiety disorder
• The impact of exercise on bone health in postmenopausal women
• The association between alcohol consumption and breast cancer risk
• The effects of blue light exposure on melatonin secretion and sleep quality
• The potential therapeutic effects of stem cells in treating Parkinson’s disease
• The role of inflammation in the development of depression
• The association between gut dysbiosis and depression
• The effectiveness of music therapy in reducing anxiety in cancer patients
• The impact of social media on mental health in adolescents
• The potential therapeutic effects of ketamine in treating post-traumatic stress disorder
• The association between vitamin D deficiency and cardiovascular disease
• The effects of chronic stress on immune function
• The potential benefits of Mediterranean diet in preventing cardiovascular disease
• The impact of noise pollution on sleep quality and quantity
• The association between sedentary behavior and depression
• The effects of air pollution on fetal development and pregnancy outcomes
• The potential therapeutic effects of acupuncture in treating anxiety disorders
• The role of microbiome in the development of multiple sclerosis
• The effectiveness of mindfulness-based stress reduction in treating chronic pain
• The impact of artificial sweeteners on metabolic health
• The association between sleep duration and cardiovascular disease
• The effects of social isolation on immune function in older adults
• The potential therapeutic effects of omega-3 fatty acids in treating depression.
• The effects of exercise on cognitive function in older adults
• The association between maternal mental health and infant development
• The potential therapeutic effects of probiotics in treating depression
• The impact of air pollution on lung health in children
• The association between sleep quality and academic performance in adolescents
• The effectiveness of cognitive-behavioral therapy in treating insomnia
• The role of gut microbiota in the development of metabolic syndrome
• The potential therapeutic effects of ayahuasca in treating addiction
• The impact of green space on mental health in urban areas
• The association between sedentary behavior and cardiometabolic risk factors
• The effects of blue light on mood and cognitive performance in shift workers
• The potential benefits of vegan diets in preventing chronic diseases
• The impact of social support on mental health in older adults
• The association between air pollution and lung cancer risk
• The effects of exercise on mental health in cancer survivors
• The potential therapeutic effects of ketamine in treating bipolar disorder
• The role of the microbiome in the development of rheumatoid arthritis
• The association between maternal nutrition and fetal development
• The effects of sleep deprivation on immune function
• The potential benefits of mindfulness meditation in managing chronic pain
• The impact of noise pollution on sleep-disordered breathing
• The association between sedentary behavior and breast cancer risk
• The effects of blue light exposure on retinal health
• The potential therapeutic effects of deep brain stimulation in treating depression
• The role of gut microbiota in the development of non-alcoholic fatty liver disease
• The association between air pollution and neurodegenerative diseases
• The effects of social support on immune function in cancer patients
• The potential therapeutic effects of acupuncture in treating migraines
• The impact of light pollution on sleep quality and quantity
• The association between sedentary behavior and type 2 diabetes risk
• The effects of mindfulness meditation on cognitive function in older adults
• The potential benefits of the DASH diet in preventing hypertension
• The impact of social media on body dissatisfaction and eating disorders in adolescents
• The association between air pollution and kidney disease
• The effects of chronic stress on cardiovascular health
• The potential therapeutic effects of gene therapy in treating inherited diseases
• The role of microbiome in the development of atopic dermatitis
• The association between maternal smoking and childhood obesity
• The effects of blue light exposure on visual function and eye health
• The potential therapeutic effects of electroconvulsive therapy in treating depression.

Healthcare Research Topics for College Students

• The impact of healthcare policies on patient outcomes
• The effectiveness of telemedicine in improving access to healthcare
• The role of cultural competency in healthcare delivery
• The impact of social determinants of health on healthcare outcomes
• The effectiveness of different types of healthcare interventions
• The role of genetics in predicting and preventing chronic diseases
• The impact of the opioid epidemic on healthcare delivery
• The effectiveness of alternative medicine in managing chronic conditions
• The role of technology in improving patient safety
• The impact of healthcare provider burnout on patient care
• The effectiveness of different healthcare models in managing chronic diseases
• The role of patient education in improving healthcare outcomes
• The impact of healthcare disparities on access to care and health outcomes
• The effectiveness of healthcare systems in responding to public health emergencies
• The role of nutrition in disease prevention and management
• The impact of healthcare policy on healthcare costs and spending
• The effectiveness of mental health interventions in improving overall health outcomes
• The role of healthcare systems in addressing health disparities
• The impact of healthcare data analytics on clinical decision making
• The effectiveness of healthcare interventions in reducing healthcare-associated infections
• The role of patient-centered care in improving healthcare outcomes
• The impact of healthcare regulations on patient safety
• The effectiveness of vaccination programs in preventing infectious diseases
• The role of healthcare systems in promoting healthy lifestyle behaviors
• The impact of chronic diseases on healthcare costs and quality of life
• The effectiveness of preventative healthcare in improving health outcomes
• The role of healthcare technology in improving healthcare delivery
• The impact of healthcare funding on healthcare outcomes
• The effectiveness of healthcare interventions in managing chronic pain
• The role of healthcare providers in promoting health equity.

Community Medicine Research Topics for Medical Students

• The impact of community-based interventions on reducing the burden of non-communicable diseases in low-income communities.
• The effectiveness of vaccination campaigns in preventing infectious diseases in marginalized communities.
• The relationship between air pollution and respiratory health in urban communities.
• The prevalence and risk factors of substance abuse among homeless populations.
• The impact of social determinants of health on health outcomes in rural communities.
• The role of community health workers in improving maternal and child health outcomes in low-resource settings.
• The association between food insecurity and obesity in low-income populations.
• The prevalence and risk factors of mental health disorders among adolescents in urban communities.
• The effectiveness of school-based health promotion programs in improving health behaviors among children and adolescents.
• The role of community-based participatory research in addressing health disparities in underserved populations.
• The impact of social support networks on mental health outcomes among elderly populations.
• The relationship between access to healthcare services and health outcomes in rural communities.
• The effectiveness of smoking cessation interventions in reducing the burden of tobacco-related diseases.
• The prevalence and risk factors of sexually transmitted infections among young adults in urban communities.
• The role of community-based organizations in promoting healthy behaviors and preventing chronic diseases.
• The impact of climate change on the incidence and distribution of infectious diseases.
• The prevalence and risk factors of intimate partner violence among women in low-income communities.
• The effectiveness of health education programs in improving health literacy and health outcomes in underserved populations.
• The relationship between social support and adherence to treatment among patients with chronic diseases.
• The prevalence and risk factors of hypertension and diabetes in urban communities.
• The impact of community-based interventions on reducing healthcare costs and improving health outcomes.
• The role of mobile health technologies in improving access to healthcare services in rural communities.
• The prevalence and risk factors of obesity among children and adolescents in low-income communities.
• The effectiveness of community-based interventions in promoting healthy behaviors among pregnant women.
• The impact of housing conditions on health outcomes in marginalized communities.
• The relationship between access to healthy food and health outcomes in urban communities.
• The prevalence and risk factors of depression among elderly populations in rural communities.
• The role of social media in promoting healthy behaviors and preventing diseases among young adults.
• The effectiveness of telemedicine in improving access to healthcare services in underserved populations.
• The prevalence and risk factors of infectious diseases among migrant populations in urban areas.

Surgery Research Topics for Medical Students

• The efficacy and safety of minimally invasive surgery for various conditions
• Comparison of laparoscopic and open surgery for common procedures
• The impact of surgeon experience on surgical outcomes
• Analysis of postoperative complications and their management
• The role of robotics in surgery
• Investigating the use of artificial intelligence in surgery
• The effectiveness of non-pharmacological pain management techniques after surgery
• The effect of preoperative anxiety on postoperative recovery
• Evaluation of different surgical approaches for breast cancer treatment
• The benefits and risks of surgical treatment for obesity
• Investigating the use of stem cells in tissue repair following surgery
• The influence of nutrition on postoperative recovery and wound healing
• Analysis of the psychological impact of surgery on patients
• The effect of different anesthesia methods on postoperative outcomes
• Comparison of outcomes between day surgery and inpatient surgery
• Evaluation of the use of surgical checklists in improving patient safety
• The impact of age on surgical outcomes and recovery
• Investigating the use of 3D printing in surgical planning and implant design
• The benefits and risks of bariatric surgery in patients with diabetes
• The role of surgery in the treatment of chronic pain
• The efficacy of arthroscopic surgery for joint conditions
• The use of lasers in surgery
• Investigating the use of virtual reality in surgical training and education
• The effect of preoperative counseling on patient satisfaction and outcomes
• The impact of comorbidities on surgical outcomes
• Analysis of the economic impact of different surgical approaches
• Investigating the use of telemedicine in surgical consultations and follow-up care
• The effectiveness of surgical treatment for endometriosis
• Comparison of outcomes between single-incision and multiport laparoscopic surgery
• The use of robotics in urologic surgery.

Research Projects for Undergraduate Medical Students

• Investigating the role of genetics in the development of cancer
• Analyzing the effectiveness of different types of pain management strategies in postoperative patients
• Evaluating the impact of diet and exercise on obesity-related health outcomes
• Examining the relationship between sleep quality and mental health in medical students
• Investigating the efficacy of different types of antibiotics in treating common bacterial infections
• Analyzing the impact of electronic medical record systems on patient care
• Evaluating the effectiveness of different types of vaccines in preventing infectious diseases
• Examining the relationship between maternal nutrition and fetal development
• Investigating the use of telemedicine in delivering healthcare services to rural populations
• Analyzing the impact of smoking on lung function and respiratory health
• Evaluating the effectiveness of different types of rehabilitation programs for stroke patients
• Examining the relationship between physical activity and cardiovascular health
• Investigating the use of stem cells in treating various medical conditions
• Analyzing the impact of stress on mental and physical health outcomes
• Evaluating the effectiveness of different types of medical interventions in managing chronic pain
• Examining the relationship between social support and mental health outcomes in patients with chronic illnesses
• Investigating the use of mindfulness-based interventions in reducing anxiety and depression
• Analyzing the impact of environmental factors on health outcomes in urban populations
• Evaluating the effectiveness of different types of cancer treatments, such as chemotherapy, radiation therapy, and surgery
• Examining the relationship between nutrition and mental health in older adults
• Investigating the use of mobile health technologies in promoting healthy behaviors
• Analyzing the impact of air pollution on respiratory health in children
• Evaluating the effectiveness of different types of treatments for substance use disorders
• Examining the relationship between socioeconomic status and health outcomes
• Investigating the use of music therapy in managing pain and anxiety in hospitalized patients
• Analyzing the impact of social media on mental health outcomes in adolescents
• Evaluating the effectiveness of different types of interventions in managing symptoms of depression and anxiety in cancer patients
• Examining the relationship between sleep and cognitive function in older adults
• Investigating the use of animal-assisted therapy in promoting physical and mental health
• Analyzing the impact of climate change on health outcomes in vulnerable populations

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Muhammad Hassan

Researcher, Academic Writer, Web developer

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100+ Medical Research Paper Topics for Students

The medical field is vast and rich, so choosing a medical topic for a research paper is easy. However, the abundance of medical topics to research can also make choosing the “best” one a daunting task. Medical research topics are about drugs and their interactions and those expounding on the root causes of diseases. There are a variety of topics in medicine to discuss, spanning the different angles of the field, including medical social issues research topics .

Tips for Choosing the Best Research Topics in Medicine

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If you find it difficult to choose a medical research topic for your paper, that is to be expected. This article will give you 100+ medical research topics to work on, spanning different aspects of medicine. However, before that, we will show you how to select the best-med research topics. Whether you’re looking for argumentative essay topics or anatomy research paper topics , there is no dearth of medical research topics.

Choosing a research topic, even if it’s an interesting thesis statement about social media , is often more challenging than the actual writing. To be able to do justice to these medical research topics, you need to choose topics that inspire you. Below are our A+ tips for choosing the best medical topics to write about:

• Choose medicine research topics you are interested in; whether you’re working on economics research paper topics or biochemistry topics , personal interest is vital.
• Choose a few med research topics first; then, sift through scholarly articles to get updated with the latest medical developments and issues.
• Understand the why, how, and what of your research; how will it contribute to the existing knowledge body?
• Choose healthcare research topics that are neither general nor too narrow; there should be sufficient research scope.
• Choose a significant medical research topic for you and your chosen career path.

You’re close to a breakthrough now that you know what factors to consider when choosing health topics to research. There are many places to get inspiration, including research topics on medicine. Below, we have compiled some of the best research topics in health.

• The genetics of epilepsy
• Clinical genetic research malpractice
• The concept of reverse genetics in creating vaccines
• GNE myopathy: therapies
• Brain imaging
• Genes behind juvenile idiopathic arthritis
• How screenings help gynecologic cancer prevention
• Drug addiction: the genetics
• Parkinson’s and Alzheimer’s disease: exploring the genetic similarities
• Genetic factors in HIV
• Telehealth: meaning and benefits
• Eating disorders
• Staying healthy while studying
• Health fraud
• Occupation diseases: how are they classified?
• Effective measures to help reduce sports injuries
• Safe use of medical devices
• Is mental disorder curable?
• Causative diseases of B vitamins deficiency
• Regular exercise and heart health
• Non-therapeutic ADHD medication use in children
• Type 1 diabetes in children: effective management
• Movement disorders in children
• Secondhand smoking: its effect on children
• Sudden infant death syndrome (SIDS)
• Children exposed to meningitis
• Autism in children
• How exposure to air pollution affects prenatal
• Diagnosis and management of childhood asthma
• Prevention strategies for obesity in children
• Human microbial ecology: the latest discoveries
• How to attenuate arthritic bone tissue destruction
• Brain changes in stroke survivors
• Cancer effect on bone marrow
• Effective diagnostic methods of endometriosis
• Photoperiodic changes and their effect on brainstem volume
• The crystal structure of human enamel
• Measuring musculoskeletal and neuromuscular function
• Extensor hallucis longus in hallux pathology
• Obesity and knee osteoarthritis
• Pandemic vs. epidemic
• The placebo effect of homeopathic medicine
• Causes and treatment for virus infection
• Brain injuries
• Chronic diseases
• Alzheimer’s
• Effects of circumcision
• Medical approaches to abortion
• Legalization of marijuana for medicine
• Effect of environmental changes on human health
• Urban pollution and respiratory diseases: exploring the relationship
• Communication disorders
• Why are cancer cases increasing?
• Latest developments in HIV/AIDs
• Medical tools and instruments: latest innovations
• Effect of terrorism on mental health
• Insulin resistance
• Genetic engineering
• Adverse effects of smoking on vital organs
• Developments in breast cancer research
• Management principle of healthcare professionals
• Private hospitals vs. public hospitals
• Who should be held responsible for surgery failures?
• The anti-vaccine movement
• Cancer treatments: estimated costs
• Hospital administration and their legal responsibilities
• The upside to national healthcare systems
• Anxiety disorders: causes and treatment
• Public policies on mental health
• Treatment of childhood trauma in public healthcare systems
• Schizophrenia
• Anorexia vs. Bulimia
• Postpartum depression
• The mental health of rape victims
• Side effects of chemotherapy
• Child vaccination programs: benefits and limitations
• Medical internships: the benefits
• Use of AI in medicine
• Doctors’ roles vs. nurses’ roles
• Poor sanitation: management in developing countries
• Sleep paralysis
• Vaccination: benefits and side effects
• Eating disorders: causes and remedies
• Sexual organ transplantation
• Challenges in biomedical research
• The importance of the lymphatic system
• Functions of thyroid glands on the body
• The digestive system
• The developmental stages of the human muscular system
• Antibiotic resistance
• Effects of air pollution on health
• Aging: biological effects
• Contraception
• Surrogacy vs. artificial insemination
• Causative diseases for hair loss
• Effect or non-effect of alcohol on the bone marrow
• Tongue disorders
• Understanding when chest pain becomes severe
• The relationship between diabetes and eye problems
• Alternative medicine and complementary medicine: is one better than the other?
• The reversal potentials of diabetic nerve damage
• Thrombocytopenia: do they cause bleeding disorders?
• Does one’s ethnic group influence one’s susceptibility to metabolic syndrome?
• Mandating flu vaccination for health workers

There are thousands of ideas and angles to explore in the medical field. With the 100+ interesting medical topics for the research papers that we have provided, you have options to work with. The tips for choosing a topic can also help you sift through research topics for STEM students , among others, to choose the best.

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150+ Medical research paper topics for students

Updated 04 Jul 2024

Med Research Topics: What Makes a Good One?

Several essential attributes characterize an excellent medical research topic. First and foremost, it should address a significant and relevant issue within the medical field. The topic must have practical implications, contributing to advancing medical knowledge and improving patient care. For example, researching a new treatment for a prevalent disease or understanding the underlying mechanisms of a standard physical and mental health condition can provide valuable insights that can be applied in clinical practice.

Furthermore, a robust medical research topic should be specific and well-defined, allowing for a focused investigation. Vague or overly broad issues can make formulating a straightforward research question and designing a robust study challenging. Interested researchers can delve deeper into the subject matter by narrowing the scope and producing more detailed and meaningful findings. For instance, instead of broadly studying "cancer and treatment options," a more defined topic like "the efficacy of a specific immunotherapy in treating melanoma" would yield more actionable results.

Another critical aspect of an excellent medical research topic is feasibility. Researchers need to consider the availability of resources, such as funding, equipment, and expertise, as well as ethical considerations. The topic should be practical to study within the given constraints and timeframe. The feasibility of interesting topics also encompasses recruiting sufficient participants if human subjects are involved, ensuring that the study can be conducted effectively and ethically.

Lastly, a compelling medical research topic should be innovative and contribute new knowledge. It should challenge existing paradigms, explore uncharted areas, or offer new perspectives on established concepts. Innovation drives progress in medicine, leading to breakthroughs that can revolutionize patient care and improve patient outcomes. By choosing a topic that pushes the boundaries of current knowledge, healthcare researchers can make a lasting impact on the medical community and beyond. Choosing compelling medical research paper topics can be challenging, but a personal statement writer can help you highlight your research interests and academic goals effectively in your application.

How to Pick a Good Medical Research Paper Topic

Selecting a good medical research paper topic involves carefully considering several key factors. Firstly, choosing a topic that addresses a significant and current issue in the medical field is essential. One such issue is healthcare access, which is crucial in addressing inequities and barriers leading to health disparities and injustices. This ensures that the research will be relevant and contribute valuable knowledge to ongoing discussions and advancements in oral health elsewhere. Reviewing recent literature on medical research topics and identifying gaps in existing research can help pinpoint areas that need further exploration.

Next, the chosen topic should be specific and focused. A narrow scope allows for a more in-depth investigation and produces more detailed and actionable findings. For example, instead of a broad topic like "diabetes management," focusing on "the impact of a specific diet on blood sugar levels in Type 2 diabetes patients" can yield more precise and practical insights.

Feasibility is another crucial aspect to consider. Ensure that the necessary resources, including time, funding, and access to data or study participants, are available to complete the research effectively. Ethical considerations should be addressed, mainly when human subjects are involved. This involves obtaining the appropriate approvals and ensuring the study design protects participants' rights and well-being.

Lastly, the topic should be innovative and advance medical knowledge or practice. Aim to explore new perspectives, challenge existing assumptions, or investigate novel treatments or interventions. By selecting a topic that pushes the boundaries of understanding herbal medicine, researchers can significantly impact trends in the field and contribute to meaningful advancements in medicine.

150 medical research topics for college students

• Impact of lifestyle changes on hypertension management
• Genetic predispositions to heart disease
• Advances in minimally invasive heart surgery
• Role of diet in preventing cardiovascular diseases
• Efficacy of new anticoagulants in stroke prevention
• Long-term effects of statins on heart health
• Emerging treatments for congestive heart failure
• Non-invasive techniques for detecting coronary artery disease
• Impact of mental health on cardiac health
• Role of inflammation in atherosclerosis development
• Immunotherapy for advanced melanoma
• Genetic markers for early cancer detection
• Impact of diet and lifestyle on cancer prognosis
• New targeted therapies for breast cancer
• Role of microRNA in cancer progression
• Advances in radiotherapy for brain tumors
• Psychological support for cancer patients
• Personalized medicine in oncology
• Impact of environmental toxins on cancer incidence
• Survivorship and quality of life post-cancer treatment
• New treatments for Alzheimer's disease
• Role of genetics in multiple sclerosis
• Advances in the understanding of Parkinson's disease
• Impact of sleep disorders on neurological health
• Efficacy of new migraine treatments
• Neuroplasticity in stroke recovery
• Role of gut microbiome in neurodegenerative diseases
• Emerging therapies for epilepsy
• Impact of chronic stress on brain health
• Non-pharmacological interventions for ADHD
• Vaccination and childhood disease prevention
• Impact of screen time on child development
• Pediatric obesity and associated health risks
• Advances in neonatal care
• Genetic disorders in children and early interventions
• Efficacy of behavioral therapies for autism
• Role of nutrition in childhood growth and development
• Preventing and treating pediatric asthma
• Long-term outcomes of premature birth
• Pediatric mental health and early intervention

Endocrinology

• New treatments for Type 1 diabetes
• Impact of thyroid disorders on overall health
• Advances in understanding insulin resistance
• Role of hormones in metabolic syndrome
• Long-term effects of hormone replacement therapy
• Efficacy of new medications for osteoporosis
• Relationship between stress and endocrine disorders
• Impact of endocrine disruptors on health
• Role of diet and exercise in managing diabetes
• Advances in adrenal gland disorder treatments

Infectious Diseases

• Impact of antibiotic resistance on public health
• New vaccines for emerging infectious diseases
• Role of climate change in disease spread
• Advances in HIV treatment and prevention
• Efficacy of antiviral therapies for hepatitis C
• Impact of global travel on infectious disease transmission
• Role of the microbiome in infection prevention
• Emerging zoonotic diseases
• Efficacy of new tuberculosis treatments
• Strategies for preventing hospital-acquired infections
• Advances in the treatment of depression
• Impact of social media on mental health
• Role of genetics in psychiatric disorders
• Efficacy of cognitive-behavioral therapy for anxiety
• Long-term effects of antipsychotic medications
• Role of Lifestyle changes in managing bipolar disorder
• Impact of trauma on mental health
• Emerging treatments for PTSD
• Role of neurobiology in addiction
• Efficacy of mindfulness-based therapies
• Insomnia effect on patients with mental health conditions

Public Health

• Impact of public health policies on smoking rates
• Role of community programs in obesity prevention
• Strategies for reducing health disparities
• Impact of urbanization on public health
• Efficacy of health education programs
• Role of public health in disaster preparedness
• Advances in global health initiatives
• Impact of socioeconomic status on health outcomes
• Role of vaccination in public health
• Efficacy of public health interventions for substance abuse
• Impact of public health regulations on social behavior and health outcomes amid COVID-19

Dermatology

• Advances in the treatment of psoriasis
• Role of diet in managing acne
• Efficacy of new therapies for eczema
• Impact of environmental factors on skin health
• Role of genetics in skin disorders
• Advances in melanoma detection
• Impact of skincare products on skin health
• Role of microbiome in skin diseases
• Efficacy of laser treatments for skin conditions
• Strategies for preventing skin cancer

Gastroenterology

• Impact of diet on gut health
• Advances in the treatment of inflammatory bowel disease
• Role of probiotics in digestive health
• Efficacy of new therapies for irritable bowel syndrome
• Effect of gut microbiome on overall health
• Role of genetics in gastrointestinal disorders
• Advances in colorectal cancer screening
• Efficacy of dietary interventions for celiac disease
• Impact of chronic stress on digestive health
• Strategies for managing liver diseases
• Impact of electronic health records on gastroenterology research

Pulmonology

• Advances in asthma management
• Role of genetics in lung diseases
• Impact of air pollution on respiratory health
• Efficacy of new treatments for COPD
• Role of Lifestyle changes in managing Sleep Apnea
• Advances in lung cancer treatment
• Effect of Smoking Cessation Programs
• Efficacy of pulmonary rehabilitation
• Role of diet in respiratory health
• Strategies for managing chronic bronchitis
• Advances in kidney transplant techniques
• Role of diet in managing kidney disease
• Impact of hypertension on kidney health
• Efficacy of new treatments for chronic kidney disease
• Role of genetics in nephrological disorders
• Advances in dialysis technology
• Impact of diabetes on kidney health
• Efficacy of lifestyle interventions for kidney stones
• Role of hydration in preventing kidney diseases
• Strategies for early detection of kidney disorders

Orthopedics

• Advances in joint replacement surgery
• Role of physical therapy in managing osteoarthritis
• Efficacy of new treatments for osteoporosis
• Impact of sports on musculoskeletal health
• Role of genetics in orthopedic disorders
• Advances in minimally invasive orthopedic surgery
• Efficacy of regenerative therapies for bone injuries
• Role of nutrition in bone health
• Strategies for preventing sports injuries
• Impact of aging on musculoskeletal health

Ophthalmology

• Advances in cataract surgery techniques
• Role of genetics in eye diseases
• Impact of screen time on vision health
• Efficacy of new treatments for glaucoma
• Role of diet in maintaining eye health
• Advances in retinal disease management
• Efficacy of laser eye surgery
• Strategies for preventing macular degeneration
• Role of lifestyle changes in managing dry eye syndrome
• Impact of environmental factors on eye health

Rheumatology

• Advances in the treatment of rheumatoid arthritis
• Role of genetics in autoimmune disorders
• Efficacy of new therapies for lupus
• Impact of diet on inflammatory conditions
• Role of physical activity in managing arthritis
• Advances in understanding fibromyalgia
• Efficacy of biologic drugs in rheumatology
• Impact of chronic inflammation on overall health
• Strategies for managing gout
• Role of complementary therapies in rheumatic diseases

Selecting a Medical Research Paper Topic

Choosing a good medical research paper topic is a critical first step in the research process, influencing the direction and impact of the study. A well-chosen topic should address a significant and current issue within the medical field, ensuring relevance and the potential to contribute valuable insights to ongoing medical discussions and advancements. By focusing research projects on areas of primary care that need further exploration, researchers can make meaningful contributions to the body of medical knowledge.

A specific and well-defined topic allows for a focused investigation, leading to detailed and actionable findings for future medical students and others. Narrowing the scope helps researchers delve deeper into the subject matter, enhancing the quality and precision of the research. This approach benefits the study and ensures that the results are practical and applicable in real-world medical scenarios. Additionally, the feasibility of the topic, considering available resources and ethical considerations, is crucial for completing the research.

Innovative research topics that push the boundaries of current understanding are essential for driving progress in medicine. Researchers can significantly impact the field by exploring new perspectives, challenging existing assumptions, and investigating novel treatments or interventions for chronic diseases. Such groundbreaking research has the potential to revolutionize patient care and improve health outcomes on a broader scale.

If you're embarking on your medical research journey, start by identifying a topic that not only fascinates you but also meets the criteria of significance, specificity, feasibility, and innovation. Dive into current literature, consult with experts, and consider the practical implications of your research. By choosing a compelling topic, you'll set the stage for a successful and impactful study that can contribute to advancing medical science and improving patient care. Don't hesitate to seek guidance and support from your peers and mentors throughout this process, as collaboration and feedback are invaluable in refining your research focus.

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Research Topics & Ideas: Public Health

50 Topic Ideas To Kickstart Your Research Project

If you’re just starting out exploring public health and/or epidemiology-related topics for your dissertation, thesis or research project, you’ve come to the right place. In this post, we’ll help kickstart your research by providing a hearty list of research ideas , including examples from recent studies in public health and epidemiology.

PS – This is just the start…

We know it’s exciting to run through a list of research topics, but please keep in mind that this list is just a starting point . These topic ideas provided here are intentionally broad and generic , so keep in mind that you will need to develop them further. Nevertheless, they should inspire some ideas for your project.

To develop a suitable research topic, you’ll need to identify a clear and convincing research gap , and a viable plan to fill that gap. If this sounds foreign to you, check out our free research topic webinar that explores how to find and refine a high-quality research topic, from scratch. Alternatively, consider our 1-on-1 coaching service .

Public Health-Related Research Topics

• Evaluating the impact of community-based obesity prevention programs in urban areas.
• Analyzing the effectiveness of public smoking bans on respiratory health outcomes.
• Investigating the role of health education in reducing the prevalence of HIV/AIDS in sub-Saharan Africa.
• The impact of air pollution on asthma rates in industrial cities.
• Evaluating the effectiveness of school nutrition programs on childhood obesity rates.
• The role of public health policies in addressing mental health stigma.
• Analyzing the impact of clean water access on infectious disease rates in rural communities.
• The effectiveness of needle exchange programs in reducing the spread of hepatitis C.
• Investigating the impact of social determinants on maternal and child health in low-income neighborhoods.
• The role of digital health interventions in managing chronic diseases.
• Analyzing the effectiveness of workplace wellness programs on employee health and productivity.
• The impact of urban green spaces on community mental health.
• Evaluating the effectiveness of vaccination campaigns in preventing outbreaks of infectious diseases.
• The role of public health initiatives in reducing alcohol-related harm.
• Analyzing the impact of aging populations on healthcare systems.
• Analyzing the impact of urbanization on mental health disorders in metropolitan areas.
• The effectiveness of telemedicine services in improving healthcare access in remote regions.
• Investigating the health impacts of electronic waste recycling practices.
• The role of health literacy in managing non-communicable diseases in aging populations.
• Evaluating the public health response to opioid addiction in rural communities.
• Analyzing the relationship between housing quality and respiratory illnesses.
• The effectiveness of community engagement in improving reproductive health services.
• Investigating the health effects of long-term exposure to low-level environmental radiation.
• The role of public health campaigns in reducing the prevalence of tobacco use among teenagers.
• Analyzing the impact of food deserts on nutritional outcomes in urban communities.

Epidemiology Research Ideas (Continued)

• Investigating the epidemiology of antibiotic-resistant infections in hospital settings.
• The impact of climate change on the spread of vector-borne diseases.
• Evaluating the factors contributing to the rise in type 2 diabetes prevalence.
• Analyzing the epidemiology of mental health disorders in conflict zones.
• The role of epidemiological surveillance in pandemic preparedness and response.
• Investigating the link between environmental exposures and the incidence of childhood cancers.
• The impact of dietary patterns on the prevalence of cardiovascular diseases.
• Evaluating the effectiveness of intervention strategies in controlling obesity epidemics.
• Analyzing the spread and control of zoonotic diseases in rural communities.
• The role of genetic factors in the epidemiology of autoimmune diseases.
• Investigating the socio-economic disparities in cancer incidence and outcomes.
• The impact of urbanization on the epidemiology of infectious diseases.
• Evaluating the public health consequences of occupational exposures to hazardous substances.
• Analyzing the trends and determinants of mental health disorders among adolescents.
• The role of lifestyle factors in the epidemiology of neurodegenerative diseases.
• Investigating the patterns of mental health service utilization during economic recessions.
• The epidemiology of sports-related concussions in youth athletics.
• Evaluating the effectiveness of public health interventions in reducing the spread of tuberculosis in high-risk populations.
• Analyzing the geographic distribution of Lyme disease in relation to climate change.
• The role of international travel in the spread of emerging infectious diseases.
• Investigating the demographic predictors of chronic kidney disease in population-based studies.
• The epidemiological impact of air pollution on asthma and other respiratory conditions.
• Evaluating the long-term health effects of exposure to endocrine-disrupting chemicals.
• Analyzing the incidence and risk factors of post-traumatic stress disorder in first responders.
• The role of socioeconomic status in the prevalence and management of diabetes.

Recent Studies: Public Health & Epidemiology

While the ideas we’ve presented above are a decent starting point for finding a research topic, they are fairly generic and non-specific. So, it helps to look at actual studies in the public health and epidemiology space to see how this all comes together in practice.

Below, we’ve included a selection of recent studies to help refine your thinking. These are actual studies,  so they can provide some useful insight as to what a research topic looks like in practice.

• Tutorials in population neuroimaging: Using epidemiology in neuroimaging research (Godina et al., 2022)
• Application of Big Data in Digital Epidemiology (Naaz & Siddiqui, 2022)
• Response to comment on: Incidence of ocular and systemic disease affecting visual function among state bus drivers (Kohli et al., 2022)
• Why epidemiology is incomplete without qualitative and mixed methods (Lane-Fall, 2023)
• Teaching epidemiology: An overview of strategies and considerations (Hossain, 2022)
• Social Epidemiology: Past, Present, and Future (Roux, 2022)
• Population health assessment project: An innovative strategy for teaching principles of epidemiology (Keen et al., 2022)
• The functions of veterinary epidemiology in public health (Shaffi, 2023)
• Readying the Applied Epidemiology Workforce for Emerging Areas of
• Public Health Practice (Daly et al., 2022)
• Some Social Epidemiologic Lessons from the COVID-19 Pandemic (Schnake-Mahl & Bilal, 2023)
• The Filth Disease: Typhoid Fever and the Practices of Epidemiology in Victorian England by Jacob Steere-Williams (review) (Steere-Williams et al., 2022)
• Epidemiology of Adult Obesity, Measurements, Global Prevalence and Risk Factors (Orukwowu, 2022).
• Which disciplines form digital public health, and how do they relate to each other? (Pan, 2022)
• Information Flow and Data Gaps in COVID-19 Recording and Reporting at National and Provincial Levels in Indonesia (Barsasella et al., 2022). Epidemiology Blog of Neal D. Goldstein, PhD, MBI (Goldstein, 2023)
• Sensitivity analysis of SEIR epidemic model of Covid 19 spread in Indonesia (Rangkuti et al., 2022)

As you can see, these research topics are a lot more focused than the generic topic ideas we presented earlier. So, for you to develop a high-quality research topic, you’ll need to get specific and laser-focused on a specific context with specific variables of interest.  In the video below, we explore some other important things you’ll need to consider when crafting your research topic.

Get 1-On-1 Help

If you’re still unsure about how to find a quality research topic, check out our Research Topic Kickstarter service, which is the perfect starting point for developing a unique, well-justified research topic.

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151+ Public Health Research Topics [Updated 2024]

The important area of public health research is essential to forming laws, influencing medical procedures, and eventually enhancing community well-being. As we delve into the vast landscape of public health research topics, it’s essential to understand the profound impact they have on society.

This blog aims to provide a comprehensive guide to selecting and understanding the diverse array of public health research topics.

Overview of Public Health Research Topics

Table of Contents

Public health research encompasses a wide range of subjects, reflecting the interdisciplinary nature of the field. From epidemiology and health policy to environmental health and infectious diseases, researchers navigate through various dimensions to address complex health challenges.

Each category holds its own significance, contributing to the overall understanding of public health dynamics.

Key Considerations in Selecting Public Health Research Topics

• Current Relevance: Assess the timeliness of potential topics by considering recent health trends, emerging issues, and societal concerns.
• Impact on Public Health: Evaluate the potential impact of the research on improving health outcomes, addressing disparities, or influencing policy and interventions.
• Feasibility and Resources: Gauge the practicality of conducting research on a particular topic, considering available resources, data accessibility, and research infrastructure.
• Ethical Considerations: Scrutinize the ethical implications of the research, ensuring it aligns with ethical standards and guidelines, especially when dealing with vulnerable populations or sensitive topics.

Top 151+ Public Health Research Topics

Epidemiology.

• The Impact of Social Determinants on Disease Outcomes
• Patterns and Trends in Emerging Infectious Diseases
• Investigating Health Disparities among Different Ethnic Groups
• Childhood Obesity and its Long-Term Health Consequences
• Assessing the Effectiveness of Contact Tracing in Disease Control

Health Policy

• Universal Healthcare: Comparative Analysis of Global Models
• The Role of Telemedicine in Improving Healthcare Access
• Evaluating Mental Health Policies and Their Impact on Communities
• Assessing the Impact of Affordable Care Act on Public Health
• Vaccine Policies and Public Perception: A Comprehensive Study

Environmental Health

• Climate Change and Health: Adapting to the Challenges
• Air Quality and Respiratory Health in Urban Environments
• Waterborne Diseases and Strategies for Safe Water Supply
• Occupational Health Hazards: A Comprehensive Workplace Analysis
• The Impact of Green Spaces on Mental Health in Urban Areas

Infectious Diseases

• Antimicrobial Resistance: Strategies for Mitigation
• Vaccination Strategies and Herd Immunity
• Global Health Security: Preparedness for Pandemics
• The Impact of Vector-Borne Diseases on Public Health
• Emerging Trends in Antibiotic-Resistant Infections

Chronic Diseases

• Lifestyle Interventions for Preventing Cardiovascular Diseases
• Genetic Factors in the Development of Cancer: A Comprehensive Study
• Aging and Health: Addressing the Healthcare Needs of the Elderly
• Diabetes Prevention Programs: Efficacy and Implementation
• Mental Health in Chronic Disease Patients: Bridging the Gap

Maternal and Child Health

• Maternal Mortality: Understanding Causes and Prevention
• The Impact of Breastfeeding on Infant Health and Development
• Childhood Immunization: Barriers and Strategies for Improvement
• Teenage Pregnancy and Its Long-Term Health Consequences
• Mental Health Support for Postpartum Women: Current Gaps and Solutions

Health Behavior and Promotion

• Smoking Cessation Programs: Effectiveness and Challenges
• Physical Activity Promotion in Schools: Strategies for Success
• Nutrition Education and Its Impact on Healthy Eating Habits
• Mental Health Awareness Campaigns: Assessing Public Perceptions
• The Role of Social Media in Health Promotion

Global Health

• Assessing the Impact of International Aid on Global Health
• Water, Sanitation, and Hygiene (WASH) Programs in Developing Countries
• The Role of Non-Governmental Organizations in Global Health
• Communicable Disease Control in Refugee Populations
• Global Access to Essential Medicines: Challenges and Solutions

Community Health

• Community-Based Participatory Research: Best Practices and Challenges
• The Impact of Community Health Workers on Health Outcomes
• Health Literacy and its Relationship to Health Disparities
• Assessing the Effectiveness of Mobile Health (mHealth) Interventions
• Community Resilience in the Face of Public Health Crises

Healthcare Quality and Patient Safety

• Hospital-Acquired Infections: Strategies for Prevention
• Patient Safety Culture in Healthcare Organizations
• Quality Improvement Initiatives in Primary Care Settings
• Healthcare Accreditation: Impact on Patient Outcomes
• Implementing Electronic Health Records: Challenges and Benefits

Mental Health

• Stigma Reduction Programs for Mental Health Disorders
• Integrating Mental Health into Primary Care Settings
• The Impact of COVID-19 on Mental Health: Long-Term Implications
• Mental Health in the Workplace: Strategies for Employee Well-being
• Suicide Prevention Programs: Effectiveness and Outreach

Health Disparities

• Racial Disparities in Healthcare: Addressing Systemic Inequities
• LGBTQ+ Health Disparities and Inclusive Healthcare Practices
• Socioeconomic Status and Access to Healthcare Services
• Geographical Disparities in Health: Rural vs. Urban
• The Impact of Gender on Health Outcomes and Access to Care

Public Health Education

• Evaluation of Public Health Education Programs
• Innovative Approaches to Teaching Public Health Concepts
• Online Health Education Platforms: Opportunities and Challenges
• Interdisciplinary Training in Public Health: Bridging Gaps
• Continuing Education for Public Health Professionals: Current Landscape

Digital Health

• The Role of Wearable Devices in Health Monitoring
• Telehealth Adoption: Barriers and Opportunities
• Health Apps for Chronic Disease Management: User Perspectives
• Blockchain Technology in Healthcare: Privacy and Security Implications
• Artificial Intelligence in Disease Diagnosis and Prediction

Health Economics

• Cost-Effectiveness of Preventive Health Interventions
• The Impact of Healthcare Financing Models on Access to Care
• Pharmaceutical Pricing and Access to Essential Medicines
• Economic Evaluation of Health Promotion Programs
• Health Insurance Coverage and Health Outcomes: A Global Perspective

Innovations in Public Health

• 3D Printing in Healthcare: Applications and Future Prospects
• Gene Editing Technologies and their Ethical Implications
• Smart Cities and Public Health: Integrating Technology for Well-being
• Nanotechnology in Medicine: Potential for Disease Treatment
• The Role of Drones in Public Health: Surveillance and Intervention

Food Safety and Nutrition

• Foodborne Illness Outbreaks: Investigating Causes and Prevention
• Sustainable Food Systems: Implications for Public Health
• Nutritional Interventions for Malnutrition in Developing Countries
• Food Labeling and Consumer Understanding: A Critical Review
• The Impact of Fast Food Consumption on Public Health

Substance Abuse

• Opioid Epidemic: Strategies for Prevention and Treatment
• Harm Reduction Approaches in Substance Abuse Programs
• Alcohol Consumption Patterns and Public Health Outcomes
• Smoking and Mental Health: Exploring the Connection
• Novel Psychoactive Substances: Emerging Threats and Strategies

Occupational Health

• Workplace Stress and Mental Health: Intervention Strategies
• Occupational Hazards in Healthcare Professions: A Comparative Analysis
• Ergonomics in the Workplace: Improving Worker Health and Productivity
• Night Shift Work and Health Consequences: Addressing Challenges
• Occupational Health and Safety Regulations: A Global Overview

Disaster Preparedness and Response

• Pandemic Preparedness and Lessons from COVID-19
• Natural Disasters and Mental Health: Post-Traumatic Stress
• Emergency Response Systems: Improving Timeliness and Efficiency
• Communicating Health Risks During Emergencies: Public Perception
• Collaborative Approaches to Disaster Response in Global Health

Cancer Research

• Precision Medicine in Cancer Treatment: Current Advancements
• Cancer Screening Programs: Efficacy and Challenges
• Environmental Factors and Cancer Risk: Exploring Connections
• Survivorship Care Plans: Enhancing Quality of Life after Cancer
• Integrative Therapies in Cancer Care: Complementary Approaches

Sexual and Reproductive Health

• Access to Contraception in Developing Countries: Challenges and Solutions
• Comprehensive Sex Education Programs: Impact on Teen Pregnancy
• Reproductive Health Rights: Global Perspectives and Challenges
• Infertility Treatment: Ethical Considerations and Societal Impact
• Maternal and Child Health in Conflict Zones: Addressing Challenges

Cardiovascular Health

• Hypertension Prevention Programs: Strategies and Effectiveness
• Cardiovascular Disease in Women: Gender-Specific Risk Factors
• Innovations in Cardiac Rehabilitation Programs
• Artificial Heart Technology: Advancements and Ethical Implications
• Impact of Air Pollution on Cardiovascular Health: A Global Concern

Social Determinants of Health

• Educational Attainment and Health Outcomes: Exploring Links
• Income Inequality and its Impact on Population Health
• Social Support Networks and Mental Health: A Comprehensive Study
• Neighborhood Environments and Health Disparities
• Employment and Health: The Interplay of Work and Well-being

Genomics and Public Health

• Population Genomics and its Implications for Public Health
• Genetic Counseling and Education: Empowering Individuals and Families
• Ethical Issues in Genetic Research: Privacy and Informed Consent
• Pharmacogenomics: Tailoring Drug Therapies to Individual Genotypes
• Gene-Environment Interactions in Disease Risk: Unraveling Complexities

Public Health Ethics

• Informed Consent in Public Health Research: Current Practices
• Ethical Challenges in Global Health Research: Balancing Priorities
• Confidentiality in Public Health Reporting: Striking the Right Balance
• Research with Vulnerable Populations: Ethical Considerations
• Ethical Implications of Emerging Technologies in Healthcare

Health Communication

• The Role of Media in Shaping Public Health Perceptions
• Health Literacy Interventions: Improving Understanding of Health Information
• Social Media Campaigns for Public Health Promotion: Best Practices
• Tailoring Health Messages for Diverse Audiences: Cultural Competency
• Risk Communication in Public Health Emergencies: Lessons Learned

Nutrigenomics

• Personalized Nutrition Plans based on Genetic Makeup
• Impact of Nutrigenomics on Chronic Disease Prevention
• Ethical Considerations in Nutrigenomics Research
• Public Perceptions of Nutrigenomic Testing: A Qualitative Study
• Integrating Nutrigenomics into Public Health Policies

Public Health and Artificial Intelligence

• Predictive Analytics in Disease Surveillance: Harnessing AI for Early Detection
• Ethical Considerations in AI-Driven Health Decision Support Systems
• Machine Learning in Epidemiology: Predicting Disease Outbreaks
• Natural Language Processing in Public Health: Text Mining for Insights
• Bias in AI Algorithms: Implications for Health Equity

Health Disparities in Aging

• Geriatric Health Disparities: Bridging the Gap in Elderly Care
• Ageism in Healthcare: Addressing Stereotypes and Discrimination
• Social Isolation and Health Consequences in Aging Populations
• Access to Palliative Care for Older Adults: A Global Perspective
• Alzheimer’s Disease and Ethnic Disparities in Diagnosis and Treatment
• Loneliness and Mental Health in the Elderly: Interventions and Support

Research Methodologies in Public Health

Public health research employs various methodologies, including quantitative, qualitative, and mixed-methods approaches. Each method brings its own strengths to the research process, allowing researchers to gain a comprehensive understanding of the complex issues they investigate. 

Community-based participatory research is another valuable approach, emphasizing collaboration with communities to address their specific health concerns.

Challenges and Opportunities in Public Health Research

While public health research is immensely rewarding, it comes with its own set of challenges. Funding constraints, ethical dilemmas, the need for interdisciplinary collaboration, and the integration of technology pose both obstacles and opportunities. 

Researchers must navigate these challenges to ensure their work has a meaningful impact on public health.

In conclusion, public health research topics are diverse and dynamic, reflecting the complex nature of the field. As researchers embark on their journeys, they must carefully consider the relevance, impact, and ethical implications of their chosen topics. 

The collaborative and interdisciplinary nature of public health research positions it as a powerful tool in addressing the health challenges of our time. By exploring the depths of these topics, researchers contribute to the collective effort to build healthier and more equitable communities. 

As we move forward, a continued exploration of relevant public health research topics is essential for shaping the future of healthcare and improving the well-being of populations worldwide.

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300+ Medical Research Topics & Ideas for Students to Choose

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Every healthcare research begins with a single step. But in the world of academia, that step often involves hours of pondering over the perfect medical research topic idea. When it comes to medical research paper topics, there's a seemingly limitless array of options that stretches as far as the mind can wander. The potential of this field is exciting but can also be challenging to explore.

To help you narrow down your choices and research effectively, our research paper writer team compiled a list of interesting medical research topics. Whether you want to write about the latest developments in public health or explore the implications of emerging technologies, this blog won't disappoint you.

What Are Medical Research Paper Topics?

Medical research topics are the ideas or concepts related to health and medicine. They often explore new treatments, developments in diagnosis, prevention of illnesses, or even the effects of lifestyle choices. The scope of topics in medicine is vast and can include such aspects:

• Clinical medicine
• Biomedical research
• Public health
• Mental health research topics
• Medical technology
• Health services research.

Your choice should stem from your interests and existing gaps that need to be filled.

Characteristics of Good Medical Research Topics

Choosing the right medical topic for a research paper is like finding a golden ticket to a successful study. Here's what makes a medicine research idea a real showstopper:

• Engagement Research should be engaging and relevant to the audience.
• Precision Good ideas are always specific, so that you can focus your research on a particular area without being too vague.
• Authenticity A good topic needs to address an issue that hasn't been studied before.
• Feasibility Ensure your topic is realistic. Good research topics in healthcare should fit within your budget, timeframe, and available resources.
• Relevance Winning medical research project topics should address current and pressing issues in healthcare.

How to Choose a Medical Research Topic?

Selecting the best idea out of multiple medicine research topics can be a daunting task, especially when you have so many fields to explore. Here are a few steps that will help you settle on a theme:

• Brainstorm and come up with as many ideas as possible.
• Narrow down your list by considering factors such as your interest and resources.
• Look for current tendencies in healthcare research.
• Consult your supervisor or a librarian to verify the pertinence of the topic that you have chosen.
• Make sure your topic is specific enough to be addressed within the scope of your project.

Once you come up with a fitting medical research topic, consider half the battle won. But in case you have difficulties creating an original title, our online paper writers prepared a list of research ideas for medical students you might like.

List of Top Medical Research Topics

Below we collected various medical topics to research in your study. From groundbreaking technologies to emerging diseases, there are countless avenues to investigate. If you're on the hunt for a compelling topic, here are some of the top medical researches topics capturing attention in 2023:

• Effective strategies for medical talent acquisition and retention.
• The best methods for enhancing preventative care measures in contemporary medicine.
• The role and impact of telemedicine in reinventing healthcare management.
• Implications of artificial intelligence on diagnostics and treatment plans.
• The rising threat of antimicrobial resistance and its effects on global health.
• The link between environmental changes and public health outcomes.
• Complexities of vaccine development and human immune responses.
• Health inequities: Causes, consequences, and potential solutions.
• New treatment approaches for neurodegenerative disorders.
• A multidisciplinary approach to tackling obesity and metabolic disorders.

Good Medical Research Topics

Navigating countless medical topics for research papers can often feel like a journey through a labyrinth. Here are some intriguing ideas that could ignite your curiosity and fuel your research:

• How does climate change impact human health?
• Communication disorders: A closer look at deafness.
• The hidden dangers of household air pollution.
• The escalating threat of diabetes in the public sphere.
• Coronavirus and how it changed the landscape of public health.
• Assessing oral health: Beyond the basics.
• Tobacco and alcohol control: A public health perspective.
• Health implications of a sedentary lifestyle.
• Urban pollution and its impact on respiratory diseases
• The role of healthy diets in disease prevention.
• Exploring the mental health impact of social media.
• How do cultural factors influence public health initiatives?
• The role of nutrition in managing chronic diseases.
• Investigating the genetics of neurodegenerative disorders.
• What are some ethical considerations in gene editing?

Interesting Medical Research Topics

Exploring the depths of medicine can be an exciting experience. You'll discover that every issue has a plethora of complexities and avenues to investigate. Here are some interesting medical topics for research paper that could pique your curiosity:

• The influence of lifestyle changes on cardiovascular health.
• What are some psychological impacts of chronic illness?
• Connection between gut health and mental well-being.
• Evaluating the effectiveness of telehealth during the pandemic.
• How do genetic factors influence addiction susceptibility?
• Autoimmune diseases and their peculiarities.
• How does stress affect immune function?
• What are some health impacts of sleep disorders?
• The link between socioeconomic status and health outcomes.
• Exploring innovations in pain management.
• Analyzing implications of artificial intelligence in healthcare.
• Effect of climate change on infectious disease patterns.
• A look into advancements in cancer immunotherapy.
• Exploring the potential of stem cells in treating degenerative diseases.
• How does diet influence the progression of Alzheimer's disease?

Easy Medical Research Topics

You may be looking for simple research topics in medicine that won't take too much time and effort to complete. Explore these straightforward ideas that could make your paper stand out:

• Importance of proper sanitation in healthcare settings.
• Exploring the role of patient support groups in disease management.
• Analyzing the efficacy of physical therapy interventions.
• What are the cost-effective interventions for healthcare delivery?
• What are some effects of new pharmaceuticals?
• What are some health consequences of air pollution?
• How does meditation improve outcomes in mental health care?
• Evaluating the role of nutritionists in weight loss management.
• An analysis of trends and patterns in emerging diseases.
• Exploring alternative medicines in contemporary healthcare.
• Examining the impact of healthcare policies on public health outcomes.
• Can the use of herbs provide an effective remedy for certain illnesses?
• How does mental health stigma affect access to treatment?
• Drug abuse: Causes, consequences and prevention strategies.
• What are some psychological issues associated with chronic illnesses?

Best Medical Research Topics

When it comes to choosing medical research topics, you need something that's striking and meaningful. Hover over these ideas to spot the fitting idea for your medical research:

• Exploring new strategies for treating neurological disorders.
• What is the role of medical ethics in modern healthcare?
• What are some implications of genetics in personalized healthcare?
• Exploring innovations in non-invasive diagnosis techniques.
• Effect of temperature on patient outcomes in critical care.
• How does air pollution influence healthcare costs?
• How do changes in lifestyle lead to better health outcomes?
• Implications of electronic health records for patient privacy.
• Role of nutritionists in disease prevention.
• How technology is being used to revolutionize healthcare?
• What are the most effective treatments for rare diseases?
• How have medical imaging techniques advanced over the years?
• Investigating potential treatments for autism spectrum disorder.
• Exploring innovative approaches to mental healthcare delivery.
• What are some implications of artificial intelligence in medical diagnosis?

Controversial Medical Topics for a Research Paper

Navigate through the most contentious research topics in health and explore the debate that surrounds them. Consider these thought-provoking ideas and medical controversial topics:

• Ethical implications of genetic engineering.
• Euthanasia and physician-assisted suicide - where do we draw the line?
• Are mandatory vaccinations an infringement on personal freedom or a public health necessity?
• Evaluating medical and legal perspectives on the use of medical marijuana.
• Ethical concerns around animal testing in medical research.
• How do we navigate the morality and legality of abortion?
• Should the criminal justice system focus more on mental health treatment than punishment?
• Is stem cell research a moral dilemma or a medical breakthrough?
• Ethical considerations in organ trading and transplantation.
• Who should shoulder the burden of healthcare costs?
• Is access to healthcare a privilege or a human right?
• Ethics of using placebo in clinical trials – is it justified?
• Assessing the role of Big Pharma in healthcare - is it a necessary evil?
• Can genetic screening lead to discrimination, despite its benefits?
• Should modern medicine take precedence over traditional medicine, or is there room for both?

New Medical Research Topics

Discover the latest studies in healthcare and explore the newest topics for a medical research paper. Below we prepared some cutting-edge topics for you to consider:

• Can gene-editing technologies such as CRISPR transform the treatment of genetic disorders?
• How does microbiome therapy potentially influence the treatment of autoimmune diseases?
• Exploring the advent of personalized medicine through genomics and precision diagnostics.
• How is virtual reality altering the landscape of surgical training and rehabilitation therapies?
• How can telehealth improve healthcare access, particularly in remote and underserved areas?
• The role of nanotechnology in developing more efficient drug delivery systems.
• What are some implications of the rising antimicrobial resistance, and where does the future of antibiotics lie?
• How are advances in non-invasive treatments changing the face of chronic disease management?
• Is precision oncology the future of cancer treatment?
• What are some implications and potential of regenerative medicine and tissue engineering?
• Can advancements in wearable technology revolutionize personal health monitoring?
• How are gut microbiota affecting our understanding and treatment of metabolic disorders?
• What role do nanobots play in medical treatments?
• Can big data analytics be used to improve the accuracy of medical diagnosis?

Medical Research Topics Ideas for Students

There are multiple medical topics to write about. But as a student, you're probably looking for something more specific. For your convenience, we divided the titles by academic levels. So, roll up your sleeves and get ready to explore these health topics for research that your professor will surely appreciate.

Medical Research Topics for High School

For students who want to investigate different aspect of healthcare, we provided these examples of ideas. Browse through these medical research topics for high school students to spot the most relevant theme:

• How does the human immune system work?
• Vaccinations as an essential tool in preventing diseases.
• A basic overview of genetic disorders.
• What makes viruses unique?
• How does the body fight off bacterial infections?
• The impact of lifestyle factors on heart health.
• Diabetes: Types, causes, and prevention strategies.
• The importance of mental health in the medical field.
• Skin health: Understanding common skin conditions like acne and eczema.
• Structure and function of the human heart.
• Role of antibiotics and how do they fight bacteria?
• Journey of a pill: From ingestion to action.
• What happens in an allergic reaction?
• How does physical exercise impact the body and mind?
• Racial disparities in healthcare and access to treatment.

Medical Research Topics for College Students

At the college level, you may be asked to write a research paper on a complex issue. We prepared these health research topics for college students to help you get started on your assignment:

• Exploring the implications of health insurance reform.
• Genomic sequencing in the early detection of genetic disorders.
• Machine learning in diagnostic imaging: A new era in radiology?
• The role of diet in the prevention and management of type 2 diabetes.
• Exploring the link between circadian rhythms and health disorders.
• The role of personalized medicine in cancer treatment.
• Development and use of prosthetics in physical rehabilitation.
• Understanding autoimmune diseases: The body fighting itself.
• Addressing health disparities through community-based interventions.
• Inflammation in the development of chronic diseases.
• The rise of antibiotic-resistant bacteria: Causes and implications.
• Innovations in drug delivery systems: From nanoparticles to smart pills.
• How can we address the opioid crisis in America?
• Investigating the use of mobile technology for delivering healthcare services.
• Exploring medical implications of 3D printing technology.

Medical Research Topics by Subjects

We've also provided some research topics for medical students grouped by specific subjects. Check them out and pick the one you find most captivating.

Medical Research Topics in Pediatrics

Pediatrics involves the care and health of children. As such, it is a broad field ripe with interesting medical topics. Given the unique physiology needs of these younger populations, pediatric research is crucial for understanding illnesses. Below you can find captivating research topics in pediatrics:

• Exploring the impact of nutrition on childhood development.
• Assessing the effects of screen time on adolescent mental health.
• Investigating genetic factors in pediatric cancers.
• The role of vaccinations in preventing common childhood illnesses.
• Strategies for managing childhood obesity.
• The impact of prenatal exposure to drugs and alcohol on infant health.
• Development and evaluation of therapies for Autism Spectrum Disorders.
• Understanding the rise of food allergies in children.
• Advances in the treatment of congenital heart defects.
• Exploring the causes and treatment strategies for pediatric asthma.
• The impact of environmental toxins on child health.
• Evaluation of therapeutic approaches for Attention Deficit Hyperactivity Disorder (ADHD).
• Implications of early life stress on mental health in adolescence.
• The role of gut microbiota in pediatric diseases.
• Understanding the genetic basis of rare childhood disorders.

Medical Research Topics on Anatomy

Anatomy is the study of the organization and structure of the body. It encompasses many topics for medical research papers, from bones and organs to cell structures. Consider these ideas when writing your next anatomy paper:

• The role of genetics in bone fragility disorders.
• A comparative study of the skeletal systems across different species.
• The role and function of the lymphatic system in human health.
• Investigating complexities of the human brain's structure.
• Development and growth of human muscles.
• Impact of aging on bone health and structure.
• Exploring the intricate workings of the human cardiovascular system.
• Understanding structural changes in lungs in chronic respiratory diseases.
• The anatomical basis of speech and language development.
• Neuroanatomy of pain: Understanding pain pathways and mechanisms.
• Structural adaptations of the human body for athletic performance.
• Anatomy of the human eye and its role in vision.
• How does connective tissue support body structures?
• How does endocrine system impact hormone production?
• How does female anatomy change during pregnancy?

Medical Anthropology Research Topics

Medical anthropology looks at health and illness from a cultural perspective. It draws on expertise from across disciplines such as biology, psychology, and sociology to better understand how medical systems can work within different communities. If you’re interested in this field, use these ideas for med research topics:

• Investigating cultural beliefs and practices surrounding childbirth.
• Impact of socioeconomic status on health outcomes in different cultures.
• Understanding the role of traditional medicine in modern healthcare systems.
• An exploration of how cultural beliefs influence mental health perceptions.
• Effect of migration on health outcomes.
• The role of diet and nutrition in health from a cultural perspective.
• Cultural competence in healthcare delivery: Challenges and opportunities.
• Intersection of gender, culture, and health.
• Impact of societal norms and values on disease prevalence.
• Health disparities among indigenous populations.
• Role of social support networks in health and wellness across cultures.
• The impact of stigma on health outcomes in HIV/AIDS patients.
• The role of cultural anthropology in global health interventions.
• Ethnobotany and its implications for drug discovery.
• Understanding health practices in post-conflict societies.

Medicine Research Topics on Physiology

Physiology studies how living organisms function. This branch covers a range of medicine topics and ideas you might like. Here are some suggestions for your next med paper in physiology:

• How does nervous system contribute to the perception of pain?
• What physiological changes are triggered by acute and chronic stress?
• How does regular exercise influence cardiovascular health and overall well-being?
• How do hormones influence our metabolic rate and energy utilization?
• A detailed study on physiological transformations during pregnancy and lactation.
• How does the process of aging affect the function and resilience of various organs?
• Exploring the role of homeostasis in maintaining the body's internal balance.
• What are the key physiological processes involved in the sleep cycle?
• Unraveling complexities of the human digestive system from ingestion to excretion.
• How does the renal system contribute to maintaining blood pressure?
• Physiological adaptations humans undergo when living at high altitudes.
• How does dehydration disrupt normal bodily functions?
• Implications of obesity on respiratory function and efficiency.
• How does the endocrine system orchestrate growth and development?
• Investigating the neurophysiological underpinnings of memory formation and retrieval.

Medical Research Topics on Dermatology

From understanding skin conditions to exploring new procedures, dermatological research is a crucial part of improving skin health. Look through these medical research ideas centered around dermatology:

• Investigating the causes and treatments of acne in adolescents.
• Diet and the development of psoriasis.
• Understanding genetic factors involved in atopic dermatitis.
• Skin cancer: Risk factors, prevention, and treatment strategies.
• How do environmental factors cause skin aging?
• Exploring new treatments for hair loss.
• Understanding the correlation between stress and skin conditions.
• The role of the microbiome in skin health and disease.
• New approaches in the treatment of vitiligo.
• The impact of UV radiation on skin health.
• Exploring the pathophysiology of rosacea.
• The role of telemedicine in dermatology.
• Clinical advancements in the treatment of fungal skin infections.
• The correlation between skin health and mental health.
• Advances in cosmetic dermatology: Safety and effectiveness of new procedures.

Medical Research Paper Topics on Nursing

Nursing is a versatile profession that covers many areas of health care. It’s also an ever-changing field, with new research and advancements being released all the time. Here are some topics for medical research paper focusing on nursing:

• The impact of nurse-patient communication on patient outcomes.
• Exploring the effects of nurse fatigue on job performance.
• How does nurse practitioner autonomy influence patient care?
• Importance of bedside manner in nursing.
• The role of technology in nursing practice.
• Understanding challenges associated with ethical decision-making in nursing.
• How does nurse burnout affect patient safety?
• Analyzing factors contributing to nurse retention and turnover rates.
• The effects of staffing ratios on nurse and patient satisfaction.
• Exploring the role of leadership in nursing practice.
• What are implications of nurse workload on healthcare outcomes?
• The impact of health policy on nursing education and practice.
• Ethical dilemmas faced by nurses in end-of-life care.
• How does culture affect perceptions of healthcare and nursing.
• What are some effects of managed care on nurse autonomy?

>> Read more: Nursing Research Paper Topics

Medical Research Topics on Primary Care

Primary care is the first point of contact between patients and medical professionals. This branch is often overlooked, but it’s an important area of research that can improve health outcomes in communities around the world. Check out these interesting health topics to discuss in primary care:

• Exploring the impact of primary care physician shortages on health outcomes.
• How do socio-economic factors influence health outcomes in primary care?
• Strategies to improve patient adherence to treatment.
• What are some challenges and opportunities of providing mental health services?
• The role of primary care in managing chronic diseases.
• Evaluating the effectiveness of preventive measures in primary care.
• How does patient education influence health outcomes in primary care?
• The role of health technology in improving primary care delivery.
• What are some best practices for managing multimorbidity in primary care?
• Developing effective communication strategies for diverse patient populations in primary care.
• The impact of health policy changes on care delivery.
• How can primary care practices be adapted to meet the needs of an aging population?
• Assessing the effectiveness of integrated care models.
• The role of primary care in addressing health disparities.
• Strategies for improving patient satisfaction in primary care.

Medical Research Topics on Public Health

Public health is an important area of research - understanding how to improve health in communities and prevent illness and injury are crucial skills for medical professionals. Here are some medical related research topics that could kick-start your next project:

• What are the causes, implications and solutions to food insecurity?
• The role of public health in the management of infectious diseases.
• Assessing the effectiveness of smoking cessation programs.
• The role of public health initiatives in combating the obesity epidemic.
• What are some policy interventions that can improve public health?
• The impact of racism and discrimination on public health outcomes.
• Exploring new models for delivering mental health services in underserved communities.
• The impact of urbanization on public health outcomes.
• Evaluating the effectiveness of school-based health education programs.
• Strategies for managing public health crises during natural disasters.
• The implications of antibiotic resistance for public health.
• How can community engagement improve public health initiatives?
• The role of public health in the prevention and control of zoonotic diseases.
• What are the effects of environmental toxins on human health?
• How can mutual efforts reduce maternal and infant mortality rates?

>> View more: Public Health Research Topics

Medical Research Topics on Mental Health

Mental health is an important area of research, as it affects so many people around the world. Here are some medical research paper ideas to get you started on your next mental health project:

• The effectiveness of cognitive-behavioral therapy in treating anxiety disorders.
• How does social media influence adolescents' mental health?
• Exploring the link between gut health and wellbeing.
• The role of mindfulness in managing stress and enhancing mental well-being.
• Understanding the genetic factors in schizophrenia.
• How can stigma associated with mental illness be reduced in society?
• How do traumatic events influence mental health?
• Potential art therapy application in emotional health treatment.
• The role of mental health in managing chronic diseases.
• The impact of the COVID-19 pandemic on global mental health.
• Understanding the correlation between sleep deprivation and emotional wellbeing.
• Strategies for improving mental health services in rural areas.
• How can nutrition benefit mental health?
• Exploring the effectiveness of peer support in mental health recovery.
• The benefits and challenges of telepsychiatry.

>> View more: Mental Health Research Paper Topics

Medical Ethics Research Topics

Medical ethics is an important direction in healthcare research. Check these fascinating health topics to research for your next paper:

• Exploring moral implications of assisted suicide.
• How do ethical considerations come into play during organ transplantation?
• The ethical conundrum of maintaining patient confidentiality in the digital age.
• The integral role of informed consent in the physician-patient relationship.
• What ethical dilemmas arise from genetic testing and gene editing technologies?
• Ethical considerations of implementing artificial intelligence in healthcare.
• Is it ethical to use placebos in clinical trials?
• Balancing individual rights and public health in the context of a pandemic.
• Navigating ethical issues surrounding end-of-life care.
• Ethical challenges involved in the rationing of limited healthcare resources.
• What ethical considerations are necessary when conducting clinical research in low-resource settings?
• Ethical debate surrounding the use of animals for medical research.
• Ethical questions raised by advancements in reproductive technologies and rights.
• What are ethical implications of mandatory vaccination policies?
• Understanding ethical dilemmas associated with using health data for research.

Extra Medical Research Papers Topics

Medical research is an important topic for many people. Below you can find more medical research topic ideas that didn't fall in any of categories offered above.

Health Research Topics

Health research paper topics are crucial to understanding the effects of trends and developments in the medical field. Here are some ideas to get you inspired:

• How does virtual reality change physical rehabilitation?
• Investigating the effects of pollution on respiratory health.
• The effectiveness of mindfulness-based interventions in mental health.
• The role of nutrition in managing cardiovascular diseases.
• Assessing health impacts of climate change.
• Evaluating the effectiveness of health education programs in schools.
• Strategies for promoting mental health in the workplace.
• Investigating the links between diet and cognitive function.
• How does health literacy influence individual health outcomes?
• Implications of stress on immune function.
• Effectiveness of public health campaigns on smoking cessation.
• Exploring the effectiveness of herbal remedies in treating diseases.
• The role of sports in promoting a healthy lifestyle.
• Strategies to reduce the prevalence of substance abuse.
• Pros and cons of electronic record systems in healthcare.

Clinical Research Topics

Clinical ideas are essential for approaching healthcare from a scientific point of view. Find some medical research paper topics to cover in your project:

• Exploring the effectiveness of novel treatments in rare diseases.
• The role of biomarkers in disease diagnosis and treatment.
• How do medical interventions influence patient satisfaction?
• Exploring links between nutrition and cancer prevention.
• How do lifestyle modifications influence diabetes management?
• Understanding the implications of drug interactions.
• How does genetic testing influence medical decision-making?
• What are some challenges associated with disseminating medical evidence?
• Predicting disease progression through machine learning.
• Assessing the accuracy of various diagnostic tools.
• Implications of medical robotics and automation in healthcare.
• Evaluating the impact of patient-centered care on quality outcomes.
• Clinical trials: Challenges and opportunities.
• How can vulnerable populations access medical care?
• How can public-private partnerships benefit healthcare delivery?

Bottom Line on Medical Topics to Research

Choosing healthcare research paper topics can be quite overwhelming. We hope our suggestions will help you in developing an engaging medical research topic for your upcoming project or assignment. Remember to always check with your instructor before starting any project, so that you are aware of all specific requirements.

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EliScholar > Medicine > Medicine Thesis Digital Library

Yale Medicine Thesis Digital Library

Starting with the Yale School of Medicine (YSM) graduating class of 2002, the Cushing/Whitney Medical Library and YSM Office of Student Research have collaborated on the Yale Medicine Thesis Digital Library (YMTDL) project, publishing the digitized full text of medical student theses on the web as a valuable byproduct of Yale student research efforts. The digital thesis deposit has been a graduation requirement since 2006. Starting in 2012, alumni of the Yale School of Medicine were invited to participate in the YMTDL project by granting scanning and hosting permission to the Cushing/Whitney Medical Library, which digitized the Library’s print copy of their thesis or dissertation. A grant from the Arcadia Fund in 2017 provided the means for digitizing over 1,000 additional theses. IF YOU ARE A MEMBER OF THE YALE COMMUNITY AND NEED ACCESS TO A THESIS RESTRICTED TO THE YALE NETWORK, PLEASE MAKE SURE YOUR VPN (VIRTUAL PRIVATE NETWORK) IS ON.

Theses/Dissertations from 2024 2024

Refractory Neurogenic Cough Management: The Non-Inferiority Of Soluble Steroids To Particulate Suspensions For Superior Laryngeal Nerve Blocks , Hisham Abdou

Percutaneous Management Of Pelvic Fluid Collections: A 10-Year Series , Chidumebi Alim

Behavioral Outcomes In Patients With Metopic Craniosynostosis: Relationship With Radiographic Severity , Mariana Almeida

Ventilator Weaning Parameters Revisited: A Traditional Analysis And A Test Of Artificial Intelligence To Predict Successful Extubation , John James Andrews

Developing Precision Genome Editors: Peptide Nucleic Acids Modulate Crispr Cas9 To Treat Autosomal Dominant Disease , Jem Atillasoy

Radiology Education For U.s. Medical Students In 2024: A State-Of-The-Art Analysis , Ryan Bahar

Out-Of-Pocket Spending On Medications For Diabetes In The United States , Baylee Bakkila

Imaging Markers Of Microstructural Development In Neonatal Brains And The Impact Of Postnatal Pathologies , Pratheek Sai Bobba

A Needs Assessment For Rural Health Education In United States Medical Schools , Kailey Carlson

Racial Disparities In Behavioral Crisis Care: Investigating Restraint Patterns In Emergency Departments , Erika Chang-Sing

Social Determinants Of Health & Barriers To Care In Diabetic Retinopathy Patients Lost To Follow-Up , Thomas Chang

Association Between Fine Particulate Matter And Eczema: A Cross-Sectional Study Of The All Of Us Research Program And The Center For Air, Climate, And Energy Solutions , Gloria Chen

Predictors Of Adverse Outcomes Following Surgical Intervention For Cervical Spondylotic Myelopathy , Samuel Craft

Genetic Contributions To Thoracic Aortic Disease , Ellelan Arega Degife

Actigraphy And Symptom Changes With A Social Rhythm Intervention In Young Persons With Mood Disorders , Gabriela De Queiroz Campos

Incidence Of Pathologic Nodal Disease In Clinically Node Negative, Microinvasive/t1a Breast Cancers , Pranammya Dey

Spinal Infections: Pathophysiology, Diagnosis, Prevention, And Management , Meera Madhav Dhodapkar

Childen's Reentry To School After Psychiatric Hospitalization: A Qualitative Study , Madeline Digiovanni

Bringing Large Language Models To Ophthalmology: Domain-Specific Ontologies And Evidence Attribution , Aidan Gilson

Surgical Personalities: A Cultural History Of Early 20th Century American Plastic Surgery , Joshua Zev Glahn

Implications Of Acute Brain Injury Following Transcatheter Aortic Valve Replacement , Daniel Grubman

Latent Health Status Trajectory Modelling In Patients With Symptomatic Peripheral Artery Disease , Scott Grubman

The Human Claustrum Tracks Slow Waves During Sleep , Brett Gu

Patient Perceptions Of Machine Learning-Enabled Digital Mental Health , Clara Zhang Guo

Variables Affecting The 90-Day Overall Reimbursement Of Four Common Orthopaedic Procedures , Scott Joseph Halperin

The Evolving Landscape Of Academic Plastic Surgery: Understanding And Shaping Future Directions In Diversity, Equity, And Inclusion , Sacha C. Hauc

Association Of Vigorous Physical Activity With Psychiatric Disorders And Participation In Treatment , John L. Havlik

Long-Term Natural History Of Ush2a-Retinopathy , Michael Heyang

Clinical Decision Support For Emergency Department-Initiated Buprenorphine For Opioid Use Disorder , Wesley Holland

Applying Deep Learning To Derive Noninvasive Imaging Biomarkers For High-Risk Phenotypes Of Prostate Cancer , Sajid Hossain

The Hardships Of Healthcare Among People With Lived Experiences Of Homelessness In New Haven, Ct , Brandon James Hudik

Outcomes Of Peripheral Vascular Interventions In Patients Treated With Factor Xa Inhibitors , Joshua Joseph Huttler

Janus Kinase Inhibition In Granuloma Annulare: Two Single-Arm, Open-Label Clinical Trials , Erica Hwang

Medicaid Coverage For Undocumented Children In Connecticut: A Political History , Chinye Ijeli

Population Attributable Fraction Of Reproductive Factors In Triple Negative Breast Cancer By Race , Rachel Jaber Chehayeb

Evaluation Of Gastroesophageal Reflux And Hiatal Hernia As Risk Factors For Lobectomy Complications , Michael Kaminski

Health-Related Social Needs Before And After Critical Illness Among Medicare Beneficiaries , Tamar A. Kaminski

Effects Of Thoracic Endovascular Aortic Repair On Cardiac Function At Rest , Nabeel Kassam

Conditioned Hallucinations By Illness Stage In Individuals With First Episode Schizophrenia, Chronic Schizophrenia, And Clinical High Risk For Psychosis , Adam King

The Choroid Plexus Links Innate Immunity To Dysregulation Of Csf Homeostasis In Diverse Forms Of Hydrocephalus , Emre Kiziltug

Health Status Changes After Stenting For Stroke Prevention In Carotid Artery Stenosis , Jonathan Kluger

Rare And Undiagnosed Liver Diseases: New Insights From Genomic And Single Cell Transcriptomic Analyses , Chigoziri Konkwo

“Teen Health” Empowers Informed Contraception Decision-Making In Adolescents And Young Adults , Christina Lepore

Barriers To Mental Health Care In Us Military Veterans , Connor Lewis

Barriers To Methadone For Hiv Prevention Among People Who Inject Drugs In Kazakhstan , Amanda Rachel Liberman

Unheard Voices: The Burden Of Ischemia With No Obstructive Coronary Artery Disease In Women , Marah Maayah

Partial And Total Tonsillectomy For Pediatric Sleep-Disordered Breathing: The Role Of The Cas-15 , Jacob Garn Mabey

Association Between Insurance, Access To Care, And Outcomes For Patients With Uveal Melanoma In The United States , Victoria Anne Marks

Urinary Vegf And Cell-Free Dna As Non-Invasive Biomarkers For Diabetic Retinopathy Screening , Mitchelle Matesva

Pain Management In Facial Trauma: A Narrative Review , Hunter Mccurdy

Meningioma Relational Database Curation Using A Pacs-Integrated Tool For Collection Of Clinical And Imaging Features , Ryan Mclean

Colonoscopy Withdrawal Time And Dysplasia Detection In Patients With Inflammatory Bowel Disease , Chandler Julianne Mcmillan

Cerebral Arachnoid Cysts Are Radiographic Harbingers Of Epigenetics Defects In Neurodevelopment , Kedous Mekbib

Regulation And Payment Of New Medical Technologies , Osman Waseem Moneer

Permanent Pacemaker Implantation After Tricuspid Valve Repair Surgery , Alyssa Morrison

Non-Invasive Epidermal Proteome-Based Subclassification Of Psoriasis And Eczema And Identification Of Treatment Relevant Biomarkers , Michael Murphy

Ballistic And Explosive Orthopaedic Trauma Epidemiology And Outcomes In A Global Population , Jamieson M. O'marr

Dermatologic Infectious Complications And Mimickers In Cancer Patients On Oncologic Therapy , Jolanta Pach

Distressed Community Index In Patients Undergoing Carotid Endarterectomy In Medicare-Linked Vqi Registry , Carmen Pajarillo

Preoperative Psychosocial Risk Burden Among Patients Undergoing Major Thoracic And Abdominal Surgery , Emily Park

Volumetric Assessment Of Imaging Response In The Pnoc Pediatric Glioma Clinical Trials , Divya Ramakrishnan

Racial And Sex Disparities In Adult Reconstructive Airway Surgery Outcomes: An Acs Nsqip Analysis , Tagan Rohrbaugh

A School-Based Study Of The Prevalence Of Rheumatic Heart Disease In Bali, Indonesia , Alysha Rose

Outcomes Following Hypofractionated Radiotherapy For Patients With Thoracic Tumors In Predominantly Central Locations , Alexander Sasse

Healthcare Expenditure On Atrial Fibrillation In The United States: The Medical Expenditure Panel Survey 2016-2021 , Claudia See

A Cost-Effectiveness Analysis Of Oropharyngeal Cancer Post-Treatment Surveillance Practices , Rema Shah

Machine Learning And Risk Prediction Tools In Neurosurgery: A Rapid Review , Josiah Sherman

Maternal And Donor Human Milk Support Robust Intestinal Epithelial Growth And Differentiation In A Fetal Intestinal Organoid Model , Lauren Smith

Constructing A Fetal Human Liver Atlas: Insights Into Liver Development , Zihan Su

Somatic Mutations In Aging, Paroxysmal Nocturnal Hemoglobinuria, And Myeloid Neoplasms , Tho Tran

Illness Perception And The Impact Of A Definitive Diagnosis On Women With Ischemia And No Obstructive Coronary Artery Disease: A Qualitative Study , Leslie Yingzhijie Tseng

Advances In Keratin 17 As A Cancer Biomarker: A Systematic Review , Robert Tseng

Regionalization Strategy To Optimize Inpatient Bed Utilization And Reduce Emergency Department Crowding , Ragini Luthra Vaidya

Survival Outcomes In T3 Laryngeal Cancer Based On Staging Features At Diagnosis , Vickie Jiaying Wang

Analysis Of Revertant Mosaicism And Cellular Competition In Ichthyosis With Confetti , Diana Yanez

A Hero's Journey: Experiences Using A Therapeutic Comicbook In A Children’s Psychiatric Inpatient Unit , Idil Yazgan

Prevalence Of Metabolic Comorbidities And Viral Infections In Monoclonal Gammopathy , Mansen Yu

Automated Detection Of Recurrent Gastrointestinal Bleeding Using Large Language Models , Neil Zheng

Vascular Risk Factor Treatment And Control For Stroke Prevention , Tianna Zhou

Theses/Dissertations from 2023 2023

Radiomics: A Methodological Guide And Its Applications To Acute Ischemic Stroke , Emily Avery

Characterization Of Cutaneous Immune-Related Adverse Events Due To Immune Checkpoint Inhibitors , Annika Belzer

An Investigation Of Novel Point Of Care 1-Tesla Mri Of Infants’ Brains In The Neonatal Icu , Elisa Rachel Berson

Understanding Perceptions Of New-Onset Type 1 Diabetes Education In A Pediatric Tertiary Care Center , Gabriel BetancurVelez

Effectiveness Of Acitretin For Skin Cancer Prevention In Immunosuppressed And Non-Immunosuppressed Patients , Shaman Bhullar

Adherence To Tumor Board Recommendations In Patients With Hepatocellular Carcinoma , Yueming Cao

Clinical Trials Related To The Spine & Shoulder/elbow: Rates, Predictors, & Reasons For Termination , Dennis Louis Caruana

Improving Delivery Of Immunomodulator Mpla With Biodegradable Nanoparticles , Jungsoo Chang

Sex Differences In Patients With Deep Vein Thrombosis , Shin Mei Chan

Incorporating Genomic Analysis In The Clinical Practice Of Hepatology , David Hun Chung

Emergency Medicine Resident Perceptions Of A Medical Wilderness Adventure Race (medwar) , Lake Crawford

Surgical Outcomes Following Posterior Spinal Fusion For Adolescent Idiopathic Scoliosis , Wyatt Benajmin David

Representing Cells As Sentences Enables Natural Language Processing For Single Cell Transcriptomics , Rahul M. Dhodapkar

Life Vs. Liberty And The Pursuit Of Happiness: Short-Term Involuntary Commitment Laws In All 50 US States , Sofia Dibich

Healthcare Disparities In Preoperative Risk Management For Total Joint Arthroplasty , Chloe Connolly Dlott

Toll-Like Receptors 2/4 Directly Co-Stimulate Arginase-1 Induction Critical For Macrophage-Mediated Renal Tubule Regeneration , Natnael Beyene Doilicho

Associations Of Atopic Dermatitis With Neuropsychiatric Comorbidities , Ryan Fan

International Academic Partnerships In Orthopaedic Surgery , Michael Jesse Flores

Young Adults With Adhd And Their Involvement In Online Communities: A Qualitative Study , Callie Marie Ginapp

Becoming A Doctor, Becoming A Monster: Medical Socialization And Desensitization In Nazi Germany And 21st Century USA , SimoneElise Stern Hasselmo

Comparative Efficacy Of Pharmacological Interventions For Borderline Personality Disorder: A Network Meta-Analysis , Olivia Dixon Herrington

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Digital Commons @ USF > USF Health > College of Public Health > Public Health Practice > Theses and Dissertations

Public Health Theses and Dissertations

Theses/dissertations from 2024 2024.

Linking Shared Decision Making to Outcomes in Simulated Prenatal Genetic Counseling Sessions , Raquel C. Chavarria

Interrelationships Among Local Values of Wet Bulb Globe Temperature, Heat Index, and Adjusted Temperature , Andrea Giraldo

Evaluation of Pediatric Genetics Clinics’ Workflows, Efficiencies, & Genetic Counselor Job Satisfaction , Ashlyn M. Keziah

Analyzing the Relationship Between Preeclamptic Severity and Placental Methylation , Mackenzie C. Maggio

A Differentially Methylated Region Analysis Between Three Disease States of Major Depressive Disorder in Primarily African-American Cohorts , Lanie KateLynn Mullins

Preliminary investigation of differences in host mitochondria membrane potential during Toxoplasma gondii infection , Bryan L. Ortega

Theses/Dissertations from 2023 2023

Needs Assessment for a Web-Based Support Resource for Patients with a Pathogenic Variant in LMNA , Dylan M. Allen

Evaluation of a Story-telling Approach to Educate Minority Populations About Inherited Cancer , Celestyn B. Angot

Using the Genetic Counseling Skills Checklist to Characterize Prenatal Genetic Counseling , David A. Cline

Reframing Resistance, Resilience, and Racial Equity in Maternal Health: A Mixed Methods Exploration of Paternal Involvement and the Racial Disparity in Severe Maternal Morbidity , Marshara G. Fross

Student Perceptions of the Nonmedical Use of Prescription Stimulants and Preferences for Health Education , Ana Gutierrez

Relationships between Leading and Trailing Indicators at Construction Sites in Yanbu Industrial City, Saudi Arabia , Anas H. Halloul

Variability of Air Sampling Results Using Air-O-Cell Cassettes , Christina M. Haworth

Use of Silica Dust and Lunar Simulants for Assessing Lunar Regolith Exposure , Layzamarie Irizarry-Colon

The Aging Workforce: How it Relates to Incident Rates within a Distribution Warehouse and a Chemical Manufacturing Building , Elisabeth V. Jones

Fuzzy KC Clustering Imputation for Missing Not At Random Data , Markku A. Malmi Jr.

Piloting a Spanish-language Web-based Tool for Hereditary Cancer Genetic Testing , Gretter Manso

Development of a ddPCR Multiplex to Measure the Immune Response to Borrelia burgdorferi. , Kailey Marie McCain

A Healthcare Claims Investigation of Parasomnia Epidemiology, Associations with Attention Deficit/Hyperactivity Disorder, and REM Sleep Behavior Disorder Correlates , Anh Thy Ha Nguyen

Diet and Salivary Microbiome on Cardiovascular Risk and Glycemic Control in Participants with and without Type 1 Diabetes: The CACTI Study , Tiantian Pang

Evaluation of Two Methods to Estimate Wet Bulb Globe Temperature from Heat Index , Stephi Pofanl

Intimate Conversations: A Mixed-Methods Study of African American Father-Adolescent Sexual Risk Communication , Shanda A. Vereen

Assessment of ISO Heart Rate Method to Estimate Metabolic Rate , Karl Williams

Theses/Dissertations from 2022 2022

Outcomes of a Periodic Exposure Assessment of Workers at a University Campus , Logan M. Armagast

Evaluating the Effect of Public Health Governance Structure and Public Opinion on COVID-19 Disease Control Interventions , Daniel Chacreton

Alpha Synuclein: A therapeutic target and biomarker for Parkinson’s Disease , Max Chase

A Study of Noise Exposures for Amusement Park Employees by Positions and Ride Categories , Danielle M. Dao

Bayesian Network-based Diagnostic Support Tool with Limited Point-of-Care Ultrasound for Work-related Elbow Injuries , Cristina Maria Franceschini Sánchez

Understanding Food Insecurity as a Multidimensional Construct: A Mixed Methods Approach to Assess Changes in Food Insecurity Status among People Seeking Emergency Food Assistance , Whitney M. Fung Uy

Host-Pathogen Coevolution Between Tasmanian Devils (Sarcophilus harrisii) and Devil Facial Tumor Disease , Dylan Garret Gallinson

Joint Models for Repeated Measured, Non-Normally Distributed Multilevel Data , Weiwei He

Crosswalking Wet Bulb Globe Temperature and Heat Index , Paul Irvin

Impact of Perinatal Exposure Counseling on Patient Reported Emotional Outcomes and Decisional Empowerment , Madison J. Lake

Measurements of Generalizability and Adjustment for Bias in Clinical Trials , Yuanyuan Lu

Examining the Relationship between Racial Respect among Black Early Childhood Professionals and their Perceptions of Black Children , Kayla Nembhard

Etiology of sterile intra-amniotic inflammation: An exploratory study , Zoe M. Taylor

Evaluating and Improving a Novel Toolkit for Implementation and Optimization of Lynch Syndrome Universal Tumor Screening , Tara M. Wolfinger

Assessing Reported Use of Clinical Genetic Counseling Skills , Nicole M. Wright

Theses/Dissertations from 2021 2021

Exploring Adult Attachment in Intimate Relationships among Women who Were Exposed to Intimate Partner Violence in Childhood: A Convergent Mixed Methods Approach , Ngozichukwuka C. Agu

Comparison of the Effectiveness of Disinfectant-Impregnated Wipes Versus Detergent Wipes for Surface Decontamination , Jacob Amadin

Limited Point of Care Ultrasound Clinical Decision Support Model for Work-related Injuries of the Shoulder Utilizing Bayesian Network , Gwen Marie Ayers

Synthesis of a Multimodal Ecological Model for Scalable, High-Resolution Arboviral Risk Prediction in Florida , Sean P. Beeman

Feasibility of a Virtual Group Nutrition Intervention for Adolescents with Autism Spectrum Disorder , Acadia W. Buro

Defining Codes Based on the Consolidated Framework for Implementation Research in the Context of the Implementing Universal Lynch Syndrome Screening , Jasmine A. Burton-Akright

Americans’ Familiarity, Interest, and Actions with Direct-to-Consumer Genetic Testing , Riley L. Carroll

Does Better A1C Control Worsen Osteoarthritis? An Electronic Health Record Cross-Sectional Study , Sarah C. Cattaneo

Analysis of Post-traumatic Stress Disorder Gene Expression Profiles in a Prospective, Community-based Cohort , Jan Dahrendorff

Differential Privacy for Regression Modeling in Health: An Evaluation of Algorithms , Joseph Ficek

Does Time-Weighted Averaging for WBGT and Metabolic Rate Work for Work-Recovery Cycles? , John W. Flach

Screening of Pregnant Women with Opioid Use Disorder: Identifying Factors Impacting Implementation of Screening Recommendations Using the Theoretical Domains Framework , Tara R. Foti

Epigenetic Potential in an Introduced Passerine , Haley E. Hanson

Face Mask Use to Protect Against COVID-19; Importance of Substrate, Fit, and User Tendencies , Evelyn Kassel

Novel Educational Material for Patients with a Variant of Uncertain Significance (VUS) in a Cancer Risk Gene , Meghan E. Kelley

Mechanisms and Mitigation: Effects of Light Pollution on West Nile Virus Dynamics , Meredith E. Kernbach

Seasonality in Competence to Transmit West Nile Virus for a Widespread Reservoir , Kyle L. Koller

Mealtimes in Early Childhood Education Centers During COVID-19: A Mixed-Methods Assessment of Responsibilities, Interactions, and Best Practices , Joanna Mackie

Development and Validation of an Isothermal Amplification Assay for Eastern Equine Encephalitis Virus , Mikayla D. Maddison

Evaluating the Development and Implementation of Campus-based Sexual and Interpersonal Violence Prevention Programming , Robyn Manning-Samuels

Bait-and-Kill: Targeting a Novel Heme Biochemical Pathway in Hundreds of Cancers , Christopher G. Marinescu

Acclimatization Protocols and Their Outcomes , Ayub M. Odera

Promoting HPV vaccination with vaccine-hesitant parents using social media: a formative research mixed-method study , Silvia Sommariva

Sleep Diagnoses and Low Back Pain in U.S. Military Veterans , Kenneth A. Taylor

Theses/Dissertations from 2020 2020

Journey Mapping the Minority Student’s Path Toward Genetic Counseling: A Holistic Picture , Tatiana E. Alvarado-Wing

Using Observations from the UAW-Ford Ergonomic Assessment Tool to Predict Distal Upper Extremity Musculoskeletal Disorders , Zachariah T. Brandes-Powell

Do Similar Exposure Groups (SEG) differ from Air Force base to Air Force base? A Combat Arms Training and Maintenance (CATM) noise exposure comparison of Moody AFB and MacDill AFB. , Miriam F. Escobar

Predictors of Premature Discontinuation from Behavioral Health Services: A Mixed Methods Study Guided by the Andersen & Newman Model of Health Care Utilization , Shawna M. Green

Non-invasive Sex Determination and Genotyping of Transgenic Brugia malayi Larvae , Santiago E. Hernandez Bojorge

Does Gestational Diabetes Mellitus Increases the Risk of Preeclampsia Among Primigravid Women? , Astha Kakkad

Evaluating Effects of Cancer Genetic Counseling on Several Brief Patient Impact Measures , Alyson Kneusel

Impact of Heat-Related Illness and Natural Environments on Behavioral Health Related Emergency and Hospital Utilization in Florida , Natasha Kurji

The Quantification of Heavy Metals in Infant Formulas Offered by the Florida WIC Program , Naya Martin

Differences in Knowledge Acquisition, Perceived Engagement and Self-Efficacy in Latino Promotores Delivering the Heart Disease Prevention Program Su Corazόn, Su Vida , Samuel Matos-Bastidas

Spatial and Temporal Determinants Associated with Eastern Equine Encephalitis Virus Activity in Florida , Kristi M. Miley

Using Observations from the UAW-Ford Ergonomic Assessment Tool to Predict Low Back Musculoskeletal Disorders , Colins Nwafor

On the Importance of Context: Examining the Applicability of Infertility Insurance Mandates in the United States Using a Mixed-Methods Study Design , Nathanael B. Stanley

Exploration of Factors Associated with Perceptions of Community Safety among Youth in Hillsborough County, Florida: A Convergent Parallel Mixed-Methods Approach , Yingwei Yang

Theses/Dissertations from 2019 2019

The Ability of the U.S. Military’s WBGT-based Flag System to Recommend Safe Heat Stress Exposures , David R. Almario

The Relationship between Continuous Glucose Monitor (CGM) Derived Metrics and Indices of Glycemic Control , Ryan Bailey

“Man plans but ultimately, God decides”: A Phenomenological Investigation of the Contextual Family Planning Beliefs of Recently Resettled Congolese Refugee Women in West Central Florida. , Linda Bomboka Wilson

‘If He Hits Me, Is That Love? I Don’t Think So’: An Ethnographic Investigation of the Multi-Level Influences Shaping Indigenous Women’s Decision-Making Around Intimate Partner Violence in the Rural Peruvian Andes , Isabella Li Chan

An Assessment of the Role of Florida Pharmacists in the Administration of Inactivated Influenza Vaccine to Pregnant Women , Oluyemisi O. Falope

Epidemiological Analysis of Malaria Decrease in El Salvador from 1955 until 2017 , Tatiana I. Gardellini Guevara

Self-Collected Sampling Methods for Chlamydia and Gonorrhea Screening Among College Women: Exploring Patient-Centered Intervention Characteristics , Stacey B. Griner

The Relationship Between Hand and Wrist Musculoskeletal Disorders and Hand Activity and Posture , Warren M. Henry

Speeding Diagnosis and Saving Money Using Point of Care Ultrasound Rather Than MRI for Work-related MSK Injuries , Jared A. Jeffries

Mitigating Barriers to Chronic Disease Risk Factor Prevention and Management in Disadvantaged Communities , Krys M. Johnson

Comparing Family Sharing Behaviors in BRCA Carriers with PALB2 Carriers , Joy E. Kechik

Investigating Air Pollution and Equity Impacts of a Proposed Transportation Improvement Program for Tampa , Talha Kemal Kocak

Exploring Young Women’s Choice to Initiate Use of Long-acting Reversible Contraception: A Mixed Methods Approach , Helen Mahony

Evaluation of Clinical Practices and Needs about Variants of Uncertain Significance Results in Inherited Cardiac Arrhythmia and Inherited Cardiomyopathy Genes , Reka D. Muller

Effects of Medications with Anticholinergic Properties and Opioids on Cognitive Function and Neural Volumetric Changes in Elderly Australians , Malinee Neelamegam

Sundaas Story: A Mixed-Methods Study of Household Sanitation Provisioning in Urban Informal Housing in India , Sarita Vijay Panchang

A Retrospective Study of the Opioid Epidemic and Fentanyl Related Overdose Fatality Cases in a Florida West Coast Medical Examiner District Population , Anne Terese Powell

Using Predicted Heat Strain to Evaluate Sustainable Exposures , Samantha L. Thacker

Isokinetic Sampling Efficiency Differences for Blunt Edge vs Sharp Edge Sampling Probes , Cory A. Treloar

Using the Consolidated Framework for Implementation Research to Investigate Daily Pre-exposure Prophylaxis (emtricitabine/tenofovir DF) Implementation via Community-based HIV Testing Sites in Florida , Deanne E. Turner

“We can learn some things from them, but they can learn some things from us too”: Intergenerational Perceptions of Shared Infant Feeding Information , Alexis L. Woods Barr

Theses/Dissertations from 2018 2018

Comparison of Modeled and Measured Pesticide Concentrations in Air , Trenell Davis Boggans

Effectiveness of Biocide Substitution and Management Plan Implementation for the Control of , Adelmarie Bones

Design, Construction, and Characterization of the University of South Florida Wind Tunnel , Jason S. Garcia

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Head Start Your Radiology Residency [Online] ↗️

• Radiology Thesis – More than 400 Research Topics (2022)!

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Introduction

A thesis or dissertation, as some people would like to call it, is an integral part of the Radiology curriculum, be it MD, DNB, or DMRD. We have tried to aggregate radiology thesis topics from various sources for reference.

Not everyone is interested in research, and writing a Radiology thesis can be daunting. But there is no escape from preparing, so it is better that you accept this bitter truth and start working on it instead of cribbing about it (like other things in life. #PhilosophyGyan!)

Start working on your thesis as early as possible and finish your thesis well before your exams, so you do not have that stress at the back of your mind. Also, your thesis may need multiple revisions, so be prepared and allocate time accordingly.

Tips for Choosing Radiology Thesis and Research Topics

Keep it simple silly (kiss).

Retrospective > Prospective

Retrospective studies are better than prospective ones, as you already have the data you need when choosing to do a retrospective study. Prospective studies are better quality, but as a resident, you may not have time (, energy and enthusiasm) to complete these.

Choose a simple topic that answers a single/few questions

Original research is challenging, especially if you do not have prior experience. I would suggest you choose a topic that answers a single or few questions. Most topics that I have listed are along those lines. Alternatively, you can choose a broad topic such as “Role of MRI in evaluation of perianal fistulas.”

You can choose a novel topic if you are genuinely interested in research AND have a good mentor who will guide you. Once you have done that, make sure that you publish your study once you are done with it.

Get it done ASAP.

In most cases, it makes sense to stick to a thesis topic that will not take much time. That does not mean you should ignore your thesis and ‘Ctrl C + Ctrl V’ from a friend from another university. Thesis writing is your first step toward research methodology so do it as sincerely as possible. Do not procrastinate in preparing the thesis. As soon as you have been allotted a guide, start researching topics and writing a review of the literature.

At the same time, do not invest a lot of time in writing/collecting data for your thesis. You should not be busy finishing your thesis a few months before the exam. Some people could not appear for the exam because they could not submit their thesis in time. So DO NOT TAKE thesis lightly.

Do NOT Copy-Paste

Reiterating once again, do not simply choose someone else’s thesis topic. Find out what are kind of cases that your Hospital caters to. It is better to do a good thesis on a common topic than a crappy one on a rare one.

Books to help you write a Radiology Thesis

Event country/university has a different format for thesis; hence these book recommendations may not work for everyone.

• Amazon Kindle Edition
• Gupta, Piyush (Author)
• English (Publication Language)
• 206 Pages - 10/12/2020 (Publication Date) - Jaypee Brothers Medical Publishers (P) Ltd. (Publisher)

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List of Radiology Research /Thesis / Dissertation Topics

• State of the art of MRI in the diagnosis of hepatic focal lesions
• Multimodality imaging evaluation of sacroiliitis in newly diagnosed patients of spondyloarthropathy
• Multidetector computed tomography in oesophageal varices
• Role of positron emission tomography with computed tomography in the diagnosis of cancer Thyroid
• Evaluation of focal breast lesions using ultrasound elastography
• Role of MRI diffusion tensor imaging in the assessment of traumatic spinal cord injuries
• Sonographic imaging in male infertility
• Comparison of color Doppler and digital subtraction angiography in occlusive arterial disease in patients with lower limb ischemia
• The role of CT urography in Haematuria
• Role of functional magnetic resonance imaging in making brain tumor surgery safer
• Prediction of pre-eclampsia and fetal growth restriction by uterine artery Doppler
• Role of grayscale and color Doppler ultrasonography in the evaluation of neonatal cholestasis
• Validity of MRI in the diagnosis of congenital anorectal anomalies
• Role of sonography in assessment of clubfoot
• Role of diffusion MRI in preoperative evaluation of brain neoplasms
• Imaging of upper airways for pre-anaesthetic evaluation purposes and for laryngeal afflictions.
• A study of multivessel (arterial and venous) Doppler velocimetry in intrauterine growth restriction
• Multiparametric 3tesla MRI of suspected prostatic malignancy.
• Role of Sonography in Characterization of Thyroid Nodules for differentiating benign from
• Role of advances magnetic resonance imaging sequences in multiple sclerosis
• Role of multidetector computed tomography in evaluation of jaw lesions
• Role of Ultrasound and MR Imaging in the Evaluation of Musculotendinous Pathologies of Shoulder Joint
• Role of perfusion computed tomography in the evaluation of cerebral blood flow, blood volume and vascular permeability of cerebral neoplasms
• MRI flow quantification in the assessment of the commonest csf flow abnormalities
• Role of diffusion-weighted MRI in evaluation of prostate lesions and its histopathological correlation
• CT enterography in evaluation of small bowel disorders
• Comparison of perfusion magnetic resonance imaging (PMRI), magnetic resonance spectroscopy (MRS) in and positron emission tomography-computed tomography (PET/CT) in post radiotherapy treated gliomas to detect recurrence
• Role of multidetector computed tomography in evaluation of paediatric retroperitoneal masses
• Role of Multidetector computed tomography in neck lesions
• Estimation of standard liver volume in Indian population
• Role of MRI in evaluation of spinal trauma
• Role of modified sonohysterography in female factor infertility: a pilot study.
• The role of pet-CT in the evaluation of hepatic tumors
• Role of 3D magnetic resonance imaging tractography in assessment of white matter tracts compromise in supratentorial tumors
• Role of dual phase multidetector computed tomography in gallbladder lesions
• Role of multidetector computed tomography in assessing anatomical variants of nasal cavity and paranasal sinuses in patients of chronic rhinosinusitis.
• magnetic resonance spectroscopy in multiple sclerosis
• Evaluation of thyroid nodules by ultrasound elastography using acoustic radiation force impulse (ARFI) imaging
• Role of Magnetic Resonance Imaging in Intractable Epilepsy
• Evaluation of suspected and known coronary artery disease by 128 slice multidetector CT.
• Role of regional diffusion tensor imaging in the evaluation of intracranial gliomas and its histopathological correlation
• Role of chest sonography in diagnosing pneumothorax
• Role of CT virtual cystoscopy in diagnosis of urinary bladder neoplasia
• Role of MRI in assessment of valvular heart diseases
• High resolution computed tomography of temporal bone in unsafe chronic suppurative otitis media
• Multidetector CT urography in the evaluation of hematuria
• Contrast-induced nephropathy in diagnostic imaging investigations with intravenous iodinated contrast media
• Comparison of dynamic susceptibility contrast-enhanced perfusion magnetic resonance imaging and single photon emission computed tomography in patients with little’s disease
• Role of Multidetector Computed Tomography in Bowel Lesions.
• Role of diagnostic imaging modalities in evaluation of post liver transplantation recipient complications.
• Role of multislice CT scan and barium swallow in the estimation of oesophageal tumour length
• Malignant Lesions-A Prospective Study.
• Value of ultrasonography in assessment of acute abdominal diseases in pediatric age group
• Role of three dimensional multidetector CT hysterosalpingography in female factor infertility
• Comparative evaluation of multi-detector computed tomography (MDCT) virtual tracheo-bronchoscopy and fiberoptic tracheo-bronchoscopy in airway diseases
• Role of Multidetector CT in the evaluation of small bowel obstruction
• Sonographic evaluation in adhesive capsulitis of shoulder
• Utility of MR Urography Versus Conventional Techniques in Obstructive Uropathy
• MRI of the postoperative knee
• Role of 64 slice-multi detector computed tomography in diagnosis of bowel and mesenteric injury in blunt abdominal trauma.
• Sonoelastography and triphasic computed tomography in the evaluation of focal liver lesions
• Evaluation of Role of Transperineal Ultrasound and Magnetic Resonance Imaging in Urinary Stress incontinence in Women
• Multidetector computed tomographic features of abdominal hernias
• Evaluation of lesions of major salivary glands using ultrasound elastography
• Transvaginal ultrasound and magnetic resonance imaging in female urinary incontinence
• MDCT colonography and double-contrast barium enema in evaluation of colonic lesions
• Role of MRI in diagnosis and staging of urinary bladder carcinoma
• Spectrum of imaging findings in children with febrile neutropenia.
• Spectrum of radiographic appearances in children with chest tuberculosis.
• Role of computerized tomography in evaluation of mediastinal masses in pediatric
• Diagnosing renal artery stenosis: Comparison of multimodality imaging in diabetic patients
• Role of multidetector CT virtual hysteroscopy in the detection of the uterine & tubal causes of female infertility
• Role of multislice computed tomography in evaluation of crohn’s disease
• CT quantification of parenchymal and airway parameters on 64 slice MDCT in patients of chronic obstructive pulmonary disease
• Comparative evaluation of MDCT  and 3t MRI in radiographically detected jaw lesions.
• Evaluation of diagnostic accuracy of ultrasonography, colour Doppler sonography and low dose computed tomography in acute appendicitis
• Ultrasonography , magnetic resonance cholangio-pancreatography (MRCP) in assessment of pediatric biliary lesions
• Multidetector computed tomography in hepatobiliary lesions.
• Evaluation of peripheral nerve lesions with high resolution ultrasonography and colour Doppler
• Multidetector computed tomography in pancreatic lesions
• Multidetector Computed Tomography in Paediatric abdominal masses.
• Evaluation of focal liver lesions by colour Doppler and MDCT perfusion imaging
• Sonographic evaluation of clubfoot correction during Ponseti treatment
• Role of multidetector CT in characterization of renal masses
• Study to assess the role of Doppler ultrasound in evaluation of arteriovenous (av) hemodialysis fistula and the complications of hemodialysis vasular access
• Comparative study of multiphasic contrast-enhanced CT and contrast-enhanced MRI in the evaluation of hepatic mass lesions
• Sonographic spectrum of rheumatoid arthritis
• Diagnosis & staging of liver fibrosis by ultrasound elastography in patients with chronic liver diseases
• Role of multidetector computed tomography in assessment of jaw lesions.
• Role of high-resolution ultrasonography in the differentiation of benign and malignant thyroid lesions
• Radiological evaluation of aortic aneurysms in patients selected for endovascular repair
• Role of conventional MRI, and diffusion tensor imaging tractography in evaluation of congenital brain malformations
• To evaluate the status of coronary arteries in patients with non-valvular atrial fibrillation using 256 multirow detector CT scan
• A comparative study of ultrasonography and CT – arthrography in diagnosis of chronic ligamentous and meniscal injuries of knee
• Multi detector computed tomography evaluation in chronic obstructive pulmonary disease and correlation with severity of disease
• Diffusion weighted and dynamic contrast enhanced magnetic resonance imaging in chemoradiotherapeutic response evaluation in cervical cancer.
• High resolution sonography in the evaluation of non-traumatic painful wrist
• The role of trans-vaginal ultrasound versus magnetic resonance imaging in diagnosis & evaluation of cancer cervix
• Role of multidetector row computed tomography in assessment of maxillofacial trauma
• Imaging of vascular complication after liver transplantation.
• Role of magnetic resonance perfusion weighted imaging & spectroscopy for grading of glioma by correlating perfusion parameter of the lesion with the final histopathological grade
• Magnetic resonance evaluation of abdominal tuberculosis.
• Diagnostic usefulness of low dose spiral HRCT in diffuse lung diseases
• Role of dynamic contrast enhanced and diffusion weighted magnetic resonance imaging in evaluation of endometrial lesions
• Contrast enhanced digital mammography anddigital breast tomosynthesis in early diagnosis of breast lesion
• Evaluation of Portal Hypertension with Colour Doppler flow imaging and magnetic resonance imaging
• Evaluation of musculoskeletal lesions by magnetic resonance imaging
• Role of diffusion magnetic resonance imaging in assessment of neoplastic and inflammatory brain lesions
• Radiological spectrum of chest diseases in HIV infected children High resolution ultrasonography in neck masses in children
• with surgical findings
• Sonographic evaluation of peripheral nerves in type 2 diabetes mellitus.
• Role of perfusion computed tomography in the evaluation of neck masses and correlation
• Role of ultrasonography in the diagnosis of knee joint lesions
• Role of ultrasonography in evaluation of various causes of pelvic pain in first trimester of pregnancy.
• Role of Magnetic Resonance Angiography in the Evaluation of Diseases of Aorta and its Branches
• MDCT fistulography in evaluation of fistula in Ano
• Role of multislice CT in diagnosis of small intestine tumors
• Role of high resolution CT in differentiation between benign and malignant pulmonary nodules in children
• A study of multidetector computed tomography urography in urinary tract abnormalities
• Role of high resolution sonography in assessment of ulnar nerve in patients with leprosy.
• Pre-operative radiological evaluation of locally aggressive and malignant musculoskeletal tumours by computed tomography and magnetic resonance imaging.
• The role of ultrasound & MRI in acute pelvic inflammatory disease
• Ultrasonography compared to computed tomographic arthrography in the evaluation of shoulder pain
• Role of Multidetector Computed Tomography in patients with blunt abdominal trauma.
• The Role of Extended field-of-view Sonography and compound imaging in Evaluation of Breast Lesions
• Evaluation of focal pancreatic lesions by Multidetector CT and perfusion CT
• Evaluation of breast masses on sono-mammography and colour Doppler imaging
• Role of CT virtual laryngoscopy in evaluation of laryngeal masses
• Triple phase multi detector computed tomography in hepatic masses
• Role of transvaginal ultrasound in diagnosis and treatment of female infertility
• Role of ultrasound and color Doppler imaging in assessment of acute abdomen due to female genetal causes
• High resolution ultrasonography and color Doppler ultrasonography in scrotal lesion
• Evaluation of diagnostic accuracy of ultrasonography with colour Doppler vs low dose computed tomography in salivary gland disease
• Role of multidetector CT in diagnosis of salivary gland lesions
• Comparison of diagnostic efficacy of ultrasonography and magnetic resonance cholangiopancreatography in obstructive jaundice: A prospective study
• Evaluation of varicose veins-comparative assessment of low dose CT venogram with sonography: pilot study
• Role of mammotome in breast lesions
• The role of interventional imaging procedures in the treatment of selected gynecological disorders
• Role of transcranial ultrasound in diagnosis of neonatal brain insults
• Role of multidetector CT virtual laryngoscopy in evaluation of laryngeal mass lesions
• Evaluation of adnexal masses on sonomorphology and color Doppler imaginig
• Role of radiological imaging in diagnosis of endometrial carcinoma
• Comprehensive imaging of renal masses by magnetic resonance imaging
• The role of 3D & 4D ultrasonography in abnormalities of fetal abdomen
• Diffusion weighted magnetic resonance imaging in diagnosis and characterization of brain tumors in correlation with conventional MRI
• Role of diffusion weighted MRI imaging in evaluation of cancer prostate
• Role of multidetector CT in diagnosis of urinary bladder cancer
• Role of multidetector computed tomography in the evaluation of paediatric retroperitoneal masses.
• Comparative evaluation of gastric lesions by double contrast barium upper G.I. and multi detector computed tomography
• Evaluation of hepatic fibrosis in chronic liver disease using ultrasound elastography
• Role of MRI in assessment of hydrocephalus in pediatric patients
• The role of sonoelastography in characterization of breast lesions
• The influence of volumetric tumor doubling time on survival of patients with intracranial tumours
• Role of perfusion computed tomography in characterization of colonic lesions
• Role of proton MRI spectroscopy in the evaluation of temporal lobe epilepsy
• Role of Doppler ultrasound and multidetector CT angiography in evaluation of peripheral arterial diseases.
• Role of multidetector computed tomography in paranasal sinus pathologies
• Role of virtual endoscopy using MDCT in detection & evaluation of gastric pathologies
• High resolution 3 Tesla MRI in the evaluation of ankle and hindfoot pain.
• Transperineal ultrasonography in infants with anorectal malformation
• CT portography using MDCT versus color Doppler in detection of varices in cirrhotic patients
• Role of CT urography in the evaluation of a dilated ureter
• Characterization of pulmonary nodules by dynamic contrast-enhanced multidetector CT
• Comprehensive imaging of acute ischemic stroke on multidetector CT
• The role of fetal MRI in the diagnosis of intrauterine neurological congenital anomalies
• Role of Multidetector computed tomography in pediatric chest masses
• Multimodality imaging in the evaluation of palpable & non-palpable breast lesion.
• Sonographic Assessment Of Fetal Nasal Bone Length At 11-28 Gestational Weeks And Its Correlation With Fetal Outcome.
• Role Of Sonoelastography And Contrast-Enhanced Computed Tomography In Evaluation Of Lymph Node Metastasis In Head And Neck Cancers
• Role Of Renal Doppler And Shear Wave Elastography In Diabetic Nephropathy
• Evaluation Of Relationship Between Various Grades Of Fatty Liver And Shear Wave Elastography Values
• Evaluation and characterization of pelvic masses of gynecological origin by USG, color Doppler and MRI in females of reproductive age group
• Radiological evaluation of small bowel diseases using computed tomographic enterography
• Role of coronary CT angiography in patients of coronary artery disease
• Role of multimodality imaging in the evaluation of pediatric neck masses
• Role of CT in the evaluation of craniocerebral trauma
• Role of magnetic resonance imaging (MRI) in the evaluation of spinal dysraphism
• Comparative evaluation of triple phase CT and dynamic contrast-enhanced MRI in patients with liver cirrhosis
• Evaluation of the relationship between carotid intima-media thickness and coronary artery disease in patients evaluated by coronary angiography for suspected CAD
• Assessment of hepatic fat content in fatty liver disease by unenhanced computed tomography
• Correlation of vertebral marrow fat on spectroscopy and diffusion-weighted MRI imaging with bone mineral density in postmenopausal women.
• Comparative evaluation of CT coronary angiography with conventional catheter coronary angiography
• Ultrasound evaluation of kidney length & descending colon diameter in normal and intrauterine growth-restricted fetuses
• A prospective study of hepatic vein waveform and splenoportal index in liver cirrhosis: correlation with child Pugh’s classification and presence of esophageal varices.
• CT angiography to evaluate coronary artery by-pass graft patency in symptomatic patient’s functional assessment of myocardium by cardiac MRI in patients with myocardial infarction
• MRI evaluation of HIV positive patients with central nervous system manifestations
• MDCT evaluation of mediastinal and hilar masses
• Evaluation of rotator cuff & labro-ligamentous complex lesions by MRI & MRI arthrography of shoulder joint
• Role of imaging in the evaluation of soft tissue vascular malformation
• Role of MRI and ultrasonography in the evaluation of multifidus muscle pathology in chronic low back pain patients
• Role of ultrasound elastography in the differential diagnosis of breast lesions
• Role of magnetic resonance cholangiopancreatography in evaluating dilated common bile duct in patients with symptomatic gallstone disease.
• Comparative study of CT urography & hybrid CT urography in patients with haematuria.
• Role of MRI in the evaluation of anorectal malformations
• Comparison of ultrasound-Doppler and magnetic resonance imaging findings in rheumatoid arthritis of hand and wrist
• Role of Doppler sonography in the evaluation of renal artery stenosis in hypertensive patients undergoing coronary angiography for coronary artery disease.
• Comparison of radiography, computed tomography and magnetic resonance imaging in the detection of sacroiliitis in ankylosing spondylitis.
• Mr evaluation of painful hip
• Role of MRI imaging in pretherapeutic assessment of oral and oropharyngeal malignancy
• Evaluation of diffuse lung diseases by high resolution computed tomography of the chest
• Mr evaluation of brain parenchyma in patients with craniosynostosis.
• Diagnostic and prognostic value of cardiovascular magnetic resonance imaging in dilated cardiomyopathy
• Role of multiparametric magnetic resonance imaging in the detection of early carcinoma prostate
• Role of magnetic resonance imaging in white matter diseases
• Role of sonoelastography in assessing the response to neoadjuvant chemotherapy in patients with locally advanced breast cancer.
• Role of ultrasonography in the evaluation of carotid and femoral intima-media thickness in predialysis patients with chronic kidney disease
• Role of H1 MRI spectroscopy in focal bone lesions of peripheral skeleton choline detection by MRI spectroscopy in breast cancer and its correlation with biomarkers and histological grade.
• Ultrasound and MRI evaluation of axillary lymph node status in breast cancer.
• Role of sonography and magnetic resonance imaging in evaluating chronic lateral epicondylitis.
• Comparative of sonography including Doppler and sonoelastography in cervical lymphadenopathy.
• Evaluation of Umbilical Coiling Index as Predictor of Pregnancy Outcome.
• Computerized Tomographic Evaluation of Azygoesophageal Recess in Adults.
• Lumbar Facet Arthropathy in Low Backache.
• “Urethral Injuries After Pelvic Trauma: Evaluation with Uretrography
• Role Of Ct In Diagnosis Of Inflammatory Renal Diseases
• Role Of Ct Virtual Laryngoscopy In Evaluation Of Laryngeal Masses
• “Ct Portography Using Mdct Versus Color Doppler In Detection Of Varices In
• Cirrhotic Patients”
• Role Of Multidetector Ct In Characterization Of Renal Masses
• Role Of Ct Virtual Cystoscopy In Diagnosis Of Urinary Bladder Neoplasia
• Role Of Multislice Ct In Diagnosis Of Small Intestine Tumors
• “Mri Flow Quantification In The Assessment Of The Commonest CSF Flow Abnormalities”
• “The Role Of Fetal Mri In Diagnosis Of Intrauterine Neurological CongenitalAnomalies”
• Role Of Transcranial Ultrasound In Diagnosis Of Neonatal Brain Insults
• “The Role Of Interventional Imaging Procedures In The Treatment Of Selected Gynecological Disorders”
• Role Of Radiological Imaging In Diagnosis Of Endometrial Carcinoma
• “Role Of High-Resolution Ct In Differentiation Between Benign And Malignant Pulmonary Nodules In Children”
• Role Of Ultrasonography In The Diagnosis Of Knee Joint Lesions
• “Role Of Diagnostic Imaging Modalities In Evaluation Of Post Liver Transplantation Recipient Complications”
• “Diffusion-Weighted Magnetic Resonance Imaging In Diagnosis And
• Characterization Of Brain Tumors In Correlation With Conventional Mri”
• The Role Of PET-CT In The Evaluation Of Hepatic Tumors
• “Role Of Computerized Tomography In Evaluation Of Mediastinal Masses In Pediatric patients”
• “Trans Vaginal Ultrasound And Magnetic Resonance Imaging In Female Urinary Incontinence”
• Role Of Multidetector Ct In Diagnosis Of Urinary Bladder Cancer
• “Role Of Transvaginal Ultrasound In Diagnosis And Treatment Of Female Infertility”
• Role Of Diffusion-Weighted Mri Imaging In Evaluation Of Cancer Prostate
• “Role Of Positron Emission Tomography With Computed Tomography In Diagnosis Of Cancer Thyroid”
• The Role Of CT Urography In Case Of Haematuria
• “Value Of Ultrasonography In Assessment Of Acute Abdominal Diseases In Pediatric Age Group”
• “Role Of Functional Magnetic Resonance Imaging In Making Brain Tumor Surgery Safer”
• The Role Of Sonoelastography In Characterization Of Breast Lesions
• “Ultrasonography, Magnetic Resonance Cholangiopancreatography (MRCP) In Assessment Of Pediatric Biliary Lesions”
• “Role Of Ultrasound And Color Doppler Imaging In Assessment Of Acute Abdomen Due To Female Genital Causes”
• “Role Of Multidetector Ct Virtual Laryngoscopy In Evaluation Of Laryngeal Mass Lesions”
• MRI Of The Postoperative Knee
• Role Of Mri In Assessment Of Valvular Heart Diseases
• The Role Of 3D & 4D Ultrasonography In Abnormalities Of Fetal Abdomen
• State Of The Art Of Mri In Diagnosis Of Hepatic Focal Lesions
• Role Of Multidetector Ct In Diagnosis Of Salivary Gland Lesions
• “Role Of Virtual Endoscopy Using Mdct In Detection & Evaluation Of Gastric Pathologies”
• The Role Of Ultrasound & Mri In Acute Pelvic Inflammatory Disease
• “Diagnosis & Staging Of Liver Fibrosis By Ultraso Und Elastography In
• Patients With Chronic Liver Diseases”
• Role Of Mri In Evaluation Of Spinal Trauma
• Validity Of Mri In Diagnosis Of Congenital Anorectal Anomalies
• Imaging Of Vascular Complication After Liver Transplantation
• “Contrast-Enhanced Digital Mammography And Digital Breast Tomosynthesis In Early Diagnosis Of Breast Lesion”
• Role Of Mammotome In Breast Lesions
• “Role Of MRI Diffusion Tensor Imaging (DTI) In Assessment Of Traumatic Spinal Cord Injuries”
• “Prediction Of Pre-eclampsia And Fetal Growth Restriction By Uterine Artery Doppler”
• “Role Of Multidetector Row Computed Tomography In Assessment Of Maxillofacial Trauma”
• “Role Of Diffusion Magnetic Resonance Imaging In Assessment Of Neoplastic And Inflammatory Brain Lesions”
• Role Of Diffusion Mri In Preoperative Evaluation Of Brain Neoplasms
• “Role Of Multidetector Ct Virtual Hysteroscopy In The Detection Of The
• Uterine & Tubal Causes Of Female Infertility”
• Role Of Advances Magnetic Resonance Imaging Sequences In Multiple Sclerosis Magnetic Resonance Spectroscopy In Multiple Sclerosis
• “Role Of Conventional Mri, And Diffusion Tensor Imaging Tractography In Evaluation Of Congenital Brain Malformations”
• Role Of MRI In Evaluation Of Spinal Trauma
• Diagnostic Role Of Diffusion-weighted MR Imaging In Neck Masses
• “The Role Of Transvaginal Ultrasound Versus Magnetic Resonance Imaging In Diagnosis & Evaluation Of Cancer Cervix”
• “Role Of 3d Magnetic Resonance Imaging Tractography In Assessment Of White Matter Tracts Compromise In Supra Tentorial Tumors”
• Role Of Proton MR Spectroscopy In The Evaluation Of Temporal Lobe Epilepsy
• Role Of Multislice Computed Tomography In Evaluation Of Crohn’s Disease
• Role Of MRI In Assessment Of Hydrocephalus In Pediatric Patients
• The Role Of MRI In Diagnosis And Staging Of Urinary Bladder Carcinoma
• USG and MRI correlation of congenital CNS anomalies
• HRCT in interstitial lung disease
• X-Ray, CT and MRI correlation of bone tumors
• “Study on the diagnostic and prognostic utility of X-Rays for cases of pulmonary tuberculosis under RNTCP”
• “Role of magnetic resonance imaging in the characterization of female adnexal  pathology”
• “CT angiography of carotid atherosclerosis and NECT brain in cerebral ischemia, a correlative analysis”
• Role of CT scan in the evaluation of paranasal sinus pathology
• USG and MRI correlation on shoulder joint pathology
• “Radiological evaluation of a patient presenting with extrapulmonary tuberculosis”
• CT and MRI correlation in focal liver lesions”
• Comparison of MDCT virtual cystoscopy with conventional cystoscopy in bladder tumors”
• “Bleeding vessels in life-threatening hemoptysis: Comparison of 64 detector row CT angiography with conventional angiography prior to endovascular management”
• “Role of transarterial chemoembolization in unresectable hepatocellular carcinoma”
• “Comparison of color flow duplex study with digital subtraction angiography in the evaluation of peripheral vascular disease”
• “A Study to assess the efficacy of magnetization transfer ratio in differentiating tuberculoma from neurocysticercosis”
• “MR evaluation of uterine mass lesions in correlation with transabdominal, transvaginal ultrasound using HPE as a gold standard”
• “The Role of power Doppler imaging with trans rectal ultrasonogram guided prostate biopsy in the detection of prostate cancer”
• “Lower limb arteries assessed with doppler angiography – A prospective comparative study with multidetector CT angiography”
• “Comparison of sildenafil with papaverine in penile doppler by assessing hemodynamic changes”
• “Evaluation of efficacy of sonosalphingogram for assessing tubal patency in infertile patients with hysterosalpingogram as the gold standard”
• Role of CT enteroclysis in the evaluation of small bowel diseases
• “MRI colonography versus conventional colonoscopy in the detection of colonic polyposis”
• “Magnetic Resonance Imaging of anteroposterior diameter of the midbrain – differentiation of progressive supranuclear palsy from Parkinson disease”
• “MRI Evaluation of anterior cruciate ligament tears with arthroscopic correlation”
• “The Clinicoradiological profile of cerebral venous sinus thrombosis with prognostic evaluation using MR sequences”
• “Role of MRI in the evaluation of pelvic floor integrity in stress incontinent patients” “Doppler ultrasound evaluation of hepatic venous waveform in portal hypertension before and after propranolol”
• “Role of transrectal sonography with colour doppler and MRI in evaluation of prostatic lesions with TRUS guided biopsy correlation”
• “Ultrasonographic evaluation of painful shoulders and correlation of rotator cuff pathologies and clinical examination”
• “Colour Doppler Evaluation of Common Adult Hepatic tumors More Than 2 Cm  with HPE and CECT Correlation”
• “Clinical Relevance of MR Urethrography in Obliterative Posterior Urethral Stricture”
• “Prediction of Adverse Perinatal Outcome in Growth Restricted Fetuses with Antenatal Doppler Study”
• Radiological evaluation of spinal dysraphism using CT and MRI
• “Evaluation of temporal bone in cholesteatoma patients by high resolution computed tomography”
• “Radiological evaluation of primary brain tumours using computed tomography and magnetic resonance imaging”
• “Three dimensional colour doppler sonographic assessment of changes in  volume and vascularity of fibroids – before and after uterine artery embolization”
• “In phase opposed phase imaging of bone marrow differentiating neoplastic lesions”
• “Role of dynamic MRI in replacing the isotope renogram in the functional evaluation of PUJ obstruction”
• Characterization of adrenal masses with contrast-enhanced CT – washout study
• A study on accuracy of magnetic resonance cholangiopancreatography
• “Evaluation of median nerve in carpal tunnel syndrome by high-frequency ultrasound & color doppler in comparison with nerve conduction studies”
• “Correlation of Agatston score in patients with obstructive and nonobstructive coronary artery disease following STEMI”
• “Doppler ultrasound assessment of tumor vascularity in locally advanced breast cancer at diagnosis and following primary systemic chemotherapy.”
• “Validation of two-dimensional perineal ultrasound and dynamic magnetic resonance imaging in pelvic floor dysfunction.”
• “Role of MR urethrography compared to conventional urethrography in the surgical management of obliterative urethral stricture.”

Search Diagnostic Imaging Research Topics

You can also search research-related resources and direct download PDFs for radiology articles on our custom radiology search engine .

Free Resources for Preparing Radiology Thesis

• Radiology thesis topics- Benha University – Free to download thesis
• Radiology thesis topics – Faculty of Medical Science Delhi
• Radiology thesis topics – IPGMER
• Fetal Radiology thesis Protocols
• Radiology thesis and dissertation topics
• Radiographics

Proofreading Your Thesis:

Make sure you use Grammarly to correct your spelling ,  grammar , and plagiarism for your thesis. Grammarly has affordable paid subscriptions, windows/macOS apps, and FREE browser extensions. It is an excellent tool to avoid inadvertent spelling mistakes in your research projects. It has an extensive built-in vocabulary, but you should make an account and add your own medical glossary to it.

Guidelines for Writing a Radiology Thesis:

These are general guidelines and not about radiology specifically. You can share these with colleagues from other departments as well. Special thanks to Dr. Sanjay Yadav sir for these. This section is best seen on a desktop. Here are a couple of handy presentations to start writing a thesis:

Read the general guidelines for writing a thesis (the page will take some time to load- more than 70 pages!

A format for thesis protocol with a sample patient information sheet, sample patient consent form, sample application letter for thesis, and sample certificate.

Resources and References:

• Guidelines for thesis writing.
• Format for thesis protocol
• Thesis protocol writing guidelines DNB
• Informed consent form for Research studies from AIIMS 
• Radiology Informed consent forms in local Indian languages.
• Sample Informed Consent form for Research in Hindi
• Guide to write a thesis by Dr. P R Sharma
• Guidelines for thesis writing by Dr. Pulin Gupta.
• Preparing MD/DNB thesis by A Indrayan
• Another good thesis reference protocol

Hopefully, this post will make the tedious task of writing a Radiology thesis a little bit easier for you. Best of luck with writing your thesis and your residency too!

More guides for residents :

• Guide for the MD/DMRD/DNB radiology exam!
• Guide for First-Year Radiology Residents
• FRCR Exam: THE Most Comprehensive Guide (2022)!
• Radiology Practical Exams Questions compilation for MD/DNB/DMRD !

Radiology Exam Resources (Oral Recalls, Instruments, etc )!

• Tips and Tricks for DNB/MD Radiology Practical Exam
• FRCR 2B exam- Tips and Tricks !
• FRCR exam preparation – An alternative take!
• Why did I take up Radiology?
• Radiology Conferences – A comprehensive guide!
• ECR (European Congress Of Radiology)
• European Diploma in Radiology (EDiR) – The Complete Guide!

Radiology NEET PG guide – How to select THE best college for post-graduation in Radiology (includes personal insights)!

• Interventional Radiology – All Your Questions Answered!
• What It Means To Be A Radiologist: A Guide For Medical Students!
• Radiology Mentors for Medical Students (Post NEET-PG)
• MD vs DNB Radiology: Which Path is Right for Your Career?
• DNB Radiology OSCE – Tips and Tricks

More radiology resources here: Radiology resources This page will be updated regularly. Kindly leave your feedback in the comments or send us a message here . Also, you can comment below regarding your department’s thesis topics.

Note: All topics have been compiled from available online resources. If anyone has an issue with any radiology thesis topics displayed here, you can message us here , and we can delete them. These are only sample guidelines. Thesis guidelines differ from institution to institution.

Image source: Thesis complete! (2018). Flickr. Retrieved 12 August 2018, from https://www.flickr.com/photos/cowlet/354911838 by Victoria Catterson

About The Author

Dr. amar udare, md, related posts ↓.

9 thoughts on “Radiology Thesis – More than 400 Research Topics (2022)!”

Amazing & The most helpful site for Radiology residents…

Thank you for your kind comments 🙂

Dr. I saw your Tips is very amazing and referable. But Dr. Can you help me with the thesis of Evaluation of Diagnostic accuracy of X-ray radiograph in knee joint lesion.

Wow! These are excellent stuff. You are indeed a teacher. God bless

Glad you liked these!

happy to see this

Glad I could help :).

Greetings Dr, thanks for your constant guides. pls Dr, I need a thesis research material on “Retrieving information from scattered photons in medical imaging”

Hey! Unfortunately I do not have anything relevant to that thesis topic.

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226 Hot Public Health Thesis Topics For Top Grades

Are you stuck trying to get the best current public health research topics for thesis and writing it? If yes, know you are not alone. A lot of students find the tasks challenging, but we are here to help. Keep reading our informative guide that demonstrates how to prepare an engaging public health paper.

We will also highlight hot 226 health policy topics for paper and other public health ideas for dissertation that you can use for top grades. Why settle for less when we can help you select the best college or university papers?

What Is Public Health?

Before looking at the top public health statistics undergraduate thesis topics or other public health research ideas, let’s start with the definition. So, what is public health?

According to the World Health Organization (WHO), public health is “the art and science of preventing diseases, helping to prolong life and promote health using organized efforts. Good examples of public health efforts include preventing outbreaks, educating the public on health choices, promoting fitness, preparing for emergencies, and avoiding the spread of infectious diseases. Public health

How To Write A Great Public Health Dissertation

If you are a graduate or masters student, one of the most comprehensive documents that you need to prepare is the dissertation. It is an expansive paper and comes at the end of your course. Remember that you need to ensure it is prepared well because a team of professors will ultimately evaluate it. So, here are the main steps that you need to follow to prepare a high quality dissertation:

Identify the topic of study Comprehensively research the topic and identify the main points to support it Develop the thesis statement for the dissertation (this thesis will ultimately be tested after gathering your data) Develop an outline for the dissertation. This guide should tell you what to write at what specific instance. Here is a sample outline: Topic of the study Introduction. Start with the thesis statement, followed by the objectives of the study. Then, the rest of the introduction should be used to set the background for the study. Literature review: Review relevant resources about the topic. Methodology: Explain the methodology that was used during the study. Is Results and analysis: Provide the results gathered during the study. Discussion and conclusion: Here, you should discuss the study results and demonstrate whether they approve or disapprove the thesis statement. If you found any gaps in the previous studies, highlight them too and call for further studies. Bibliography: This is a list of all the resources you used to prepare the paper. Write the first draft following the outline we have just listed above. Write the final copy by refining the first draft, proofreading, and editing it.

Awesome Public Health Thesis Topics

Here are the leading thesis topics in public health for top grades. You can use them as they are or tweak a little to suit your preference.

Public Health Thesis Topics In Mental Issues

• What is the role of public health in addressing mental issues in society?
• Seasonal affective disorder: A review of the disorder’s prevalence rates.
• Society should always listen to the needs of mentally ill persons.
• Eating disorders in adults: A review of the treatment strategies used for adults in the UK.
• What is the relation between climate change and emerging public health issues?
• Comparing depression prevalence rates in the UK to those of the US.
• What are the main causes of anxiety disorders in society?
• A review of the connection between HIV/AIDS and mental health issues in society.
• Running a public health facility: What is the most important equipment?
• Emerging public health issues in developing countries.
• Analyzing the psychological problems of breast cancer.
• What strategies should people use to prevent their mental health from social media dangers?
• A review of the public health benefits associated with active lifestyles.
• Stress: Why is it a major risk factor for mental health in many communities?
• What are the most common mental health issues in society today?
• Comparing the rates of depression and stress in China and the UK.
• Addressing anxiety-related disorders: Is cognitive-behavior therapy the best treatment method?
• A review of the economic burden of living with a person suffering from anxiety disorders.
• How does depression impact the quality of life?
• Comparing training of public health officers in the US to India.

Unique Research Topics In Public Health

• Surrogacy: A review of associated ethical issues.
• Prevalence of medical errors in hospitals: A review of the policies used to prevent the problem in the United States.
• Blood transfusion: What are the side effects?
• A review of doctors’ roles in promoting healthy lifestyles.
• Maintaining healthy body weight: Comparing the effectiveness of the recommended methods.
• A review of organ donation trends in Europe and Asia.
• Analyzing the ethical factors around cloning: When should it be allowed?
• The ethics of human experimentation.
• Comparing the rates of heart attacks in women to men in the United States.
• What are the main causes of heart attacks? Can it be prevented?
• Progress in diabetes studies and treatment: Is it possible to get a cure in the future?
• Biological weapons and their impacts on society: A review of the Leukemia rates in Japan.
• Pre-diabetes in children: What are the main symptoms, and how can it be addressed?

Public Health Paper Topics On COVID-19

• How will COVID-19 change life?
• What are the advantages and disadvantages of self-isolation?
• Life lessons that you learned during the COVID-19 pandemic.
• What challenges has your community faced during COVID-19 pandemic?
• School life during COVID-19 pandemic.
• A review of mass media operations during pandemic.
• What projects did you undertake during the pandemic?
• A review of projects that your community undertook during the COVID-19 pandemic.
• A closer look at the backlash against Asians in Europe at the start COVID-19 pandemic period.
• Preparing for the next pandemic: What lessons did the world learn from the COVID-19 pandemic?
• The best strategies for staying healthy during a pandemic.
• Is there anything that we could have done to prevent the COVID-19 pandemic?
• Comparing the effectiveness of Europe and American healthcare preparedness for tackling disasters.
• A review of mental health status in a community of your choice during the COVID-19 pandemic.
• A review of COVID-19 emergence theories: Which one do you think is more credible?
• Comparing the impacts of the COVID-19 pandemic to Ebola.
• Vaccines development for viral infections: What made the development of the COVID-19 vaccine possible so fast, whereas that of HIV/AIDS has taken so long?
• A review of the vaccine development process.
• Time for review: How effectively do you think your government responded to the COVID-19 pandemic?
• Rethinking public health on a global scale: Demonstrating why effective healthcare is only possible when looked at globally.

Interesting Public Health Research Topic Ideas

• What is the importance of learning public health in school?
• Identify and review a common public health issue in your community.
• The history of human health: Comparing what was considered healthy in ancient times to what is referred to as healthy today.
• Going vegan: How can it impact your health?
• Excessive weight: Is it the new threat to human civilization?
• Is bodybuilding healthy?
• Body positive: Is it a new health standard or ignorance of body issues?
• Things to consider when selecting healthy food to eat.
• Why psychological health should be part of every community in society.
• The health of newborns: What is the difference between their healthcare and that of adults?
• Emerging trends in the healthcare industry: How can the latest trends benefit society?
• Comparing depression and anxiety in two countries of your choice.
• Physical wellness must include healthy behavioral patterns and nutrition.
• A sense of belonging is paramount to personal and community health.
• What is the relationship between spirituality and public health?
• A review of stigmatization of mental health issues in a community of your choice.
• Is it possible to prevent depression?
• At what point should children start learning sex-related education?
• Comparing the two main public health issues in two cities: London and New York.
• What is the relationship between poverty and public health?

Hot Researchable Topics In Public Health

• The resurgence of measles in society: The best guidance for clinicians.
• Tackling the growing national drug problem.
• Bioterrorism preparedness for global disasters.
• A review of recent vitamin D recommendations for older adults.
• Strategies for maintaining maternal mortality at low levels across the globe.
• Efforts by Asian governments to reduce infections from using unsafe water.
• Over-the-counter drug abuse in Europe: Compare two countries of your choice.
• Health care providers’ roles in preventing bullying in society.
• Knowledge management in the UK healthcare organizations.
• The health benefits of good healthcare waste management.
• Characteristics of dental wastes in hospitals.
• Comparing the most prevalent public health issues in developed and developing nations.
• Latest trends in financing public health.
• The relevance of clinical epidemiology in public health.
• Evidence based public health.
• Epidemiological burden of HIV/AIDS in developing countries.
• Addressing cervical cancer in developing countries: Is it possible to eliminate it completely?
• Ethics in public health clinical research.
• Comparing the strategies used in teaching and motivating public health professionals in developing and developed countries.

Research Topics In Public Health For Masters

• Advertising and impacts on food choices in the community.
• The use of stem cell technologies for cancer treatment: What are the latest trends?
• Bio-printing: Is it the future of organ transplants?
• Nutrition education: How does it promote healthy diets?
• Exercising: What role does it play in promoting strength and balance in the elderly?
• Weight loss surgery: What are the key advantages and disadvantages?
• Heart disease is a major public health issue in society.
• Alternative strategies for treating depression in society: Are they effective?
• Healthcare leadership and its importance in public health.
• Legal aspects of public health care in the society.
• Mental disabilities in patients: A review of the emerging trends in the UK.
• How does the United States promote the development of public health?
• Inequalities in medicine: What impact does it have in public health?
• The most controversial issues in public health in the UK.
• What are the most preferred storage systems for medical supplies in the UK public health facilities?
• Reimagining the public health systems on the globe: Where do you see the UK health system in the next 20 years?

Top Thesis Topics In Dental Public Health

• Common oral health issues in Ireland.
• A review of common problems of endodontically treated teeth.
• The role of good leadership skills in dental education.
• Child management techniques between male and female practitioners.
• What role does ergonomics play in dentistry?
• Dental material and bio-engineering: What are the latest trends?
• A review of the relationship between diabetes and oral health in the society.
• The role of electronic health care record systems used in public health.
• Comparing dental health issues in the developing and developed countries.
• A review of public awareness of dental health issues in a community of choice.
• How can you ensure that all the food you buy is safe and healthy?
• What strategies are used by your local health community to promote dental awareness?
• Dental health management in California: What do you think should be done differently?
• Are you satisfied with the strategies used to address dental issues?

Hot Thesis Topics Public Health

• Mandatory overtime work for medical staff: How does it impact their commitment to their job?
• Nursing shortage and its impact in public health.
• Strategies for improving public health in the EU.
• Mental health issues among asylum seekers in the United States.
• Common mental issues among veterans returning from war: A case study of the United States.
• What functions does management play in healthcare settings when handling key public health issues?
• How poor relationships between nurses and doctors can impact public health services delivery.
• Third-party players in public health and their roles.
• Financial reporting standards in public health facilities.
• What is the correlation between revenue collection in society and the quality of patient services?
• Reviewing the coordination of public health officials during disasters.
• The importance of staff training on quality of health services.
• Comparing the differences between alternative medicine and conventional medicine in addressing public health issues in society.
• Obesity: What are the main causes in child-going age?
• A review of health consequences of caffeine.
• Medical marijuana: What are the main pros and cons?
• A review of the US Farm Bill Amendments that legalized use of cannabis in the US.
• Doing sports: Is it always healthy?
• Low-fat or low-carb diet: Which one is better in addressing overweight and diabetes issues?
• Preventing communicable diseases: Evaluating the prevention strategies used in Asia.
• What is the estimated cost of treating heart problems?

Controversial Public Health Dissertation Topics

• Smoking and impacts of current efforts to address cancer in the society.
• A review of the main causes of heart attacks in society today.
• Tobacco ads: Evaluating their impacts and the relationship to the current cancer trends in the society.
• Sleep disorders: Explain why they should be considered a public health issue.
• Staffing shortage and the impacts in fighting COVID-19 pandemic in Asia.
• Analyzing risk management of treating different diseases in the community.
• COVID-19 pandemic in numbers: Comparing the infection rates in the developed and developing countries.
• Reviewing strategies used in the US public health system to achieve equity: How effective are they?
• Analyzing the main challenges in the UK medical care system.
• Rising cases of suicides in the society: What are the main causes?
• A comprehensive review of strategies used to prevent suicides in the 21st century in the US.
• Use of vaccines to prevent diseases: Do adults still need the vaccines?
• Heat-related deaths: What strategies should be adopted?
• Chronic-diseases prevention: Comparing the strategies used in developing and developed countries.
• Are we becoming too dependent on antibiotics in fighting diseases?
• Opioid crisis: Are the doctors to blame for it?
• Use of blockchain in growing accuracy of clinical trials in medicine.
• What dangers are posed by nuclear wastes in society?
• Assessing US industrial facilities compliance rates to cut down emissions.
• Using clean energy as a strategy of improving public health: What are the expectations?
• What is the healthiest country?
• Evaluating the correlation between gaming and deviant behavior among children in society.
• COVID-19 could have been prevented if WHO was more vigilant?

Public Health Research Questions

• Is the high cost of medical healthcare in the United States justified?
• What is the correlation between poverty and poor health in society?
• Should health care for homeless people be free?
• Unconventional medicine: Should it be part of the UK healthcare system?
• Should doctors be responsible for medical errors?
• Should medical officers or health facilities be allowed to promote selective medical products?
• Should all healthcare facilities in the UK be required to have translators for non-English speaking clients?
• Mental health issues associated with domestic violence: A case study of France.
• Is it a good idea to legalize euthanasia?
• What are the benefits of using surgical masks in public?
• What are the most important lessons from the different waves of the COVID-19 pandemic reported on the globe?
• Who is more responsible for the COVID-19 pandemic?
• Ebola or COVID-19 pandemic: Which is worse?
• What are the main causes of epidemics on the globe?
• Public health planning: What are the most important things to think about?
• Should governments pay the cost of rehabilitating drug addicts in society?
• Teaching children healthy lifestyles: What are the best strategies?
• What problems do people with autism face in society?
• What are the leading causes of child mortality in your community?
• Gun violence in the United States: Should it be considered a public health issue?
• What illnesses are considered foodborne?

Easy Topics In Public Health

• All workplaces should support breastfeeding.
• What are the best strategies to reduce pollution in society?
• Public health benefits of recycling waste in society.
• Reviewing the causes of poor water quality in the developing world.
• Comparing water quality standards policies in the UK and US.
• Health impacts of the rapid depletion of o-zone depletion.
• Better planning of infrastructural development is important for healthier societies: Discuss.
• The US is better prepared to handle pandemics that might arise after the COVID-19 pandemic. Discuss.
• A review of common diseases spread by vectors.
• A review of key policies installed to protect employee health.
• Legal age for consuming energy drinks should be set by the government to address the problem of diabetes.
• Smoking: Should it be banned in public?
• What are the best strategies for raising awareness in public?
• Can reducing the workload of employees in manufacturing facilities improve their health?
• Sunbathing should be restricted to prevent the risk of cancer: Discuss.
• Should abortion be banned in society?
• School-related stress: How can it be prevented?
• Should birth control be made available and free for all teenagers?
• What should be categorized as a bad health habit?
• Compare and contrast two common treatment methods for treating behavioral disorders.
• Internet addiction: What are the main dangers of internet addiction?

Other Public Health Topics For Research

• How to stay healthy and safe during a pandemic.
• Using a bicycle instead of driving is healthier.
• Common mental disorders in India.
• What is the biggest health issue among young people?
• The impact of exercising in teenagers.
• Why do teenagers experiment with drugs?
• What impact does dispositional violence have on mental disorders?
• Is telemedicine helpful in promoting better healthcare?
• Unproven alternative medicine: What are the associated risks?
• What alternatives do we have for antibiotics?
• What is the difference between private and public healthcare?
• A review of the main health issues associated with puberty.
• What is the most dangerous disease of the 21st century?
• Why are some people still afraid of vaccines?
• Experimental treatment: Why do people agree to undergo it?
• How can we improve the health of people living with chronic illnesses?
• The best strategies to make people aware of the basics of healthcare.
• A review of the growing awareness about reproductive health in the society.

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Formal MD Thesis Requirement

All students at Yale School of Medicine engage in research and are required to write an MD thesis during medical school. The only exceptions are students who have earned a PhD degree in the health sciences before matriculation and students enrolled in Yale’s MD-PhD program. The YSM MD Thesis is under the governance of the EPCC, which meets regularly to recommend rules, regulations, and deadlines.

Students should review the 2024-2025 Research Guide for Students , known as the Thesis Guide, for all information pertaining to the YSM thesis and associated processes and deadlines.

Deadlines/Important Dates

Thesis approval process, thesis prizes, required formatting and components of the md thesis, examples for reference section formatting, avoiding the risk of copyright violation when submitting the md thesis, thesis deadlines for the 2024-2025 academic year, md students:.

The Office of Student Research has worked with the Dean’s Office and other educational stakeholders to establish deadlines for theses submitted in partial fulfillment of the requirements for graduation in May 2025. The deadlines ensure that students have sufficient time to complete their theses and that there is sufficient time for rigorous assessment and revision before final approval. These deadlines are strictly followed. Students are strongly encouraged to submit their theses well before the Class of 2025 Thesis Deadlines provided below. This timeline provides students, mentors/advisors, and sponsoring departments sufficient time for useful review and revision. It should be recognized by all concerned that the integrity of the thesis requirement and effective, rigorous review requires adherence to these deadlines. OSR will hold periodic Zoom “Class of 2025 Thesis Check-in Sessions” and will distribute reminder emails with more detailed instructions as these deadlines approach.

*Students missing the August 22nd, January 17th, and/or March 28th deadlines will be referred to the Progress Committee to ensure they receive adequate support to make progress towards this graduation requirement. Students missing the January 17th and/or March 28th deadlines will be ineligible for thesis prizes at graduation .

Extensions beyond the above thesis deadlines will be granted only for special circumstances and must have the approval of the student’s thesis mentor/advisor, Head of Advisory College, and the Departmental Thesis Chairperson . Students seeking an extension for the January 17, 2025, deadline must submit a Thesis Deadline Extension Request Form to their Head of Advisory College, and the Departmental Thesis Chairperson, for approval. Extensions, if granted, are granted in 2-week increments. An OSR staff member will confirm that an extension for the student has been received and will provide an updated timetable of deadlines that the student must adhere to. If a student is unable to meet the extended deadline for thesis submission, they must submit a new Thesis Deadline Extension Request Form following the same process listed above. A new Thesis Deadline Extension Request Form is required for each 2-week extension period. In the event of an extension, if granted, the following ABSOLUTE Class of 2025 Thesis Extension Deadlines will apply:

*All late theses require an extension. The student must submit the Thesis Deadline Extension Request Form by January 17, 2025, at 5 pm.

MD/MHS Students:

Consistent with degree requirements, MD-MHS students must present their thesis to their three-person committee prior to the January 17th deadline. Students are encouraged to start arranging the date of this committee meeting in the fall to avoid unanticipated delays. The MD-MHS process will be tracked in Medtrics.

*Students missing the August 22nd, January 17th, and/or March 28th deadlines will be referred to the Progress Committee to ensure they receive adequate support to make progress towards this graduation requirement. Students missing the January 17th and/or March 28th deadlines will be ineligible for thesis prizes at graduation.

MD-PhD Students:

A different process applies to students in the MD-PhD program. For students enrolled in the combined MD-PhD Program, the dissertation submitted to and approved by the Graduate School will satisfy the MD thesis requirement. Therefore, MD-PhD students who have already defended their dissertation and received their PhD should provide this information to OSR via Medtrics.

To ensure compliance with YSM graduation deadlines, MD-PhD students in the class of 2025 who have not defended and submitted their dissertation to the Graduate School by the October 1, 2024, deadline will be required to submit a copy of their dissertation directly to the OSR in order to fulfill the MD thesis requirement. Further instructions and deadlines will be provided in the fall of 2024. Please note that MD-PhD students must also defend and submit their dissertation to the Graduate School no later than March 15, 2025, to meet the Graduate School spring degree deadline for conferral of the PhD degree. MD-PhD students who have not yet defended their dissertation should provide this information to OSR via Medtrics. If there are any questions about the process, please contact the MD-PhD Office.

Financial support is not provided for writing the thesis.

Thesis Preparation and Approval

Preparation for thesis submission begins in the summer of the fourth year. At this time, timeline and practices are posted to the OSR website, distributed via email, and reviewed with students in class meetings. Because thesis approval is a lengthy process involving three levels of review, students are encouraged to manage their time well and start writing their first draft early in the fall semester of their final year of medical school. The thesis approval process will be tracked in Medtrics.

July: OSR website is updated, thesis deadlines are distributed via email to all students in the graduating class, and an informational session is held. Students should be on track to complete their thesis research by early-fall. Any student anticipating a challenge in this regard should contact the OSR as soon as possible. By mid-August, all students expecting to graduate in May must submit their tentative thesis title and thesis mentor/advisor through Medtrics. The OSR will contact all thesis mentors/advisors to confirm this role and to provide information and expectations regarding the thesis process. Therefore, students should confirm the faculty member’s willingness to serve as thesis mentor. Students missing this deadline, or whose mentors/advisors express concern regarding the student’s progress, will be referred to the Progress Committee to ensure adequate support for this graduation requirements.

August – December: Students should finalize research and draft their thesis. As the semester progresses, activities should shift from the data generation/analysis to thesis writing. Students should do their best to complete the first draft of the thesis by mid-late December. Because students are also involved in the residency application and interview process, they are discouraged from starting new projects at this time.

December – January: This period is devoted to reviewing and editing of the thesis draft that is ultimately approved by the faculty thesis mentor/advisor and submitted by the student to the Thesis Chair of their sponsoring department. The YSM faculty thesis mentor/advisor will be asked to complete a thesis assessment that evaluates the student’s performance on YSM’s research-related educational objectives and provides formative summative feedback via Medtrics.

January – March: The Departmental Thesis Chair coordinates thesis review by external reviewers. An “external reviewer” is defined as an individual who is not directly involved in the project. This individual may be a Yale faculty member internal/external to YSM or may hold a faculty appointment at an outside institution. This reviewer reads the thesis, completes the assessment, provides formative summative feedback, and makes recommendations for any required changes to the thesis. Departmental Thesis Chairs review assessments and transmit thesis approvals to the OSR. These assessments and approvals will be managed via Medtrics.

March: Theses and their associated assessments undergo school-level review by the OSR. Students receive YSM approval of their thesis along with summative feedback obtained during the review process. Students incorporate any required changes into their thesis and upload to the Yale Medicine Digital Thesis Library/Eli Scholar via the ProQuest platform.

April: The OSR confirms that theses have been deposited into the Yale Medicine Digital Thesis Library and the YSM registrar receives the names of students who have completed the thesis requirement.

The central role of the medical student thesis is to assess student’s performance on the YSM’s research-related educational program objectives. As such, all students are expected to produce an excellent piece of scholarly work. In recognition of these achievements, the OSR has worked to develop an award process that celebrates the outstanding research done by YSM students without creating a competitive atmosphere. Hence, thesis awards are based on milestone-based assessments submitted by thesis mentors/advisors and reviewers during the approval process, and internal review of the final thesis that was deposited into the Yale Medicine Digital Thesis Library. Consistent with all other graduation prizes, YSM MD Thesis Awards will remain confidential until they are announced in the YSM Commencement Program on May 19, 2025. While some departments may elect to confer thesis “honors” based upon their own internal review, this recognition is distinct from YSM graduation prizes and is not under OSR’s purview.

Read about the required formatting and components for the thesis .

See helpful examples for reference section formatting.

Read about avoiding the risk of copyright violation when submitting the MD Thesis.

2024-2025 Research Guide for Students

Apply for a thesis extension.

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Thesis Topics and Ideas

This page provides a comprehensive list of 1000 thesis topics and ideas designed to assist students from a wide array of academic disciplines in identifying and selecting their research subjects. Whether you are at the beginning stages of your research or refining your thesis topic, this resource offers valuable guidance and an extensive array of ideas to inspire and inform your academic work. Spanning 25 fields, from Accounting to Science, each category includes 40 specific topics, ensuring a broad and inclusive range for every scholar’s interests. With an emphasis on the significance of choosing a suitable thesis topic, this page serves as an essential starting point for any student embarking on their thesis journey.

1000 Thesis Topics and Ideas

Academic Writing, Editing, Proofreading, And Problem Solving Services

Get 10% off with 24start discount code, 25 thesis topics categories:.

• Accounting Thesis Topics
• Art Thesis Topics
• Banking Thesis Topics
• Biology Thesis Topics
• Computer Science Thesis Topics
• Economics Thesis Topics
• Education Thesis Topics
• Engineering Thesis Topics
• Entrepreneurship Thesis Topics
• Environmental Science Thesis Topics
• Finance Thesis Topics
• Geography Thesis Topics
• Geology Thesis Topics
• Health Thesis Topics
• Immigration Thesis Topics
• Law Thesis Topics
• Nutrition Thesis Topics
• Leadership Thesis Topics
• Literature Thesis Topics
• Management Thesis Topics
• Marketing Thesis Topics
• Nursing Thesis Topics
• Philosophy Thesis Topics
• Psychology Thesis Topics
• Science Thesis Topics

1. Accounting Thesis Topics

• The impact of blockchain technology on traditional accounting practices.
• Comparative analysis of international accounting standards and local practices.
• Ethical considerations in managerial accounting.
• The role of artificial intelligence in financial fraud detection.
• Sustainability reporting: Standards and implications for global firms.
• Cybersecurity risks in cloud-based accounting systems.
• The future of forensic accounting in a digital age.
• Behavioral finance: How cognitive biases affect accounting decisions.
• The effectiveness of audit committees in emerging economies.
• Tax evasion and government policy in developing countries.
• Cryptocurrency and its implications for financial reporting.
• Implementing lean accounting in the manufacturing sector.
• The impact of culture on international accounting practices.
• Carbon credits accounting: Challenges and opportunities.
• The role of accounting in corporate social responsibility.
• Innovations in non-profit accounting.
• Accounting ethics and online privacy.
• Big data and predictive analytics for risk management.
• Revenue recognition in the digital economy.
• Accounting for startups: Challenges and best practices.
• The effect of global economic crises on accounting norms.
• Corporate governance and its impact on accounting standards.
• Integration of ESG (Environmental, Social, Governance) factors in financial reporting.
• The evolution of cost accounting in the healthcare sector.
• Financial literacy and its impact on business success.
• Mergers and acquisitions: Accounting and cultural integration.
• The changing landscape of pension accounting.
• Real-time accounting: Implementation and effects.
• Transparency in government accounting: A comparative study.
• Intellectual property valuation and its accounting challenges.
• Impact of tariffs and trade barriers on accounting policies.
• Accounting for climate change: Risks and opportunities.
• The role of accountants in corporate turnaround strategies.
• Auditing automation and its impact on audit quality.
• The influence of technology on the evolution of accounting standards.
• Risk management in financial services: An accounting perspective.
• Outsourcing accounting services: Benefits and risks.
• The future of professional ethics in accounting.
• The role of accounting in enhancing organizational efficiency.
• Exploring the relationship between accounting information systems and organizational performance.

2. Art Thesis Topics

• Digital media and the transformation of traditional art forms.
• The influence of social media on contemporary art and artist visibility.
• Art as a form of political resistance in authoritarian regimes.
• The evolution of street art and its acceptance in mainstream galleries.
• Feminist art movements in the 21st century.
• The intersection of technology and art: Virtual reality as a new canvas.
• Postmodernism in art: Origins and future directions.
• The role of art therapy in mental health treatment.
• Cultural appropriation vs. appreciation in global art forms.
• The impact of global warming on artistic expression.
• Art in times of crisis: A study of pandemic-driven art.
• Sustainable art: Materials and practices for the eco-conscious artist.
• The commercialization of indigenous art.
• The role of galleries in shaping art trends.
• Art education and its impact on career success in the arts.
• The depiction of race and gender in modern sculptures.
• Art curation and digital exhibitions: The future of museums.
• The influence of celebrity culture on art valuation.
• Collaborative art projects and their impact on community development.
• The ethics of restoring ancient artworks.
• Animation as a form of contemporary art.
• The rise of performance art and its social implications.
• Exploring the relationship between art and technology.
• The resurgence of handicrafts in a digital age.
• The impact of economic crises on art production.
• The role of art in promoting sustainability.
• The dynamics of art fairs and their influence on the art market.
• Consumer culture and its representation in contemporary art.
• The role of public art in urban regeneration.
• The influence of migration on artistic expression.
• Decolonizing art history: Perspectives and methodologies.
• The impact of AI-generated art on the concept of authorship.
• The role of art in enhancing intercultural dialogue.
• Art and propaganda: A historical analysis.
• Graffiti as a tool for social change.
• The psychology of color in artistic expression.
• The effect of global tourism on local art scenes.
• Art as a vehicle for social justice.
• The relationship between art and fashion design.
• The future of biographical films on artists.

3. Banking Thesis Topics

• The future of cryptocurrencies in global banking systems.
• The impact of mobile banking on traditional banking practices.
• The role of central banks in stabilizing economic crises.
• Consumer behavior in digital banking: Trust and security aspects.
• The effect of banking regulations on international investments.
• Financial inclusion: Strategies for reaching the unbanked populations.
• The role of microfinance in poverty alleviation.
• Banking secrecy and its impact on tax evasion.
• The influence of fintech innovations on traditional banking models.
• The sustainability of peer-to-peer lending platforms.
• The impact of Brexit on the UK banking sector.
• Cybersecurity strategies in online banking.
• The future of Islamic banking in non-Muslim countries.
• The role of green banking in promoting environmental sustainability.
• The effectiveness of anti-money laundering policies.
• The impact of negative interest rates on banking profitability.
• Risk management in banking: Current strategies and future challenges.
• Customer loyalty in retail banking.
• The evolution of credit scoring models in the age of big data.
• The role of banks in supporting SMEs during economic downturns.
• Ethical banking: Concepts and real-world applications.
• The impact of regulatory changes on banking innovation.
• The role of banking in economic development of rural areas.
• Customer satisfaction and service quality in online banking.
• The challenges of implementing blockchain technology in banking.
• The future of offshore banking.
• The impact of artificial intelligence on banking services.
• The role of central banks in managing climate risk.
• The effects of global political instability on banking security.
• Banking for the elderly: Adapting services for an aging population.
• The role of banks in fostering entrepreneurship.
• Digital wallets: Adoption rates and consumer trust.
• The impact of the gig economy on banking products.
• The role of emotional intelligence in banking leadership.
• Compliance challenges in global banking.
• The future of bank branch design in the digital era.
• Innovations in payment systems and their impact on consumer behavior.
• The role of banks in funding renewable energy projects.
• The impact of pandemics on banking behavior.
• Cross-border banking challenges and opportunities.

4. Biology Thesis Topics

• CRISPR and its implications for genetic diseases.
• The role of microbiomes in human health.
• Synthetic biology: Designing life for industrial purposes.
• Conservation genetics: Saving species from extinction.
• The impact of climate change on marine biodiversity.
• The ethics of cloning: From animals to humans.
• The future of bioinformatics in personalized medicine.
• The role of epigenetics in cancer development.
• Bioremediation techniques in oil spill recovery.
• The influence of urban environments on avian species.
• The application of stem cell therapy in regenerative medicine.
• The potential of algae as a biofuel source.
• The impact of invasive species on ecosystem balance.
• The role of plants in mitigating air pollution.
• The genetics of aging and longevity.
• The impact of microplastics on freshwater ecosystems.
• The evolution of antibiotic resistance.
• The role of wildlife in the spread of zoonotic diseases.
• The potential of biotechnology in food security.
• The ethical considerations of using animals in research.
• The future of GMOs in global agriculture.
• The impact of deforestation on biodiversity.
• The role of citizen science in biological research.
• The use of drones in wildlife monitoring.
• The challenges of conserving migratory bird species.
• The role of genetic modification in pest control.
• The potential for bioluminescent plants in urban lighting.
• The impact of ocean acidification on coral reefs.
• The genetics of plant adaptation to climate change.
• The role of animal behavior in conservation strategies.
• The potential of synthetic meat in reducing environmental impact.
• The impact of global warming on polar ecosystems.
• The role of fungi in ecosystem services.
• The challenges of wildlife conservation in conflict zones.
• The future of ecological restoration techniques.
• The impact of human activity on natural selection.
• The potential of venomous animals in medical research.
• The role of genetic diversity in species resilience.
• The use of environmental DNA in biodiversity monitoring.
• The ethical implications of de-extinction technologies.

5. Computer Science Thesis Topics

• Quantum computing and its future applications.
• The impact of machine learning on healthcare diagnostics.
• The ethics of artificial intelligence in decision making.
• Cybersecurity in the age of Internet of Things (IoT).
• The role of virtual reality in education.
• The challenges of data privacy in social media.
• The future of blockchain beyond cryptocurrencies.
• The potential of augmented reality in retail.
• The impact of 5G technology on mobile computing.
• The use of big data in predictive policing.
• The challenges of software engineering in space missions.
• The role of AI in combating climate change.
• The impact of computer vision in autonomous vehicles.
• The ethics of facial recognition technology.
• The potential of AI in artistic creation.
• The role of robotics in elderly care.
• The impact of digital twins in industry 4.0.
• The challenges of maintaining digital heritage.
• The potential of internet governance in global diplomacy.
• The role of deep learning in language translation.
• The future of bioinformatics in genomics.
• The challenges of ethical hacking.
• The role of cloud computing in disaster management.
• The impact of wearable technology on personal health.
• The future of digital currencies in global economies.
• The challenges of data sovereignty.
• The role of machine learning in financial fraud detection.
• The impact of smart cities on urban planning.
• The potential of drones in logistics.
• The role of AI in predictive maintenance.
• The future of edge computing.
• The challenges of implementing AI in legal systems.
• The role of virtual agents in customer service.
• The impact of gaming technology on learning.
• The potential of digital marketing in the era of AI.
• The challenges of AI ethics.
• The role of data analytics in sports performance.
• The impact of e-learning platforms on traditional education.
• The potential of digital assistants in enhancing productivity.
• The challenges of securing IoT devices.

6. Economics Thesis Topics

• The impact of global trade wars on small economies.
• The role of economic policy in climate change mitigation.
• The effects of universal basic income experiments.
• The challenges of economic integration in emerging markets.
• The future of cryptocurrency regulation.
• The impact of remote work on urban economies.
• The role of tourism in economic recovery post-pandemic.
• The challenges of pension systems in aging populations.
• The potential of green bonds in financing sustainable development.
• The impact of artificial intelligence on labor markets.
• The challenges of economic sanctions.
• The role of microfinance in women’s empowerment.
• The impact of Brexit on the European Union.
• The future of trade agreements in a multipolar world.
• The potential of social entrepreneurship in economic development.
• The challenges of income inequality.
• The role of digital currencies in global finance.
• The impact of climate change on agricultural economics.
• The potential of sustainable tourism.
• The challenges of financial literacy education.
• The role of government in innovation ecosystems.
• The impact of healthcare reform on national economies.
• The potential of renewable energy markets.
• The challenges of housing markets in global cities.
• The future of economic theories in the digital age.
• The role of central banks in managing economic crises.
• The impact of population growth on resource allocation.
• The potential of cooperative businesses in sustainable economies.
• The challenges of water scarcity on economic policies.
• The role of technology in economic forecasting.
• The future of economic globalization.
• The challenges of corporate social responsibility.
• The role of public-private partnerships in infrastructure development.
• The impact of big data on economic decision-making.
• The potential of fintech in emerging markets.
• The challenges of trade barriers in Africa.
• The role of economic planning in post-conflict societies.
• The impact of oil price fluctuations on global economies.
• The potential of agrotechnology in enhancing food security.
• The challenges of sustainable development goals.

7. Education Thesis Topics

• The impact of digital classrooms on learning outcomes.
• The challenges of multicultural education in primary schools.
• The role of technology in special education.
• The future of higher education post-pandemic.
• The impact of parental involvement on student achievement.
• The challenges of teacher training in digital skills.
• The potential of gamification in education.
• The impact of school leadership on educational reform.
• The challenges of educational equity in rural areas.
• The role of student voice in educational policy development.
• The future of educational funding models.
• The challenges of adult education in the digital age.
• The potential of mobile learning in developing countries.
• The impact of arts education on academic performance.
• The challenges of standardized testing.
• The role of community partnerships in education.
• The future of educational psychology.
• The challenges of early childhood education policies.
• The potential of blended learning environments.
• The impact of language barriers in bilingual education.
• The challenges of educational technology integration.
• The role of mentorship in teacher development.
• The future of global education initiatives.
• The challenges of education for sustainable development.
• The potential of STEM education in girls’ empowerment.
• The impact of nutrition on cognitive development in children.
• The challenges of refugee education.
• The role of outdoor education in child development.
• The future of vocational training.
• The challenges of distance learning in higher education.
• The role of social media in educational engagement.
• The impact of bullying on student well-being.
• The future of academic libraries in the digital era.
• The challenges of home schooling.
• The potential of interdisciplinary studies.
• The impact of school infrastructure on learning.
• The challenges of teacher retention.
• The role of sports in educational settings.
• The future of educational research methodologies.
• The challenges of academic freedom in authoritarian regimes.

8. Engineering Thesis Topics

• The future of sustainable building materials.
• The role of robotics in disaster response.
• The challenges of renewable energy technologies.
• The future of bioengineering in healthcare.
• The impact of 3D printing on manufacturing industries.
• The challenges of transportation systems in megacities.
• The potential of smart grids in energy management.
• The impact of nanotechnology in material science.
• The challenges of water resource management in arid regions.
• The future of aerospace engineering.
• The role of artificial intelligence in civil engineering.
• The impact of virtual reality in construction planning.
• The challenges of biofuels in sustainable transport.
• The potential of geotechnical engineering in urban development.
• The impact of automation in industrial processes.
• The challenges of cybersecurity in critical infrastructure.
• The future of environmental engineering.
• The role of genetic engineering in agriculture.
• The impact of smart materials in wearable technology.
• The challenges of structural health monitoring.
• The future of electrical engineering in the IoT era.
• The role of mechanical engineering in renewable energy systems.
• The impact of machine learning on engineering design.
• The challenges of climate adaptation in coastal engineering.
• The potential of data analytics in traffic management.
• The impact of augmented reality on maintenance procedures.
• The future of chemical engineering in pharmaceuticals.
• The role of systems engineering in complex projects.
• The impact of drones in environmental monitoring.
• The challenges of acoustic engineering in urban areas.
• The future of automotive engineering in electric vehicles.
• The role of engineering in space exploration.
• The impact of digital twins in asset management.
• The challenges of agricultural engineering in climate-resilient farming.
• The potential of hydraulic engineering in flood prevention.
• The impact of thermal engineering in energy efficiency.
• The challenges of marine engineering in deep-sea exploration.
• The role of process engineering in sustainable manufacturing.
• The future of telecommunications engineering.
• The challenges of safety engineering in high-risk industries.

9. Entrepreneurship Thesis Topics

• The role of startups in economic recovery post-COVID-19.
• The impact of entrepreneurial ecosystems on regional development.
• The challenges of female entrepreneurship in technology sectors.
• The future of social entrepreneurship in addressing global issues.
• The impact of government policies on startup success.
• The challenges of venture capital in emerging markets.
• The potential of digital platforms in fostering entrepreneurship.
• The impact of coworking spaces on entrepreneurial collaboration.
• The challenges of scaling small businesses.
• The future of innovation in entrepreneurial ventures.
• The role of universities in promoting entrepreneurship.
• The impact of business incubators on startup growth.
• The challenges of entrepreneurial education in developing economies.
• The potential of green entrepreneurship in sustainable development.
• The impact of crowdfunding on new venture financing.
• The challenges of intellectual property in startup ecosystems.
• The future of entrepreneurial leadership.
• The role of technology transfer in innovation.
• The impact of e-commerce on small and medium enterprises.
• The challenges of global expansion for startups.
• The future of gig economy and its impact on entrepreneurship.
• The role of corporate entrepreneurship in fostering innovation.
• The impact of digital marketing strategies on entrepreneurial success.
• The challenges of regulatory compliance for new businesses.
• The potential of blockchain technology in entrepreneurial finance.
• The impact of artificial intelligence on small business operations.
• The future of entrepreneurial networking.
• The role of demographic changes in entrepreneurial opportunities.
• The impact of climate change on business innovations.
• The challenges of entrepreneurship in the arts.
• The future of family businesses in modern economies.
• The role of psychological resilience in entrepreneurial success.
• The impact of migration on entrepreneurial diversity.
• The challenges of supply chain management for entrepreneurs.
• The potential of biotechnology startups in healthcare.
• The impact of urbanization on entrepreneurial opportunities.
• The future of virtual reality in business applications.
• The role of data privacy in consumer-oriented startups.
• The impact of mobile payments on small business transactions.
• The challenges of energy efficiency in entrepreneurial ventures.

10. Environmental Science Thesis Topics

• The role of urban green spaces in combating air pollution.
• The impact of plastic pollution on marine ecosystems.
• The challenges of sustainable agriculture in water-scarce regions.
• The future of renewable energy technologies in mitigating climate change.
• The challenges of waste management in urban areas.
• The potential of ecosystem services in urban planning.
• The impact of climate change on freshwater resources.
• The challenges of environmental policy in developing countries.
• The future of conservation strategies for endangered species.
• The role of citizen science in environmental monitoring.
• The impact of industrial pollution on public health.
• The challenges of restoring ecosystems after natural disasters.
• The potential of green chemistry in reducing environmental impact.
• The impact of global warming on polar regions.
• The challenges of air quality monitoring in megacities.
• The future of oceanography in climate research.
• The role of environmental education in sustainability.
• The impact of sustainable tourism on natural reserves.
• The challenges of geothermal energy exploitation.
• The future of bioenergy in global energy markets.
• The role of public awareness in environmental conservation.
• The impact of agricultural runoff on water quality.
• The challenges of noise pollution in urban environments.
• The potential of green roofs in energy conservation.
• The impact of invasive species on local ecosystems.
• The future of wildlife corridors in promoting biodiversity.
• The role of policy in shaping environmental technologies.
• The impact of land use change on ecosystem services.
• The challenges of sustainable fishing practices.
• The future of environmental impact assessments.
• The role of community engagement in conservation projects.
• The impact of climate change on agricultural pests.
• The challenges of sustainable urban drainage systems.
• The potential of natural resource management in conflict zones.
• The impact of eco-labeling on consumer behavior.
• The future of environmental justice in policy making.
• The role of geospatial technologies in environmental management.
• The impact of renewable energy subsidies on market development.
• The challenges of carbon capture and storage technologies.

11. Finance Thesis Topics

• The role of financial technology in shaping banking services.
• The impact of global economic policies on stock markets.
• The challenges of financial inclusion in low-income countries.
• The future of cryptocurrency in global trade.
• The impact of interest rate fluctuations on consumer behavior.
• The challenges of corporate finance in multinational companies.
• The potential of microfinance in supporting small businesses.
• The impact of stock market volatility on retirement savings.
• The challenges of insurance models in climate-sensitive regions.
• The future of investment strategies in a low-yield environment.
• The role of central banks in stabilizing financial markets.
• The impact of Brexit on European financial stability.
• The challenges of ethical investing in emerging markets.
• The potential of blockchain in reducing financial fraud.
• The impact of monetary policies on economic recovery.
• The challenges of financial literacy in developing a sustainable economy.
• The future of digital currencies in monetary systems.
• The role of financial regulations in promoting transparency.
• The impact of artificial intelligence on financial services.
• The challenges of managing public debt in developing countries.
• The future of real estate investment in urban areas.
• The role of crowdfunding in financing innovation.
• The impact of global trade tensions on foreign exchange markets.
• The challenges of pension fund management in an aging population.
• The potential of sustainable finance in corporate strategies.
• The impact of inflation on spending patterns.
• The future of risk management in financial institutions.
• The role of international financial organizations in crisis resolution.
• The impact of technology on personal financial planning.
• The challenges of financial sanctions on global banking.
• The future of financial derivatives in market stability.
• The role of consumer protection in financial services.
• The impact of e-commerce on global economic growth.
• The challenges of financial market regulation in a digital age.
• The potential of impact investing in addressing social issues.
• The impact of climate change on insurance risk assessments.
• The future of global financial cooperation.
• The role of data analytics in financial forecasting.
• The impact of mobile banking on financial accessibility.
• The challenges of financial crime prevention.

12. Geography Thesis Topics

• The impact of climate change on coastal erosion patterns globally
• Urban heat islands: Mitigation strategies for mega-cities
• Geographic information systems (GIS) applications in disaster management
• The role of green spaces in enhancing urban resilience to climate change
• Water scarcity and conflict in the Middle East: A spatial analysis
• Mapping pandemic outbreaks: The role of geographic factors in disease spread
• The effects of urbanization on biodiversity in metropolitan areas
• Sustainable tourism and its impact on indigenous communities
• Deforestation patterns and their impact on local climates
• Geospatial analysis of renewable energy potential in developing countries
• The political geography of borders in post-conflict regions
• Land use changes and their impacts on suburban wildlife
• Analyzing the socioeconomic impacts of natural disasters using spatial data
• The future of Arctic navigation routes: Geopolitical and environmental considerations
• GIS in urban planning: Case studies on efficient city layouts
• Sea level rise and its implications for island nations
• The geography of refugee flows and human migration patterns
• Comparative analysis of urban sprawl in Europe and Asia
• Remote sensing applications in monitoring deforestation efforts
• The dynamics of river pollution and its effects on surrounding populations
• Climate adaptation strategies in drought-prone regions
• The impact of transportation networks on rural development
• Spatial patterns of agricultural productivity shifts due to technological advancements
• Historical cartography and its influence on modern territorial disputes
• The role of geospatial data in shaping public health policies
• Assessing the impact of mega-dams on river ecosystems
• The cultural geography of food security in sub-Saharan Africa
• Urban-rural migration patterns and their effects on regional development
• The evolution of coastal cities’ defense mechanisms against rising sea levels
• Spatial justice and accessibility in metropolitan public services
• Modeling the spread of invasive species using GIS
• The economic geography of global supply chains disrupted by political instability
• Land rights disputes and their environmental consequences
• The role of satellite imagery in enforcing environmental regulations
• Geographical analysis of electoral patterns in democratic nations
• The socioeconomic effects of mining in developing regions
• Water resource management in arid climates: Case studies from around the world
• The use of geospatial data in predicting volcanic eruptions
• The impact of global warming on polar glacial movements
• Urban biodiversity: Strategies for preserving green spaces in large cities

13. Geology Thesis Topics

• The impact of hydraulic fracturing on local groundwater systems
• Volcanic activity and its influence on climate patterns
• Sedimentary records and climate change: A deep-time perspective
• The role of geology in sustainable urban planning
• Mineralogy of subduction zones and its implications for seismic activity
• Geotechnical assessment of landslide-prone areas
• Paleoceanography: Studying ancient marine environments through sediment analysis
• The geochemistry of deep-sea hydrothermal vents and their ecosystems
• Earthquake prediction: Advances in seismic monitoring and data analysis
• The effects of mining on ecosystem dynamics
• Geophysical techniques in oil and gas exploration
• The evolution of continental crust through geological time
• The geology of planetary bodies: Insights from Mars and the Moon
• Coral reef degradation: Geological perspectives on a biological crisis
• The dynamics of groundwater flow in karst environments
• Radioisotope dating: Techniques and applications in geological research
• Impact of glacial movements on alpine landscapes
• Geothermal energy: Mapping potential sites for sustainable power
• The formation and significance of geological faults
• Soil erosion processes and their impact on agricultural land
• Geological mapping of underexplored regions for mineral resources
• The influence of tectonic activity on biodiversity hotspots
• Techniques in paleomagnetism and their applications in plate tectonics
• The impact of coastal erosion on human settlements
• Studying basaltic rock formations to understand volcanic activity
• The role of geology in the carbon cycle and climate regulation
• Advances in geological remote sensing and satellite imagery
• Geoarchaeology: Uncovering human history through geological methods
• Geology and public health: Understanding natural sources of toxic elements
• Modeling the future impacts of sea level rise on coastal geology
• The geological implications of artificial islands and land reclamation
• Preservation of geological heritage sites under threat from tourism
• The role of sediment transport in shaping river deltas
• Geological considerations in the construction of large-scale infrastructure
• The environmental impacts of deep-sea mining
• Assessing the risk of tsunamis in the Pacific Rim
• Geological factors in the siting of nuclear facilities
• The relationship between geological structures and biodiversity in national parks
• Studying the geology of sinkholes: Causes and consequences
• The science of gemstones: From geological formation to market trends

14. Health Thesis Topics

• The impact of telemedicine on healthcare delivery in rural areas
• Nutritional strategies in the prevention of type 2 diabetes
• The role of genetic factors in the development of Alzheimer’s disease
• Mental health outcomes among refugees: A cross-cultural study
• Evaluating the effectiveness of mindfulness-based therapies on chronic pain
• Vaccine hesitancy: Causes and public health implications
• The effects of air pollution on respiratory health in urban areas
• Opioid addiction treatment: New approaches and their effectiveness
• Health disparities in cardiovascular disease outcomes by ethnicity
• The influence of social media on adolescent mental health
• Maternal health and neonatal outcomes in low-resource settings
• The impact of sleep quality on cognitive decline in the elderly
• Public health strategies to combat obesity in children
• The effectiveness of public smoking bans in reducing lung disease rates
• Exploring the relationship between gut microbiota and immune function
• The use of AI in predicting epidemic outbreaks
• Strategies for increasing physical activity among office workers
• The effects of climate change on vector-borne diseases
• Healthcare systems’ responsiveness to the needs of diverse populations
• The role of patient education in managing chronic diseases
• Mental health interventions in primary care settings
• Assessing the impact of dietary supplements on health outcomes
• The role of healthcare policy in improving population health
• The ethical implications of genetic screening for hereditary diseases
• The challenge of antibiotic resistance: Strategies for global response
• Health implications of long-term space travel: A study of astronaut health
• The use of blockchain technology in securing patient health records
• Addressing mental health stigma in various cultural contexts
• The impact of economic downturns on public health systems
• Preventive measures against sports-related concussions
• The role of occupational therapy in stroke rehabilitation
• The effects of urban green spaces on mental health
• Developing effective interventions for teenage substance abuse
• The global impact of non-communicable diseases on economic development
• The use of mobile health applications in patient management
• Strategies for reducing maternal mortality rates in developing countries
• The role of health informatics in improving patient care
• The impact of chronic stress on health: Physiological and psychological aspects
• Evaluating the global response to the COVID-19 pandemic
• The relationship between health literacy and health outcomes

15. Immigration Thesis Topics

• The impact of immigration policies on national security in various countries
• Economic effects of mass migration on host countries
• Cultural integration challenges faced by immigrants in urban settings
• The role of international laws in protecting the rights of refugees
• Effects of brain drain on developing countries due to emigration
• Analysis of the socio-economic impacts of undocumented workers in the United States
• Long-term demographic changes resulting from immigration trends
• The influence of immigrant communities on local election outcomes
• Comparative study of refugee resettlement programs across Western countries
• The role of language barriers in immigrant education and integration
• Mental health issues among immigrant populations
• Impact of remittances on the economy of origin countries
• Legal challenges and pathways to citizenship for immigrants
• The effects of religious diversity brought by immigrants
• Strategies for managing cultural diversity in multinational corporations
• Xenophobia and racism: Social tensions in immigrant-dense areas
• The role of social media in shaping immigrant identity
• The impact of climate change on patterns of global migration
• Comparative analysis of asylum policies in EU countries
• The role of international NGOs in aiding immigrants and refugees
• Gender-specific challenges faced by female immigrants
• The economic contribution of refugees to local economies
• The effect of immigration on public health systems
• Policies to combat human trafficking across borders
• The role of education in facilitating immigrant integration
• Historical patterns of immigration and their impact on modern policies
• Challenges to law enforcement in regions with high levels of immigration
• The impact of deportation on families and communities
• The effectiveness of border security measures in controlling illegal immigration
• Immigration as a tool for diplomatic leverage in international relations
• The role of the media in influencing public opinion on immigration
• Challenges of second-generation immigrants in maintaining cultural heritage
• Impact of immigration on urban planning and infrastructure
• Immigration and the changing landscape of political power in host countries
• Ethical considerations in the treatment of detained immigrants
• The relationship between immigration and global economic crises
• Success stories of immigrant entrepreneurs and their impact on global markets
• The role of immigrant labor in the sustainability of pension systems
• Comparative analysis of immigrant integration in rural vs. urban areas
• The impact of expatriate communities on global cultural exchange

16. Law Thesis Topics

• The implications of artificial intelligence on copyright and intellectual property laws.
• Analyzing the effectiveness of hate speech laws in various jurisdictions.
• The impact of international trade laws on emerging economies.
• Legal challenges in the enforcement of global environmental protection laws.
• The evolution of privacy laws in the digital age.
• Comparative analysis of drug decriminalization policies across countries.
• The role of the judiciary in upholding democratic values in times of political crises.
• Legal frameworks for combating cybercrime: A global perspective.
• The influence of legal systems on minority rights protection.
• Assessing the impact of legal aid services on access to justice.
• The role of law in regulating unmanned aerial vehicles (drones).
• Legal and ethical issues surrounding euthanasia and assisted suicide.
• The enforcement of international human rights laws in conflict zones.
• Analyzing the legal responses to domestic violence in different cultures.
• The effectiveness of anti-corruption laws in public sector governance.
• Intellectual property rights and access to medication in developing countries.
• Legal aspects of international adoptions and child rights.
• The role of law in managing global refugee crises.
• Employment law and its impact on gender equality in the workplace.
• Legal challenges in the adoption of renewable energy sources.
• The impact of forensic science on criminal justice systems.
• Legal issues related to the commercialization of space.
• The role of legal institutions in addressing economic inequality.
• Animal rights and legal protections: A comparative study.
• The future of international law in governing maritime disputes.
• Legal strategies to combat human trafficking across continents.
• The role of customary law in modern legal systems.
• The implications of Brexit on European Union law.
• Legal responses to global pandemics and health emergencies.
• The influence of shareholder activism on corporate governance.
• Rights and legal protections for gig economy workers.
• Legal frameworks governing artificial reproductive technologies.
• The impact of climate change legislation on industrial sectors.
• The role of international courts in resolving territorial disputes.
• The legality and ethics of surveillance in national security.
• Legal implications of genetic data storage and usage.
• The intersection of religion and law in secular societies.
• Legal considerations in the regulation of virtual currencies.
• Comparative legal analysis of same-sex marriage laws.
• The role of law in combating racial discrimination in education and employment.

17. Nutrition Thesis Topics

• The impact of plant-based diets on long-term health outcomes.
• Nutritional strategies for managing autoimmune diseases.
• The role of gut microbiota in weight management and obesity prevention.
• Comparative effectiveness of dietary interventions in reducing cardiovascular risk.
• The influence of nutritional education on childhood obesity rates.
• The effects of intermittent fasting on metabolic health.
• Nutritional deficiencies and their impact on mental health.
• The role of antioxidants in cancer prevention.
• Trends in global dietary patterns and their environmental impacts.
• The effectiveness of school-based nutritional programs on student health.
• The impact of ultra-processed foods on chronic disease rates.
• Nutritional genomics: Personalizing diet plans based on genetic profiles.
• The relationship between dietary patterns and aging.
• The effects of caffeine and other stimulants on athletic performance.
• The role of omega-3 fatty acids in cognitive development and function.
• Dietary interventions in the management of Type 2 diabetes.
• The impact of alcohol consumption on nutritional status.
• Strategies to improve nutritional intake in elderly populations.
• The role of nutrition in the recovery and rehabilitation of sports injuries.
• Ethical considerations in the marketing of dietary supplements.
• The influence of socio-economic status on nutritional choices and health outcomes.
• The role of dietary fiber in digestive health and disease prevention.
• Nutrition and skin health: The impact of diet on skin condition and aging.
• The relationship between nutrition and sleep quality.
• The effect of maternal nutrition on fetal development and birth outcomes.
• The impact of geographic and cultural factors on dietary practices.
• The effectiveness of community gardens in improving access to nutritious foods.
• The role of policy in shaping public nutrition and food security.
• Nutritional challenges in vegan and vegetarian diets.
• The science of food addiction and its implications for dietary guidelines.
• The impact of pesticides and other chemicals on food safety and nutritional value.
• The role of protein in muscle synthesis and body composition.
• Nutritional interventions in the treatment of mood disorders.
• The effects of global warming on food production and nutritional quality.
• The impact of fast food globalization on worldwide obesity rates.
• Nutritional considerations in palliative care settings.
• The role of nutrition in the prevention and management of Alzheimer’s disease.
• The impact of mindful eating on health and well-being.
• Nutrient timing: The implications of when we eat on health and performance.
• The effectiveness of nutritional labeling in influencing consumer choices.

18. Leadership Thesis Topics

• The impact of transformational leadership on employee engagement and retention.
• The role of leadership in shaping organizational culture and performance.
• Leadership strategies for managing diversity and inclusion in multinational corporations.
• The effectiveness of servant leadership in nonprofit organizations.
• Leadership in crisis: Evaluating the responses of business leaders during the COVID-19 pandemic.
• The influence of gender on leadership styles and effectiveness.
• The role of emotional intelligence in leadership success.
• Leadership development programs: Assessing their impact on career progression.
• Ethical leadership and its effects on corporate governance.
• Leadership and innovation: How leaders foster a culture of innovation within organizations.
• The impact of leadership on team dynamics and conflict resolution.
• Cross-cultural leadership: The challenges and strategies for leading in a globalized market.
• The role of leadership in successful change management initiatives.
• The relationship between leadership styles and employee job satisfaction.
• Millennials in leadership: Their approach and impact on organizational practices.
• The effect of leadership coaching on personal and organizational outcomes.
• Leadership succession planning in family-owned businesses.
• The impact of digital transformation on leadership practices.
• Leadership and sustainability: Integrating environmental concerns into business strategies.
• The role of leadership in enhancing customer satisfaction and loyalty.
• Distributed leadership in educational institutions: A path to improved school outcomes.
• The influence of political leadership on national economic development.
• Leadership in healthcare: Strategies for handling administrative and ethical challenges.
• Virtual leadership: Leading remote teams effectively in the digital age.
• The role of leadership in driving corporate social responsibility initiatives.
• Adaptive leadership in dynamic markets: Responding to technological disruptions.
• Leadership under pressure: The skills needed for high-stakes decision-making.
• The impact of authoritarian versus democratic leadership styles on organizational efficiency.
• The role of leadership in promoting workplace safety and well-being.
• Leadership in the arts sector: Challenges and strategies for inspiring creative teams.
• The effectiveness of leadership training in the public sector.
• Leadership and accountability: Mechanisms for transparent governance in organizations.
• Women in leadership: Barriers and enablers for gender equity at the top.
• Leadership during mergers and acquisitions: Key strategies for smooth transitions.
• The impact of social media on leadership and personal branding.
• The relationship between leadership and mental health in the workplace.
• Leadership in small and medium-sized enterprises (SMEs): Unique challenges and opportunities.
• The role of leadership in disaster recovery and resilience building.
• Charismatic leadership: Its influence on followers and organizational outcomes.
• Leadership and corporate culture: How leaders influence organizational values and norms.

19. Literature Thesis Topics

• The evolution of the narrative structure in modernist literature.
• Themes of alienation and identity in post-colonial literature.
• The representation of gender and sexuality in contemporary young adult fiction.
• The role of dystopian literature in critiquing current societal norms.
• Magical realism as a tool for political commentary in Latin American novels.
• The influence of the Beat Generation on American literature and culture.
• Intersections of race and class in the works of Toni Morrison.
• The depiction of mental health in 20th-century literature.
• Eco-criticism and the portrayal of nature in Romantic poetry.
• The impact of digital media on the form and content of contemporary poetry.
• Intertextuality in the works of James Joyce and T.S. Eliot.
• The narrative techniques of unreliable narration in modern novels.
• The role of mythology in shaping modern fantasy literature.
• Feminist re-readings of classic Victorian novels.
• The portrayal of historical events in Holocaust literature.
• The influence of existential philosophy on European plays of the 20th century.
• The treatment of exile and displacement in the literature of the Middle East.
• Comparative analysis of Gothic elements in 19th-century British and American literature.
• The role of the supernatural in the development of horror literature.
• The representation of urban spaces in modernist poetry.
• Postmodern narrative strategies in contemporary cinema.
• The literary legacy of the Harlem Renaissance.
• Memory and trauma in post-war European literature.
• The impact of censorship on the dissemination of radical ideas in literature.
• The dynamics of power and corruption in political novels.
• Psychoanalytic interpretations of children’s fairy tales.
• Consumer culture and its critique in postmodern American fiction.
• The concept of the anti-hero in modern drama and its societal implications.
• Literary expressions of religious doubt from the Enlightenment to modernism.
• The evolution of the vampire myth in literature from Dracula to today.
• The influence of African oral traditions on contemporary African-American literature.
• Depictions of artificial intelligence in science fiction: ethical and philosophical implications.
• The portrayal of indigenous cultures in settler colonial narratives.
• Gender dynamics in the epistolary novel form.
• Literature as a form of resistance in totalitarian regimes.
• The intersection of literature and film in adapting classical texts.
• Archetypes and their transformations in world literature.
• The narrative function of space in graphic novels.
• Literary adaptations and their impact on understanding original works.
• The role of paratexts in shaping reader reception of literary texts.

20. Management Thesis Topics

• The impact of remote work on team dynamics and productivity.
• Strategies for managing global teams across different time zones and cultures.
• The role of management in fostering innovation within organizations.
• The effectiveness of agile management techniques in software development projects.
• The influence of corporate social responsibility on brand loyalty and consumer behavior.
• Crisis management: Best practices for handling public relations disasters.
• The impact of generational differences on management styles and employee satisfaction.
• Strategies for effective change management in rapidly evolving industries.
• The role of emotional intelligence in leadership and management.
• The impact of artificial intelligence on strategic decision-making processes.
• Sustainability in supply chain management: Practices and outcomes.
• The effectiveness of performance management systems in multinational corporations.
• Workplace diversity: Management strategies for fostering inclusivity.
• Conflict resolution: Techniques and systems for managing workplace disputes.
• The role of management in preventing workplace harassment and ensuring safety.
• The impact of digital transformation on traditional management practices.
• Strategies for managing customer relationships in the digital era.
• The influence of organizational culture on employee productivity and morale.
• Talent management strategies for attracting and retaining top talent.
• Management challenges in the healthcare sector: Improving efficiency and patient care.
• The role of management in promoting ethical practices within corporations.
• The impact of e-commerce on retail management.
• Risk management strategies in the finance industry.
• The role of project management in successful infrastructure development.
• The impact of leadership development programs on organizational success.
• Managing innovation: How companies can cultivate and sustain innovative practices.
• The influence of management practices on employee well-being and work-life balance.
• The role of data analytics in management decision-making.
• Best practices for managing non-profit organizations.
• The impact of international trade policies on business management.
• Employee engagement strategies: What works and what doesn’t?
• The effect of management styles on the adoption of technology in the workplace.
• The challenges of managing a multi-generational workforce.
• The role of strategic planning in business growth and development.
• Corporate governance and its impact on company performance and accountability.
• The management of mergers and acquisitions: Integration strategies and challenges.
• The effect of global economic conditions on management practices.
• Consumer behavior insights for strategic management decisions.
• Outsourcing strategies: Management challenges and benefits.
• The role of mentorship programs in management training and development.

21. Marketing Thesis Topics

• The effectiveness of social media influencers in brand promotion.
• Consumer behavior analysis in the era of digital transformation.
• The impact of virtual reality marketing on consumer purchase intentions.
• Green marketing: Strategies and challenges in promoting sustainable products.
• The role of emotional appeals in advertising effectiveness.
• The evolution of consumer privacy concerns in digital marketing.
• Brand loyalty: Factors influencing consumer loyalty in competitive markets.
• The impact of cultural factors on global marketing strategies.
• Neuromarketing: How brain science is influencing advertising strategies.
• The effectiveness of content marketing in building brand awareness.
• The role of customer feedback in shaping product development.
• Marketing automation: Tools, benefits, and potential pitfalls.
• The influence of economic downturns on marketing strategies.
• The impact of customer relationship management (CRM) systems on sales performance.
• Ethical concerns in marketing: A study of deceptive advertising practices.
• The role of packaging design in consumer decision-making.
• The effectiveness of loyalty programs in retaining customers.
• The challenges of marketing pharmaceutical products in a regulated environment.
• The impact of global events on sports marketing and sponsorship.
• The role of search engine optimization (SEO) in modern marketing strategies.
• Mobile marketing: Trends, effectiveness, and consumer reception.
• The influence of brand storytelling on emotional connection and engagement.
• Comparative analysis of traditional vs. digital marketing budgets and ROI.
• The challenges and opportunities of affiliate marketing.
• Consumer resistance to digital advertising and ways to overcome it.
• The impact of artificial intelligence on personalized marketing campaigns.
• The role of gender in marketing: Tailoring messages to diverse audiences.
• The effectiveness of video marketing on social media platforms.
• The influence of corporate social responsibility on consumer perceptions.
• The role of market segmentation in effective targeting.
• The impact of pop-up retail on consumer engagement and sales.
• The role of public relations in crisis management and brand rehabilitation.
• The effectiveness of experiential marketing campaigns.
• The challenges of marketing in the non-profit sector.
• The impact of data breaches on brand trust and loyalty.
• Influencer marketing vs. celebrity endorsements: A comparative study.
• The role of sensory marketing in enhancing customer experience.
• The impact of augmented reality on shopping experiences.
• The role of analytics in predicting consumer behavior.
• The effectiveness of cross-channel marketing strategies.

22. Nursing Thesis Topics

• The impact of nurse-patient ratios on patient outcomes in critical care units.
• Strategies for managing nurse burnout and job satisfaction.
• The effectiveness of telehealth nursing and its implications for rural healthcare.
• The role of nurses in managing chronic diseases in outpatient settings.
• Innovations in nursing education and their impact on clinical practice.
• The challenges of cultural competence in nursing: Strategies for improvement.
• The impact of evidence-based practice on nursing care quality.
• The role of nursing leadership in fostering interdisciplinary collaboration.
• Patient safety in hospitals: The contribution of nursing protocols.
• The effects of advanced nurse practitioner roles on patient access to care.
• The impact of simulation-based training on nursing competency.
• Nursing interventions to reduce the incidence of hospital-acquired infections.
• The role of nurses in end-of-life care: Ethical and practical considerations.
• Mental health nursing: Best practices for patient engagement and recovery.
• The challenges of pediatric nursing and family care coordination.
• The effectiveness of community nursing programs in improving public health.
• The impact of nursing informatics on patient care and data management.
• The role of nurses in the management of medical emergencies in remote areas.
• Nursing approaches to pain management: Traditional vs. alternative methods.
• The impact of maternal health nursing on neonatal outcomes.
• Nursing strategies for improving vaccination rates among different population groups.
• The role of nurses in health promotion and disease prevention.
• The challenges of geriatric nursing and the management of age-related diseases.
• The effectiveness of nursing interventions in psychiatric care.
• The role of nurse-led clinics in improving healthcare accessibility.
• Nursing and public health emergencies: Lessons from the COVID-19 pandemic.
• The impact of nursing on patient satisfaction and hospital readmission rates.
• The role of nurses in managing diabetes care and patient education.
• Ethical dilemmas in nursing: A study of decision-making processes.
• The effectiveness of pressure ulcer prevention protocols in nursing homes.
• The impact of mobile health applications on nursing practice and patient engagement.
• Nursing perspectives on the management of cancer pain.
• The role of nursing in the treatment of opioid addiction and recovery.
• The impact of legal and regulatory changes on nursing practice.
• Nursing and the management of rare diseases: Challenges and opportunities.
• The effectiveness of wound care management techniques in nursing.
• Nursing roles in cardiac rehabilitation: Patient outcomes and practices.
• The influence of nursing care on the psychological outcomes of ICU patients.
• The impact of global health initiatives on nursing practices.
• The role of nurses in promoting mental health in primary care settings.

23. Philosophy Thesis Topics

• The ethical implications of artificial intelligence and machine learning.
• The concept of justice in modern political philosophy.
• Exploring the philosophy of mind: consciousness and cognitive science.
• The role of intuition in moral decision-making.
• Nietzsche’s critique of traditional morality and its contemporary relevance.
• The influence of existentialism on modern individualism.
• The intersection of philosophy and literature: Analyzing philosophical narratives.
• The problem of evil: Philosophical approaches to understanding suffering.
• Environmental ethics: The philosophical basis for ecological responsibility.
• The philosophy of language: Understanding how language shapes our reality.
• The concept of freedom in the works of Jean-Paul Sartre and Simone de Beauvoir.
• Epistemology in the digital age: The impact of information technology on knowledge.
• The ethics of care: A critical look at moral development and relational ethics.
• The philosophy of science: Analyzing scientific rationality and progress.
• Buddhist philosophy and its approach to the self and no-self.
• Analyzing the philosophical underpinnings of human rights.
• The notion of happiness in ancient versus modern philosophical texts.
• The impact of Stoicism on modern self-help movements.
• The concept of ‘Otherness’ in Continental philosophy.
• The role of skepticism in shaping modern epistemology.
• Phenomenology and the arts: Understanding aesthetic experiences.
• The ethics of genetic engineering and human enhancement.
• The political philosophy of anarchism: Theory and practice.
• The philosophy of education: Analyzing educational paradigms and their impacts.
• The debate on free will and determinism: Philosophical perspectives.
• Virtue ethics: From Aristotle to modern applications.
• The philosophy of religion: Analyzing the rationality of faith.
• The role of metaphor in shaping philosophical thought.
• The ethics of consumption: A philosophical inquiry into consumer culture.
• The concept of power in Foucault’s works and its influence on social theory.
• The philosophy of time: Understanding temporal experiences and theories.
• Memory and identity: Philosophical examinations of personal continuity.
• The ethics of global poverty and international justice.
• Exploring the philosophical aspects of quantum mechanics.
• The social contract theory in the age of globalization.
• The influence of philosophy on cognitive behavioral therapy.
• Philosophical analysis of postmodernism and its criticisms.
• The notion of duty in Kantian ethics and its relevance today.
• The metaphysics of causation: from Aristotle to contemporary theories.
• Analyzing the concept of autonomy in bioethics.

24. Psychology Thesis Topics

• The psychological impact of social media on teen self-esteem and body image.
• Cognitive behavioral therapy vs. mindfulness-based stress reduction: Efficacy in treating anxiety disorders.
• The role of attachment styles in adult relationships.
• Neuroplasticity and recovery from brain injury: Strategies and outcomes.
• The effects of sleep deprivation on cognitive performance and mental health.
• Psychological resilience: Factors that contribute to mental toughness in athletes.
• The influence of parental involvement on child educational outcomes.
• The efficacy of psychoeducational interventions in managing ADHD in children.
• The role of personality traits in workplace performance.
• The impact of childhood trauma on adult psychological disorders.
• Psychological strategies for coping with chronic pain.
• The effects of aging on memory and how to mitigate cognitive decline.
• Eating disorders: Psychological underpinnings and treatment outcomes.
• The effectiveness of virtual reality therapy in treating phobias.
• Social psychology: The impact of group dynamics on individual behavior.
• The role of psychological factors in cardiovascular health.
• The impact of pet ownership on mental health and social well-being.
• The psychology of addiction: Understanding mechanisms and pathways to recovery.
• The effect of mindfulness meditation on emotional regulation.
• The psychological implications of genetic testing for hereditary diseases.
• The role of gender identity in psychological health and development.
• The impact of bullying on adolescent mental health and academic performance.
• The influence of cultural factors on mental health treatment preferences and outcomes.
• Psychological aspects of cyberbullying: Victim and perpetrator profiles.
• The role of art therapy in the treatment of depression and anxiety.
• The psychology of leadership: Key traits and behaviors of effective leaders.
• The effects of prenatal exposure to stress on child development.
• The role of music therapy in cognitive and emotional rehabilitation.
• Psychological interventions in the treatment of post-traumatic stress disorder (PTSD).
• The relationship between job satisfaction and mental health among healthcare professionals.
• The impact of climate change anxiety on mental health.
• The psychology of procrastination: Causes and interventions.
• The role of optimism and pessimism in coping with life stressors.
• The influence of social isolation on psychological health during the COVID-19 pandemic.
• The effectiveness of community-based mental health initiatives.
• The psychological impacts of long-term space travel on astronauts.
• The role of stigma in accessing mental health care.
• The psychological effects of consumer behavior and marketing.
• The impact of early retirement on mental health and identity.
• The role of exercise in enhancing cognitive function and mental health.

25. Science Thesis Topics

• The role of CRISPR technology in advancing gene editing: Opportunities and ethical challenges.
• The impact of microplastics on marine ecosystems and biodiversity.
• The effectiveness of renewable energy sources in reducing global carbon emissions.
• Advances in quantum computing: Potential impacts on data security.
• The use of biotechnology in agriculture to enhance crop resistance and yield.
• The potential of nanotechnology in medical diagnostics and treatment.
• Climate change and its effects on global weather patterns.
• The influence of artificial intelligence on scientific research methodologies.
• The development and impact of vaccines in managing global health crises.
• The role of robotics in industrial automation and its economic implications.
• The physics of black holes and their significance in understanding the universe.
• The chemistry of non-toxic materials for sustainable manufacturing processes.
• The study of exoplanets and the possibility of life beyond Earth.
• The role of citizen science in expanding research data collection and analysis.
• The impact of deforestation on the atmospheric carbon cycle.
• The role of genetic diversity in species conservation.
• The potential of stem cells in regenerative medicine and therapy.
• The integration of technology in environmental conservation efforts.
• The applications and implications of 3D printing in medical prosthetics.
• The dynamics of ocean currents and their effects on climate regulation.
• The challenges and advancements in antimicrobial resistance.
• The use of geographic information systems (GIS) in tracking biodiversity changes.
• The ethical considerations of human-animal chimeras in research.
• The influence of space exploration on technological advancement.
• The role of machine learning in predicting epidemic outbreaks.
• The implications of deep-sea exploration on our understanding of marine life.
• The potential of augmented reality in enhancing interactive learning environments.
• The effects of urbanization on local wildlife and ecosystems.
• The role of women in the advancement of science and technology.
• The impact of agricultural practices on soil health and sustainability.
• The relationship between genetics and behavior in mammals.
• The advancements in battery technology and their impact on electric vehicles.
• The role of science in formulating public health policy.
• The impact of social media on scientific communication and misinformation.
• The potential of synthetic biology in producing biofuels.
• The challenges of waste management in space missions.
• The role of molecular biology in understanding the mechanisms of aging.
• The implications of climate change for Arctic marine species.
• The development of technologies for sustainable fishing practices.
• The impact of scientific literacy on public decision-making processes.

As we conclude our extensive exploration of thesis topics across a wide array of disciplines, it becomes evident that the landscape of academic research is both vast and vibrant. The topics listed here span from the intricacies of molecular biology to the expansive strategies of global marketing, each designed to spark curiosity and drive innovation within their respective fields. This collection serves not only as a repository of ideas but also as a launchpad for the next generation of scholars eager to contribute to the ongoing conversations in their areas of study.

The breadth of thesis topics provided here underscores the interdisciplinary nature of contemporary research and the myriad ways in which academic inquiries can intersect and influence one another. Whether you are drawn to the urgent environmental issues discussed under Environmental Science, intrigued by the ethical questions in Philosophy, or captivated by the technological advancements in Computer Science, these topics offer avenues to delve deeply and make your mark within your chosen field.

Students are encouraged to approach these topics with a spirit of inquiry and rigor. As you select your thesis topic, consider not only what interests you but also what will contribute to the broader academic community and society at large. Each thesis topic has the potential to expand knowledge, inform practices, and propose new solutions to complex problems.

Moreover, the diversity of these topics reflects the dynamic nature of academic disciplines that evolve with societal changes and technological progress. By engaging with these thesis topics, students are participating in a global dialogue that shapes our understanding of the world and charts the course for future developments.

In summary, this comprehensive list of thesis topics is more than just a guide—it is an invitation to challenge and be challenged, to discover and innovate. We hope that students will embrace the opportunity to explore these ideas, using them as stepping stones to develop unique insights and contribute meaningful research to their fields. So, delve into these topics, choose one that resonates with your academic passions and career aspirations, and begin the exciting journey of crafting a compelling and significant thesis.

How to Choose a Thesis Topic

Selecting a fitting and feasible thesis topic is a crucial first step for any graduate student. The choice of a thesis topic not only determines the direction of your academic journey but also impacts your motivation, career trajectory, and the contribution you will make to your field of study. Therefore, understanding how to effectively choose a thesis topic is foundational to your success both as a student and as a budding scholar.

What Makes a Good Thesis Topic

• Relevance: A good thesis topic should be relevant to current issues or questions in your field. It should aim to fill a gap in knowledge or contribute to ongoing debates among scholars. Relevance ensures that your research findings will be of interest to others in your discipline and could potentially influence future research, policy, or practice.
• Originality: Originality involves bringing new insights or proposing a novel approach to a problem. It doesn’t necessarily mean venturing into a completely unexplored territory but can involve taking a fresh perspective on existing questions. A thesis that introduces original concepts or challenges established norms tends to stand out and captivate the interest of the academic community.
• Manageability: A feasible thesis topic is one that can realistically be researched and completed within the constraints of your resources, time frame, and academic requirements. Manageability requires careful consideration of the scope of the research and the availability of data and methods needed to conduct it effectively.
• Interest and passion: Passion fuels perseverance, which is crucial in the long and sometimes daunting process of completing a thesis. Choosing a topic that genuinely interests you will keep you engaged and motivated during your research journey. It also often leads to more profound and insightful scholarly work because you are more likely to go above and beyond in exploring something you care deeply about.

Moving from a Thesis Idea to a Thesis Topic

• Initial brainstorming techniques: Begin by jotting down various ideas that spark your interest. This initial phase is about exploring broadly and creatively without restricting your thoughts. Use mind mapping, lists, or free-writing techniques to generate and record ideas as they come to you.
• Narrowing down ideas based on research feasibility and interest: Once you have a list of potential ideas, evaluate each based on how interesting they are to you and how feasible they are in terms of research scope and resources available. Discard ideas that are too broad, too narrow, or not sufficiently supported by available data or methods.
• Importance of preliminary research: Conducting preliminary research is essential to determine if there is enough existing material to support your topic. This research can also reveal whether your idea has already been extensively covered, prompting you to adjust your angle or approach to ensure originality.

Connecting a Specific Thesis Topic to a Bigger Idea

• Aligning the topic with broader themes and research questions: Your thesis should not only address a specific issue but also connect to larger conceptual or empirical questions in your field. This alignment helps to position your research within broader scholarly conversations and enhances its impact and relevance.
• Ensuring the topic contributes to the field: The best thesis topics are those that contribute something valuable and substantive to their disciplines. Your topic should promise to provide insights, solutions, or new understandings that will add to the knowledge base of your field.

How to Refine Your Thesis Topic

• Seeking feedback from advisors and peers: Regular feedback is invaluable in refining your topic. Advisors can provide perspective on the significance and feasibility of your topic, while peers might offer fresh ideas or pose questions you hadn’t considered.
• Refining research questions: As you delve deeper into your topic, refine your research questions to ensure they are clear, focused, and answerable within the scope of your study. This might involve narrowing or sometimes slightly broadening the scope of your inquiry.
• Adjusting the scope of research: Based on feedback and preliminary findings, adjust the scope of your research as needed to ensure that it remains manageable and within the bounds of available resources, time, and academic requirements.

Choosing and refining a thesis topic is a dynamic and iterative process that requires thoughtful consideration, preliminary research, and ongoing adjustments. The journey from a broad idea to a refined research question involves not only identifying a subject that is relevant, original, and manageable but also one that ignites your passion and curiosity. By following these steps and continually seeking feedback, you can ensure that your thesis will be a meaningful and rewarding endeavor.

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iResearchNet prides itself on providing exceptional writing services tailored specifically for students embarking on the challenging journey of thesis creation. Understanding the complexities involved in thesis projects, iResearchNet offers a comprehensive suite of services designed to support students at every stage of their research and writing process. From initial topic selection to the final draft, our services are structured to meet the diverse needs and expectations of students across all academic disciplines.

• Expert Degree-Holding Writers: Our team comprises highly qualified writers who hold advanced degrees in their respective fields. With their profound academic backgrounds and specialized expertise, these writers bring depth, rigor, and precision to your thesis project.
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• Top Quality: Quality is at the heart of our services. Each thesis undergoes rigorous checks and revisions to meet the highest academic standards. Our internal quality assurance process guarantees that your thesis is not only well-written but also analytically sound and argumentatively persuasive.
• Customized Solutions: We recognize that each thesis project has its own unique challenges and requirements. Our approach is to provide customized solutions that address the specific needs of each student, whether it’s a particular chapter, statistical analysis, or a complete thesis.
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At iResearchNet, we are dedicated to upholding the highest standards of academic integrity and excellence. Our team is committed to delivering personalized, top-quality research and writing services that you can rely on. With our expert writers, customized solutions, and robust support system, we ensure that your thesis project not only meets but exceeds your academic expectations. Trust iResearchNet to be your partner in your academic journey, helping you to achieve the success and recognition you deserve.

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Embarking on your thesis journey represents a pivotal moment in your academic career. It’s your opportunity to shine, to show what you’ve learned, and to contribute something meaningful to your field of study. However, we understand that the thesis writing process can be daunting, which is why iResearchNet is here to help you every step of the way.

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• Pak J Med Sci
• v.32(2); Mar-Apr 2016

How to write a Doctoral Thesis

Prof. HR Ahmad, Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan. E-mail: [email protected]

Note: * Ahmad HR. In: Medical Writing. Eds. SA Jawaid, MH Jafary & SJ Zuberi. PMJA, 1997 Ed II: 133-142.

PATIENT care and teaching are rather well established components of our medical career. However, with the passage of time a third component has started to influence our medical culture, namely research. 1 - 4 How to accept this challenge is a question. 5 Indeed, teaching and research form a dialectic unit, meaning that teaching without a research component is like a soup without salt. It is a well-established fact that the research activity of an institution is directly proportional to the number of qualified and committed PhD candidates. An inspiring infrastructure, laboratory facilities and libraries are pre-requisites for a research culture to grow. 6 - 8 This forms the basis of a generation cycle for an institution, so that research activity and its culture continues to grow from one generation to the next. The main objective of doctoral work in biomedical sciences is to develop a galaxy of scientist physicians and surgeons possessing high degree of humility, selflessness and ethical superiority. Such a programme will add a scholastic dimension to the clinical faculty.

Education in how to write a doctoral thesis or dissertation should be a part of the postgraduate curriculum, parallel to the laboratory work and Journal Club activities during the PhD studies and/or residency levels. 9 , 10 The overall structure of a doctoral thesis is internationally standardized. However, it varies in style and quality, depending upon how original the work is, and how much the author has understood the work. Therefore a thorough discussion with supervisor, colleagues and assistance from other authors through correspondence can be useful sources for consultation.

The choice of a topic for a doctoral thesis is a crucial step. It should be determined by scanning the literature whether the topic is original or similar work has already been done even a hundred years ago. It is the responsibility of both the supervisor and the PhD candidate to sort out this problem by continuous use of internet and a library. 11 The work leading to the PhD degree can originate from research in following spheres: 12

• b) Methodology
• c) Diagnostic
• d) Therapeutic and Management
• e) Epidemiology

The availability of internationally standardized methods, as well as research committed supervisors can enable physicians and surgeons to do PhD work in both basic and clinical health sciences. The importance of research in basic health sciences cannot be overemphasized. It is rather the base of the applied sciences. There are many instances where the elucidation of a mechanism involved in a process awaits the development of an adequate methodology. 13 In such a scenario; a new method is like a new eye. Research activity in the field of (a) and (b) illuminates the research directions for (c) (d) and (e). It is worth noting that sometimes important basic questions can come from (e) and stimulate research activity in the domain of basic health sciences. 14 , 15

Types of Doctoral Thesis

TYPE-I: Book Form: a classical style. The blueprint of this form is shown in Table-I .

Type-I: The Classical Book Form

TYPE-II: Cumulative Doctoral thesis: A modem but quite useful practice.

INTRODUCTION

A book containing the pearls of a PhD work has standardized divisions and formats, where the number of pages should be weighted in terms of content rather than container. The book includes summary, introduction, materials and methods, results, discussion, conclusions, references and acknowledgements.

Two exercises are mandatory before starting a PhD programme:

• Literature survey using a regular library hours and internet surfing
• Familiarization with the hands-on-experience of methodology involved in the work
• The importance of a continuous literature survey using library, internet and direct correspondence with authors across the globe in the same field cannot be over-emphasized. The main goal of this exercise is to pinpoint the unresolved problem in the literature. An attempt to solve this problem now becomes the topic of the PhD thesis. All the relevant references should be collected, and carefully preserved in the form of a card system arranged alphabetically according to themes and authors. The introduction of the thesis should be styled like a review article with a critical analysis of the work of authors in the literature. The aims of the present PhD work can then also be addressed in the form of questions. The objectives would then deal with how to achieve the aims of the proposed study.

MATERIALS / SUBJECTS AND METHODS

Now comes the most crucial and functional part of the doctoral work, the materials/subjects and methods section. This part can be considered as the motor of the PhD work. The reliability, sensitivity and specificity of the motor must be checked before embarking on a long journey. Controlling the controls is the best guide for a precise and authentic work. Usually materials and methods contain components such as a description of the species involved, their number, age, weight and anthropometric parameters, types of surgical procedures and anesthesia if applied, and a detailed description of methodology. Continuous or point measurements should be thoroughly described. However, a dynamic method should always be preferred to static one.

The experimental protocol should be designed after a small pilot study, which is especially advisable in research on human subjects. A detailed and well-thought experimental protocol forms the basis of conditions under which the results would be obtained. Any deviation from the experimental protocol will affect the outcome, and the interpretation of results. It may be noted that great discoveries are usually accidental and without a protocol, based merely on careful observation! However, for the sake of a publication, a protocol has to be designed after the discovery. After having described the different phases of the experimental protocol with the help of a schematic diagram e.g., showing variables, time period and interventions, the selection of a statistical method should be discussed. Negative results should not be disregarded because they represent the boundary conditions of positive results. Sometimes the negative results are the real results.

It is usual practice that most PhD candidates start writing the methodological components first. This is followed by writing the results. The pre-requisites for writing results are that all figures, tables, schematic diagrams of methods and a working model should be ready. They should be designed in such a way that the information content of each figure should, when projected as a frame be visually clear to audience viewing it from a distance of about fifty feet. It is often observed that the presenters themselves have difficulty in deciphering a frame of the Power-Point being projected in a conference.

The results of a doctoral thesis should be treated like a bride. The flow of writing results becomes easier if all figures and tables are well prepared. This promotes the train of thoughts required to analyze the data in a quantitative fashion. The golden rule of writing results of a thesis is to describe what the figure shows. No explanation is required. One should avoid writing anything which is not there in a figure. Before writing one should observe each diagram for some time and make a list of observations in the form of key words. The more one has understood the information content of a figure; the better will be the fluency of writing. The interruption of the flow in writing most often indicates that an author has not understood the results. Discussion with colleagues or reference to the literature is the only remedy, and it functions sometimes like a caesarean procedure.

Statistical methods are good devices to test the degree of authenticity and precision of results if appropriately applied. The application of statistical technique in human studies poses difficulties because of large standard deviations. Outliers must be discussed, if they are excluded for the sake of statistical significance. Large standard deviations can be minimized by increasing the number of observations. If a regression analysis is not weighted, it gives faulty information. The correlation coefficient value can change from 0.7 to 0.4 if the regression analysis is weighted using Fisher’s test. The dissection of effect from artifact should be analysed in such a way that the signal to noise ratio of a parameter should be considered. A competent statistician should always be consulted in order to avoid the danger of distortion of results.

The legend of a figure should be well written. It contains a title, a brief description of variables and interventions, the main effect and a concluding remark conveying the original message. The writing of PhD work is further eased by a well maintained collection of data in the form of log book, original recordings, analyzed references with summaries and compiling the virgin data of the study on master plan sheet to understand the original signals before submitting to the procedures of statistics. The original data belong to the laboratory of an institution where it came into being and should be preserved for 5-7 years in the archive for the sake of brevity.

This is the liveliest part of a thesis. Its main goal is to defend the work by staging a constructive debate with the literature. The golden rule of this written debate should be that a rigid explanation looks backward and a design looks forward. The object is to derive a model out of a jig-saw puzzle of information. It should be designed in such a way that the results of the present study and those of authors from the literature can be better discussed and interpreted. Agreement and disagreement can be better resolved if one considers under what experimental conditions the results were obtained by the various authors. It means that the boundary conditions for each result should be carefully analyzed and compared.

The discussion can be divided into the following parts:

• criticism of material/subjects and methods
• a list of important observations of the present study
• interpretation and comparison of results of other authors using a literature table
• design of a model
• claim of an original research work
• The criticism of the methodological procedure enables a candidate to demonstrate how precisely the research work has been carried out. The interpretation of results depends critically on the strict experimental protocol and methods. For example, an epidemiological work is a study of a population. However, if the population sampling is done regularly at a specific location; the question arises as to how a result derived from a localized place can be applied to the whole population.
• After having discussed at length the strong and weak points of material/subjects and methods, one should list in a telegraphic design the most important observations of the present study. This may form a good agenda to initiate interpretation, argument, reasoning and comparison with results of other authors. The outcome of this constructive debate should permit the design of a working model in the form of a block diagram. All statements should be very carefully referenced. The ratio of agreement and disagreement should indicate the ability of the author to reconcile conflicting data in an objective and quantitative way. Attempts should be made to design a solution out of the given quantum of information. It is also well known that most of the processes of human physiology can only be understood if their time course is known. The dynamic aspect of interpretation of results is therefore more powerful and superior to the static one. 16 Therefore a continuous record of variables should be preferred and sought to reveal the secrets hidden in the kinetics.
• Finally, the discussion should conclude how far the study was successful in answering the questions being posed at the end of the introduction part. Usually a doctoral thesis raises more questions than it answers. In this way research does not come to a standstill and does become a life time engagement for a committed scientist. Also it is important to note that all scientific theses should be quantifiable and falsifiable, otherwise they lose the spirit and fragrance of a scientific research.
• The author’s claim of original work is finally decided by the critical review of his research work by the literature and the number of times being cited. It can be easily read by a high rate of a citation index of a publication and invitation. When a methodological research clicks, one becomes a star overnight.

Type-II: CUMULATIVE DOCTORAL THESES

Another way of writing a doctoral work is a cumulative type of thesis. 11 It consists of a few original publications in refereed journals of repute. It is supplemented by a concise summary about the research work. This type of thesis is usually practiced in Sweden, Germany and other countries. It has the advantage of being doubly refereed by the journals and the faculty of health sciences. Additionally, papers are published during a doctoral work. A declaration has to be given to the faculty of science about the sharing of research work in publications, provided there are co-authors. The weightage should be in favour of the PhD candidate, so that the thesis can ethically be better defended before the team of august research faculty.

ACKNOWLEDGEMENTS

A critical review of this manuscript by Dr. Roger Sutton, Dr. Khalid Khan, Dr. Bukhtiar Shah and Dr. Satwat Hashmi is gratefully acknowledged.

Dedicated to the memory of Mr. Azim Kidwai for his exemplary academic commitment and devotion to the science journalism in Pakistan.

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Doctoral Dissertations and Projects

Exploring health science students' perception of the influence of health precaution practices during the covid-19 pandemic.

Marquitta L. Foster , Liberty University Follow

School of Health Sciences

Doctor of Philosophy

The COVID-19 Pandemic, Health Science Students, Health Precautions Practices, During the COVID-19 Pandemic

Disciplines

Health and Physical Education

Recommended Citation

Foster, Marquitta L., "Exploring Health Science Students' Perception of the Influence of Health Precaution Practices During the COVID-19 Pandemic" (2024). Doctoral Dissertations and Projects . 5957. https://digitalcommons.liberty.edu/doctoral/5957

The purpose of this phenomenological study was to address a lack of research on health science students’ perceptions and use of health precautions during the COVID-19 pandemic. Albert Bandura’s Social Cognitive Theory frames this study of bachelor's, master’s and doctoral level students at Liberty University, George Mason University, and Norfolk State University. Data was gathered via surveys, interviews, and observations from 35 students across the three universities, providing a diverse pool of age, gender, and ethnicity. The initial survey gathered demographic data on whether students considered themselves immunocompromised, their view on COVID-19's severity for the immunocompromised, and whether they felt COVID-19 had increased the need for medical check-ups and vaccinations. Follow-up interviews were conducted, transcribed, and coded, identifying themes related to students’ awareness of COVID-19, the influence of students’ knowledge on their behavior, attitudes toward pandemic-era restrictions and contact tracing, and their use of health precautions. Many students reported increased use of health precautions during the pandemic, and those students with experience with vulnerable populations expressed using more health precautions out of concern for others’ well-being both during and after the pandemic. Students at all educational levels mentioned the importance of sharing accurate information. The findings suggest that enhancing students’ understanding of disease transmission, and effective strategies for communicating with lay people, could be productive. Practice communicating with non-scientists should be integrated into health science classes to capitalize on health science students’ care for others and position as trusted resources. Future research could explore the impact of these changes on students’ understanding of disease transmission, communication skills, and self-efficacy.

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Day Two: Placebo Workshop: Translational Research Domains and Key Questions

July 11, 2024

July 12, 2024

Day 1 Recap and Day 2 Overview

ERIN KING: All right. It is 12:01 so we'll go ahead and get started. And so on behalf of the Co-Chairs and the NIMH Planning Committee, I'd like to welcome you back to day two of the NIMH Placebo Workshop, Translational Research Domains and Key Questions. Before we begin, I will just go over our housekeeping items again. So attendees have been entered into the workshop in listen-only mode with cameras disabled. You can submit your questions via the Q&A box at any time during the presentation. And be sure to address your question to the speaker that you would like to respond.

For more information on today's speakers, their biographies can be found on the event registration website. If you have technical difficulties hearing or viewing the workshop, please note these in the Q&A box and our technicians will work to fix the problem. And you can also send an e-mail to [email protected]. And we'll put that e-mail address in the chat box for you. This workshop will be recorded and posted to the NIMH event web page for later viewing.

Now I would like to turn it over to our workshop Co-Chair, Dr. Cristina Cusin, for today's introduction.

CRISTINA CUSIN: Thank you so much, Erin. Welcome, everybody. It's very exciting to be here for this event.

My job is to provide you a brief recap of day one and to introduce you to the speakers of day two. Let me share my slides.

Again, thank you to the amazing Planning Committee. Thanks to their effort, we think this is going to be a success. I learned a lot of new information and a lot of ideas for research proposals and research projects from day one. Very briefly, please go and watch the videos. They are going to be uploaded in a couple of weeks if you missed them.

But we had an introduction from Tor, my Co-Chair. We had an historic perspective on clinical trials from the industry regulatory perspective. We had the current state from the FDA on placebo.

We had an overview of how hard it is to sham, to provide the right sham for device-based trials, and the challenges for TMS. We have seen some new data on the current state of placebo in psychosocial trials and what is the equivalent of a placebo pill for psychosocial trials. And some social neuroscience approach to placebo analgesia. We have come a long way from snake oil and we are trying to figure out what is placebo.

Tor, my Co-Chair, presented some data on the neurocircuitry underlying placebo effect and the questions that how placebo is a mixture of different elements including regression to the mean, sampling bias, selective attrition for human studies, the natural history of illness, the placebo effect per se that can be related to expectations, context, learning, interpretation.

We have seen a little bit of how is the impact on clinical trial design and how do we know that something, it really works. Or whatever this "it" is. And why do even placebo effect exists? It's fascinating idea that placebo exists as a predictive control to anticipate threats and the opportunity to respond in advance and to provide causal inference, a construct perception to infer the underlying state of body and of world.

We have seen historical perspective. And Ni Aye Khin and Mike Detke provided some overview of 25 years of randomized control trials from the data mining in major depressive disorders, schizophrenia trials and the lessons we have learned.

We have seen some strategies, both historical strategies and novel strategies to decrease placebo response in clinical trials and the results. Start from trial design, SPCD, lead-in, placebo phase and flexible dosing. Use of different scales. The use of statistical approaches like last observation carried forward or MMRM. Centralized ratings, self-rating, computer rating for different assessments. And more issues in clinical trials related to patient selection and professional patients.

Last, but not least, the dream of finding biomarkers for psychiatric conditions and tying response, clinical response to biomarkers. And we have seen how difficult it is to compare more recent studies with studies that were started in the '90s.

We have the FDA perspective with Tiffany Farchione in this placebo being a huge issue from the FDA. Especially the discussion towards the end of the day was on how to blind psychedelics.

We have seen an increasing placebo response rate in randomized controlled trials, also in adolescents, that is. And the considerations from the FDA of novel design models in collaboration with industry. We had examples of drugs approved for other disorders, not psychiatric condition, and realized -- made me realize how little we know about the true pathophysiology of psychiatric disorders, likely also heterogeneous conditions.

It made me very jealous of other fields because they have objective measures. They have biology, they have histology, they have imaging, they have lab values. While we are -- we are far behind, and we are not really able to explain to our patients why our mitigations are supposed to work or how they really work.

We heard from Holly Lisanby and Zhi-De Deng. The sham, the difficulty in producing the right sham for each type of device because most of them have auxiliary effects that are separate from the clinical effect like the noise or the scalp stimulation for TMS.

And it's critical to obtain a true blinding and separating sham from verum. We have seen how in clinical trials for devices expectancy from the patient, high tech environment and prolonged contact with clinicians and staff may play a role. And we have seen how difficult it is to develop the best possible sham for TMS studies in tDCS. It's really complicated and it's so difficult also to compare published studies in meta-analysis because they've used very different type of sham. Not all sham are created equal. And some of them could have been biologically active, so therefore invalidating the result or making the study uninformative.

Then we moved on to another fascinating topic with Dr. Rief and Dr. Atlas. What is the impact of psychological factors when you're studying a psychological intervention. Expectations, specific or nonspecific factors in clinical trials and what is interaction between those factors.

More, we learned about the potential nocebo effect of standard medical care or being on a wait list versus being in the active arm of a psychotherapy trial. And the fact that we are not accurately measuring the side effect of psychotherapy trial itself. And we heard more a fascinating talk about the neurocircuitry mediating placebo effect -- salience, affective value, cognitive control. And how perception of provider, perception of his or her warmth and competence and other social factors can affect response and placebo response, induce bias in evaluation of acute pain of others. Another very interesting field of study.

From a clinician perspective, this is -- and from someone who conduct clinical trials, all this was extremely informative because in many case in our patient situation no matter how good the treatment is, they have severe psychosocial stressors. They have difficulties to accessing food, to access treatment, transportation, or they live in an extremely stressful environment. So to disentangle other psychosocial factors from the treatment, from the biology is going to be critical to figure out how to treat best our patients.

And there is so much more work to do. Each of us approach the placebo topic for research from a different perspective. And like the blind man trying to understand what is an elephant, we have to endure it, we have to talk to each other, we have to collaborate and understand better the underlying biology, understand different aspect of the placebo phenomena.

And this lead us to the overview for day two. We are going to hear more about other topic that are so exciting. The placebo, the nocebo effect and other predictive factors in laboratory setting. We are going to hear about genetic of the placebo response to clinical trials. More physiological and psychological and neuromechanism for analgesia. And after a brief break around 1:30, we are going to hear about novel biological and behavioral approaches for the placebo effect.

We are going to hear about brain mapping. We are going to hear about other findings from imaging. And we're going to hear about preclinical modeling. There were some questions yesterday about animal models of placebo. And last, but not least, please stay around because in the panel discussion, we are going to tackle some of your questions. And we are going to have two wonderful moderators, Ted Kaptchuk and Matthew Rudorfer. So please stay with us and ask questions. We love to see more challenges for our speakers. And we're going to be all of the panelists from yesterday, from today are going to be present. Thank you so much.

Now we're going to move on to our first speaker of the day. If I am correct according to the last -- Luana.

Measuring & Mitigating the Placebo Effect

LUANA COLLOCA: Thank you very much, Cristina. First, I would love to thank the organizer. This is a very exciting opportunity to place our awareness about this important phenomenon for clinical trials and the clinical practice.

And today, I wish to give you a very brief overview of the psychoneurobiological mechanism of a placebo and nocebo, the description of some pharmacological studies, and a little bit of information on social learning. That is a topic that has been mentioned a little bit yesterday. And finally, the translational part. Can we translate what we learn from mechanistic approach to placebo and nocebo in terms of a disease and symptomatology and eventually predictors is the bigger question.

So we learned yesterday that placebo effects are generated by verbal suggestion, this medication has strong antidepressant effects. Therapeutic prior experience, merely taking a medication weeks, days before being substitute with a simulation of placebo sham treatment. Observation of a benefit in other people, contextual and treatment cue, and interpersonal interactions.

Especially in the fields of pain where we can simulate nociception, painful experience in laboratory setting, we learn a lot about the modulation related to placebo. In particular, expectation can provide a reaction and activation of parts of the brain like frontal area, nucleus accumbens, ventral striatum. And this kind of mechanism can generate a descending stimulation to make the painful nociceptive stimulus less intense.

The experience of analgesia at the level of a pain mechanism translate into a modulation reduction of a pain intensity. But most important, pain unpleasantness and the effective components of the pain. I will show today some information about the psychological factor, the demographic factor as well as genetic factors that can be predictive of placebo effects in the context of a pain.

On the other hand, a growing interest is related to nocebo effects, the negative counter sides of this phenomenon. When we talk about nocebo effects, we refer to increase in worsening of outcome in symptoms related to negative expectation, prior negative therapeutic experience, observing a negative outcome in others, or even mass psychogenic modeling such as some nocebo-related response during the pandemic. Treatment leaflets, the description of all side effects related to a medication. Patient-clinician communication. The informed consent where we list all of the side effects of a procedure or medication as well as contextual cues in clinical encounters.

And importantly, internal factor like emotion, mood, maladaptive cognitive appraisal, negative valence, personality traits, somatosensory features and omics can be predictive of negative worsening of symptom and outcome related to placebo and nocebo effects. In terms of a nocebo very briefly, there is a lot of attention again related to brain imaging with beautiful data show that the brainstem, the spinal cord, the hippocampus play a critical role during nocebo hyperalgesic effects.

And importantly, we learn that about placebo and nocebo through different approach including brain imaging, as we saw yesterday, but also pharmacological approach. We start from realizing that placebo effects are really neurobiological effects with the use of agonist or antagonist.

In other words, we can use a drug to mimic the action of that drug when we replace the drug with a saline solution, for example. In the cartoon here, you can see a brief pharmacological conditioning with apomorphine. Apomorphine is a dopamine agonist. And after three days of administration, apomorphine was replaced with saline solution in the intraoperative room to allow us to understand if we can mimic at the level of neuronal response the effects of apomorphine.

So in brief these are patients undergoing subthalamic EEG installation of deep brain stimulation. You can see here reaching the subthalamic nucleus. So after crossing the thalamus, the zona incerta, the STN, and the substantia nigra, the surgeon localized the area of stimulation. Because we have two subthalamic nuclei, we can use one as control and the other one as target to study in this case the effects of saline solution given after three days of apomorphine.

What we found was in those people who respond, there was consistency in reduction of clinical symptoms. As you can see here, the UPDRS, a common scale to measure rigidity in Parkinson, the frequency of a discharge at the level of neurons and the self-perception, patients with sentences like I feel like after Levodopa, I feel good. This feeling good translate in less rigidity, less tremor in the surgical room.

On the other hand, some participants didn't respond. Consistently we found no clinical improvement, no difference in preference over this drug at the level of a single unit and no set perception of a benefit. This kind of effects started to trigger the questions what is the reason why some people who responded to placebo and pharmacological conditioning and some other people don't. I will try to address this question in the second part of my talk.

On the other hand, we learn a lot about the endogenous modulation of pain and true placebo effects by using in this case an antagonist. The goal in this experiment was to create a painful sensation through a tourniquet. Week one with no treatment. Week two we pre-inject healthy participant with morphine. Week three the same morphine. And week four we replace morphine with placebo.

And you can see that a placebo increase the pain tolerance in terms of imminent. And this was not carryover effects. In fact, the control at week five showed no differences. Part of the participants were pre-injected with an antagonist Naloxone that when we use Naloxone at high dose, we can block the opioids delta and K receptors. You can see that by pre-injecting Naloxone there is a blockage of placebo analgesia, and I would say this morphine-like effects related to placebo given after morphine.

We start to then consider this phenomenon. Is this a way for tapering opioids. And we called this sort of drug-like effects as dose-extending placebo. The idea is that if we use a pharmacological treatment, morphine, apomorphine, as I showed to you, and then we replace the treatment with a placebo, we can create a pharmacological memory, and this can translate into a clinical benefit. Therefore, the dose-extending placebo can be used to extend the benefit of the drug, but also to reduce side effects related to the active drug.

In particular for placebo given after morphine, you can see on this graph, the effects is similarly strong if we do the repetition of a morphine one day apart or one week apart. Interestingly, this is the best model to be used in animal research.

Here at University of Maryland in collaboration with Todd Degotte, we create a model of anhedonia in mice and we condition animals with Ketamine. The goal was to replace Ketamine with a placebo. There are several control as you can see. But what is important for us, we condition animal with Ketamine week one, three and five. And then we substitute Ketamine with saline along with the CS. The condition of the stimulus was a light, a low light. And we want to compare this with an injection of Ketamine given at week seven.

So as you can see here, of course Ketamine was inducing a benefit as compared to saline and the Ketamine. But what is seen testing when we compare Ketamine week seven with saline replacing the Ketamine, we found no difference; suggesting that even in animals, in mice we were able to create drug-related effects. In this case, a Ketamine antidepressant-like placebo effects. These effects also add dimorphic effects in the sense that we observed this is in males but not in females.

So another approach to use agonist, like I mentioned for apomorphine in Parkinson patient, was to use vasopressin and oxytocin to increase placebo effects. In this case, we used verbal suggestion that in our experience especially with healthy participants tended to create very small sample size in terms of placebo analgesic effects. So we knew that from the literature that there is a dimorphic effects for this hormone. So we inject people with intranasal vasopressin, saline, oxytocin in low dose and no treatment. You can see there was a drug effects in women whereby vasopressin boost placebo analgesic effects, but not in men where yet we found many effects of manipulation but not drug effects.

Importantly, vasopressin affect dispositional anxiety as well as cortisol. And there is a negative correlation between anxiety and cortisol in relationship to vasopressin-induced placebo analgesia.

Another was, can we use medication to study placebo in laboratory setting or can we study placebo and nocebo without any medication? One example is to use a manipulation of the intensity of the painful stimulations. We use a thermal stimulation tailored at three different levels. 80 out of 100 with a visual analog scale, 50 or 20, as you can see from the thermometer.

We also combined the level of pain with a face. So first to emphasize there is three level of pain, participants will see an anticipatory cue just before the thermal stimulation. Ten seconds of the thermal stimulation to provide the experience of analgesia with the green and the hyperalgesia with the red as compared to the control, the yellow condition.

Therefore, the next day we move in the fMRI. And the goal was to try to understand to what extent expectation is relevant in placebo and nocebo effects. We mismatch what they anticipate, and they learn the day before. But also you can see we tailored the intensity at the same identical level. 50 for each participant.

We found that when expectation matched the level of the cues, anticipatory cue and face, we found a strong nocebo effects and placebo effects. You can see in red that despite the level of pain were identical, the perceived red-related stimuli as higher in terms of intensity, and the green related the stimuli as lower when compared to the control. By mismatching what they expect with what they saw, we blocked completely placebo effects and still nocebo persist.

So then I showed to you that we can use conditioning in animals and in humans to create placebo effects. But also by suggestion, the example of vasopressin. Another important model to study placebo effects in laboratory setting is social observation. We see something in other people, we are not told what we are seeing and we don't experience the thermal stimulation. That is the setting. A demonstrator receiving painful or no painful stimulation and someone observing this stimulation.

When we tested the observers, you can see the level of pain were tailored at the same identical intensity. And these were the effects. In 2009, when we first launched this line of research, this was quite surprising. We didn't anticipate that merely observing someone else could boost the expectations and probably creating this long-lasting analgesic effect. This drove our attention to the brain mechanism of what is so important during this transfer of placebo analgesia.

So we scanned participants when they were observing a video this time. And a demonstrator receiving control and placebo cream. We counterbalance the color. We controlled for many variables. So during the observation of another person when they were not stimulated, they didn't receive the cream, there is an activation of the left and right temporoparietal junction and a different activation of the amygdala with the two creams. And importantly, an activation of the periaqueductal gray that I show to you is critical in modulating placebo analgesia.

Afterwards we put both the placebo creams with the two different color. We tailored the level of pain at the identical level of intensity. And we saw how placebo effects through observation are generated. They create strong different expectation and anxiety. And importantly, we found that the functional connectivity between the dorsolateral prefrontal cortex and temporoparietal junction that was active during the observation mediate the behavior results. Suggesting that there is some mechanism here that may be relevant to exploit in clinical trials and clinical practice.

From this, I wish to switch to a more translational approach. Can we replicate these results observed in health participant for nociception in people suffering from chronic pain. So we chose as population of facial pain that is an orphan disease that has no consensus on how to treat it, but also it affects the youngest including children.

So participants were coming to the lab. And thus you can see we used the same identical thermal stimulation, the same electrodes, the same conditioning that I showed to you. We measured expectation before and after the manipulation. The very first question was can we achieve similar monitored distribution of placebo analgesia in people suffering chronically from pain and comorbidities. You can see that we found no difference between temporo parenthala, between TMD and controls. Also, we observed that some people responded to the placebo manipulation with hyperalgesia. We call this nocebo effect.

Importantly, these affects are less relevant than the benefit that sometime can be extremely strong show that both health control and TMD. Because we run experiment in a very beautiful ecological environment where we are diverse, the lab, the experimenters as well as the population we recruit in the lab has a very good distribution of race, ethnicity.

So the very first question was we need to control for this factor. And this turned out to be a beautiful model to study race, ethnicity in the lab. So when chronic pain patient were studied by same experimenter race, dark blue, we observe a larger placebo effect. And this tell us about the disparity in medicine. In fact, we didn't see these effects in our controls.

In chronic pain patient, we also saw a sex concordance influence. But in the opposite sense in women studied by a man experimenter placebo effects are larger. Such an effect was not seen in men.

The other question that we had was what about the contribution of psychological factors. At that stage, there were many different survey used by different labs. Some are based on the different area of, you know, the states of the world, there were trends where in some people in some study they observe an effects of neurodisease, more positive and negative set, that refer to the words. Instead of progressing on single survey, and now we have a beautiful meta-analysis today that is not worth in the sense that it is not predictive of placebo effects.

We use the rogue model suggested by the NIMH. And by doing a sophisticated approach we were able to combine this into four balances. Emotional distress, reward-seeking, pain related fear catastrophizing, empathy and openness. These four valences then were interrelated to predict placebo effects. And you can see that emotional distress is associated with lower magnitude of placebo effects extinguishing over time and lower proportion of placebo responsivity.

Also people who tend to catastrophizing display lower magnitude of placebo effects. In terms of expectation, it is also interesting patients expect to benefit, they have this desire for a reward. But also those people who are more open and characterized by empathy tend for the larger expectations. But this doesn't translate necessarily in larger placebo effects, somehow hinting that the two phenomenon can be not necessarily linked.

Because we study chronic pain patients they come with their own baggage of disease comorbidities. And Dr. Wang in his department look at insomnia. Those people suffering from insomnia tends to have lower placebo analgesic effects along with those who have a poor pattern of sleep, suggesting that clinical factor can be relevant when we wish to predict placebo effects.

Another question that we address how simple SNPs, single nucleotide polymorphism variants in three regions that have been published can be predictive of placebo effects. In particular, I'm referring to OPRM1 that is linked to the gene for endogenous opioids. COMT linked to endogenous dopamine. And FAAH linked to endogenous cannabinoids. And we will learn about that more with the next talk.

And you can see that there is a prediction. These are rogue codes that can be interesting. We model all participants with verbal suggestion alone, the conditioning. There isn't really a huge difference between using one SNP versus two or three. What is truly impact and was stronger in terms of prediction was accounting for the procedure we used to study placebo. Whether by suggestion alone versus condition. When we added the manipulation, the prediction becomes stronger.

More recently, we started gene expression transcriptomic profile associated with placebo effects. We select from the 402 participants randomly 54. And we extract their transcriptomic profiles. Also we select a validation cohort to see if we can't replicate what we discover in terms of mRNA sequencing. But we found over 600 genes associated with the discovered cohort. In blue are the genes downregulated and in red upregulated.

We chose the top 20 genes and did the PCA to validate the top 20. And we found that six of them were replicated and they include all these genes that you see here. The Selenom for us was particularly interesting, as well as the PI3, the CCDC85B, FBXL15, HAGHL and the TNFRSF4. So with this --

LUANA COLLOCA: Yes, I'm done. With this, that is the goal probably one day with AI and other approach to combine clinical psychological brain imaging and so on, characteristic and behavior to predict a level of transitory response to placebo. That may guide us in clinical trials and clinical path to tailor the treatment. Therefore, the placebo and nocebo biological response can be to some extent predicted. And identify those who responded to placebo can help tailoring drug development and symptom management.

Thank you to my lab. All of you, the funding agencies. And finally, for those who like to read more about placebo, this book is available for free to be downloaded. And they include many of the speakers from this two-day event as contributors to this book. Thank you very much.

CRISTINA CUSIN: Thank you so much, Luana. It was a wonderful presentation. We have one question in the Q&A.

Elegant studies demonstrating powerful phenomena. Two questions. Is it possible to extend or sustain placebo-boosting effect? And what is the dose response relationship with placebo or nocebo?

LUANA COLLOCA: Great questions. The goal is to boost a placebo effects. And one way, as I showed was, for example, using intranasal vasopressin. But also extending relationship with placebo we know that we need the minimum of a three or four other administration before boosting this sort of pharmacological memory. And the longer is the administration of the active drug before we replace with placebo, the larger the placebo effects.

For nocebo, we show similar relationship with the collaborators. So again, the longer we condition, the stronger the placebo or nocebo effects. Thank you so much.

CRISTINA CUSIN: I wanted to ask, do you have any theory or interpretation about the potential for transmit to person a placebo response between the observer or such, do you have any interpretation of this phenomenon?

LUANA COLLOCA: It is not completely new in the literature. There is a lot of studies show that we can transfer pain in both animal models and humans.

So transfer analgesia is a natural continuation of that line of research. And the fact that we mimic things that we see in some other people, this is the very most basic form of learning when we grow up. But also from a revolutionary point of view protect us from predators and animals and us as human beings observing is a very good mechanism to boost behaviors and in this case placebo effects. Thank you.

CRISTINA CUSIN: Okay. We will have more time to ask questions.

We are going to move on to the next speaker. Dr. Kathryn Hall.

KATHRYN HALL: Thank you. Can you see my screen okay? Great.

So I'm going to build on Dr. Colloca's talk to really kind of give us a deeper dive into the genetics of the placebo response in clinical trials.

So I have no disclosures. So as we heard and as we have been hearing over the last two days, there is -- there are physiological drivers of placebo effects, whether they are opioid signaling or dopamine signaling. And these are potentiated by the administration or can be potentiated by saline pills, saline injections, sugar pills. And what's really interesting here, I think, is this discussion about how drugs impact the drivers of placebo response. In particular we heard about Naloxone yesterday and proglumide.

What I really want to do today is think about the next layer. Like how do the genes that shape our biology and really drive or influence that -- those physiological drivers of placebo response, how do the genes, A, modify our placebo response? But also, how are they modifying the effect of the drugs and the placebos on this basic -- this network?

And if you think about it, we really don't know much about all of the many interactions that are happening here. And I would actually argue that it goes even beyond genetic variation to other factors that lead to heterogeneity in clinical trials. Today I'm going to really focus on genes and variations in the genome.

So let's go back so we have the same terminology. I'm going to be talking about placebo-responsing trials. And so we saw this graph or a version of this graph yesterday where in clinical trials when we want to assess the effect of a drug, we subtract the outcomes in the placebo arm from the outcomes in the drug treatment arm. And there is a basic assumption here that the placebo response is additive to the drug response.

And what I want to do today is to really challenge that assumption. I want to challenge that expectation. Because I think we have enough literature and enough studies that have already been done that demonstrate that things are not as simple as that and that we might be missing a lot from this basic averaging and subtracting that we are doing.

So the placebo response is that -- is the bold lines there which includes placebo effects which we have been focusing on here. But it also includes a natural history of the disease or the condition, phenomenon such as statistical regression not mean, blinding and bias and Hawthorn effects. So we lump all of those together in the placebo arm of the trial and subtract the placebo response from the drug response to really understand the drug effect.

So one way to ask about, well, how do genes affect this is to look at candidate genes. And as Dr. Colloca pointed out and has done some very elegant studies in this area, genes like COMT, opioid receptors, genes like OPRM1, the FAAH endocannabinoid signaling genes are all candidate genes that we can look at in clinical trials and ask did these genes modify what we see in the placebo arm of trials?

We did some studies in COMT. And I want to just show you those to get a -- so you can get a sense of how genes can influence placebo outcomes. So COMT is catacholamethyl transferase. And it's a protein, an enzyme that metabolizes dopamine which as you saw is important in mediating the placebo response. COMT also metabolizes epinephrin, norepinephrine and catecholest estrogen. So the fact that COMT might be involved in placebo response is really interesting because it might be doing more than just metabolizing dopamine.

So we asked the question what happens if we look at COMT genetic variation in clinical trials of irritable bowel syndrome? And working with Ted Kaptchuk and Tony Lembo at Beth Israel Deaconess Medical Center, we did just that. We looked at COMT effects in a randomized clinical trial of irritable bowel syndrome. And what we did see was that for the gene polymorphism RS46AD we saw that people who had the weak version of the COMT enzyme actually had more placebo response. These are the met/met people here shown on this, in this -- by this arrow. And that the people who had less dopamine because that enzyme didn't work as well for this polymorphism, they had less of a placebo response in one of the treatment arms. And we would later replicate this study in another clinical trial that was recently concluded in 2021.

So to get a sense, as you can see, we are somewhat -- we started off being somewhat limited by what was available in the literature. And so we wanted to expand on that to say more about genes that might be associated with placebo response. So we went back, and we found 48 studies in the literature where there was a gene that was looked at that modified the placebo response.

And when we mapped those to the interactome, which is this constellation of all gene products and their interactions, their physical interactions, we saw that the placebome or the placebo module had certain very interesting characteristics. Two of those characteristics that I think are relevant here today are that they overlapped with the targets of drugs, whether they were analgesics, antidepressive drugs, anti-Parkinson's agents, placebo genes putatively overlapped with drug treatment genes or targets.

They also overlapped with disease-related genes. And so what that suggests is that when we were looking at the outcomes of clinical trial there might be a lot more going on that we are missing.

And let's just think about that for a minute. On the left is what we expect. We expect that we are going to see an effect in the drug, it's going to be greater than the effect of the placebo and that difference is what we want, that drug effect. But what we often see is on the right here where there is really no difference between drug and placebo. And so we are left to scratch our heads. Many companies go out of business. Many sections of companies close. And, quite frankly, patients are left in need. Money is left on the table because we can't discern between drug and placebo.

And I think what is interesting is that's been a theme that's kind of arisen since yesterday where oh, if only we had better physiological markers or better genes that targeted physiology then maybe we could see a difference and we can, you know, move forward with our clinical trials.

But what I'm going to argue today is actually what we need to do is to think about what is happening in the placebo arm, what is contributing to the heterogeneity in the placebo arm, and I'm going to argue that when we start to look at that compared to what is happening in the drug treatment arm, oftentimes -- and I'm going to give you demonstration after demonstration. And believe me, this is just the tip of the iceberg.

What we are seeing is there are differential effects by genotype in the drug treatment arm and the placebo treatment arm such that if you average out what's happening in these -- in these drug and placebo arms, you would basically see that there is no difference. But actually there's some people that are benefiting from the drug but not placebo. And conversely, benefiting from placebo but not drug. Average out to no difference.

Let me give you some examples. We had this hypothesis and we started to look around to see if we could get partners who had already done clinical trials that had happened to have genotyped COMT. And what we saw in this clinical trial for chronic fatigue syndrome where adolescents were treated with clonidine was that when we looked in the placebo arm, we saw that the val/val patients, so this is the COMT genotype. The low activity -- sorry, that is high activity genotype. They had the largest number increase in the number of steps they were taking per week. In contrast, the met/met people, the people with the weaker COMT had fewer, almost no change in the number of steps they were taking per week.

So you would look at this and you would say, oh, the val/val people were the placebo responders and the met/met people didn't respond to placebo. But what we saw when we looked into the drug treatment arm was very surprising. We saw that clonidine literally erased the effect that we were seeing in placebo for the val/val participants in this trial. And clonidine basically was having no effect on the heterozygotes, the val/mets or on the met/mets. And so this trial rightly concluded that there was no benefit for clonidine.

But if they hadn't taken this deeper look at what was happening, they would have missed that clonidine may potentially be harmful to people with chronic fatigue in this particular situation. What we really need to do I think is look not just in the placebo or not just in the drug treatment arm but in both arms to understand what is happening there.

And I'm going to give you another example. And, like I said, the literature is replete with these examples. On the left is an example from a drug that was used to test cognitive -- in cognitive scales, Tolcupone, which actually targets COMT. And what you can see here again on the left is differential outcomes in the placebo arm and in the drug treatment arm that if you were to just average these two you would not see the differences.

On the right is a really interesting study looking at alcohol among people with alcohol disorder, number of percent drinking days. And they looked at both COMT and OPRM1. And this is what Dr. Colloca was just talking about there seemed to be not just gene-placebo drug interactions but gene-gene drug placebo interactions. This is a complicated space. And I know we like things to be very simple. But I think what these data are showing is we need to pay more attention.

So let me give you another example because these -- you know, you could argue, okay, those are objective outcomes -- sorry, subjective outcomes. Let's take a look at the Women's Health Study. Arguably, one of the largest studies on aspirin versus placebo in history. 30,000 women were randomized to aspirin or placebo. And lo and behold, after 10 years of following them the p value was nonsignificant. There was no difference between drug and placebo.

So we went to this team, and we asked them, could we look at COMT because we had a hypothesis that COMT might modify the outcomes in the placebo arm and potentially differentially modify the treatments in the drug treatment arm. You might be saying that can't have anything to do with the placebo effect and we completely agree. This if we did find it would suggest that there might be something to do with the placebo response that is related to natural history. And I'm going to show you the data that -- what we found.

So when we compared the outcomes in the placebo arm to the aspirin arm, what we found was the met/met women randomized to placebo had the highest of everybody rates of cardiovascular disease. Which means the highest rates of myocardial infarction, stroke, revascularization and death from a cardiovascular disease cause. In contrast, the met/met women on aspirin had benefit, had a statistically significant reduction in these rates.

Conversely, the val/val women on placebo did the best, but the val/val women on aspirin had the highest rates, had significantly higher rates than the val/val women on placebo. What does this tell us? Well, we can't argue that this is a placebo effect because we don't have the control for placebo effects, which is a no treatment control.

But we can say that these are striking differences that, like I said before, if you don't pay attention to them, you miss the point that there are subpopulations for benefit or harm because of differential outcomes in the drug and placebo arms of the trial.

And so I'm going to keep going. There are other examples of this. We also partnered with a group at Brigham and Women's Hospital that had done the CAMP study, the Childhood Asthma Management Study. And in this study, they randomized patients to placebo, Budesonide or Nedocromil for five years and study asthma outcomes.

Now what I was showing you previously was candidate gene analyses. What this was, was a GWAS. We wanted to be agnostic and ask are there genes that modify the placebo outcomes and are these outcomes different in the -- when we look in the drug treatment arm. And so that little inset is a picture of all of the genes that were looked at in the GWAS. And we had a borderline genome Y significant hit called BBS9. And when we looked at BBS9 in the placebo arm, those white boxes at the top are the baseline levels of coughing and wheezing among these children. And in the gray are at the end of the treatment their level of coughing and wheezing.

And what you can see here is that participants with the AA genotype were the ones that benefited from the Bedenoside -- from placebo, whereas the GG, the patients with the GG genotype really there was no significant change.

Now, when we looked in the drug treatment arms, we were surprised to see that the outcomes were the same, of course, at baseline. There is no -- everybody is kind of the same. But you can see the differential responses depending on the genotype. And so, again, not paying attention to these gene drug/placebo interactions we miss another story that is happening here among our patients.

Now, I just want to -- I added this one because it is important just to realize that this is not just about gene-drug placebo. But these are also about epigenetic effects. And so here is the same study that I showed earlier on alcohol use disorder. They didn't just stop at looking at the polymorphisms or the genetic variants. This team also went so far as to look at methylation of OPRM1 and COMT.

So methylation is basically when the promoter region of a gene is basically blocked because it has a methyl group. It has methylation on some of the nucleotides in that region. So you can't make the protein as efficiently. And if you look on the right, what you can see in the three models that they looked at, they looked at other genes. They also looked at SLC6A3 that's involved in dopamine transport. And what you can see here is that there is significant gene by group by time interactions for all these three genes, these are candidate genes that they looked at.

And even more fascinating is their gene-by-gene interactions. Basically it is saying that you cannot say what the outcome is going to be unless you know the patient's or the participant's COMT or OPRM genotype A and also how methylated the promoter region of that -- of these genes are. So this makes for a very complicated story. And I know we like very simple stories.

But I want to say that I'm just adding to that picture that we had before to say that it's not just in terms of the gene's polymorphisms, but as Dr. Colloca just elegantly showed it is transcription as well as methylation that might be modifying what is happening in the drug treatment arm and the placebo treatment arm. And to add to this it might also be about the natural history of the condition.

So BBS9 is actually a gene that is involved in the cilia, the activity of the formation of the cilia which is really important in breathing in the nasal canal. And so, you can see that it is not just about what's happening in the moment when you are doing the placebo or drug or the clinical trial, it also might -- the genes might also be modifying where the patient starts out and how the patient might develop over time. So, in essence, we have a very complicated playground here.

But I think I have shown you that genetic variation, whether it is polymorphisms in the gene, gene-gene interactions or epigenetics or all of the above can modify the outcomes in placebo arms of clinical trials. And that this might be due to the genetic effects on placebo effects or the genetic effects on natural history. And this is something I think we need to understand and really pay attention to.

And I also think I've showed you, and these are just a few examples, there are many more. But genetic variation can differentially modify drugs and placebos and that these potential interactive effects really challenge this basic assumption of additivity that I would argue we have had for far too long and we really need to rethink.

TED KAPTCHUK: (Laughing) Very cool.

KATHRYN HALL: Hi, Ted.

TED KAPTCHUK: Oh, I didn't know I was on.

KATHRYN HALL: Yeah, that was great. That's great.

So in summary, can we use these gene-placebo drug interactions to improve clinical trials. Can we change our expectations about what is happening. And perhaps as we have been saying for the last two days, we don't need new drugs with clear physiological effects, what we need is to understand drug and placebo interactions and how they impact subpopulations and can reveal who benefits or is harmed by therapies.

And finally, as we started to talk about in the last talk, can we use drugs to boost placebo responses? Perhaps some drugs already do. Conversely, can we use drugs to block placebo responses? And perhaps some drugs already do.

So I just want to thank my collaborators. There was Ted Kaptchuk, one of my very close mentors and collaborators. And really, thank you for your time.

CRISTINA CUSIN: Thank you so much. It was a terrific presentation. And definitely Ted's captured laugh, it was just one of the best spontaneous laughs.

We have a couple of questions coming through the chat. One is about the heterogeneity of response in placebo arms. It is not uncommon to see quite a dispersion of responses at trials. Was that thought experiment, if one looks at the fraction of high responders in the placebo arms, would one expect to see, enrich for some of the genetic marker for and as placebo response?

KATHRYN HALL: I absolutely think so. We haven't done that. And I would argue that, you know, we have been having kind of quiet conversation here about Naloxone because I think as Lauren said yesterday that the findings of Naloxone is variable. Sometimes it looks like Naloxone is blocking placebo response and sometimes it isn't.

We need to know more about who is in that trial, right? Is this -- I could have gone on and showed you that there is differences by gender, right. And so this heterogeneity that is coming into clinical trials is not just coming from the genetics. It's coming from race, ethnicity, gender, population. Like are you in Russia or are you in China or are you in the U.S. when you're conducting your clinical trial? We really need to start unpacking this and paying attention to it. I think because we are not paying attention to it, we are wasting a lot of money.

CRISTINA CUSIN: And epigenetic is another way to consider traumatic experiences, adverse event learning. There is another component that we are not tracking accurately in clinical trials. I don't think this is a one of the elements routinely collected. Especially in antidepressant clinical trials it is just now coming to the surface.

KATHRYN HALL: Thank you.

CRISTINA CUSIN: Another question comes, it says the different approaches, one is GWAS versus candidate gene approach.

How do you start to think about genes that have a potential implication in neurophysiological pathways and choosing candidates to test versus a more agnostic U.S. approach?

KATHRYN HALL: I believe you have to do both because you don't know what you're going to find if you do a GWAS and it's important to know what is there.

At the same time, I think it's also good to test our assumptions and to replicate our findings, right? So once you do the GWAS and you have a finding -- for instance, our BBS9 finding would be amazing to replicate or to try and test in another cohort. But, of course, it is really difficult to do a whole clinical trial again. These are very expensive, and they last many years.

And so, you know, I think replication is something that is tough to do in this space, but it is really important. And I would do both.

CRISTINA CUSIN: Thank you. We got a little short on time. We are going to move on to the next speaker. Thank you so much.

FADEL ZEIDAN: Good morning. It's me, I imagine. Or good afternoon.

Let me share my screen. Yeah, so good morning. This is going to be a tough act to follow. Dr. Colloca and Dr. Hall's presentations were really elegant. So manage your expectations for mine. And, Ted, please feel free to unmute yourself because I think your laugh is incredibly contagious, and I think we were all were laughing as well.

So my name is Fadel Zeidan, I'm at UC San Diego. And I'll be discussing mostly unpublished data that we have that's under review examining if and how mindfulness meditation assuages pain and if the mechanism supporting mindfulness meditation-based analgesia are distinct from placebo.

And so, you know, this is kind of like a household slide that we all are here because we all appreciate how much of an epidemic chronic pain is and, you know, how significant it is, how much it impacts our society and the world. And it is considered a silent epidemic because of the catastrophic and staggering cost to our society. And that is largely due to the fact that the subjective experience of pain is modulated and constructed by a constellation of interactions between sensory, cognitive, emotional dimensions, genetics, I mean I can -- the list can go on.

And so what we've been really focused on for the last 20 years or so is to appreciate if there is a non-pharmacological approach, a self-regulated approach that can be used to directly assuage the experience of pain to acutely modify exacerbated pain.

And to that extent, we've been studying meditation, mindfulness-based meditation. And mindfulness is a very nebulous construct. If you go from one lab to another lab to another lab, you are going to get a different definition of what it is. But obviously my lab's definition is the correct one. And so the way that we define it is awareness of arising sensory events without reaction, without judgment.

And we could develop this construct, this disposition by practicing mindfulness-based meditation, which I'll talk about here in a minute. And we've seen a lot of -- and this is an old slide -- a lot of new evidence, converging evidence demonstrating that eight weeks of manualized mindfulness-based interventions can produce pretty robust improvements in chronic pain and opiate misuse. These are mindfulness-based stress reduction programs, mindfulness-oriented recovery enhancement, mindfulness-based cognitive therapy which are about eight weeks long, two hours of formalized didactics a week, 45 minutes a day of homework.

There is yoga, there is mental imagery, breathing meditation, walking meditation, a silent retreat and about a $600 tab. Which may not be -- I mean although they are incredibly effective, may not be targeting demographics and folks that may not have the time and resources to participate in such an intense program.

And to that extent and, you know, as an immigrant to this country I've noticed that we are kind of like this drive-thru society where, you know, we have a tendency to eat our lunches and our dinners in our cars. We're attracted to really brief interventions for exercise or anything really, pharmaceuticals, like ":08 Abs" and "Buns of Steel." And we even have things called like the military diet that promise that you'll lose ten pounds in three days without dying.

So we seemingly are attracted to these fast-acting interventions. And so to this extent we've worked for quite some time to develop a very user friendly, very brief mindfulness-based intervention. So this is an intervention that is about four sessions, 20 minutes each session. And participants are -- we remove all religious aspects, all spiritual aspects. And we really don't even call it meditation, we call it mindfulness-based mental training.

And our participants are taught to sit in a straight posture, close their eyes, and to focus on the changing sensations of the breath as they arise. And what we've seen is this repetitive practice enhances cognitive flexibility and the ability to -- flexibility and the ability to sustain attention. And when individual's minds drift away from focusing on the breath, they are taught to acknowledge distractive thoughts, feelings, emotions without judging themselves or the experience. Doing so by returning their attention back to the breath.

So there is really a one-two punch here where, A, you're focusing on the breath and enhancing cognitive flexibility; and, B, you're training yourself to not judge discursive events. And that we believe enhances emotion regulation. So quite malleable to physical training we would say mental training. Now that we have the advent of imaging, we can actually see that there are changes in the brain related to this.

But as many of you know, mindfulness is kind of like a household term now. It's all over our mainstream media. You know, we have, you know, Lebron meditating courtside. Oprah meditating with her Oprah blanket. Anderson Cooper is meditating on TV. And Time Magazine puts, you know, people on the cover meditating. And it's just all over the place.

And so these types of images and these types of, I guess, insinuations could elicit nonspecific effects related to meditation. And for quite some time I've been trying to really appreciate not is meditation more effective than placebo, although that's interesting, but does mindfulness meditation engage mechanisms that also are shared by placebo? So beliefs that you are meditating could elicit analgesic responses.

The majority of the manualized interventions in their manuals they use terms like the power of meditation, which I guarantee you is analgesic. To focus on the breath, we need to slow the breath down. Not implicit -- not explicitly, but it just happens naturally. And slow breathing can also reduce pain. Facilitator attention, social support, conditioning, all factors that are shared with other therapies and interventions but in particular are also part of meditation training.

So the question is because of all this, is mindfulness meditation merely -- or not merely after these two rich days of dialogue -- but is mindfulness meditation engaging processes that are also shared by placebo.

So if I apply a placebo cream to someone's calf and then throw them in the scanner versus asking someone to meditate, the chances are very high that the brain processes are going to be distinct. So we wanted to create a -- and validate an operationally matched mindfulness meditation intervention that we coined as sham mindfulness meditation. It's not sham meditation because it is meditation. It's a type of meditative practice called Pranayama.

But here in this intervention we randomize folks, we tell folks that they've been randomized to a genuine mindfulness meditation intervention. Straight posture, eyes closed. And every two to three minutes they are instructed to, quote-unquote, take a deep breath as we sit here in mindfulness meditation. We even match the time giving instructions between the genuine and the sham mindfulness meditation intervention.

So the only difference between the sham mindfulness and the genuine mindfulness is that the genuine mindfulness is taught to explicitly focus on the changing sensations of the breath without judgment. The sham mindfulness group is just taking repetitive deep, slow breaths. So if the magic part of mindfulness, if the active component of mindfulness is this nonjudgmental awareness, then we should be able to see disparate mechanisms between these.

And we also use a third arm, a book listening control group called the "Natural History of Selborne" where it's a very boring, arguably emotionally pain-evocating book for four days. And this is meant to control for facilitator time and -- sorry, facilitator attention and the time elapsed in the other group's interventions.

So we use a very high level of noxious heat to the back of the calf. And we do so because imaging is quite expensive, and we want to ensure that we can see pain-related processing within the brain. Here and across all of our studies, we use ten 12-second plateaus of 49 degrees to the calf, which is pretty painful.

And then we assess pain intensity and pain unpleasantness using a visual analog scale, where here the participants just see red the more they pull on the algometer the more in pain they are. But on the back, the numbers fluoresce where 0 is no pain and 10 is the worst pain imaginable.

So pain intensity can be considered like sensory dimension of pain, and pain unpleasantness could be more like I don't want to say pain affect but more like the bothersome component of pain, pain unpleasantness. So what we did was we combined all of our studies that have used the mindfulness, sham mindfulness in this book listing control, to see does mindfulness meditation engage is mindfulness meditation more effective than sham mindfulness meditation at reducing pain.

We also combined two different fMRI techniques: Blood oxygen dependent level signalling, bold, which allows us a higher temporal resolution and signal to noise ratio than, say, perfusion imaging technique and allows us to look at connectivity. However, meditation is also predicated on changes in respiration rate which could elicit pretty dramatic artifacts in the brain, breathing related artifacts explicitly related to CO2 output.

So using the perfusion based fMRI technique like arterial spin labeling is really advantageous as well, although it's not as temporally resolute as bold, it provides us a direct quantifiable measurement of cerebral blood flow.

So straight to the results. On the Y axis we have the pain ratings, and on the X axis are book listening controls sham mindfulness meditation, mindfulness meditation. Here are large sample sizes. Blue is intensity and red is unpleasantness. This is the post intervention fMRI scans where we see the first half of the scan to the second half of the scan our controlled participants are simply resting and pain just increases because of pain sensitization and being in a claustrophobic MRI environment.

And you can see here that sham mindfulness meditation does produce pretty significant reduction in pain intensity and unpleasantness, more than the control book. But mindfulness meditation is more effective than sham mindfulness and the controls at reducing pain intensity and pain unpleasantness.

There does seem to be some kind of additive component to the genuine intervention, although this is a really easy practice, the sham techniques.

So for folks that have maybe fatigue or cognitive deficits or just aren't into doing mindfulness technique, I highly recommend this technique, which is just a slow breathing approach, and it's dead easy to do.

Anyone that's practiced mindfulness for the first time or a few times can state that it can be quite difficult and what's the word? -- involving, right?

So what happened in the brain? These are our CBF maps from two studies that we replicated in 2011 and '15 where we found that higher activity, higher CBF in the right anterior insula, which is ipsilateral to the stimulation site and higher rostral anterior cingulate cortex subgenual ACC was associated with greater pain relief, pain intensity, and in the context of pain unpleasantness, higher over the frontal cortical activity was associated with lower pain, and this is very reproducible where we see greater thalamic deactivation predicts greater analgesia on the unpleasantness side.

These areas, obviously right entry insula in conjunction with other areas is associated with interoceptive processing awareness of somatic sensations. And then the ACC and the OFC are associated with higher order cognitive flexibility, emotional regulation processes. And the thalamus is really the gatekeeper from the brain -- I'm sorry, from the body to the brain. Nothing can enter the brain except unless it goes through the thalamus, except if it's the sense of smell.

So it's really like this gatekeeper of arising nociceptive information.

So the takehome here is that mindfulness is engaging multiple neural processes to assuage pain. It's not just one singular pathway.

Our gold studies were also pretty insightful. Here we ran a PPI analysis, psychophysiologic interaction analysis and this was whole brain to see what brain regions are associated with pain relief on the context of using the bold technique, and we find that greater ventral medial prefrontal cortical activity deactivation I'm sorry is associated with lower pain, and the vmPFC is a super evolved area that's associated with, like, higher order processes relating to self. It's one of the central nodes of the so called default mode network, a network supporting self referential processing. But in the context of the vmPFC, I like the way that Tor and Mathieu reflect the vmPFC as being more related to affective meaning and has a really nice paper showing that vmPFC is uniquely involved in, quote/unquote, self ownership or subjective value, which is particularly interesting for the context of pain because pain is a very personal experience that's directly related to the interpretation of arising sensations and what they mean to us.

And seemingly -- I apologize for the reverse inferencing here -- but seemingly mindfulness meditation based on our qualitative assessments as well is reducing the ownership or the intrinsic value, the contextual value of those painful sensations, i.e., they don't feel like they bother -- that pain is there but it doesn't bother our participants as much, which is quite interesting as a manipulation.

We also ran our connectivity analysis between the contralateral thalamus and the whole brain, and we found that greater decoupling between the contralateral thalamus and the precuneus, another central node of the default mode network predicted greater analgesia.

This is a really cool, I think, together mechanism showing that two separate analyses are indicating that the default mode network could be an analgesic system which we haven't seen before. We have seen the DMN involved in chronic pain and pain related exacerbations, but I don't think we've seen it as being a part of an analgesic, like being a pain relieving mechanism. Interestingly, the thalamus and precuneus together are the first two nodes to go offline when we lose consciousness, and they're the first two nodes to come back online when we recover from consciousness, suggesting that these two -- that the thalamus and precuneus are involved in self referential awareness, consciousness of self, things of this nature.

Again, multiple processes involved in meditation based pain relief which maybe gives rise to why we are seeing consistently that meditation could elicit long lasting improvements in pain unpleasantness, in particular, as compared to sensory pain. Although it does that as well.

And also the data gods were quite kind on this because these mechanisms are also quite consistent with the primary premises of Buddhist and contemplative scriptures saying that the primary principle is that your experiences are not you.

Not that there is no self, but that the processes that arise in our moment to moment experience are merely reflections and interpretations in judgments, and that may not be the true inherent nature of mind.

And so before I get into more philosophical discourse, I'm going to keep going for the sake of time. Okay.

So what happened with the sham mindfulness meditation intervention?

We did not find any neural processes predicted analgesia significantly and during sham mindfulness meditation. What did predict analgesia during sham mindfulness was slower breathing rate, which we've never seen before with mindfulness. We've never seen a significant or even close to significant relationship between mindfulness based meditation analgesia and slow breathing. But over and over we see that sham mindfulness based analgesia is related to slower breathing which provides us this really cool distinct process where kind of this perspective where mindfulness is engaging higher order top down type processes to assuage pain while sham mindfulness may be engaging this more bottom up type response to assuage pain.

I'm going to move on to some other new work, and this is in great collaboration with the lovely Tor Wager, and he's developed, with Marta and Woo, these wonderful signatures, these machine learned multivariate pattern signatures that are remarkably accurate at predicting pain over I think like 98, 99 percent.

His seminal paper, the Neurological Pain Signature, was published in the New England Journal of Medicine that showed that these signatures can predict nociceptive specific, in particular, for this particular, thermal heat pain with incredible accuracy.

And it's not modulated by placebo or affective components, per se. And then the SIIPS is a machine learned signature that is, as they put it, associated with cerebral contributions to pain. But if you look at it closely, these are markers that are highly responsive to the placebo response.

So the SIIPS can be used -- he has this beautiful pre print out, showing that it does respond with incredible accuracy to placebo, varieties of placebo.

So we used this MVPA to see if meditation engages signature supporting placebo responses.

And then Marta Ceko's latest paper with Tor published in Nature and Neuro found that the negative affect of signature predicts pain responses above and beyond nociceptive related processes. So this is pain related to negative affect, which again contributes to the multimodal processing of pain and how now we could use these elegant signatures to kind of disentangle which components of pain meditation and other techniques assuage. Here's the design.

We had 40 -- we combined two studies. One with bold and one with ASL. So this would be the first ASL study with signatures, with these MVPA signatures.

And we had the mindfulness interventions that I described before, the book listing interventions I described before and a placebo cream intervention which I'll describe now, all in response to 49 degrees thermal stimuli.

So across again all of our studies we use the same methods. And the placebo group -- I'll try to be quick about this -- this is kind of a combination of Luana Colloca, Don Price and Tor's placebo conditioning interventions where we administer 49 degrees -- we tell our participants that we're testing a new form of lidocaine, and the reason that it's new is that the more applications of this cream, the stronger the analgesia.

And so in the conditioning sessions, they come in, administer 49 degrees, apply and remove this cream, which is just petroleum jelly after 10 minutes, and then we covertly reduce the temperature to 48.

And then they come back in in session two and three, after 49 degrees and removing the cream, we lower the temperature to 47. And then on the last conditioning session, after we remove the cream, we lower the temperature to 46.5, which is a qualitatively completely different experience than 49.

And we do this to lead our participants to believe that the cream is actually working.

And then in a post intervention MRI session, after we remove the cream, we don't modulate the temperature, we just keep it at 49, and that's how we measured placebo in these studies. And then so here, again -- oops -- John Dean and Gabe are coleading this project.

Here, pain intensity on this axis, pain unpleasantness on that axis, controls from the beginning of the scan to the end of the scan significantly go up in pain.

Placebo cream was effective at reducing intensity and unpleasantness, but we see mindfulness meditation was more effective than all the conditions at reducing pain. The signatures, we see that the nociceptive specific signature, the controls go up in pain here.

No change in the placebo and mindfulness meditation you can see here produces a pretty dramatic reduction in the nociceptive specific signature.

The same is true for the negative affective pain signature. Mindfulness meditation uniquely modifies this signature as well which I believe this is one of the first studies to show something like this.

But it does not modulate the placebo signature. What does modulate the placebo signature is our placebo cream, which is a really nice manipulation check for these signatures.

So here, taken together, we show that mindfulness meditation, again, is engaging multiple processes and is reducing pain by directly assuaging nociceptive specific markers as well as markers supporting negative affect but not modulating placebo related signatures, providing further credence that it's not a placebo type response, and we're also demonstrating this granularity between a placebo mechanism that's not being shared by another active mechanism. While we all assume that active therapies and techniques are using a shared subset of mechanisms or processes with placebo, here we're providing accruing evidence that mindfulness is separate from a placebo.

I'll try to be very quick on this last part. This is all not technically related placebo, but I would love to hear everyone's thoughts on these new data we have.

So as we've seen elegantly that pain relief by placebo, distraction, acupuncture, transcranial magnetic stimulation, prayer, are largely driven by endogenous opioidergic release. And, yes, there are other systems. A prime other system is the (indiscernible) system, serotonergic system, dopamine. The list can go on. But it's considered by most of us that the endogenous opioidergic system is this central pain modulatory system.

And the way we do this is by antagonizing endogenous opioids by employing incredibly high administration dosage of naloxone.

And I think this wonderful paper by Ciril Etnes's (phonetic) group provides a nice primer on the appropriate dosages for naloxone to antagonize opiates. And I think a lot of the discussions here where we see differences in naloxone responses are really actually reflective of differences in dosages of naloxone.

It metabolizes so quickly that I would highly recommend a super large bolus with a maintenance infusion IV.

And we've seen this to be a quite effective way to block endogenous opioids. And across four studies now, we've seen that mindfulness based pain relief is not mediated by endogenous opioids. It's something else. We don't know what that something else is but we don't think it's endogenous opioids. But what if it's sex differences that could be driving these opioidergic versus non opioid opioidergic differences?

We've seen that females require -- exhibit higher rates of chronic pain than males. They are prescribed opiates at a higher rate than men. And when you control for weight, they require higher dosages than men. Why?

Well, there's excellent literature in rodent models and preclinical models that demonstrate that male rodents versus female -- male rodents engage endogenous opioids to reduce pain but female rodents do not.

And this is a wonderful study by Ann Murphy that basically shows that males, in response to morphine, have a greater latency and paw withdrawal when coupled with morphine and not so much with females.

But when you add naloxone to the picture, with morphine, the latency goes down. It basically blocks the analgesia in male rodents but enhances analgesia in female rodents.

We basically asked -- we basically -- Michaela, an undergraduate student doing an odyssey thesis asked this question: Are males and females in humans engaging in distinct systems to assuage pain?

She really took off with this and here's the design. We had heat, noxious heat in the baseline.

CRISTINA CUSIN: Doctor, you have one minute left. Can you wrap up?

FADEL ZEIDAN: Yep. Basically we asked, are there sex differences between males and females during meditation in response to noxious heat? And there are.

Baseline, just change in pain. Green is saline. Red is naloxone. You can see that with naloxone onboard, there's greater analgesia in females, and we reversed the analgesia. Largely, there's no differences between baseline in naloxone in males, and the males are reducing pain during saline.

We believe this is the first study to show something like this in humans. Super exciting. It also blocked the stress reduction response in males but not so much in females. Let me just acknowledge our funders. Some of our team. And I apologize for the fast presentation. Thank you.

CRISTINA CUSIN: Thank you so much. That was awesome.

We're a little bit on short on time.

I suggest we go into a short break, ten minute, until 1:40. Please continue to add your questions in Q&A. Our speakers are going to answer or we'll bring some of those questions directly to the discussion panel at the end of the session today. Thank you so much.

Measuring & Mitigating the Placebo Effect (continued)

CRISTINA CUSIN: Hello, welcome back. I'm really honored to introduce our next speaker, Dr. Marta Pecina. And she's going to talk about mapping expectancy-mood interactions in antidepressant placebo effects. Thank you so much.

MARTA PECINA: Thank you, Cristina. It is my great pleasure to be here. And just I'm going to switch gears a little bit to talk about antidepressant placebo effects. And in particular, I'm going to talk about the relationship between acute expectancy-mood neural dynamics and long-term antidepressant placebo effects.

So while we all know that depression is a very prevalent disorder, and just in 2020, Major Depressive Disorder affected 21 million adults in the U.S. and 280 million adults worldwide. And current projections indicate that by the year 2030 it will be the leading cause of disease burden globally.

Now, response rates to first-line treatments, antidepressant treatments are approximately 50%. And complete remission is only achieved in 30 to 35% of individuals. Also, depression tends to be a chronic disorder with 50% of those recovering from a first episode having an additional episode. And 80% of those with two or more episodes having another recurrence.

And so for patients who are nonresponsive to two intervention, remission rates with subsequent therapy drop significantly to 10 to 25%. And so, in summary, we're facing a disorder that is very resistant or becomes resistant very easily. And in this context, one would expect that antidepressant placebo effects would actually be low. But we all know that this is not the case. The response rate to placebos is approximately 40% compared to 50% response rates to antidepressants. And obviously this varies across studies.

But what we do know and learned yesterday as well is that response rates to placebos have increased approximately 7% over the last 40 years. And so these high prevalence of placebo response in depressions have significantly contributed to the current psychopharmacology crisis where large pharma companies have reduced at least in half the number of clinical trials devoted to CNS disorders.

Now, antidepressant placebo response rates among individuals with depression are higher than in any other psychiatric condition. And this was recently published again in this meta-analysis of approximately 10,000 psychiatric patients. Now, other disorders where placebo response rates are also prevalent are generalized anxiety disorder, panic disorders, HDHC or PTSD. And maybe less frequent, although still there, in schizophrenia or OCD.

Now, importantly, placebo effects appear not only in response to pills but also surgical interventions or devices, as it was also mentioned yesterday. And this is particularly important today where there is a very large development of device-based interventions for psychiatric conditions. So, for example, in this study that also was mentioned yesterday of deep brain stimulation, patients with resistant depression were assigned to six months of either active or some pseudo level DBS. And this was followed by open level DBS.

As you can see here in this table, patients from both groups improved significantly compared to baseline, but there were no significant differences between the two groups. And for this reason, DBS has not yet been approved by the FDA for depression, even though it's been approved for OCD or Parkinson's disease as we all know.

Now what is a placebo effect, that's one of the main questions of this workshop, and how does it work from a clinical neuroscience perspective? Well, as it's been mentioned already, most of what we know about the placebo effect comes from the field of placebo analgesia. And in summary, classical theories of the placebo effect have consistently argued that placebo effects results from either positive expectancies regarding the potential beneficial effects of a drug or classical conditioning where the pairing of a neutral stimulus, in this case the placebo pill, with an unconditioned stimulus, in this case the active drug, results in a conditioned response.

Now more recently, theories of the placebo effect have used computational models to predict placebo effects. And these theories posit that individuals update their expectancies as new sensory evidence is accumulated by signaling the response between what is expected and what is perceived. And this information is then used to refine future expectancies. Now these conceptual models have been incorporated into a trial-by-trial manipulation of both expectancies of pain relief and pain sensory experience. And this has rapidly advanced our understanding of the neural and molecular mechanisms of placebo analgesia.

And so, for example, in these meta analytic studies using these experiments they have revealed really two patterns of distinct activations with decreases in brain activity in regions involving brain processing such as the dorsal medial prefrontal cortex, the amygdala and the thalamus; and increases in brain activity in regions involving effective appraisal, such as the vmDFC, the nucleus accumbens, and the PAG.

Now what happens in depression? Well, in the field of antidepressant placebo effects, the long-term dynamics of mood and antidepressant responses have not allowed us to have such trial-by-trial manipulation of expectancies. And so instead researchers have used broad brain changes in the context of a randomized control trial or a placebo lead-in phase which has, to some extent, limited the progress of the field.

Now despite these methodological limitations of these studies, they provide important insights about the neural correlates of antidepressant placebo effects. In particular, from studies -- two early on studies we can see the placebo was associated with increased activations broadly in cortical regions and decreased activations in subcortical regions. And these deactivations in subcortical regions were actually larger in patients who were assigned to an SSRI drug treatment.

We also demonstrated that there is similar to pain, antidepressant placebo effects were associated with enhanced endogenous opiate release during placebo administration, predicting the response to open label treatment after ten weeks. And we have also -- we and others have demonstrated that increased connectivity between the salience network and the rostral anterior cingulate during antidepressant placebo effects can actually predict short-term and long-term placebo effects.

Now an important limitation, and as I already mentioned, is that this study is basically the delay mechanism of action of common antidepressant and this low dynamics of mood which really limit the possibility of actively manipulating antidepressant expectancies.

So to address this important gap, we develop a trial-by-trial manipulation of antidepressant expectancies to be used inside of the scanner. And the purpose was really to be able to further disassociate expectancy and mood dynamics during antidepressant placebo effects.

And so the basic structure of this test involved an expectancy condition where subjects are presented with a four-second infusion cue followed by an expectancy rating cue, and a reinforcement condition which consist of 20 seconds of some neurofeedback followed by a mood rating cue. Now the expectancy and the reinforcement condition map onto the classical theories of the placebo effect that I explained earlier.

During the expectancy condition, the antidepressant infusions are compared to periods of calibration where no drug is administered. And during the reinforcement condition, on the other hand, some neurofeedback of positive sign 80% of the time as compared to some neurofeedback of baseline sign 80% of the time. And so this two-by-two study design results in four different conditions. The antidepressant reinforced, the antidepressant not reinforced, the calibration reinforced, and the calibration not reinforced.

And so the cover story is that we tell participants that we are testing the effects of a new fast-acting antidepressant compared to a conventional antidepressant, but in reality, they are both saline. And then we tell them that they will receive multiple infusions of these drugs inside of the scanner while we record their brain activity which we call neurofeedback. So then patients learn that positive neurofeedback compared to baseline is more likely to cause mood improvement. But they are not told that the neurofeedback is simulated.

Then we place an intravenous line for the administration of the saline infusion, and we bring them inside of the scanner. For these kind of experiments we recruit individuals who are 18 through 55 with or without anxiety disorders and have a HAMD depression rating scale greater than 16, consistent with moderate depression. They're antidepressant medication free for at least 25 -- 21 days and then we use consenting procedures that involve authorized deception.

Now, as suspected, behavioral results during this test consistently show that antidepressant expectancies are higher during the antidepressant infusions compared to the calibration, especially when they are reinforced by positive sham neurofeedback. Now mood responses also are significantly higher during positive sham neurofeedback compared to baseline. But this is also enhanced during the administration of the antidepressant infusions.

Now interestingly, these effects are moderated by the present severity such that the effects of the test conditions and the expectancies and mood ratings are weaker in more severe depression even though their overall expectancies are higher, and their overall mood are lower.

Now at a neuron level, what we see is that the presentation of the infusion cue is associated with an increased activation in the occipital cortex and the dorsal attention network suggesting greater attention processing engaged during the presentation of the treatment cue. And similarly, the reinforcement condition revealed increased activations in the dorsal attention network with additional responses in the ventral striatum suggesting that individuals processed the sham positive neurofeedback cue as rewarding.

Now an important question for us was now that we can manipulate acute placebo -- antidepressant placebo responses, can we use this experiment to understand the mechanisms implicated in short-term and long-term antidepressant placebo effects. And so as I mentioned earlier, there was emerging evidence suggesting that placebo analgesic could be explained by computational models, in particular reinforcement learning.

And so we tested the hypothesis that antidepressant placebo effects could be explained by similar models. So as you know, under these theories, learning occurs when an experienced outcome differs from what is expected. And this is called the prediction error. And then the expected value of the next possible outcome is updated with a portion of this prediction error as reflected in this cue learning rule.

Now in the context of our experiment, model predicted expectancies for each of the four trial conditions would be updated every time the antidepressant or the calibration infusion cue is presented and an outcome, whether positive or baseline neurofeedback, is observed based on a similar learning rule.

Now this basic model was then compared against two alternative models. One which included differential learning rates to account for the possibility that learning would depend on whether participants were updating expectancies for the placebo or the calibration. And then an additional model to account for the possibility that subjects were incorporating positive mood responses as mood rewards.

And then finally, we constructed this additional model to allow the possibility of the combination of models two and three. And so using patient model comparison, we found that the model -- the fourth model, model four which included a placebo bias learning in our reinforcement by mood dominated all the other alternatives after correction for patient omnibus risk.

Now we then map the expected value and reward predictions error signals from our reinforcement learning models into our raw data. And what we found was that expected value signals map into the salience network raw responses; whereas reward prediction errors map onto the dorsal attention network raw responses. And so all together, the combination of our model-free and model-based results reveal that the processing of the antidepressant in patient cue increase activation in the dorsal attention network; whereas, the encoding of the expectancies took place in the salience network once salience had been attributed to the cue.

And then furthermore, we demonstrated that the reinforcement learning model predicted expectancies in coding the salience network triggered mood changes that are perceived as reward signals. And then these mood reward signals further reinforce antidepressant expectancies through the information of expectancy mood dynamics defined by models of reinforcement learning, an idea that could possibly contribute to the formation of long-lasting antidepressant placebo effects.

And so the second aim was really -- was going to look at these in particular how to use behavioral neuroresponses of placebo effects to predict long-term placebo effects in the context of a clinical trial. And so our hypothesis was that during placebo administration greater salient attribution to the contextual cue in the salience network would transfer to regions involved in mood regulation to induce mood changes. So in particular we hypothesized that the DMN would play a key role in belief-induced mood regulation.

And why the DMN? Well, we knew that activity in the rostral anterior cingulate, which is a key node of the DMN, is a robust predictor of mood responses to both active antidepressant and placebos, implying its involvement in nonspecific treatment response mechanisms. We also knew that the rostral anterior cingulate is a robust predicter of placebo analgesia consistent with its role in cognitive appraisals, predictions and evaluation. And we also had evidence that the SN to DMN functional connectivity appears to be a predictor of placebo and antidepressant responses over ten weeks of treatment.

And so in our clinical trial, which you can see the cartoon diagram here, we randomized six individuals to placebo or escitalopram 20 milligrams. And this table is just to say there were no significant differences between the two groups in regard to the gender, race, age, or depression severity. But what we found interesting is that there were also no significant differences in the correct belief assignment with 60% of subjects in each group approximately guessing that they were receiving escitalopram.

Now as you can see here, participants showed lower MADR scores at eight weeks in both groups. But there was no significant differences between the two groups. However, when split in the two groups by the last drug assignment belief, subjects with the drug assignment belief improved significantly compared to those with a placebo assignment belief.

And so the next question was can we use neuroimaging to predict these responses? And what we found was at a neural level during expectancy process the salience network had an increased pattern of functional connectivity with the DMN as well as with other regions of the brainstem including the thalamus. Now at the end -- we also found that increased SN to DMN functional connectivity predicted expectancy ratings during the antidepressant placebo fMRI task such that higher connectivity was associated with greater modulation of the task conditions on expectancy ratings.

Now we also found that enhanced functional connectivity between the SN and the DMN predicted the response to eight weeks of treatment, especially on individuals who believed that they were of the antidepressant group. Now this data supports that during placebo administration, greater salient attributions to the contextual cue is encoded in the salience network; whereas belief-induced mood regulation is associated with an increased functional connectivity between the SN and DMN and altogether this data suggest that enhancements to DMN connectivity enables the switch from greater salient attribution to the treatment cue to DMN-mediated mood regulation.

And so finally, and this is going to be brief, but the next question for us was can we modulate these networks to actually enhance placebo-related activity. And in particular, we decided to use theta burst stimulation which can potentiate or depotentiate brain activity in response to brief periods of stimulation. And so in this study participants undergo three counterbalance sessions of TBS with either continuous, intermittent, or sham known to depotentiate, potentiate, and have no effect.

So each TBS is followed by an fMRI session during the antidepressant placebo effect task which happens approximately an hour after stimulation. The inclusive criteria are very similar to all of our other studies. And our pattern of stimulation is pretty straightforward. We do two blocks of TBS. And during the first block stimulation intensity is gradually escalated in 5% increments in order to enhance tolerability. And during the second session the stimulation is maintained constant at 80% of the moderate threshold.

Then we use the modified cTBS session consisting of three stimuli applied at intervals of 30 hertz. We first repeat it at 6 hertz for a total of 600 stimuli in a continuous train of 33.3 seconds. Then we did the iTBS session consist of a burst of three stimuli applied at intervals of 50 hertz with bursts repeated at 5 hertz for a total of 600 stimulus during 192 seconds. We also use a sham condition where 50% of subjects are assigned to sham TBS simulating the iTBS stimulus pattern, and 50% are assigned to sham TBS simulating the cTBS pattern.

Now our target is the DMN which is the cortical target for the dorsal medial -- the cortical target for the DMN -- sorry, the dmPFC which is the cortical target for the DMN. And this corresponds to the -- and we found these effects based on the results from the antidepressant placebo fMRI task.

And so this target corresponds to our neurosynth scalp which is located 30% of the distance from the nasion-to-inion forward from the vertex and 5% left which corresponds to an EEG location of F1. And the connectivity map of these regions actually result in activation of the DMN. Now we can also show here the E-Field map of this target which basically demonstrates supports a nice coverage of the DMN.

And so what we found here is that the iTBS compared to sham and cTBS enhances the effect of the reinforcement condition of mood responses. And we also found that at a neural level iTBS compared to cTBS shows significant greater bold responses during expectancy processing within the DMN with sham responses in the middle but really not significantly different from iTBS. Now, increased bold responses in the ventral medial prefrontal cortex were associated with a greater effect of the task conditions of mood responses.

And so all together our results suggest that first trial-by-trial modulation of antidepressant expectancies effectively disassociates expectancy mood dynamics. Antidepressant expectancies are predicted by models of reinforcement learning and they're encoded in the salience network. We also showed that enhanced SN to DMN connectivity enables the switch from greater salient attribution to treatment cues to DMN-mediated mood regulation, contributing to the formation of acute expectancy-mood interactions and long-term antidepressant placebo effects. And iTBS potentiation of the DMN enhances placebo-induced mood responses and expectancy processing.

With this, I would just like to thank my collaborators that started this work with me at the University of Michigan and mostly the people in my lab and collaborators at the University of Pittsburgh as well as the funding agencies.

CRISTINA CUSIN: Wonderful presentation. Really terrific way of trying to untangle different mechanism in placebo response in depression, which is not an easy feat.

There are no specific questions in the Q&A. I would encourage everybody attending the workshop to please post your question to the Q&A. Every panelist can answer in writing. And then we will answer more questions during the discussion, but please don't hesitate.

I think I will move on to the next speaker. We have only a couple of minutes so we're just going to move on to Dr. Schmidt. Thank you so much. We can see your slides. We cannot hear you.

LIANE SCHMIDT: Can you hear me now?

CRISTINA CUSIN: Yes, thank you.

LIANE SCHMIDT: Thank you. So I'm Liane Schmidt. I'm an INSERM researcher and team leader at the Paris Brain Institute. And I'm working on placebo effects but understanding the appetitive side of placebo effects. And what I mean by that I will try to explain to you in the next couple of slides.

NIMH Staff: Can you turn on your video?

LIANE SCHMIDT: Sorry?

NIMH Staff: Can you please turn on your video, Dr. Schmidt?

LIANE SCHMIDT: Yeah, yes, yes, sorry about that.

So it's about the appetitive side of placebo effects because actually placebo effects on cognitive processes such as motivation and biases and belief updating because these processes actually play also a role when patients respond to treatment. And when we measure placebo effects, basically when placebo effects matter in the clinical setting.

And this is done at the Paris Brain Institute. And I'm working also in collaboration with the Pitie-Salpetriere Hospital Psychiatry department to get access to patients with depression, for example.

So my talk will be organized around three parts. On the first part, I will show you some data about appetitive placebo effects on taste pleasantness, hunger sensations and reward learning. And this will make the bridge to the second part where I will show you some evidence for asymmetrical learning biases that are more tied to reward learning and that could contribute actually or can emerge after fast-acting antidepressant treatment effects in depression.

And why is this important? I will try to link these two different parts, the first and second part, in the third part to elaborate some perspectives on the synergies between expectations, expectation updating through learning mechanisms, motivational mechanisms, motivational processes and drug experiences and which we can -- might harness actually by using computational models such as, for example, risk-reward Wagner models as Marta just showed you all the evidence for this in her work.

The appetitive side of placebo effects is actually known very well from the field of research in consumer psychology and marketing research where price labels, for example, or quality labels can affect decision-making processes and also experiences like taste pleasantness experience. And since we are in France, one of the most salient examples for these kind of effects comes from wine tasting. And many people have shown -- many studies have shown that basically the price of wine can influence how pleasant it tastes.

And we and other people have shown that this is mediated by activation in what is called the brain valuation systems or regions that encode expected and experienced reward. And one of the most prominent hubs in this brain valuation system is the ventral medial prefrontal cortex, what you see here on the SPM on the slide. That can explain, that basically translates these price label effects on taste pleasantness liking. And what is interesting is also that its sensitivity to monetary reward, for example, obtaining by surprise a monetary reward. It activates, basically the vmPFC activates when you obtain such a reward surprisingly.

And the more in participants who activate the vmPFC more in these kind of positive surprises, these are also the participants in which the vmPFC encoded more strongly the difference between expensive and cheap wines, which makes a nice parallel to what we know from placebo hyperalgesia where it has also been shown that the sensitivity of the reward system in the brain can moderate placebo analgesia with participants with higher reward sensitivity in the ventral striatum, for example, another region showing stronger placebo analgesia.

So this is to basically hope to let you appreciate that these effects parallel nicely what we know from placebo effects in the pain and also in disease. So we went further beyond actually, so beyond just taste liking which is basically experiencing rewards such as wine. But what could be -- could placebos also affect motivational processes per se? So when we, for example, want something more.

And one way to study is to study basic motivation such as, for example, hunger. It is long thought, for instance, eating behavior that is conceptualized to be driven by homeostatic markers, hormone markers such as Ghrelin and Leptin that signal satiety and energy stores. And as a function of these different hormonal markers in our blood, we're going to go and look for food and eat food. But we also know from the placebo effects on taste pleasantness that there is a possibility that our higher order beliefs about our internal states not our hormones can influence whether we want to eat food, whether we engage in these types of very basic motivations. And that we tested that, and other people also, that's a replication.

In the study where we gave healthy participants who came into the lab in a fasted state a glass of water. And we told them well, water sometimes can stimulate hunger by stimulating the receptors in your mouth. And sometimes you can also drink a glass of water to kill your hunger. And a third group, a control group was given a glass of water and told it's just water; it does nothing to hunger. And then we asked them to rate how hungry they feel over the course of the experiment. And it's a three-hour experiment. Everybody has fasted. And they have to do this food choice task in an fMRI scanner so they get -- everybody gets hungry over this three hours.

But what was interesting and what you see here on this rain cloud plot is that participants who believed or drank the water suggested to be a hunger killer increased in their hunger rating less than participants who believed the water will enhance their hunger. So this is a nice replication what we already know from the field; other people have shown this, too.

And the interesting thing is that it also affected this food wanting, this motivational process how much you want to eat food. So when people laid there in the fMRI scanner, they saw different food items, and they were asked whether they want to eat it or not for real at the end of the experiment. So it's incentive compatible. And what you see here is basically what we call stimulus value. So how much do you want to eat this food.

And the hunger sensation ratings that I just showed you before parallel what we find here. The people in the decreased hunger suggestion group wanted to eat the food less than in the increased hunger suggestion group, showing that it is not only an effect on subjective self-reports or how you feel your body signals about hunger. It's also about what you would actually prefer, what your subjective preference of food that is influenced by the placebo manipulation. And it's also influencing how your brain valuation system again encodes the value for your food preference. And that's what you see on this slide.

Slide two, you see the ventral medial prefrontal cortex. The yellow boxes that the more yellow they are, the stronger they correlate to your food wanting. And you see on the right side with the temporal time courses of the vmPFC that that food wanting encoding is stronger when people were on the increased hunger suggestion group than in the decreased hunger suggestion group.

So basically what I've showed you here is three placebo effects. Placebo effects on subjective hunger ratings, placebo effects on food choices, and placebo effects on how the brain encodes food preference and food choices. And you could wonder -- these are readouts. So these are behavioral readouts, neural readouts. But you could wonder what is the mechanism behind? Basically what is in between the placebo intervention here and basically the behavior feed and neural readout of this effect.

And one snippet of the answer to this question is when you look at the expectation ratings. For example, expectations have long been shown to be one of the mediators, the cognitive mediators of placebo effects across domains. And that's what we see here, too. Especially in the hunger killer suggestion group. The participants who believed that the hunger -- that the drug will kill their hunger more strongly were also those whose hunger increased less over the course of the experiment experience.

And this moderated activity in the region that you see here, which is called the medial prefrontal cortex, that basically activated when people saw food on the screen and thought about whether they want to eat it or not. And this region activated by that activity was positively moderated by the strength of the expectancy about the glass of water to decrease their hunger. So the more you expect that the water will decrease your hunger, the more the mPFC activates when you see food on the screen.

It's an interesting brain region because it's right between the ventral medial prefrontal cortex that encodes the value, the food preference, and the dorsal lateral prefrontal cortex. And it has been shown by past research to connect to the vmPFC when participants self-control, especially during food decision-making paradigms.

But another mechanism or another way to answer the question about the mechanism of how the placebo intervention can affect this behavior in neural effects is to use computational modelings to better understand the preference formation -- the preference formation basically. And one way is that -- is drift diffusion modeling. So these drift diffusion models come from perceptual research for understanding perception. And they are recently also used to better understand preference formation. And they assume that your preference for a yes or no food choice, for example, is a noisy accumulation of evidence.

And there are two types of evidence you accumulate in these two -- in these decision-making paradigms is basically how tasty and how healthy food is. How much you like the taste, how much you consider the health. And this could influence this loop of your evidence accumulation how rapidly basically you reach a threshold towards yes or no.

It could also be that the placebo and the placebo manipulation could influence this loop. But the model loops test several other hypotheses. It could be that the placebo intervention basically affected also just the threshold like that reflects how carefully you made the decision towards a yes or no choice. It could be your initial bias; that is, basically initially you were biased towards a yes or a no response. Or it could be the nondecision time which reflects more sensory motor integration.

And the answer to this question is basically that three parameters were influenced by the placebo manipulation. Basically how much you integrated healthiness and tastiness in your initial starting bias. So you paid more attention to the healthiness when you believed that you were on a hunger killer. And more the tastiness when you believed that you were on a hunger enhancer. And similarly, you were initially biased towards accepting food more when participants believed they were on a hunger enhancer than on a hunger killer.

Interestingly, so this basically shows that this decision-making process is biased by the placebo intervention and basically also how much you filter information that is most relevant. When you are hungry, basically taste is very relevant for your choices. When you are believing you are less hungry, then you have more actually space or you pay less attention to taste, but you can also pay attention more to healthiness of food.

And so the example that shows that this might be a filtering of expectation-relevant information is to use psychophysiologic interaction analyzers that look basically at the brain activity in the vmPFC, that's our seed region. Where in the brain does it connect when people, when participants see food on a computer screen and have to think about whether they want to eat this food or not?

And what we observed there that's connected to the dlPFC, the dorsal lateral prefrontal cortex region. And it's a region of interest that we localized first to be sure it is actually a region that is inter -- activating through an interference resolution basically when we filter -- have to filter information that is most relevant to a task in a separate Stroop localizer task.

So the vmPFC connects stronger to this dlPFC interference resolution region and this is moderated especially in the decreased hunger suggestion group by how much participants considered the healthiness against the tastiness of food.

To wrap this part up, it's basically that we replicated findings from previous studies about appetitive placebo effects by showing that expectancies about efficiency of a drink can affect hunger sensations. How participants make -- form their food preferences, make food choices. And value encoding in the ventral medial prefrontal cortex.

But we also provided evidence for underlying neurocognitive mechanisms that involve the medial prefrontal cortex that is moderated by the strengths of the hunger expectation. That the food choice formation is biased in the form of attention-filtering mechanism toward expectancy congruent information that is taste for an increased hunger suggestion group, and healthiness for a decreased hunger suggestion group. And this is implemented by regions that are linked to interference resolution but also to valuation preference encoding.

And so why should we care? In the real world, it is not very relevant to provide people with deceptive information about hunger-influencing ingredients of drinks. But studies like this one provide insights into cognitive mechanisms of beliefs about internal states and how these beliefs can affect the interoceptive sensations and also associated motivations such as economic choices, for example.

And this can actually also give us insights into the synergy between drug experiences and outcome expectations. And that could be harnessed via motivational processes. So translated basically via motivational processes. And then through it maybe lead us to better understand active treatment susceptibility.

And I'm going to elaborate on this in the next part of the talk by -- I'm going a little bit far, coming a little bit far, I'm not talking about or showing evidence about placebo effects. But yes -- before that, yes, so basically it is.

Links to these motivational processes have long been suggested actually to be also part of placebo effects or mechanisms of placebo effect. And that is called the placebo-reward hypothesis. And that's based on findings in Parkinson's disease that has shown that when you give Parkinson's patients a placebo but tell them it's a dopaminergic drug, then you can measure dopamine in the brain. And the dopamine -- especially the marker for dopamine, its binding potential decreases. That is what you see here on this PET screen -- PET scan results.

And that suggests that the brain must have released endogenous dopamine. And dopamine is very important for expectations and learning. Basically learning from reward. And clinical benefit is the kind of reward that patients expect. So it might -- it is possible that basically when a patient expects reward clinical benefit, its brain -- their brain releases dopamine in remodulating that region such as the vmPFC or the ventral striatum.

And we have shown this in the past that the behavioral consequence of such a nucleus dopamine release under placebo could be linked to reward learning, indeed. And what we know is that, for example, that Parkinson patients have a deficit in learning from reward when they are off dopaminergic medication. But this normalizes when they are under active dopaminergic medication.

So we wondered if based on these PET studies under placebo, the brain releases dopamine, does this also have behavior consequences on their reward learning ability. And that is what you see here on the screen on the right side on the screen is that the Parkinson patients basically tested on placebo shows similar reward learning abilities as under active drug.

And this again was also underpinned by increased correlation of the ventral medial prefrontal cortex. Again, this hub of the brain valuation system to the learned reward value. That was stronger in the placebo and active drug condition compared to baseline of drug condition.

And I want to make now this -- a link to another type of disease where also the motivation is deficitary, and which is depression. And depression is known to be maintained or is sympathized to be maintained by this triad of very negative beliefs about the world, the future and one's self. Which is very insensitive to belief disconfirming information, especially if the belief disconfirming information is positive, so favorable. And this has been shown by cognitive neuroscience studies to be reflected by a thought of like of good news/bad news bias or optimism biases and belief updating in depression. And this good news/bad news bias is basically a bias healthy people have to consider favorable information that contradicts initial negative beliefs more than negative information.

And this is healthy because it avoids reversing of beliefs. And it also includes a form of motivational process because good news have motivational salience. So it should be more motivating to update beliefs about the future, especially if these beliefs are negative, then when we learn that our beliefs are way too negative and get information about that disconfirms this initial belief. But depressed patients, they like this good news/bad news bias. So we wonder what happens when patients respond to antidepressant treatments that give immediate sensory evidence about being on an antidepressant.

And these new fast-acting antidepressants such as Ketamine, these types of antidepressants that patients know right away whether they got the treatment through dissociative experiences. And so could it be that this effect or is it a cognitive model of depression. So this was the main question of the study. And then we wondered again what is the computational mechanism. And is it linked again also, as shown in the previous studies, to reward learning mechanisms, so biased updating of beliefs. And is it linked to clinical antidepressant effects and also potentially outcome expectations makes the link to placebo effects.

So patients were given the -- were performing a belief updating task three times before receiving Ketamine infusions. And then after first infusion and then one week after the third infusion, each time, testing time we measured the depression with the Montgomery-Asberg Depression Rating Scale. And patients performed this belief updating task where they were presented with different negative life events like, for example, getting a disease, losing a wallet here, for example.

And they were asked to estimate their probability of experiencing this life event in the near future. And they were presented with evidence about the contingencies of this event in the general population, what we call the base rate. And then they had the possibility to update their belief knowing now the base rate.

And this is, for example, a good news trial where participants initially overestimated the chance for losing a wallet and then learn it's much less frequent than they initially thought. Updates, for example, 15%. And in a bad news trial, it's you initially underestimated your probability of experiencing this adverse life event. And if you have a good news/bad news bias, well, you're going to consider this information to a lesser degree than in a good news trial.

And that's what -- exactly what happens in the healthy controls that you see on the left most part of the screen. I don't know whether you can see the models, but basically we have the belief updating Y axis. And this is healthy age-matched controls to patients. And you can see updating of the good news. Updating of the bad news. We tested the participants more than two times within a week. You can see the bias. There is a bias that decreases a little bit with more sequential testing in the healthy controls. But importantly, in the patients the bias is there although before Ketamine treatment.

But it becomes much more stronger after Ketamine treatment. It emerged basically. So patients become more optimistically biased after Ketamine treatment. And this correlates to the MADRS scores. Patients who improve more with treatment are also those who show a stronger good news/bad news bias after one week of treatment.

And we wondered again about the computational mechanisms. So one way to get at this using a Rescoria-Wagner model reward reinforcement learning model that basically assumes that updating is proportional to your surprise which is called the estimation error.

The difference between the initial estimate and the base rate. And this is weighted by learning rate. And the important thing here is the learning rate has got two components, a scaling parameter and an asymmetry parameter. And the asymmetry parameter basically weighs in how much the learning rate varies after good news, after positive estimation error, than after negative estimation errors.

And what we can see that in healthy controls, there is a stronger learning rate for positive estimation errors and less stronger for negative estimation errors translating this good news/bad news bias. It's basically an asymmetrical learning mechanism. And in the patients, the asymmetrical learning is non-asymmetrical before Ketamine treatment. And it becomes asymmetrical as reflected in the learning rates after Ketamine treatment.

So what we take from that is basically that Ketamine induced an optimism bias. But an interesting question is whether -- basically what comes first. Is it basically the improvement in the depression that we measured with the Montgomery-Asberg Depression Rating Scale, or is it the optimism bias that emerged and that triggered basically. Since it's a correlation, we don't know what comes first.

And an interesting side effect or aside we put in the supplement was that in 16 patients, it's a very low sample size, the expectancy about getting better also correlated to the clinical improvement after Ketamine treatment. We have two expectancy ratings here about the efficiency about Ketamine and also what patients expect their intensity of depression will be after Ketamine treatment.

And so that suggested the clinical benefit is kind of in part or synergistically seems to interact with the drug experience that emerges that generates an optimism bias. And to test this more, we continued data collection just on the expectancy ratings. And basically wondered how the clinical improvement after first infusion links to the clinical improvement after third infusion.

And we know from here that patients improve after first infusion are also those that improved after a third infusion. But is it mediated by their expectancy about the Ketamine treatment? And that's what we indeed found is that basically the more patients expected to get better, the more they got better after one week of treatment. But it mediated this link between the first drug experience and the later drug experiences and suggested there might not be an additive effect as other panelist members today already put forward today, it might be synergetic link.

And one way to get at these synergies is basically again use computational models. And this idea has been around although yesterday that basically there could be self-fulfilling prophesies that could contribute to the treatment responsiveness and treatment adherence. And these self-fulfilling prophesies are biased symmetrically learning mechanisms that are more biased when you have positive treatment experiences, initial positive treatment experiences, and then might contribute how you adhere to the treatment in the long term and also how much you benefit from it in the long term. So it's both drug experience and an expectancy.

And so this is nonpublished work where we played with this idea basically using a reinforcement learning model. This is also very inspired by we know from placebo analgesia. Tor and Luana Kuven, they have a paper on showing that self-fulfilling prophecies can be harnessed with biased patient and reinforcement learning models. And the idea of these models is that there are two learning rates, alpha plus and alpha minus. And these learning rates rate differently into the updating of your expectation after drug experience.

LIANE SCHMIDT: Okay, yeah, I'm almost done.

So rate differently on these drug experiences and expectations as a function of whether the initial experience was congruent to your expectations. So a positive experience, then a negative one. And here are some simulations of this model. I'm showing this basically that your expectation is getting more updated the more bias, positively biased you are. Then when you are negatively biased. And these are some predictions of the model concerning depression improvement.

To wrap this up, the conclusion about this is that there seems to be asymmetrical learning that can capture self-fulfilling prophesies and could be a mechanism that translates expectations and drug experiences potentially across domains from placebo hypoalgesia to antidepressant treatment responsiveness. And the open question is obviously to challenge these predictions of these models more with empirical data in pain but also in mood disorders as Marta does and as we do also currently at Cypitria where we test the mechanisms of belief updating biases in depression with fMRI and these mathematical models.

And this has a direct link implication because it could help us to better understand how these fast-acting antidepressants work and what makes patients adhere to them and get responses to them. Thank you for your attention. We are the control-interoception-attention team. And thank you to all the funders.

CRISTINA CUSIN: Fantastic presentation. Thank you so much. Without further ado, let's move on to the next speaker. Dr. Greg Corder.

GREG CORDER: Did that work? Is it showing?

GREG CORDER: Awesome, all right. One second. Let me just move this other screen. Perfect. All right.

Hi, everyone. My name is Greg Corder. I'm an Assistant Professor at the University of Pennsylvania. I guess I get to be the final scientific speaker in this session over what has been an amazing two-day event. So thank you to the organizers for also having me get the honor of representing the entire field of preclinical placebo research as well.

And so I'm going to give a bit of an overview, some of my friends and colleagues over the last few years and then tell you a bit about how we're leveraging a lot of current neuroscience technologies to really identify the cell types and circuits building from, you know, the human fMRI literature that's really honed in on these key circuits for expectations, belief systems as well as endogenous antinociceptive symptoms, in particular opioid cell types.

So the work I'm going to show from my lab has really been driven by these two amazing scientists. Dr. Blake Kimmey, an amazing post-doc in the lab. As well as Lindsay Ejoh, who recently last week just received her D-SPAN F99/K00 on placebo circuitry. And we think this might be one of the first NIH-funded animal projects on placebo. So congratulations, Lindsay, if you are listening.

Okay. So why use animals, right? We've heard an amazing set of stories really nailing down the specific circuits in humans leveraging MRI, fMRI, EEG and PET imaging that give us this really nice roadmap and idea of how beliefs in analgesia might be encoded within different brain circuits and how those might change over times with different types of patient modeling or updating of different experiences.

And we love this literature. We -- in the lab we read it in depth as best as we can. And we use this as a roadmap in our animal studies because we can take advantage of animal models that really allow us to dive deep into the very specific circuits using techniques like that on the screen here from RNA sequencing, electrophysiology really showing that those functional measurements in fMRI are truly existent with the axons projecting from one region to another.

And then we can manipulate those connections and projections using things like optogenetics and chemogenetics that allow us really tight temporal coupling to turn cells on and off. And we can see the effects of that intervention in real time on animal behavior. And that's really the tricky part is we don't get to ask the animals do you feel pain? Do you feel less pain? It's hard to give verbal suggestions to animals.

And so we have to rely on a lot of different tricks and really get into the heads of what it's like to be a small prey animal existing in a world with a lot of large monster human beings around them. So we really have to be very careful about how we design our experiments. And it's hard. Placebo in animals is not an easy subject to get into. And this is reflected in the fact that as far as we can tell, there is only 24 published studies to date on placebo analgesia in animal models.

However, I think this is an excellent opportunity now to really take advantage of what has been the golden age of neuroscience technologies exploding in the last 10-15 years to revisit a lot of these open questions about when are opioids released, are they released? Can animals have expectations? Can they have something like a belief structure and violations of those expectations that lead to different types of predictions errors that can be encoded in different neural circuits. So we have a chance to really do that.

But I think the most critical first thing is how do we begin to behaviorally model placebo in these preclinical models. So I want to touch on a couple of things from some of my colleagues. So on the left here, this is a graph that has been shown on several different presentations over the past two days from Benedetti using these tourniquet pain models where you can provide pharmacological conditioning with an analgesic drug like morphine to increase this pain tolerance.

And then if it is covertly switched out for saline, you can see that there is an elevation in that pain tolerance reflective of something like a placebo analgesic response overall. And this is sensitive to Naloxone, the new opioid receptor antagonist, suggesting endogenous opioids are indeed involved in this type of a placebo-like response.

And my colleague, Dr. Matt Banghart, at UCSD has basically done a fantastic job of recapitulating this exact model in mice where you can basically use morphine and other analgesics to condition them. And so if I just kind of dive in a little bit into Matt's model here.

You can have a mouse that will sit on a noxious hot plate. You know, it's an environment that's unpleasant. You can have contextual cues like different types of patterns on the wall. And you can test the pain behavior responses like how much does the animal flick and flinch and lick and bite and protect itself to the noxious hot plate.

And then you can switch the contextual cues, provide an analgesic drug like morphine, see reductions in those pain behaviors. And then do the same thing in the Benedetti studies, you switch out the morphine for saline, but you keep the contextual cues. So the animal has effectively created a belief that when I am in this environment, when I'm in this doctor's office, I'm going to receive something that is going to reduce my perceptions of pain.

And, indeed, Matt sees a quite robust effect here where this sort of placebo response is -- shows this elevated paw withdrawal latency indicating that there is endogenous nociception occurring with this protocol. And it happens, again, pretty robustly. I mean most of the animals going through this conditioning protocol demonstrate this type of antinociceptive behavioral response. This is a perfect example of how we can leverage what we learn from human studies into rodent studies for acute pain.

And this is also really great to probe the effects of placebo in chronic neuropathic pain models. And so here this is Dr. Damien Boorman who was with Professor Kevin Key in Australia, now with Lauren Martin in Toronto.

And here Damien really amped up the contextual cues here. So this is an animal who has had an injury to the sciatic nerve with this chronic constriction injury. So now this animal is experiencing something like a tonic chronic neuropathic pain state. And then once you let the pain develop, you can have the animals enter into this sort of placebo pharmacological conditioning paradigm where animals will go onto these thermal plates, either hot or cool, in these rooms that have a large amount of visual tactile as well as odorant cues. And they are paired with either morphine or a controlled saline.

Again, the morphine is switched for saline on that last day. And what Damien has observed is that in a subset of the animals, about 30%, you can have these responder populations that show decreased pain behavior which we interpret as something like analgesia overall. So overall you can use these types of pharmacological conditionings for both acute and chronic pain.

So now what we're going to do in our lab is a bit different. And I'm really curious to hear the field's thoughts because all -- everything I'm about to show is completely unpublished. Here we're going to use an experimenter-free, drug-free paradigm of instrumental conditioning to instill something like a placebo effect.

And so this is what Blake and Lindsay have been working on since about 2020. And this is our setup in one of our behavior rooms here. Our apparatus is this tiny little device down here. And everything else are all the computers and optogenetics and calcium imaging techniques that we use to record the activity of what's going on inside the mouse's brain.

But simply, this is just two hot plates that we can control the temperature of. And we allow a mouse to freely explore this apparatus. And we can with a series of cameras and tracking devices plot the place preference of an animal within the apparatus. And we can also record with high speed videography these highly conserved sort of protective recuperative pain-like behaviors that we think are indicative of the negative affect of pain.

So let me walk you through our little model here real quick. Okay. So we call this the placebo analgesia conditioning assay or PAC assay. So here is our two-plate apparatus here. So plate number one, plate number two. And the animal can always explore whichever plate it wants. It's never restricted to one side. And so we have a habituation day, let the animal familiarize itself. Like oh, this is a nice office, I don't know what's about to happen.

And then we have a pretest. And in this pretest, importantly, we make both of these plates, both environments a noxious 45-degree centigrade. So this will allow the animal to form an initial expectation that the entire environment is noxious and it's going to hurt. So both sides are noxious. Then for our conditioning, this is where we actually make one side of the chamber non-noxious. So it's just room temperature. But we keep one side noxious. So now there is a new expectation for the animal that it learns that it can instrumentally move its body from one side to the other side to avoid and escape feeling pain.

And so we'll do this over three days, twice per day. And then on our post tester placebo day we make both environments hot again. So now we'll start the animal off over here and the animals will get to freely choose do they want to go to the side that they expect should be non-noxious? Or what happens? So what happens?

Actually, if you just look at the place preference for this, over the course of conditioning we can see that the animals will, unsurprisingly, choose the environment that is non-noxious. And they spend 100% of their time there basically. But when we flip the plates or flip the conditions such that everything is noxious on the post test day, the animals will still spend a significant amount of time on the expected analgesia side. So I'm going to show you some videos here now and you are all going to become mouse pain behavior experts by the end of this.

So what I'm going to show you are both side by side examples of conditioned and unconditioned animals. And try to follow along with me as you can see what the effect looks like. So on this post test day. Oh, gosh, let's see if this is going to -- here we go. All right. So on the top we have the control animal running back and forth. The bottom is our conditioned animal.

And you'll notice we start the animal over here and it's going to go to the side that it expects it to not hurt. Notice the posture of the animals. This animal is sitting very calm. It's putting its entire body down on the hot plate. This animal, posture up, tail up. It's running around a little bit frantically. You'll notice it start to lick and bite and shake its paws. This animal down here might have a couple of flinches so it's letting you know that some nociception is getting into the nervous system overall.

But over the course of this three-minute test, the animals will rightly choose to spend more time over here. And if we start to quantify these types of behaviors that the animals are doing in both conditions, what we find is that there is actually a pretty significant reduction in these nociceptive behaviors. But it's not across the entire duration of this placebo day or post test day.

So this trial is three minutes long. And what we see is that this antinociceptive and preference choice only exists for about the first 90 seconds of this assay. So this is when the video I just showed, the animal goes to the placebo side, it spends a lot of its time there, does not seem to be displaying pain-like behaviors.

And then around 90 seconds, the animal -- it's like -- it's almost like the belief or the expectation breaks. And at some point, the animal realizes oh, no, this is actually quite hot. It starts to then run around and starts to show some of the more typical nociceptive-like behaviors. And we really like this design because this is really, really amenable to doing different types of calcium imaging, electrophysiology, optogenetics because now we have a really tight timeline that we can observe the changing of neural dynamics at speeds that we can correlate with some type of behavior.

Okay. So what are those circuits that we're interested in overall that could be related to this form of placebo? Again, we like to use the human findings as a wonderful roadmap. And Tor has demonstrated, and many other people have demonstrated this interconnected distributed network involving prefrontal cortex, nucleus accumbens, insula, thalamus, as well as the periaqueductal gray.

And so today I'm going to talk about just the periaqueductal gray. Because there is evidence that there is also release of endogenous opioids within this system here. And so we tend to think that the placebo process and the encoding, whatever that is, the placebo itself is likely not encoded in the PAG. The PAG is kind of the end of the road. It's the thing that gets turned on during placebo and we think is driving the antinociceptive or analgesic effects of the placebo itself.

So the PAG, for anyone who's not as familiar, we like it because it's conserved across species. We look at in a mouse. There's one in a human. So potentially it's really good for translational studies as well. It has a very storied past where it's been demonstrated that the PAG subarchitecture has these beautiful anterior to posterior columns that if you electrically stimulate different parts of PAG, you can produce active versus passive coping mechanisms as well as analgesia that's dependent on opioids as well as endocannabinoids.

And then the PAG is highly connected. Both from ascending nociception from the spinal cord as well as descending control systems from prefrontal cortex as well as the amygdala. So with regard to opioid analgesia. If you micro infuse morphine into the posterior part of the PAG, you can produce an analgesic effect in rodents that is across the entire body. So it's super robust analgesia from this very specific part of the PAG.

If you look at the PAG back there and you do some of these techniques to look for histological indications that the mu opioid receptor is there, it is indeed there. There is a large amount of mu opioid receptors, it's OPRM1. And it's largely on glutamatergic neurons. So the excitatory cells, not the inhibitory cells. They are on some of them.

And as far as E-phys data goes as well, we can see that the mu opioid receptor is there. So DAMGOs and opioid agonist. We can see activation of inhibitory GIRK currents in those cells. So the system is wired up for placebo analgesia to happen in that location. Okay. So how are we actually going to start to tease this out? By finding these cells where they go throughout the brain and then understanding their dynamics during placebo analgesia.

So last year we teamed up with Karl Deisseroth's lab at Stanford to develop a new toolkit that leverages the genetics of the opioid system, in particular the promoter for the mu opioid receptor. And we were able to take the genetic sequence for this promoter and package it into adeno associated viruses along with a range of different tools that allow us to turn on or turn off cells or record their activity. And so we can use this mu opioid receptor promoter to gain genetic access throughout the brain or the nervous system for where the mu opioid receptors are. And we can do so with high fidelity.

This is just an example of our mu opioid virus in the central amygdala which is a highly mu opioid specific area. But so Blake used this tool using the promoter to drive a range of different trans genes within the periaqueductal gray. And right here, this is the G camp. So this is a calcium indicator that allows us to in real time assess the calcium activity of PAG mu opioid cells.

And so what Blake did was he took a mouse, and he recorded the nociceptive responses within that cell type and found that the mu opioid cell types are actually nociceptive. They respond to pain, and they do so with increasing activity to stronger and stronger and more salient and intense noxious stimuli. So these cells are actually nociceptive.

And if we look at a ramping hot plate, we can see that those same mu opioid cell types in the PAG increase the activity as this temperature on this hot plate increases. Those cells can decrease that activity if we infuse morphine.

Unsurprisingly, they express the mu opioid receptor and they're indeed sensitive to morphine. If we give naltrexone to block the mu opioid receptors, we can see greater activity to the noxious stimuli, suggesting that there could be an opioid tone or some type of an endogenous opioid system that's keeping this system in check, that it's repressing its activity. So when we block it, we actually enhance that activity. So it's going to be really important here. The activity of these mu opioid PAG cells correlates with affective measures of pain.

When animals are licking, shaking, biting, when it wants to escape away from noxious stimuli, that's when we see activity within those cells. So this is just correlating different types of behavior when we see peak amplitudes within those cell types. So let me skip that real quick.

Okay. So we have this ability to look and peek into the activity of mu opioid cell types. Let's go back to that placebo assay, our PAC assay I mentioned before. If we record from the PAG on that post test day in an animal that has not undergone conditioning, when the plates are super hot, we see a lot of nocioceptive activity in these cells here. They're bouncing up and down.

But if we look at the activity of the nociception in an animal undergoing placebo, what we see is there's a suppression of neural activity within that first 90 seconds. And this actually does seem to extinguish within the lighter 90 seconds. So kind of tracks along with the behavior of those animals. When they're showing anti nocioceptive behavior, that's when those cells are quiet.

When the pain behavior comes back, that's when those cell types are ramping up. But what about the opioids too? Mu opioid receptor cell type's decreasing activity. What about the opioids themselves here? The way to do this in animals has been to use microdialysis, fantastic technique but it's got some limitations to it. This is a way of sampling peptides in real time and then using liquid chromatography to tell if the protein was present. However, the sampling rate is about 10 minutes.

And in terms of the brain processing, 10 minutes might as well be an eternity. If we're talking about milliseconds here. But we want to know what these cells here and these red dots are doing. These are the enkephaliner cells in the PAG. We needed revolution in technologies. One of those came several years ago from Dr. Lin Tian, who developed some of the first sensors for dopamine. Some of you may have heard of it. It's called D-Light.

This is a version of D-Light. But it's actually an enkephalin opioid sensor. What Lin did to genetically engineer this is to take the delta opioid receptor, highly select it for enkephalin, and then link it with this GFP molecule here such that when enkephalin binds to the sensor it will fluoresce.

We can capture that florescence with microscopes that we implant over the PAG and we can see when enkephalin is being released with subsecond resolution. And so what we did for that is we want to see if enkephalin is indeed being released onto those mu opioid receptor expressing pain encoding neurons in the PAG. What I showed you before is that those PAG neurons, they ramp up their activity as the nociception increases, a mouse standing on a hot plate. We see nociception ramp up. What do you all think happened with the opoids?

It wasn't what we expected. It actually drops. So what we can tell is that there's a basal opioid tone within the PAG, but that as nociception increases, acute nociception, we see a decrease suppression of opioid peptide release.

We think this has to do with stuff that Tor has published on previously that the PAG is more likely involved in updating prediction errors. And this acute pain phenomenon we think is reflective of the need to experience pain to update your priors about feeling pain and to bias the selection of the appropriate behaviors, like affect related things to avoid pain. However, what happens in our placebo assay?

We actually see the opposite. So if we condition animals to expect pain relief within that PAC assay, we actually see an increase from the deltoid sensor suggesting that there is an increase in enkephalin release post conditioning. So there can be differential control of the opioid system within this brain region. So this next part is the fun thing you can do with animals. What if we just bypassed the need to do the placebo assay?

If we know that we just need to cause release of enkephalin within the PAG to produce pain relief, we could just directly do that with optigenetics. So we tried to us this animal that allows us to put a red light sensitive opsin protein into the enkephalinergic interneurons into the PAG.

When we shine red light on top of these cells, they turn on and they start to release their neurotransmitters. These are GABAergic and enkephalinergic. So they're dumping out GABA and now dumping out enkephalin into the ERG. We can visualize that using the Delta Light sensor from Lin Tien.

So here is an example of optogenetically released enkephalin within the PAG over 10 minutes. The weird thing that we still don't fully understand is that this signal continues after the optogenetic stimulation. So can we harness the placebo effect in mice? At least it seems we can. So if we turn on these cells strongly, cause them to release enkephalin and put animals back on these ramping hot plate tests we don't see any changes in the latency to detect pain, but we see specific ablation or reductions in these affective motivational pain like behaviors overall. Moderator: You have one minute remaining.

GREGORY CORDER: Cool. In this last minutes, people are skeptical. Can we actually test these higher order cognitive processes in animals? And for anyone who is not a behavioral preclinical neural scientist, you might not be aware there's an absolute revolution happening in behavior with the use of deep learning modules that can precisely and accurately quantify animal behavior. So this is an example of a deep learning tracking system.

We've built the Light Automated Pain Evaluator that can capture a range of different pain related behaviors fully automated without human intervention whatsoever that can be paired with brain reporting techniques like calcium imaging, that allow us to fit a lot of different computational models to understand what the activity of single neurons might be doing, let's say, in the cingulate cortex that might be driving that placebo response.

We can really start to tie now in at single cell resolution the activity of prefrontal cortex to drive these placebo effects and see if that alters anti nocioceptive behavior endogenously. I'll stop there and thank all the amazing people, Blake, Greg, and Lindsay, who did this work, as well as all of our funders and the numerous collaborators who have helped us do this. So thank you.

CRISTINA CUSIN: Terrific talk. Thank you so much. We're blown away. I'll leave the discussion to our two moderators. They're going to gather some of the questions from the chat and some of their own questions for all the presenters from today and from yesterday as well.

TED KAPTCHUK: Matt, you start gathering questions. I got permission to say a few moments of comments. I wanted to say this is fantastic. I actually learned an amazing amount of things. The amount of light that was brought forward about what we know about placebos and how we can possibly control placebo effects, how we can possibly harness placebo effects.

There was so much light and new information. What I want to do in my four minutes of comments is look to the future. What I mean by that is -- I want to give my comments and you can take them or leave them but I've got a few minutes.

What I want to say is we got the light, but we didn't put them together. There's no way we could have. We needed to be more in the same room. How does this fit in with your model? It's hard to do. What I mean by putting things together is I'll give you an example. In terms of how do we control placebo effects in clinical trials. I not infrequently get asked by the pharmaceutical industry, when you look at our placebo data -- we just blew it. Placebo was good as or always as good as the drug.

And the first thing I say is I want to talk to experts in that disease. I want to know the natural history. I want to know how you made your entry criteria so I can understand regression to the mean.

I want to know what's the relationship of the objective markers and subjective markers so I can begin to think about how much is the placebo response. I always tell them I don't know. If I knew how to reduce -- increase the difference between drug and placebo I'd be a rich man, I wouldn't be an academic. What I usually wind up saying is, get a new drug. And they pay me pretty well for that. And the reason is that they don't know anything about natural history. We're trying to harness something, and I just want to say -- I've done a lot of natural history controls, and that's more interesting than the rest of the experiments because they're unbelievable, the amount of improvement people show entering the trial without any treatment.

I just want to say we need to look at other things besides the placebo effect. We want to control the placebo response in a randomized control trial. I want to say that going forward. But I also want to say that we need a little bit of darkness. We need to be able to say, you know, I disagree with you. I think this other data, and one of the things I've learned doing placebo reach there's a paper that contradicts your paper real quickly and there's lots of contradictory information. It's very easy to say you're wrong, and we don't say it enough.

I want to take one example -- please forgive me -- I know that my research could be said that, Ted, you're wrong. But I just want to say something. Consistently in the two days of talk everyone talks about the increase of the placebo response over time. No one refers to the article published in 2022 in BMJ, first author was Mark Stone and senior author was Irving Kirsch. And they analyzed all FDA Mark Stone is in the Division of Psychiatry at CDER at the FDA. They analyzed all data of placebo controlled trials in major depressive disorder. They had over 230 trials, way more than 70,000 patients, and they analyzed the trend over time, in 1979 to the present, the publication. There was no increase in the placebo effect.

Are they right or are other people right? Nothing is one hundred percent clear right now and we need to be able to contradict each other when we get together personally and say, I don't think that's right, maybe that's right. I think that would help us. And the last thing I want to say is that some things were missing from the conference that we need to include in the future. We need to have ethics. Placebo is about ethics. If you're a placebo researcher in placebo controlled trials, that's an important question:

What are we talking about in terms of compromising ethics? There's no discussion that we didn't have time but in the future, let's do that.

And the last thing I would say is, we need to ask patients what their experience is. I've got to say I've been around for a long time. But the first time I started asking patients what their experiences were, they were in double blind placebo or open label placebo, I did it way after they finished the trial, the trial was over, and I actually took notes and went back and talked to people. They told me things I didn't even know about. And we need to have that in conferences. What I want to say, along those lines, is I feel so much healthier because I'm an older person, and I feel with this younger crowd here is significantly younger than me.

Maybe Matt and I are the same age, I don't know, but I think this is really one of the best conferences I ever went to. It was real clear data. We need to do lots of other things in the future. So with that, Matt, feed me some questions.

MATTHEW RUDORFER: Okay. Thanks. I didn't realize you were also 35. But okay. [LAUGHTER].

MATTHEW RUDORFER: I'll start off with a question of mine. The recent emergence of intravenous ketamine for resistant depression has introduced an interesting methodologic approach that we have not seen in a long time and that is the active placebo. So where the early trials just used saline, more recently we have seen benzodiazapine midazolam, while not mimicking really the full dissociative effect that many people get from ketamine, but the idea is for people to feel something, some kind of buzz so that they might believe that they're on some active compound and not just saline. And I wonder if the panel has any thoughts about the merits of using an active placebo and is that something that the field should be looking into more?

TED KAPTCHUK: I'm going to say something. Irving Kirsch published a meta analysis of H studies that used atropine as a control in depression studies. He felt that it made it difficult to detect a placebo drug difference. But in other meta analysis said that was not true. That was common in the '80s. People started thinking about that. But I have no idea how to answer your question.

MICHAEL DETKE: I think that's a great question. And I think in the presentations yesterday about devices, Dr. Lisanby was talking about the ideal sham. And I think it's very similar, the ideal active placebo would have none of the axia of the drug, of the drug in question, but would have, you know, exactly the same side effects and all other features, and of course that's attractive, but of course we probably would never have a drug that's exactly like that. I think midazolam was a great thing to try with ketamine. It's still not exactly the same. But I'd also add that it's not black and white. It's not like we need to do this with ketamine and ignore it for all of our other drugs. All of our drugs have side effects.

Arguably, if you do really big chunks, like classes of relatively modern antidepressants, antipsychotics and the psychostimulants, those are in order of bigger effect sizes in clinical trials, psychostimulants versus anti psychotics, versus -- and they're also in the order of roughly, I would argue, of unblinding, of functional unblinding. And in terms of more magnitude, Zyprexa will make you hungry. And also speed of onset of some of the adverse effects, stimulants and some of the Type II -- the second generation and beyond -- anti psychotics, they have pretty noticeable side effects for many subjects and relatively rapidly. So I think those are all important features to consider.

CRISTINA CUSIN: Dr. Schmidt?

LIANE SCHMIDT: I think using midazolam could give, like, some sensory sensations so the patients actually can say there's some effect on the body like immediately. But this raises actually a question whether these dissociations we observe in some patients of ketamine infusions we know have, will play a role for the antidepressant response. It's still an open question. So I don't have the answer to that question. And I think with midazolam doesn't really induce dissociations. I don't know, maybe you can isolate the dissociations you get on ketamine. But maybe even patients might be educated, expecting scientific reaction experiences and basically when they don't have -- so they make the midazolam experience something negative. So yeah, just self fulfilling prophesies might come into play.

CRISTINA CUSIN: I want to add for five seconds. Because I ran a large ketamine clinic. We know very little about cyto placebo maintaining an antidepressant response while the dissociation often wears off over time. It's completely separate from the anti depressant effect. We don't have long term placebo studies. The studies are extremely short lived and we study the acute effect. But we don't know how to sustain or how to maintain, what's the role of placebo effect in long term treatments. So that's another field that really is open to investigations. Dr. Rief.

WINFRIED RIEF: Following up on the issue of active placebos. I just want to mention that we did a study comparing active placebos to passive placebos and showing that active placebos are really more powerful. And I think the really disappointing part of this news is that it questions the blinding of our typical RCTs comparing antidepressants versus placebos because many patients who are in the active group or the tracked group, they perceive these onset effects and this will further boost the placebo mechanisms in the track group that are not existing in the passive placebo group. This is a challenge that further questions the validity of our typical RCTs.

CRISTINA CUSIN: Marta.

MARTA PECINA : Just a quick follow up to what Cristina was saying, too, that we need to clarify whether we want to find an active control for the dissociative effects or for the antidepressive effects. I think the approach will be very different. And this applies to ketamine but also psychodelics because we're having this discussion as well. So when thinking about how to control for or how to blind or how we just -- these treatments are very complicated. They have multiple effects. We just need to have the discussion of what are we trying to blind because the mechanism of action of the blinding drug will be very different.

TED KAPTCHUK: Can I say something about blinding? Robertson, who is the author of the 1970 -- no -- 1993 New England Journal paper saying that there's no that the placebo effect is a myth.

In 2022, published in BMJ, the largest -- he called it a mega meta analysis on blinding. And he took 144 randomized control trials that included nonblinded evidence on the drug versus blinded evidence of the drug. I'm not going to tell you the conclusion because it's unbelievable. But you should read it because it really influences -- it would influence what we think about blinding. That study was just recently replicated on a different set of patients with procedures in JAMA Surgery three months ago. And blinding like placebo is more complicated than we think. That's what I wanted to say.

MATTHEW RUDORFER: Another clinical factor that's come up during our discussion has been the relationship of the patient to the provider that we saw data showing that a warm relationship seemed to enhance therapeutic response, I believe, to most interventions. And I wonder what the panel thinks about the rise on the one hand of shortened clinical visits now that, for example, antidepressants are mostly given by busy primary care physicians and not specialists and the so called med check is a really, kind of, quickie visit, and especially since the pandemic, the rise of telehealth where a person might not ever even meet their provider in person, and is it possible we're on our way to where a clinical trial could involve, say, mailing medication every week to a patient, having them do their weekly ratings online and eliminating a provider altogether and just looking at the pharmacologic effect?

I mean, that probably isn't how we want to actually treat people clinically, but in terms of research, say, early phase efficacy, is there merit to that kind of approach?

LUANA COLLOCA: I'll comment on this, Dr. Rudorfer. We're very interested to see how the telemedicine or virtual reality can affect placebo effects, and we're modeling in the lab placebo effects induced via, you know, in person interaction.

There's an Avatar and virtual reality. And actually we found placebo effects with both the settings. Or whether, when we look at empathy, the Avatar doesn't elicit any empathy in the relationship. We truly need the in person connection to have empathy. So that suggests that our outcome that are affected by having in person versus telemedicine/para remote interactions, but yet the placebo effects persist in both the settings. The empathy is differently modulated and the empathy mediated, interestingly in our data, placebo effects only in the in person interactions. There is still a value in telemedicine. Effects that bypass empathy completely in competence.

MATTHEW RUDORFER: Dr. Hall.

KATHRYN HALL: Several of the large studies, like the Women's Health Study, Physicians' Health Study and, more recently, Vital, they did exactly that, where they mail these pill packs. And I mean, the population, obviously, is clinicians. So they are very well trained and well behaved. And they follow them for years but there's very little contact with the providers, and you still have these giant -- I don't know if you can call them placebo effects -- but certainly many of these trials have not proven to be more effective, the drugs they're studying, than placebo.

MATTHEW RUDORFER: Dr. Atlas.

LAUREN ATLAS: I wanted to chime in briefly on this important question. I think that the data that was presented yesterday in terms of first impressions of providers is relevant for this because it suggests that even when we use things like soft dot (phonetic) to select physicians and we have head shots (phonetic), that really we're making these decisions about who to see based on these kinds of just first impressions and facial features and having the actual interactions by providers is critical for sort of getting beyond that kind of factor that may drive selection. So I think if we have situations where there's reduced chances to interact, first of all, people are bringing expectations to the table based on what they know about the provider and then you don't really have the chance to build on that without the actual kind of therapeutic alliance. That's why I think, even though our study was done in an artificial setting, it really does show how we make these choices when there are bios for physicians and things available for patients to select from. I think there's a really important expectation being brought to the table before the treatment even occurs.

MATTHEW RUDORFER: Thanks. Dr. Lisanby.

SARAH “HOLLY” LISANBY: Thanks for raising this great question, Matt. I have a little bit of a different take on it. Equity in access to mental health care is a challenge. And the more that we can leverage technology to provide and extend the reach of mental health care the better. And so telemedicine and telepsychiatry, we've been thrust into this era by the pandemic but it existed before the pandemic as well. And it's not just about telepsychotherapy or teleprescription from monitoring pharmacotherapy, but digital remote neuromodulation is also a thing now. There are neuromodulation interventions that can be done at home that are being studied, and so there have been trials on transcranial direct current stimulation at home with remote monitoring. There are challenges in those studies differentiating between active and sham. But I think you're right in that we may have to rethink how do we control remote studies when the intensity of the clinician contact is very different, but I do think that we should explore these technologies so that we can extend the reach and extend access to research and to care for people who are not able to come into the research lab setting.

TED KAPTCHUK: May I add something on this? It's also criticizing myself. In 2008, I did this very nice study showing you could increase the doctor/patient relationship. And as you increase it, the placebo effect got bigger and bigger, like a dose response. A team in Korea that I worked with replicated that. I just published that replication.

The replication came out with the exact opposite results. The less doctor/patient relationship, the less intrusive, the less empathy got better effects. We're dealing with very complicated culturally constructed issues, and I just want to put it out there, the sand is soft. I'm really glad that somebody contradicted a major study that I did.

LUANA COLLOCA: Exactly. The central conference is so critical, what we observed in one context in one country, but even within the same in group or out group can be completely different in Japan, China or somewhere else. So the Americas, South Africa. So we need larger studies and more across country collaborations.

MATTHEW RUDORFER: Dr. Schmidt.

LIANE SCHMIDT: I just wanted to raise a point not really like -- it's more like a comment, like there's also very interesting research going on in the interactions between humans and robots, and usually humans treat robots very badly. And so I wonder what could be like -- here we focus on very human traits, like empathy, competence, what we look at. But when it comes to artificial intelligence, for example, and when we have to interact with algorithms, basically, like all these social interactions might completely turn out completely different, actually, and all have different effects on placebo effects. Just a thought.

MATTHEW RUDORFER: Dr. Rief.

WINFRIED RIEF: Yesterday, I expressed a belief for showing more warmth and competence, but I'll modify it a little bit today because I think the real truth became quite visible today, and that is that there is an interaction between these non specific effect placebo effects and the track effect. In many cases, at least. We don't know whether there are exceptions from this rule, but in many cases we have an interaction. And to learn about the interaction, we instead need study designs that modulate track intake versus placebo intake, but they also modulate the placebo mechanisms, the expectation mechanisms, the context of the treatment. And only if we have these 2 by 2 designs, modulating track intake and modulating context and psychological factors, then we learn about the interaction. You cannot learn about the interaction if you modulate only one factor.

And, therefore, I think what Luana and others have said that interact can be quite powerful and effective in one context but maybe even misleading in another context. I think this is proven. We have to learn more about that. And all the studies that have been shown from basic science to application that there could be an interaction, they're all indicating this line and to this necessity that we use more complex designs to learn about the interaction.

MATTHEW RUDORFER: Yes. And the rodent studies we've seen, I think, have a powerful message for us just in terms of being able to control a lot of variables that are just totally beyond our control in our usual human studies. It always seemed to me, for example, if you're doing just an antidepressant versus placebo trial in patients, well, for some people going into the clinic once a week to get ratings, that might be the only day of the week that they get up and take a shower, get dressed, have somebody ask them how they're doing, have some human interaction. And so showing up for your Hamilton rating could be a therapeutic intervention that, of course, we usually don't account for in the pharmacotherapy trial. And the number of variables really can escalate in a hurry when we look at our trials closely.

TED KAPTCHUK: Tor wants to say something.

TOR WAGER: Thanks, Ted.

I wanted to add on to the interaction issue, which came up yesterday, which Winfried and others just commented on, because it seems like it's really a crux issue. If the psychosocial or expectation effects and other things like that are entangled with specific effects so that one can influence the other and they might interact, then, yeah, we need more studies that independently manipulate specific drug or device effects and other kinds of psychological effects independently. And I wanted to bring this back up again because this is an idea that's been out here for a long time. I think the first review on this was in the '70s, like '76 or something, and it hasn't really been picked up for a couple of reasons. One, it's hard to do the studies. But second, when I talk to people who are in industry and pharma, they are very concerned about changing the study designs at all for FDA approval.

And since we had some, you know, FDA and regulatory perspectives here yesterday, I wanted to bring that up and see what people think, because I think that's been a big obstacle. And if it is, then that may be something that would be great for NIH to fund instead of pharma companies because then there's a whole space of drugs, psychological or neurostimulation psychological interactions, that can be explored.

MATTHEW RUDORFER: We also had a question. Yesterday there was discussion in a naloxone trial in sex differences in placebo response. And wonder if there's any further thoughts on studies of sex differences or diversity in general in placebo trials. Yes.

LUANA COLLOCA: We definitely see sex differences in placebo effect, and I show also, for example, women responded to arginine vasopressin in a way that we don't observe in men.

But also you asked about diversity. Currently actually in our paper just accepted today where we look at where people are living, the Maryland states, and even the location where they are based make a difference in placebo effects. So people who live in the most distressed, either the greatest Baltimore area, tended to have lower placebo effects as compared to a not distressful location. And we define that the radius of the criteria and immediately it's a race but we take into account the education, the income and so on. So it is interesting because across studies consistently we see an impact of diversity. And in that sense, I echo, listen to the comment that we need to find a way to reach out to these people and truly improve access and the opportunity for diversity. Thank you for asking.

MATTHEW RUDORFER: Thank you. Another issue that came up yesterday had to do with the pharmacogenomics. And there was a question or a question/comment about using candidate approaches and are they problematic.

KATHRYN HALL: What approaches.

MATTHEW RUDORFER: Candidate genes.

KATHRYN HALL: I think we have to start where we are. I think that the psychiatric field has had a really tough time with genetics. They've invested a lot and, sadly, don't have as much to show for it as they would like to. And I think that that has really tainted this quest for genetic markers of placebo and related studies, these interaction factors. But it's really important to not, I think, to use that to stop us from looking forward and identifying what's there. Because when you start to scratch the surface, there are interactions. You can see them. They're replete in the literature. And what's really fascinating is everybody who finds them, they don't see them when they report their study. And even some of these vasopressin studies, not obviously, Tor, yours, but I was reading one the other day where they had seen tremendous differences by genetics in response to arginine vasopressin. And they totally ignored what they were seeing in placebo and talked about who responds to drug. And so I think that not only do we need to start looking for what's happening, we need to start being more open minded and paying attention to what we're seeing in the placebo arm and accounting for that, taking that into account to understand what we're seeing across a trial in total.

CRISTINA CUSIN: I'll take a second to comment on sufficient selection and trying to figure out, depending on the site who are the patients who went there, treatment and depression clinical trial. If we eliminate from the discussion professional patient and we think about the patients who are more desperate, patients who don't have access to care, patients who are more likely to have psychosocial stressors or the other extreme, there are patients who are highly educated. The trials above and they search out, but they're certainly not representative of the general populations we see in the clinical setting.

They are somewhat different. And then if you think about the psychedelics trial, they go from 5,000 patients applying for a study and the study ends up recruiting 20, 30. So absolutely not representative of the general population we see in terms of diversity, in terms of comorbidities, in terms of psychosocial situations. So that's another factor that adds to the complexity of differentiating what happens in the clinical setting versus artificial setting like a research study. Tor.

MATTHEW RUDORFER: The question of who enters trials and I think the larger issue of diagnosis in general has, I think, really been a challenge to the field for many years. Ted and I go back a ways, and just looking at depression, of course, has dominated a lot of our discussion these last couple of days, with good reason. Now I realize the good database, my understanding is that the good database of placebo controlled trials go back to the late '90s, is what we heard yesterday. And if you go back further, the tricyclic era not only dealt with different medications, which we don't want to go back to, but if you think about practice patterns then, on the one hand, the tricyclics, most nonspecialists steered clear of, they required a lot of hands on. They required titration slowly up. They had some concerning toxicities, and so it was typical that psychiatrists would prescribe them but family docs would not. And that also had the effect of a naturalistic screening, that is, people would have to reach a certain level of severity before they were referred to a psychiatrist to get a prescription for medication.

More mildly ill people either wound up, probably inappropriately, on tranquilizers or no treatment at all and moderately to severely ill people wound up on tricyclics, and of course inpatient stays were common in those days, which again was another kind of screening. So it was the sort of thing, I mean, in the old days I heard of people talk about, well, you could, if you go to the inpatient board, you could easily collect people to be in clinical trial and you kind of knew that they were vetted already. That they had severe depression, the general sense was that the placebo response would be low. Though there's no real evidence for that. But the thing is, once we had the SSRIs on the one hand, the market vastly expanded because they're considered more broad spectrum. People with milder illness and anxiety disorders now are appropriate candidates and they're easier to dispense. The concern about overdose is much less, and so they're mostly prescribed by nonspecialists. So it's the sort of thing where we've seen a lot of large clinical trials where it doesn't take much to reach the threshold for entry, being if I go way back and this is just one of my personal concerns over many years the finer criteria, which I think were the first good set of diagnostic criteria based on data, based on literature, those were published in 1972 to have a diagnosis of major depression, called for four weeks of symptoms. Actually, literally, I think it said one month.

DSM III came out in 1980 and it called for two weeks of symptoms. I don't know -- I've not been able to find any documentation of how the one month went to two weeks, except that the DSM, of course, is the manual that's used in clinical practice. And you can understand, well, you might not want to have too high a bar to treat people who are seeking help. But I think one of the challenges of DSM, it was not meant as a research manual. Though that's often how it's used. So ever since that time, those two weeks have gotten reified, and so my point is it doesn't take much to reach diagnostic criteria for DSM, now, 5TR, major depression. So if someone is doing a clinical trial of an antidepressant, it is tempting to enroll people who meet, honestly meet those criteria but the criteria are not very strict. So I wonder whether that contributes to the larger placebo effect that we see today.

End of soapbox. The question -- I'd like to revisit an excellent point that Dr. Lisanby raised yesterday which has to do with the research domain criteria, the RDOC criteria. I don't know if anyone on the panel has had experience in using that in any trials and whether you see any merit there. Could RDOC criteria essentially enrich the usual DSM type clinical criteria in terms of trying to more finely differentiate subtypes of depression, might respond differently to different treatments.

MODERATOR: I think Tor has been patient on the hand off. Maybe next question, Tor, I'm not sure if you had comments on previous discussion.

TOR WAGER: Sure, thanks. I wanted to make a comment on the candidate gene issue. And I think it links to what you were just saying as well, doctor, in a sense. I think it relates to the issue of predicting individual differences in placebo effects and using that to enhance clinical trials, which has been really sort of a difficult issue. And in genetics, I think what's happened, as many of us know, is that there were many findings on particular candidate genes, especially comped and other particular set of genes in Science and Nature, and none of those really replicated when larger GWA studies started being done. And the field of genetics really focused in on reproducibility and replicability in one of our sample sizes. So I think my genetics colleagues tell me something like 5,000 is a minimum for even making it into their database of genetic associations. And so that makes it really difficult to study placebo effects in sample sizes like that. And at the same time, there's been this trend in psychology and in science, really, in general, towards reproducibility and replicability that probably in part are sort of evoked by John Ioannidis's provocative claims that most findings are false, but there's something really there.

There's been many teams of people who have tried to pull together, like Brian Nosek's work with Open Science Foundation, and many lab studies to replicate effects in psychology with much higher power. So there's this sort of increasing effort to pull together consortia to really test these things vigorously. And I wonder if -- we might not have a GWA study of placebo effects in 100,000 people or something, which is what would convince a geneticist that there's some kind of association. I'm wondering what the ways forward are, and I think one way is to increasingly come together to pull studies or do larger studies that are pre registered and even registered reports which are reviewed before they're published so that we can test some of these associations that have emerged in these what we call early studies of placebo effects.

And I think if we preregister and found something in sufficiently large and diverse samples, that might make a dent in convincing the wider world that essentially there is something that we can use going forward in clinical trials. And pharma might be interested in, for example, as well. That's my take on that. And wondering what people think.

KATHRYN HALL: My two cents. I completely agree with you. I think the way forward is to pull our resources to look at this and not simply stop -- I think when things don't replicate, I think we need to understand why they don't replicate. I think there's a taboo on looking beyond, if you prespecified it and you don't see it, then it should be over. I think in at least this early stage, when we're trying to understand what's happening, I think we need to allow ourselves deeper dives not for action but for understanding.

So I agree with you. Let's pull our resources and start looking at this. The other thing I would like to point out that's interesting is when we've looked at some of these clinical trials at the placebo arm, we actually learn a lot about natural history. We just did one in Alzheimer's disease and in the placebo arm the genome wide significant hit was CETP, which is now a clinical target in Alzheimer's disease. You can learn a lot by looking at the placebo arms of these studies not just about whether or not the drug is working or how the drug is working, but what's happening in the natural history of these patients that might change the effect of the drug.

TED KAPTCHUK: Marta, did you have something to say; you had your hand up.

MARTA PECINA: Just a follow up to what everybody is saying. I do think the issue of individualability is important. I think that one thing that maybe kind of explains some of the things that was also saying at the beginning that there's a little bit of lack of consistency or a way to put all of these findings together. The fact that we think about it as a one single placebo effect and we do know that there's not one single placebo effect, but even within differing clinical conditions is the newer value placebo effect the same in depression as it is in pain?

Or are there aspects that are the same, for example, expectancy processing, but there's some other things that are very specific to the clinical condition, whether it's pain processing, mood or some others. So I think we face the reality of use from a neurobiology perspective that a lot of the research has been done in pain and still there's very little being done at least in psychiatry across many other clinical conditions that we just don't know. And we don't really even know if the placebo how does the placebo effect look when you have both pain and depression, for example?

And so those are still very open questions that kind of reflect our state, right, that we're making progress but there's a lot to do.

TED KAPTCHUK: Winfried, did you want to say something? You have your hand up.

WINFRIED RIEF: I wanted to come back to the question of whether we really understand this increase of placebo effects. I don't know whether you have (indiscernible) for that. But I'm more like a scientist I can't believe that people are nowadays more reacting to placebos than they did 20 years ago. So there might be other explanations for this effect, like we changed the trial designs. We have more control visits maybe nowadays compared to 30 years ago, but there could be also other factors like publication bias which was maybe more frequent, more often 30 years ago than it is nowadays with the need for greater registration. So there are a lot of methodological issues that could explain this increase of placebo effects or of responses in the placebo groups. I would be interested whether you think that this increase is well explained or what your explanations are for this increase.

TED KAPTCHUK: Winfried, I want to give my opinion. I did think about this issue. I remember the first time it was reported in scientists in Cleveland, 40, 50 patients, and I said, oh, my God, okay, and the newspapers had it all over: The placebo effect is increasing. There's this boogie man around, and everyone started believing it. I've been consistently finding as many papers saying there's no -- I've been collecting them. There's no change over time there are changes over time. When I read the original article, I said, of course there's differences. The patients that got recruited in 1980 were different than the patients in 1990 or 2010. They were either more chronic, less chronic.

They were recruited in different ways, and that's really an easy explanation of why things change. Natural history changes. People's health problems are different, and I actually think that the Stone's meta analysis with 70,033 patients says it very clearly. It's a flat line from 1979. And the more data you have, the more you have to believe it. That's all. That's my personal opinion. And I think we actually are very deeply influenced by the media. I mean, I can't believe this:

The mystery of the placebo. We know more about placebo effects at least compared to many drugs on the market. Thanks my opinion. Thanks, Winfried, for letting me say it.

MATTHEW RUDORFER: Thanks, Ted.

We have a question for Greg. The question is, I wonder what the magic of 90 seconds is? Is there a physiologic basis to the turning point when the mouse changes behavior?

GREGORY CORDER: I think I addressed it in a written post somewhere. We don't know. We see a lot of variability in those animals. So like in this putative placebo phase, some mice will remain on that condition side for 40 seconds, 45 seconds, 60 seconds. Or they'll stay there the entire three minutes of the test. We're not exactly sure what's driving the difference in those different animals. These are both male and females. We see the effect in both male and female C57 black six mice, a genetically inbred animal. We always try to restrict the time of day of testing. We do reverse light testing. This is the animal wake cycle.

And there are things like dominance hierarchies within the cages, alpha versus betas. They may have different levels of pain thresholds. But the breaking of whatever the anti nocioceptive effect is they're standing on a hot plate for quite a long time. At some point those nociceptors in the periphery are going to become sensitized and signal. And to some point it's to the animal's advantage to pay attention to pain. You don't want to necessarily go around not paying attention to something that's potentially very dangerous or harmful to you. We would have to scale up the number of animals substantially I think, to really start parse out what the difference is that would account for that. But that's an excellent point, though.

MATTHEW RUDORFER: Carolyn.

CAROLYN RODRIGUEZ: I want to thank all today's speakers and wonderful presentations today. I just wanted to just go back for a second to Dr. Pecina's point about thinking about a placebo effect is not a monolith and also thinking about individual disorders.

And so I'm a clinical trialist and do research in obsessive compulsive disorder, and a lot of the things that are written in the literature meta analysis is that OCD has one of the lowest placebo rates. And so, you know, from what we gathered today, I guess to turn the question on its head is, is why is that, is that the case, why is that the case, and does that say something about OCD pathology, and what about it? Right? How can we really get more refined in terms of different domains and really thinking about the placebo effect.

So just want to say thank you again and to really having a lot of food for thought.

MATTHEW RUDORFER: Thanks. As we're winding down, one of the looming questions on the table remains what are research gaps and where do you think the next set of studies should go. And I think if anyone wants to put some ideas on the table, they'd be welcome.

MICHAEL DETKE: One of the areas that I mentioned in my talk that is hard for industry to study, or there's a big incentive, which is I talked about having third party reviewers review source documents and videos or audios of the HAM D, MADRS, whatever, and that there's not much controlled evidence.

And, you know, it's a fairly simple design, you know, within our largest controlled trial, do this with half the sites and don't do it with the other half.

Blinding isn't perfect. I haven't thought about this, and it can probably be improved upon a lot, but imagine you're the sponsor who's paying the $20 million in three years to run this clinical trial. You want to test your drug as fast as you possibly can. You don't want to really be paying for this methodology.

So that might be -- earlier on Tor or someone mentioned there might be some specific areas where this might be something for NIH to consider picking up. Because that methodology is being used in hundreds of trials, I think, today, the third party remote reviewer. So there's an area to think about.

MATTHEW RUDORFER: Thanks. Holly.

SARAH “HOLLY” LISANBY: Yeah. Carolyn just mentioned one of the gap areas, really trying to understand why some disorders are more amenable to the placebo response than others and what can that teach us. That sounds like a research gap area to me.

Also, throughout these two days we've heard a number of research gap areas having to do with methodology, how to do placebos or shams, how to assess outcome, how to protect the blind, how do you select what your outcome measures should be.

And then also today my mind was going very much towards what can preclinical models teach us and the genetics, the biology of a placebo response, the biogender line, individual differences in placebo response.

There may be clues there. Carolyn, to your point to placebo response being lower in OCD, and yet there are some OCD patients who respond, what's different about them that makes them responders?

And so studies that just look at within a placebo response versus nonresponse or gradation response or durability response and the mechanisms behind that.

These are questions that I think may ultimately facilitate getting drugs and devices to market, but certainly are questions that might be helpful to answer at the research stage, particularly at the translational research stage, in order to inform the design of pivotal trials that you would ultimately do to get things to market.

So it seems like there are many stages before getting to the ideal pivotal trial. So I really appreciate everyone's input. Let me stop talking because I really want to hear what Dr. Hall has to say.

KATHRYN HALL: I wanted to just come back for one of my favorite gaps to this question increasing the placebo effect. I think it's an important one because so many trials are failing these days. And I think it's not all trials are the same.

And what's really fascinating to me is that you see in Phase II clinical trials really great results, and then what's the first thing you do as a pharma company when you got a good result? You get to put out a press release.

And what's the first thing you're going to go do when you enroll in a clinical trial? You're going to read a press release. You're going to read as much as you can about the drug or the trial you're enrolling in. And how placebo boosting is it going to be to see that this trial had amazing effects on this condition you're struggling with.

If lo and behold we go to Phase III, and you can -- we're actually writing a paper on this, how many times we see the words "unexpected results," and I think we saw them here today, today or yesterday. Like, this should not be unexpected. When your Phase III trial fails, you should not be surprised because this is what's happening time and time again.

And I think some of the -- yeah, I agree, Ted, it's like this is a modern time, but there's so much information out there, so much information to sway us towards placebo responses that I think that's a piece of the problem. And finding out what the problem is I think is a really critical gap.

MATTHEW RUDORFER: Winfried.

WINFRIED RIEF: Yeah. May I follow up in that I think it fits quite nicely to what has been said before, and I want to direct I want to answer directly to Michael Detke.

On first glance, it seems less expensive to do the trials the way we do it with one placebo group and one drug arm, and we try to keep the context constant. But this is the problem. We have a constant context without any variation, so we don't learn under which context conditions is this drug really effective and what are the context conditions the drug might not be effective at all.

And therefore I think the current strategy is more like a lottery. It's really by chance it can happen that you are in this little window where the drug can show the most positive effectivity, but it can also be that you are in this little window or the big window where the drug is not able to show its effectivity.

And therefore I think, on second glance, it's a very expensive strategy only to use one single context to evaluate a drug.

MATTHEW RUDORFER: If I have time for--

TED KAPTCHUK: Marta speak, and then Liane should speak.

MARTA PECINA: I just wanted to add kind of a minor comment here, which is this idea that we're going to have to move on from the idea that giving someone a placebo is enough to induce positive expectancies and the fact that expectancies evolve over time.

So at least in some of the data that we've shown, and it's a small sample, but still we see that 50% of those subjects who are given a placebo don't have drug assignment beliefs. And so that is a very large amount of variability there that we are getting confused with everything else.

And so I do think that it is really important, whether in clinical trials, in research, to really come up with very and really develop new ways of measuring expectancies and allow expectancies to be measured over time. Because they do change. We have some prior expectancies, and then we have some expectancies that are learned based on experience. And I do think that this is an area of improvement that the field could improve relatively easily, you know, assess expectancies better, measure expectancies better.

TED KAPTCHUK: Liane, why don't you say something, and Luana, and then Cristina.

LIANE SCHMIDT: So I wanted to -- maybe one -- another open gap is like about the cognition, like what studying placebo, how can it help us to better understand human reasoning, like, and vice versa, actually, all the biases we have, these cognitive processes like motivation, for example, or memory, and yet all the good news about optimism biases, how do they contribute to placebo effects on the patient side but also on the clinician side when the clinicians have to make diagnosis or judge, actually, treatment efficiency based on some clinical scale.

So basically using like tools from cognition, like psychology or cognitive neuroscience, to better understand the processes, the cognitive processes that intervene when we have an expectation and behavior reach out, a symptom or neural activation, what comes in between, like how is it translated, basically, from cognitive predictability.

LUANA COLLOCA: I think we tended to consider expectation as static measurement when in reality we know that what we expect at the beginning of this workshop is slightly different by the end of what we are hearing and, you know, learning.

So expectation is a dynamic phenomenon, and the assumption that we can predict placebo effects with our measurement of expectation can be very limiting in terms of, you know, applications. Rather, it is important to measure expectation over time and also realize that there are so many nuance, like Liane just mentioned, of expectations, you know.

There are people who say I don't expect anything, I try everything, or people who say, oh, I truly want, I will be I truly want to feel better. And these also problematic patients because having an unrealistic expectation can often destroy, as I show, with a violation of expectancies of placebo effects.

TED KAPTCHUK: Are we getting close? Do you want to summarize? Or who's supposed to do that? I don't know.

CRISTINA CUSIN: I think I have a couple of minutes for remarks. There's so much going on, and more questions than answers, of course.

That has been a fantastic symposium, and I was trying to pitch some idea about possibly organizing a summit with all the panelists, all the presenters, and everyone else who wants to join us, because I think that with a coffee or a tea in our hands and talking not through a Zoom video, we could actually come up with some great idea and some collaboration projects.

Anyone who wants to email us, we'll be happy to answer. And we're always open to collaborating and starting a new study, bouncing off each other new ideas. This is what we do for a living. So we're very enthusiastic about people asking difficult questions.

And some of the questions that are ongoing and I think would be future areas is what we were talking a few minutes ago, we don't know if a placebo responder in a migraine study, for example, would be a placebo responder of depression study or IBS study. We don't know if this person is going to be universal placebo responder or is the context include the type of disease they're suffering from so it's going to be fairly different, and why some disorders have lower placebo response rate overall compared to others. Is that a chronicity, a relaxing, remitting disorder, has higher chance of placebo because the system can be modulated, versus a disorder that is considered more chronic and stable? A lot of this information is not known in the natural history.

Also comes to mind the exact trial it is because we almost never have a threshold for number of prior episodes of depression to enter a trial or how chronic has it been or years of depression or other factors that can clearly change our probability of responding to a treatment.

We heard about methodology for clinical trial design and how patients could be responsive to placebo responses or sham, responsive to drug. How about patients who could respond to both? We have no idea how many of those patients are undergoing a trial, universal responders, unless we do a crossover. And we know that crossover is not a popular design for drug trials.

So we need to figure out also aspects of methodology, how to assess outcome, what's the best way to assess the outcome that we want, is it clinically relevant, how to protect the blind aspect, assess expectations and how expectations change over time.

We didn't hear much during the discussion about the role of mindfulness in pain management, and I would like to hear much more about how we're doing in identifying the areas and can we actually intervene on those areas with devices to help with pain management. That's one of the biggest problems we have in terms of clinical care.

In the eating disorder aspect, creating computational models to influence food choices. And, again, with devices or treatments specifically changing the balance about making healthier food choices, I can see an entire field developing. Because most of the medications we prescribe for psychiatric disorders affect food choices and there's weight gain, potentially leading to obesity and cardiovascular complications. So there's an entire field of research we have not touched on.

And the role of animal models in translational results, I don't know if animal researchers, like Greg, talk much with clinical trialists. I think that would be a cross fertilization that is much needed, and we can definitely learn from each other.

And just fantastic. I thank all the panelists for their willingness to work with us and their time, dedication, and just so many meetings to discuss to agree on the program and to divide and conquer different topics. Has been a phenomenal experience, and I'm very, very grateful.

And the NIMH staff has been also amazing, having to collaborate with all of them, and they were so organized. And just a fantastic panel. Thank you, everybody.

MATTHEW RUDORFER: Thank you.

TOR WAGER: Thank you.

NIMH TEAM: Thanks from the NIMH team to all of our participants here.

(Meeting adjourned)

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A distinct 'repair' role of regulatory T cells in fracture healing

by Higher Education Press

A study in Frontiers of Medicine uncovers a unique reparative function of regulatory T cells (Tregs) in the process of fracture healing, a discovery that adds a new dimension to our understanding of the immune response in tissue regeneration.

Tregs, a subset of T cells known for their role in maintaining immune tolerance and preventing autoimmunity, are now shown to play a critical part in the intricate interplay between the immune system and bone repair .

Fracture healing is a complex process that involves a sequence of events, including inflammation, repair, and remodeling. While the initial inflammatory phase is crucial for setting the stage for repair, an excessive or unresolved inflammatory response can impair the healing process . The research highlights how Tregs can modulate this inflammatory response, thereby facilitating the transition to the repair phase.

The study uses a combination of in vivo experiments and in vitro analyses to investigate the role of Tregs in fracture healing. It demonstrates that the presence of Tregs at the site of injury is associated with improved healing outcomes. Tregs are shown to exert their reparative effects by secreting specific cytokines that promote the resolution of inflammation and enhance the activity of osteoblasts, the cells responsible for bone formation.

Furthermore, the research reveals that Tregs can directly interact with other immune cells, such as macrophages, to modulate their activity. This interaction is important for shifting the wound environment from a pro-inflammatory state to one that is more conducive to tissue repair.

The study also examines the molecular mechanisms by which Tregs influence the behavior of osteoblasts, identifying a signaling pathway that is activated by Treg-derived cytokines and leads to increased bone matrix production.

The findings suggest that Tregs have a distinct "repair" role in fracture healing, distinct from their well-known immunosuppressive functions. This dual role of Tregs in both regulating immune responses and promoting tissue regeneration could have significant implications for the development of therapeutic strategies to improve fracture healing, particularly in cases where the healing process is delayed or impaired.

The study also acknowledges the complexity of the immune environment in wound healing and the need for further research to fully understand the interactions between different immune cell types and their contributions to the healing process.

It calls for a more nuanced approach to modulating the immune response in clinical practice , one that takes into account the potential for immune cells to promote tissue repair as well as maintain immune homeostasis.

In conclusion, the research provides compelling evidence for the reparative role of Tregs in fracture healing. By enhancing our understanding of the crosstalk between the immune system and bone regeneration, the study opens up new avenues for the development of targeted therapies to promote healing and improve outcomes for patients with fractures.

The findings also contribute to the broader field of regenerative medicine, highlighting the potential of modulating immune responses to enhance tissue repair and recovery.

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