what is the function of the introduction in a research paper

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How to Write a Research Paper Introduction (with Examples)

The research paper introduction section, along with the Title and Abstract, can be considered the face of any research paper. The following article is intended to guide you in organizing and writing the research paper introduction for a quality academic article or dissertation.

The research paper introduction aims to present the topic to the reader. A study will only be accepted for publishing if you can ascertain that the available literature cannot answer your research question. So it is important to ensure that you have read important studies on that particular topic, especially those within the last five to ten years, and that they are properly referenced in this section. 1 What should be included in the research paper introduction is decided by what you want to tell readers about the reason behind the research and how you plan to fill the knowledge gap. The best research paper introduction provides a systemic review of existing work and demonstrates additional work that needs to be done. It needs to be brief, captivating, and well-referenced; a well-drafted research paper introduction will help the researcher win half the battle.

The introduction for a research paper is where you set up your topic and approach for the reader. It has several key goals:

• Present your research topic
• Capture reader interest
• Summarize existing research
• Position your own approach
• Define your specific research problem and problem statement
• Highlight the novelty and contributions of the study
• Give an overview of the paper’s structure

The research paper introduction can vary in size and structure depending on whether your paper presents the results of original empirical research or is a review paper. Some research paper introduction examples are only half a page while others are a few pages long. In many cases, the introduction will be shorter than all of the other sections of your paper; its length depends on the size of your paper as a whole.

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Table of Contents

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The introduction in a research paper is placed at the beginning to guide the reader from a broad subject area to the specific topic that your research addresses. They present the following information to the reader

• Scope: The topic covered in the research paper
• Context: Background of your topic
• Importance: Why your research matters in that particular area of research and the industry problem that can be targeted

The research paper introduction conveys a lot of information and can be considered an essential roadmap for the rest of your paper. A good introduction for a research paper is important for the following reasons:

• It stimulates your reader’s interest: A good introduction section can make your readers want to read your paper by capturing their interest. It informs the reader what they are going to learn and helps determine if the topic is of interest to them.
• It helps the reader understand the research background: Without a clear introduction, your readers may feel confused and even struggle when reading your paper. A good research paper introduction will prepare them for the in-depth research to come. It provides you the opportunity to engage with the readers and demonstrate your knowledge and authority on the specific topic.
• It explains why your research paper is worth reading: Your introduction can convey a lot of information to your readers. It introduces the topic, why the topic is important, and how you plan to proceed with your research.
• It helps guide the reader through the rest of the paper: The research paper introduction gives the reader a sense of the nature of the information that will support your arguments and the general organization of the paragraphs that will follow. It offers an overview of what to expect when reading the main body of your paper.

What are the parts of introduction in the research?

A good research paper introduction section should comprise three main elements: 2

• What is known: This sets the stage for your research. It informs the readers of what is known on the subject.
• What is lacking: This is aimed at justifying the reason for carrying out your research. This could involve investigating a new concept or method or building upon previous research.
• What you aim to do: This part briefly states the objectives of your research and its major contributions. Your detailed hypothesis will also form a part of this section.

How to write a research paper introduction?

The first step in writing the research paper introduction is to inform the reader what your topic is and why it’s interesting or important. This is generally accomplished with a strong opening statement. The second step involves establishing the kinds of research that have been done and ending with limitations or gaps in the research that you intend to address. Finally, the research paper introduction clarifies how your own research fits in and what problem it addresses. If your research involved testing hypotheses, these should be stated along with your research question. The hypothesis should be presented in the past tense since it will have been tested by the time you are writing the research paper introduction.

The following key points, with examples, can guide you when writing the research paper introduction section:

• Highlight the importance of the research field or topic
• Describe the background of the topic
• Present an overview of current research on the topic

Example: The inclusion of experiential and competency-based learning has benefitted electronics engineering education. Industry partnerships provide an excellent alternative for students wanting to engage in solving real-world challenges. Industry-academia participation has grown in recent years due to the need for skilled engineers with practical training and specialized expertise. However, from the educational perspective, many activities are needed to incorporate sustainable development goals into the university curricula and consolidate learning innovation in universities.

• Reveal a gap in existing research or oppose an existing assumption
• Formulate the research question

Example: There have been plausible efforts to integrate educational activities in higher education electronics engineering programs. However, very few studies have considered using educational research methods for performance evaluation of competency-based higher engineering education, with a focus on technical and or transversal skills. To remedy the current need for evaluating competencies in STEM fields and providing sustainable development goals in engineering education, in this study, a comparison was drawn between study groups without and with industry partners.

• State the purpose of your study
• Highlight the key characteristics of your study
• Describe important results
• Highlight the novelty of the study.
• Offer a brief overview of the structure of the paper.

Example: The study evaluates the main competency needed in the applied electronics course, which is a fundamental core subject for many electronics engineering undergraduate programs. We compared two groups, without and with an industrial partner, that offered real-world projects to solve during the semester. This comparison can help determine significant differences in both groups in terms of developing subject competency and achieving sustainable development goals.

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Paperpal Copilot is a generative AI-powered academic writing assistant. It’s trained on millions of published scholarly articles and over 20 years of STM experience. Paperpal Copilot helps authors write better and faster with:

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With Paperpal Copilot, create a research paper introduction effortlessly. In this step-by-step guide, we’ll walk you through how Paperpal transforms your initial ideas into a polished and publication-ready introduction.

How to use Paperpal to write the Introduction section

Step 1: Sign up on Paperpal and click on the Copilot feature, under this choose Outlines > Research Article > Introduction

Step 2: Add your unstructured notes or initial draft, whether in English or another language, to Paperpal, which is to be used as the base for your content.

Step 3: Fill in the specifics, such as your field of study, brief description or details you want to include, which will help the AI generate the outline for your Introduction.

Step 4: Use this outline and sentence suggestions to develop your content, adding citations where needed and modifying it to align with your specific research focus.

Step 5: Turn to Paperpal’s granular language checks to refine your content, tailor it to reflect your personal writing style, and ensure it effectively conveys your message.

You can use the same process to develop each section of your article, and finally your research paper in half the time and without any of the stress.

The purpose of the research paper introduction is to introduce the reader to the problem definition, justify the need for the study, and describe the main theme of the study. The aim is to gain the reader’s attention by providing them with necessary background information and establishing the main purpose and direction of the research.

The length of the research paper introduction can vary across journals and disciplines. While there are no strict word limits for writing the research paper introduction, an ideal length would be one page, with a maximum of 400 words over 1-4 paragraphs. Generally, it is one of the shorter sections of the paper as the reader is assumed to have at least a reasonable knowledge about the topic. 2 For example, for a study evaluating the role of building design in ensuring fire safety, there is no need to discuss definitions and nature of fire in the introduction; you could start by commenting upon the existing practices for fire safety and how your study will add to the existing knowledge and practice.

When deciding what to include in the research paper introduction, the rest of the paper should also be considered. The aim is to introduce the reader smoothly to the topic and facilitate an easy read without much dependency on external sources. 3 Below is a list of elements you can include to prepare a research paper introduction outline and follow it when you are writing the research paper introduction. Topic introduction: This can include key definitions and a brief history of the topic. Research context and background: Offer the readers some general information and then narrow it down to specific aspects. Details of the research you conducted: A brief literature review can be included to support your arguments or line of thought. Rationale for the study: This establishes the relevance of your study and establishes its importance. Importance of your research: The main contributions are highlighted to help establish the novelty of your study Research hypothesis: Introduce your research question and propose an expected outcome. Organization of the paper: Include a short paragraph of 3-4 sentences that highlights your plan for the entire paper

Cite only works that are most relevant to your topic; as a general rule, you can include one to three. Note that readers want to see evidence of original thinking. So it is better to avoid using too many references as it does not leave much room for your personal standpoint to shine through. Citations in your research paper introduction support the key points, and the number of citations depend on the subject matter and the point discussed. If the research paper introduction is too long or overflowing with citations, it is better to cite a few review articles rather than the individual articles summarized in the review. A good point to remember when citing research papers in the introduction section is to include at least one-third of the references in the introduction.

The literature review plays a significant role in the research paper introduction section. A good literature review accomplishes the following: Introduces the topic – Establishes the study’s significance – Provides an overview of the relevant literature – Provides context for the study using literature – Identifies knowledge gaps However, remember to avoid making the following mistakes when writing a research paper introduction: Do not use studies from the literature review to aggressively support your research Avoid direct quoting Do not allow literature review to be the focus of this section. Instead, the literature review should only aid in setting a foundation for the manuscript.

Remember the following key points for writing a good research paper introduction: 4

• Avoid stuffing too much general information: Avoid including what an average reader would know and include only that information related to the problem being addressed in the research paper introduction. For example, when describing a comparative study of non-traditional methods for mechanical design optimization, information related to the traditional methods and differences between traditional and non-traditional methods would not be relevant. In this case, the introduction for the research paper should begin with the state-of-the-art non-traditional methods and methods to evaluate the efficiency of newly developed algorithms.
• Avoid packing too many references: Cite only the required works in your research paper introduction. The other works can be included in the discussion section to strengthen your findings.
• Avoid extensive criticism of previous studies: Avoid being overly critical of earlier studies while setting the rationale for your study. A better place for this would be the Discussion section, where you can highlight the advantages of your method.
• Avoid describing conclusions of the study: When writing a research paper introduction remember not to include the findings of your study. The aim is to let the readers know what question is being answered. The actual answer should only be given in the Results and Discussion section.

To summarize, the research paper introduction section should be brief yet informative. It should convince the reader the need to conduct the study and motivate him to read further. If you’re feeling stuck or unsure, choose trusted AI academic writing assistants like Paperpal to effortlessly craft your research paper introduction and other sections of your research article.

1. Jawaid, S. A., & Jawaid, M. (2019). How to write introduction and discussion. Saudi Journal of Anaesthesia, 13(Suppl 1), S18.

2. Dewan, P., & Gupta, P. (2016). Writing the title, abstract and introduction: Looks matter!. Indian pediatrics, 53, 235-241.

3. Cetin, S., & Hackam, D. J. (2005). An approach to the writing of a scientific Manuscript1. Journal of Surgical Research, 128(2), 165-167.

4. Bavdekar, S. B. (2015). Writing introduction: Laying the foundations of a research paper. Journal of the Association of Physicians of India, 63(7), 44-6.

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• USC Libraries
• Research Guides

Organizing Your Social Sciences Research Paper

• 4. The Introduction
• Purpose of Guide
• Design Flaws to Avoid
• Independent and Dependent Variables
• Glossary of Research Terms
• Reading Research Effectively
• Narrowing a Topic Idea
• Broadening a Topic Idea
• Extending the Timeliness of a Topic Idea
• Academic Writing Style
• Applying Critical Thinking
• Choosing a Title
• Making an Outline
• Paragraph Development
• Research Process Video Series
• Executive Summary
• The C.A.R.S. Model
• Background Information
• The Research Problem/Question
• Theoretical Framework
• Citation Tracking
• Content Alert Services
• Evaluating Sources
• Primary Sources
• Secondary Sources
• Tiertiary Sources
• Scholarly vs. Popular Publications
• Qualitative Methods
• Quantitative Methods
• Insiderness
• Using Non-Textual Elements
• Limitations of the Study
• Common Grammar Mistakes
• Writing Concisely
• Avoiding Plagiarism
• Footnotes or Endnotes?
• Further Readings
• Generative AI and Writing
• USC Libraries Tutorials and Other Guides
• Bibliography

The introduction leads the reader from a general subject area to a particular topic of inquiry. It establishes the scope, context, and significance of the research being conducted by summarizing current understanding and background information about the topic, stating the purpose of the work in the form of the research problem supported by a hypothesis or a set of questions, explaining briefly the methodological approach used to examine the research problem, highlighting the potential outcomes your study can reveal, and outlining the remaining structure and organization of the paper.

Key Elements of the Research Proposal. Prepared under the direction of the Superintendent and by the 2010 Curriculum Design and Writing Team. Baltimore County Public Schools.

Importance of a Good Introduction

Think of the introduction as a mental road map that must answer for the reader these four questions:

• What was I studying?
• Why was this topic important to investigate?
• What did we know about this topic before I did this study?
• How will this study advance new knowledge or new ways of understanding?

According to Reyes, there are three overarching goals of a good introduction: 1) ensure that you summarize prior studies about the topic in a manner that lays a foundation for understanding the research problem; 2) explain how your study specifically addresses gaps in the literature, insufficient consideration of the topic, or other deficiency in the literature; and, 3) note the broader theoretical, empirical, and/or policy contributions and implications of your research.

A well-written introduction is important because, quite simply, you never get a second chance to make a good first impression. The opening paragraphs of your paper will provide your readers with their initial impressions about the logic of your argument, your writing style, the overall quality of your research, and, ultimately, the validity of your findings and conclusions. A vague, disorganized, or error-filled introduction will create a negative impression, whereas, a concise, engaging, and well-written introduction will lead your readers to think highly of your analytical skills, your writing style, and your research approach. All introductions should conclude with a brief paragraph that describes the organization of the rest of the paper.

Hirano, Eliana. “Research Article Introductions in English for Specific Purposes: A Comparison between Brazilian, Portuguese, and English.” English for Specific Purposes 28 (October 2009): 240-250; Samraj, B. “Introductions in Research Articles: Variations Across Disciplines.” English for Specific Purposes 21 (2002): 1–17; Introductions. The Writing Center. University of North Carolina; “Writing Introductions.” In Good Essay Writing: A Social Sciences Guide. Peter Redman. 4th edition. (London: Sage, 2011), pp. 63-70; Reyes, Victoria. Demystifying the Journal Article. Inside Higher Education.

Structure and Writing Style

I.  Structure and Approach

The introduction is the broad beginning of the paper that answers three important questions for the reader:

• What is this?
• Why should I read it?
• What do you want me to think about / consider doing / react to?

Think of the structure of the introduction as an inverted triangle of information that lays a foundation for understanding the research problem. Organize the information so as to present the more general aspects of the topic early in the introduction, then narrow your analysis to more specific topical information that provides context, finally arriving at your research problem and the rationale for studying it [often written as a series of key questions to be addressed or framed as a hypothesis or set of assumptions to be tested] and, whenever possible, a description of the potential outcomes your study can reveal.

These are general phases associated with writing an introduction: 1.  Establish an area to research by:

• Highlighting the importance of the topic, and/or
• Making general statements about the topic, and/or
• Presenting an overview on current research on the subject.

2.  Identify a research niche by:

• Opposing an existing assumption, and/or
• Revealing a gap in existing research, and/or
• Formulating a research question or problem, and/or
• Continuing a disciplinary tradition.

3.  Place your research within the research niche by:

• Stating the intent of your study,
• Outlining the key characteristics of your study,
• Describing important results, and
• Giving a brief overview of the structure of the paper.

NOTE:   It is often useful to review the introduction late in the writing process. This is appropriate because outcomes are unknown until you've completed the study. After you complete writing the body of the paper, go back and review introductory descriptions of the structure of the paper, the method of data gathering, the reporting and analysis of results, and the conclusion. Reviewing and, if necessary, rewriting the introduction ensures that it correctly matches the overall structure of your final paper.

II.  Delimitations of the Study

Delimitations refer to those characteristics that limit the scope and define the conceptual boundaries of your research . This is determined by the conscious exclusionary and inclusionary decisions you make about how to investigate the research problem. In other words, not only should you tell the reader what it is you are studying and why, but you must also acknowledge why you rejected alternative approaches that could have been used to examine the topic.

Obviously, the first limiting step was the choice of research problem itself. However, implicit are other, related problems that could have been chosen but were rejected. These should be noted in the conclusion of your introduction. For example, a delimitating statement could read, "Although many factors can be understood to impact the likelihood young people will vote, this study will focus on socioeconomic factors related to the need to work full-time while in school." The point is not to document every possible delimiting factor, but to highlight why previously researched issues related to the topic were not addressed.

Examples of delimitating choices would be:

• The key aims and objectives of your study,
• The research questions that you address,
• The variables of interest [i.e., the various factors and features of the phenomenon being studied],
• The method(s) of investigation,
• The time period your study covers, and
• Any relevant alternative theoretical frameworks that could have been adopted.

Review each of these decisions. Not only do you clearly establish what you intend to accomplish in your research, but you should also include a declaration of what the study does not intend to cover. In the latter case, your exclusionary decisions should be based upon criteria understood as, "not interesting"; "not directly relevant"; “too problematic because..."; "not feasible," and the like. Make this reasoning explicit!

NOTE:   Delimitations refer to the initial choices made about the broader, overall design of your study and should not be confused with documenting the limitations of your study discovered after the research has been completed.

ANOTHER NOTE : Do not view delimitating statements as admitting to an inherent failing or shortcoming in your research. They are an accepted element of academic writing intended to keep the reader focused on the research problem by explicitly defining the conceptual boundaries and scope of your study. It addresses any critical questions in the reader's mind of, "Why the hell didn't the author examine this?"

III.  The Narrative Flow

Issues to keep in mind that will help the narrative flow in your introduction :

• Your introduction should clearly identify the subject area of interest . A simple strategy to follow is to use key words from your title in the first few sentences of the introduction. This will help focus the introduction on the topic at the appropriate level and ensures that you get to the subject matter quickly without losing focus, or discussing information that is too general.
• Establish context by providing a brief and balanced review of the pertinent published literature that is available on the subject. The key is to summarize for the reader what is known about the specific research problem before you did your analysis. This part of your introduction should not represent a comprehensive literature review--that comes next. It consists of a general review of the important, foundational research literature [with citations] that establishes a foundation for understanding key elements of the research problem. See the drop-down menu under this tab for " Background Information " regarding types of contexts.
• Clearly state the hypothesis that you investigated . When you are first learning to write in this format it is okay, and actually preferable, to use a past statement like, "The purpose of this study was to...." or "We investigated three possible mechanisms to explain the...."
• Why did you choose this kind of research study or design? Provide a clear statement of the rationale for your approach to the problem studied. This will usually follow your statement of purpose in the last paragraph of the introduction.

IV.  Engaging the Reader

A research problem in the social sciences can come across as dry and uninteresting to anyone unfamiliar with the topic . Therefore, one of the goals of your introduction is to make readers want to read your paper. Here are several strategies you can use to grab the reader's attention:

• Open with a compelling story . Almost all research problems in the social sciences, no matter how obscure or esoteric , are really about the lives of people. Telling a story that humanizes an issue can help illuminate the significance of the problem and help the reader empathize with those affected by the condition being studied.
• Include a strong quotation or a vivid, perhaps unexpected, anecdote . During your review of the literature, make note of any quotes or anecdotes that grab your attention because they can used in your introduction to highlight the research problem in a captivating way.
• Pose a provocative or thought-provoking question . Your research problem should be framed by a set of questions to be addressed or hypotheses to be tested. However, a provocative question can be presented in the beginning of your introduction that challenges an existing assumption or compels the reader to consider an alternative viewpoint that helps establish the significance of your study. 
• Describe a puzzling scenario or incongruity . This involves highlighting an interesting quandary concerning the research problem or describing contradictory findings from prior studies about a topic. Posing what is essentially an unresolved intellectual riddle about the problem can engage the reader's interest in the study.
• Cite a stirring example or case study that illustrates why the research problem is important . Draw upon the findings of others to demonstrate the significance of the problem and to describe how your study builds upon or offers alternatives ways of investigating this prior research.

NOTE:   It is important that you choose only one of the suggested strategies for engaging your readers. This avoids giving an impression that your paper is more flash than substance and does not distract from the substance of your study.

Freedman, Leora  and Jerry Plotnick. Introductions and Conclusions. University College Writing Centre. University of Toronto; Introduction. The Structure, Format, Content, and Style of a Journal-Style Scientific Paper. Department of Biology. Bates College; Introductions. The Writing Center. University of North Carolina; Introductions. The Writer’s Handbook. Writing Center. University of Wisconsin, Madison; Introductions, Body Paragraphs, and Conclusions for an Argument Paper. The Writing Lab and The OWL. Purdue University; “Writing Introductions.” In Good Essay Writing: A Social Sciences Guide . Peter Redman. 4th edition. (London: Sage, 2011), pp. 63-70; Resources for Writers: Introduction Strategies. Program in Writing and Humanistic Studies. Massachusetts Institute of Technology; Sharpling, Gerald. Writing an Introduction. Centre for Applied Linguistics, University of Warwick; Samraj, B. “Introductions in Research Articles: Variations Across Disciplines.” English for Specific Purposes 21 (2002): 1–17; Swales, John and Christine B. Feak. Academic Writing for Graduate Students: Essential Skills and Tasks . 2nd edition. Ann Arbor, MI: University of Michigan Press, 2004 ; Writing Your Introduction. Department of English Writing Guide. George Mason University.

Writing Tip

Avoid the "Dictionary" Introduction

Giving the dictionary definition of words related to the research problem may appear appropriate because it is important to define specific terminology that readers may be unfamiliar with. However, anyone can look a word up in the dictionary and a general dictionary is not a particularly authoritative source because it doesn't take into account the context of your topic and doesn't offer particularly detailed information. Also, placed in the context of a particular discipline, a term or concept may have a different meaning than what is found in a general dictionary. If you feel that you must seek out an authoritative definition, use a subject specific dictionary or encyclopedia [e.g., if you are a sociology student, search for dictionaries of sociology]. A good database for obtaining definitive definitions of concepts or terms is Credo Reference .

Saba, Robert. The College Research Paper. Florida International University; Introductions. The Writing Center. University of North Carolina.

Another Writing Tip

When Do I Begin?

A common question asked at the start of any paper is, "Where should I begin?" An equally important question to ask yourself is, "When do I begin?" Research problems in the social sciences rarely rest in isolation from history. Therefore, it is important to lay a foundation for understanding the historical context underpinning the research problem. However, this information should be brief and succinct and begin at a point in time that illustrates the study's overall importance. For example, a study that investigates coffee cultivation and export in West Africa as a key stimulus for local economic growth needs to describe the beginning of exporting coffee in the region and establishing why economic growth is important. You do not need to give a long historical explanation about coffee exports in Africa. If a research problem requires a substantial exploration of the historical context, do this in the literature review section. In your introduction, make note of this as part of the "roadmap" [see below] that you use to describe the organization of your paper.

Introductions. The Writing Center. University of North Carolina; “Writing Introductions.” In Good Essay Writing: A Social Sciences Guide . Peter Redman. 4th edition. (London: Sage, 2011), pp. 63-70.

Yet Another Writing Tip

Always End with a Roadmap

The final paragraph or sentences of your introduction should forecast your main arguments and conclusions and provide a brief description of the rest of the paper [the "roadmap"] that let's the reader know where you are going and what to expect. A roadmap is important because it helps the reader place the research problem within the context of their own perspectives about the topic. In addition, concluding your introduction with an explicit roadmap tells the reader that you have a clear understanding of the structural purpose of your paper. In this way, the roadmap acts as a type of promise to yourself and to your readers that you will follow a consistent and coherent approach to addressing the topic of inquiry. Refer to it often to help keep your writing focused and organized.

Cassuto, Leonard. “On the Dissertation: How to Write the Introduction.” The Chronicle of Higher Education , May 28, 2018; Radich, Michael. A Student's Guide to Writing in East Asian Studies . (Cambridge, MA: Harvard University Writing n. d.), pp. 35-37.

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Home » Research Paper Introduction – Writing Guide and Examples

Research Paper Introduction – Writing Guide and Examples

Table of Contents

Research Paper Introduction

Research paper introduction is the first section of a research paper that provides an overview of the study, its purpose, and the research question (s) or hypothesis (es) being investigated. It typically includes background information about the topic, a review of previous research in the field, and a statement of the research objectives. The introduction is intended to provide the reader with a clear understanding of the research problem, why it is important, and how the study will contribute to existing knowledge in the field. It also sets the tone for the rest of the paper and helps to establish the author’s credibility and expertise on the subject.

How to Write Research Paper Introduction

Writing an introduction for a research paper can be challenging because it sets the tone for the entire paper. Here are some steps to follow to help you write an effective research paper introduction:

• Start with a hook : Begin your introduction with an attention-grabbing statement, a question, or a surprising fact that will make the reader interested in reading further.
• Provide background information: After the hook, provide background information on the topic. This information should give the reader a general idea of what the topic is about and why it is important.
• State the research problem: Clearly state the research problem or question that the paper addresses. This should be done in a concise and straightforward manner.
• State the research objectives: After stating the research problem, clearly state the research objectives. This will give the reader an idea of what the paper aims to achieve.
• Provide a brief overview of the paper: At the end of the introduction, provide a brief overview of the paper. This should include a summary of the main points that will be discussed in the paper.
• Revise and refine: Finally, revise and refine your introduction to ensure that it is clear, concise, and engaging.

Structure of Research Paper Introduction

The following is a typical structure for a research paper introduction:

• Background Information: This section provides an overview of the topic of the research paper, including relevant background information and any previous research that has been done on the topic. It helps to give the reader a sense of the context for the study.
• Problem Statement: This section identifies the specific problem or issue that the research paper is addressing. It should be clear and concise, and it should articulate the gap in knowledge that the study aims to fill.
• Research Question/Hypothesis : This section states the research question or hypothesis that the study aims to answer. It should be specific and focused, and it should clearly connect to the problem statement.
• Significance of the Study: This section explains why the research is important and what the potential implications of the study are. It should highlight the contribution that the research makes to the field.
• Methodology: This section describes the research methods that were used to conduct the study. It should be detailed enough to allow the reader to understand how the study was conducted and to evaluate the validity of the results.
• Organization of the Paper : This section provides a brief overview of the structure of the research paper. It should give the reader a sense of what to expect in each section of the paper.

Research Paper Introduction Examples

Research Paper Introduction Examples could be:

Example 1: In recent years, the use of artificial intelligence (AI) has become increasingly prevalent in various industries, including healthcare. AI algorithms are being developed to assist with medical diagnoses, treatment recommendations, and patient monitoring. However, as the use of AI in healthcare grows, ethical concerns regarding privacy, bias, and accountability have emerged. This paper aims to explore the ethical implications of AI in healthcare and propose recommendations for addressing these concerns.

Example 2: Climate change is one of the most pressing issues facing our planet today. The increasing concentration of greenhouse gases in the atmosphere has resulted in rising temperatures, changing weather patterns, and other environmental impacts. In this paper, we will review the scientific evidence on climate change, discuss the potential consequences of inaction, and propose solutions for mitigating its effects.

Example 3: The rise of social media has transformed the way we communicate and interact with each other. While social media platforms offer many benefits, including increased connectivity and access to information, they also present numerous challenges. In this paper, we will examine the impact of social media on mental health, privacy, and democracy, and propose solutions for addressing these issues.

Example 4: The use of renewable energy sources has become increasingly important in the face of climate change and environmental degradation. While renewable energy technologies offer many benefits, including reduced greenhouse gas emissions and energy independence, they also present numerous challenges. In this paper, we will assess the current state of renewable energy technology, discuss the economic and political barriers to its adoption, and propose solutions for promoting the widespread use of renewable energy.

Purpose of Research Paper Introduction

The introduction section of a research paper serves several important purposes, including:

• Providing context: The introduction should give readers a general understanding of the topic, including its background, significance, and relevance to the field.
• Presenting the research question or problem: The introduction should clearly state the research question or problem that the paper aims to address. This helps readers understand the purpose of the study and what the author hopes to accomplish.
• Reviewing the literature: The introduction should summarize the current state of knowledge on the topic, highlighting the gaps and limitations in existing research. This shows readers why the study is important and necessary.
• Outlining the scope and objectives of the study: The introduction should describe the scope and objectives of the study, including what aspects of the topic will be covered, what data will be collected, and what methods will be used.
• Previewing the main findings and conclusions : The introduction should provide a brief overview of the main findings and conclusions that the study will present. This helps readers anticipate what they can expect to learn from the paper.

When to Write Research Paper Introduction

The introduction of a research paper is typically written after the research has been conducted and the data has been analyzed. This is because the introduction should provide an overview of the research problem, the purpose of the study, and the research questions or hypotheses that will be investigated.

Once you have a clear understanding of the research problem and the questions that you want to explore, you can begin to write the introduction. It’s important to keep in mind that the introduction should be written in a way that engages the reader and provides a clear rationale for the study. It should also provide context for the research by reviewing relevant literature and explaining how the study fits into the larger field of research.

Advantages of Research Paper Introduction

The introduction of a research paper has several advantages, including:

• Establishing the purpose of the research: The introduction provides an overview of the research problem, question, or hypothesis, and the objectives of the study. This helps to clarify the purpose of the research and provide a roadmap for the reader to follow.
• Providing background information: The introduction also provides background information on the topic, including a review of relevant literature and research. This helps the reader understand the context of the study and how it fits into the broader field of research.
• Demonstrating the significance of the research: The introduction also explains why the research is important and relevant. This helps the reader understand the value of the study and why it is worth reading.
• Setting expectations: The introduction sets the tone for the rest of the paper and prepares the reader for what is to come. This helps the reader understand what to expect and how to approach the paper.
• Grabbing the reader’s attention: A well-written introduction can grab the reader’s attention and make them interested in reading further. This is important because it can help to keep the reader engaged and motivated to read the rest of the paper.
• Creating a strong first impression: The introduction is the first part of the research paper that the reader will see, and it can create a strong first impression. A well-written introduction can make the reader more likely to take the research seriously and view it as credible.
• Establishing the author’s credibility: The introduction can also establish the author’s credibility as a researcher. By providing a clear and thorough overview of the research problem and relevant literature, the author can demonstrate their expertise and knowledge in the field.
• Providing a structure for the paper: The introduction can also provide a structure for the rest of the paper. By outlining the main sections and sub-sections of the paper, the introduction can help the reader navigate the paper and find the information they are looking for.

About the author

Muhammad Hassan

Researcher, Academic Writer, Web developer

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Introductions

What this handout is about.

This handout will explain the functions of introductions, offer strategies for creating effective introductions, and provide some examples of less effective introductions to avoid.

The role of introductions

Introductions and conclusions can be the most difficult parts of papers to write. Usually when you sit down to respond to an assignment, you have at least some sense of what you want to say in the body of your paper. You might have chosen a few examples you want to use or have an idea that will help you answer the main question of your assignment; these sections, therefore, may not be as hard to write. And it’s fine to write them first! But in your final draft, these middle parts of the paper can’t just come out of thin air; they need to be introduced and concluded in a way that makes sense to your reader.

Your introduction and conclusion act as bridges that transport your readers from their own lives into the “place” of your analysis. If your readers pick up your paper about education in the autobiography of Frederick Douglass, for example, they need a transition to help them leave behind the world of Chapel Hill, television, e-mail, and The Daily Tar Heel and to help them temporarily enter the world of nineteenth-century American slavery. By providing an introduction that helps your readers make a transition between their own world and the issues you will be writing about, you give your readers the tools they need to get into your topic and care about what you are saying. Similarly, once you’ve hooked your readers with the introduction and offered evidence to prove your thesis, your conclusion can provide a bridge to help your readers make the transition back to their daily lives. (See our handout on conclusions .)

Note that what constitutes a good introduction may vary widely based on the kind of paper you are writing and the academic discipline in which you are writing it. If you are uncertain what kind of introduction is expected, ask your instructor.

Why bother writing a good introduction?

You never get a second chance to make a first impression. The opening paragraph of your paper will provide your readers with their initial impressions of your argument, your writing style, and the overall quality of your work. A vague, disorganized, error-filled, off-the-wall, or boring introduction will probably create a negative impression. On the other hand, a concise, engaging, and well-written introduction will start your readers off thinking highly of you, your analytical skills, your writing, and your paper.

Your introduction is an important road map for the rest of your paper. Your introduction conveys a lot of information to your readers. You can let them know what your topic is, why it is important, and how you plan to proceed with your discussion. In many academic disciplines, your introduction should contain a thesis that will assert your main argument. Your introduction should also give the reader a sense of the kinds of information you will use to make that argument and the general organization of the paragraphs and pages that will follow. After reading your introduction, your readers should not have any major surprises in store when they read the main body of your paper.

Ideally, your introduction will make your readers want to read your paper. The introduction should capture your readers’ interest, making them want to read the rest of your paper. Opening with a compelling story, an interesting question, or a vivid example can get your readers to see why your topic matters and serve as an invitation for them to join you for an engaging intellectual conversation (remember, though, that these strategies may not be suitable for all papers and disciplines).

Strategies for writing an effective introduction

Start by thinking about the question (or questions) you are trying to answer. Your entire essay will be a response to this question, and your introduction is the first step toward that end. Your direct answer to the assigned question will be your thesis, and your thesis will likely be included in your introduction, so it is a good idea to use the question as a jumping off point. Imagine that you are assigned the following question:

Drawing on the Narrative of the Life of Frederick Douglass , discuss the relationship between education and slavery in 19th-century America. Consider the following: How did white control of education reinforce slavery? How did Douglass and other enslaved African Americans view education while they endured slavery? And what role did education play in the acquisition of freedom? Most importantly, consider the degree to which education was or was not a major force for social change with regard to slavery.

You will probably refer back to your assignment extensively as you prepare your complete essay, and the prompt itself can also give you some clues about how to approach the introduction. Notice that it starts with a broad statement and then narrows to focus on specific questions from the book. One strategy might be to use a similar model in your own introduction—start off with a big picture sentence or two and then focus in on the details of your argument about Douglass. Of course, a different approach could also be very successful, but looking at the way the professor set up the question can sometimes give you some ideas for how you might answer it. (See our handout on understanding assignments for additional information on the hidden clues in assignments.)

Decide how general or broad your opening should be. Keep in mind that even a “big picture” opening needs to be clearly related to your topic; an opening sentence that said “Human beings, more than any other creatures on earth, are capable of learning” would be too broad for our sample assignment about slavery and education. If you have ever used Google Maps or similar programs, that experience can provide a helpful way of thinking about how broad your opening should be. Imagine that you’re researching Chapel Hill. If what you want to find out is whether Chapel Hill is at roughly the same latitude as Rome, it might make sense to hit that little “minus” sign on the online map until it has zoomed all the way out and you can see the whole globe. If you’re trying to figure out how to get from Chapel Hill to Wrightsville Beach, it might make more sense to zoom in to the level where you can see most of North Carolina (but not the rest of the world, or even the rest of the United States). And if you are looking for the intersection of Ridge Road and Manning Drive so that you can find the Writing Center’s main office, you may need to zoom all the way in. The question you are asking determines how “broad” your view should be. In the sample assignment above, the questions are probably at the “state” or “city” level of generality. When writing, you need to place your ideas in context—but that context doesn’t generally have to be as big as the whole galaxy!

Try writing your introduction last. You may think that you have to write your introduction first, but that isn’t necessarily true, and it isn’t always the most effective way to craft a good introduction. You may find that you don’t know precisely what you are going to argue at the beginning of the writing process. It is perfectly fine to start out thinking that you want to argue a particular point but wind up arguing something slightly or even dramatically different by the time you’ve written most of the paper. The writing process can be an important way to organize your ideas, think through complicated issues, refine your thoughts, and develop a sophisticated argument. However, an introduction written at the beginning of that discovery process will not necessarily reflect what you wind up with at the end. You will need to revise your paper to make sure that the introduction, all of the evidence, and the conclusion reflect the argument you intend. Sometimes it’s easiest to just write up all of your evidence first and then write the introduction last—that way you can be sure that the introduction will match the body of the paper.

Don’t be afraid to write a tentative introduction first and then change it later. Some people find that they need to write some kind of introduction in order to get the writing process started. That’s fine, but if you are one of those people, be sure to return to your initial introduction later and rewrite if necessary.

Open with something that will draw readers in. Consider these options (remembering that they may not be suitable for all kinds of papers):

• an intriguing example —for example, Douglass writes about a mistress who initially teaches him but then ceases her instruction as she learns more about slavery.
• a provocative quotation that is closely related to your argument —for example, Douglass writes that “education and slavery were incompatible with each other.” (Quotes from famous people, inspirational quotes, etc. may not work well for an academic paper; in this example, the quote is from the author himself.)
• a puzzling scenario —for example, Frederick Douglass says of slaves that “[N]othing has been left undone to cripple their intellects, darken their minds, debase their moral nature, obliterate all traces of their relationship to mankind; and yet how wonderfully they have sustained the mighty load of a most frightful bondage, under which they have been groaning for centuries!” Douglass clearly asserts that slave owners went to great lengths to destroy the mental capacities of slaves, yet his own life story proves that these efforts could be unsuccessful.
• a vivid and perhaps unexpected anecdote —for example, “Learning about slavery in the American history course at Frederick Douglass High School, students studied the work slaves did, the impact of slavery on their families, and the rules that governed their lives. We didn’t discuss education, however, until one student, Mary, raised her hand and asked, ‘But when did they go to school?’ That modern high school students could not conceive of an American childhood devoid of formal education speaks volumes about the centrality of education to American youth today and also suggests the significance of the deprivation of education in past generations.”
• a thought-provoking question —for example, given all of the freedoms that were denied enslaved individuals in the American South, why does Frederick Douglass focus his attentions so squarely on education and literacy?

Pay special attention to your first sentence. Start off on the right foot with your readers by making sure that the first sentence actually says something useful and that it does so in an interesting and polished way.

How to evaluate your introduction draft

Ask a friend to read your introduction and then tell you what he or she expects the paper will discuss, what kinds of evidence the paper will use, and what the tone of the paper will be. If your friend is able to predict the rest of your paper accurately, you probably have a good introduction.

Five kinds of less effective introductions

1. The placeholder introduction. When you don’t have much to say on a given topic, it is easy to create this kind of introduction. Essentially, this kind of weaker introduction contains several sentences that are vague and don’t really say much. They exist just to take up the “introduction space” in your paper. If you had something more effective to say, you would probably say it, but in the meantime this paragraph is just a place holder.

Example: Slavery was one of the greatest tragedies in American history. There were many different aspects of slavery. Each created different kinds of problems for enslaved people.

2. The restated question introduction. Restating the question can sometimes be an effective strategy, but it can be easy to stop at JUST restating the question instead of offering a more specific, interesting introduction to your paper. The professor or teaching assistant wrote your question and will be reading many essays in response to it—he or she does not need to read a whole paragraph that simply restates the question.

Example: The Narrative of the Life of Frederick Douglass discusses the relationship between education and slavery in 19th century America, showing how white control of education reinforced slavery and how Douglass and other enslaved African Americans viewed education while they endured. Moreover, the book discusses the role that education played in the acquisition of freedom. Education was a major force for social change with regard to slavery.

3. The Webster’s Dictionary introduction. This introduction begins by giving the dictionary definition of one or more of the words in the assigned question. Anyone can look a word up in the dictionary and copy down what Webster says. If you want to open with a discussion of an important term, it may be far more interesting for you (and your reader) if you develop your own definition of the term in the specific context of your class and assignment. You may also be able to use a definition from one of the sources you’ve been reading for class. Also recognize that the dictionary is also not a particularly authoritative work—it doesn’t take into account the context of your course and doesn’t offer particularly detailed information. If you feel that you must seek out an authority, try to find one that is very relevant and specific. Perhaps a quotation from a source reading might prove better? Dictionary introductions are also ineffective simply because they are so overused. Instructors may see a great many papers that begin in this way, greatly decreasing the dramatic impact that any one of those papers will have.

Example: Webster’s dictionary defines slavery as “the state of being a slave,” as “the practice of owning slaves,” and as “a condition of hard work and subjection.”

4. The “dawn of man” introduction. This kind of introduction generally makes broad, sweeping statements about the relevance of this topic since the beginning of time, throughout the world, etc. It is usually very general (similar to the placeholder introduction) and fails to connect to the thesis. It may employ cliches—the phrases “the dawn of man” and “throughout human history” are examples, and it’s hard to imagine a time when starting with one of these would work. Instructors often find them extremely annoying.

Example: Since the dawn of man, slavery has been a problem in human history.

5. The book report introduction. This introduction is what you had to do for your elementary school book reports. It gives the name and author of the book you are writing about, tells what the book is about, and offers other basic facts about the book. You might resort to this sort of introduction when you are trying to fill space because it’s a familiar, comfortable format. It is ineffective because it offers details that your reader probably already knows and that are irrelevant to the thesis.

Example: Frederick Douglass wrote his autobiography, Narrative of the Life of Frederick Douglass, An American Slave , in the 1840s. It was published in 1986 by Penguin Books. In it, he tells the story of his life.

And now for the conclusion…

Writing an effective introduction can be tough. Try playing around with several different options and choose the one that ends up sounding best to you!

Just as your introduction helps readers make the transition to your topic, your conclusion needs to help them return to their daily lives–but with a lasting sense of how what they have just read is useful or meaningful. Check out our handout on  conclusions for tips on ending your paper as effectively as you began it!

Works consulted

We consulted these works while writing this handout. This is not a comprehensive list of resources on the handout’s topic, and we encourage you to do your own research to find additional publications. Please do not use this list as a model for the format of your own reference list, as it may not match the citation style you are using. For guidance on formatting citations, please see the UNC Libraries citation tutorial . We revise these tips periodically and welcome feedback.

Douglass, Frederick. 1995. Narrative of the Life of Frederick Douglass, an American Slave, Written by Himself . New York: Dover.

You may reproduce it for non-commercial use if you use the entire handout and attribute the source: The Writing Center, University of North Carolina at Chapel Hill

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How to Write an Introduction for a Research Paper

Table of Contents

Writing an introduction for a research paper is a critical element of your paper, but it can seem challenging to encapsulate enormous amount of information into a concise form. The introduction of your research paper sets the tone for your research and provides the context for your study. In this article, we will guide you through the process of writing an effective introduction that grabs the reader's attention and captures the essence of your research paper.

Understanding the Purpose of a Research Paper Introduction

The introduction acts as a road map for your research paper, guiding the reader through the main ideas and arguments. The purpose of the introduction is to present your research topic to the readers and provide a rationale for why your study is relevant. It helps the reader locate your research and its relevance in the broader field of related scientific explorations. Additionally, the introduction should inform the reader about the objectives and scope of your study, giving them an overview of what to expect in the paper. By including a comprehensive introduction, you establish your credibility as an author and convince the reader that your research is worth their time and attention.

Key Elements to Include in Your Introduction

When writing your research paper introduction, there are several key elements you should include to ensure it is comprehensive and informative.

• A hook or attention-grabbing statement to capture the reader's interest.  It can be a thought-provoking question, a surprising statistic, or a compelling anecdote that relates to your research topic.
• A brief overview of the research topic and its significance. By highlighting the gap in existing knowledge or the problem your research aims to address, you create a compelling case for the relevance of your study.
• A clear research question or problem statement. This serves as the foundation of your research and guides the reader in understanding the unique focus of your study. It should be concise, specific, and clearly articulated.
• An outline of the paper's structure and main arguments, to help the readers navigate through the paper with ease.

Preparing to Write Your Introduction

Before diving into writing your introduction, it is essential to prepare adequately. This involves 3 important steps:

• Conducting Preliminary Research: Immerse yourself in the existing literature to develop a clear research question and position your study within the academic discourse.
• Identifying Your Thesis Statement: Define a specific, focused, and debatable thesis statement, serving as a roadmap for your paper.
• Considering Broader Context: Reflect on the significance of your research within your field, understanding its potential impact and contribution.

By engaging in these preparatory steps, you can ensure that your introduction is well-informed, focused, and sets the stage for a compelling research paper.

Structuring Your Introduction

Now that you have prepared yourself to tackle the introduction, it's time to structure it effectively. A well-structured introduction will engage the reader from the beginning and provide a logical flow to your research paper.

Starting with a Hook

Begin your introduction with an attention-grabbing hook that captivates the reader's interest. This hook serves as a way to make your introduction more engaging and compelling. For example, if you are writing a research paper on the impact of climate change on biodiversity, you could start your introduction with a statistic about the number of species that have gone extinct due to climate change. This will immediately grab the reader's attention and make them realize the urgency and importance of the topic.

Introducing Your Topic

Provide a brief overview, which should give the reader a general understanding of the subject matter and its significance. Explain the importance of the topic and its relevance to the field. This will help the reader understand why your research is significant and why they should continue reading. Continuing with the example of climate change and biodiversity, you could explain how climate change is one of the greatest threats to global biodiversity, how it affects ecosystems, and the potential consequences for both wildlife and human populations. By providing this context, you are setting the stage for the rest of your research paper and helping the reader understand the importance of your study.

Presenting Your Thesis Statement

The thesis statement should directly address your research question and provide a preview of the main arguments or findings discussed in your paper. Make sure your thesis statement is clear, concise, and well-supported by the evidence you will present in your research paper. By presenting a strong and focused thesis statement, you are providing the reader with the information they could anticipate in your research paper. This will help them understand the purpose and scope of your study and will make them more inclined to continue reading.

Writing Techniques for an Effective Introduction

When crafting an introduction, it is crucial to pay attention to the finer details that can elevate your writing to the next level. By utilizing specific writing techniques, you can captivate your readers and draw them into your research journey.

Using Clear and Concise Language

One of the most important writing techniques to employ in your introduction is the use of clear and concise language. By choosing your words carefully, you can effectively convey your ideas to the reader. It is essential to avoid using jargon or complex terminology that may confuse or alienate your audience. Instead, focus on communicating your research in a straightforward manner to ensure that your introduction is accessible to both experts in your field and those who may be new to the topic. This approach allows you to engage a broader audience and make your research more inclusive.

Establishing the Relevance of Your Research

One way to establish the relevance of your research is by highlighting how it fills a gap in the existing literature. Explain how your study addresses a significant research question that has not been adequately explored. By doing this, you demonstrate that your research is not only unique but also contributes to the broader knowledge in your field. Furthermore, it is important to emphasize the potential impact of your research. Whether it is advancing scientific understanding, informing policy decisions, or improving practical applications, make it clear to the reader how your study can make a difference.

By employing these two writing techniques in your introduction, you can effectively engage your readers. Take your time to craft an introduction that is both informative and captivating, leaving your readers eager to delve deeper into your research.

Revising and Polishing Your Introduction

Once you have written your introduction, it is crucial to revise and polish it to ensure that it effectively sets the stage for your research paper.

Self-Editing Techniques

Review your introduction for clarity, coherence, and logical flow. Ensure each paragraph introduces a new idea or argument with smooth transitions.

Check for grammatical errors, spelling mistakes, and awkward sentence structures.

Ensure that your introduction aligns with the overall tone and style of your research paper.

Seeking Feedback for Improvement

Consider seeking feedback from peers, colleagues, or your instructor. They can provide valuable insights and suggestions for improving your introduction. Be open to constructive criticism and use it to refine your introduction and make it more compelling for the reader.

Writing an introduction for a research paper requires careful thought and planning. By understanding the purpose of the introduction, preparing adequately, structuring effectively, and employing writing techniques, you can create an engaging and informative introduction for your research. Remember to revise and polish your introduction to ensure that it accurately represents the main ideas and arguments in your research paper. With a well-crafted introduction, you will capture the reader's attention and keep them inclined to your paper.

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How to Write an Introduction for a Research Paper

How to write an introduction for a research paper? Eventually (and with practice) all writers will develop their own strategy for writing the perfect introduction for a research paper. Once you are comfortable with writing, you will probably find your own, but coming up with a good strategy can be tough for beginning writers.

The Purpose of an Introduction

Your opening paragraphs, phrases for introducing thesis statements, research paper introduction examples, using the introduction to map out your research paper.

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• First write your thesis.Your thesis should state the main idea in specific terms.
• After you have a working thesis, tackle the body of your paper before you write the rest of the introduction. Each paragraph in the body should explore one specific topic that proves, or summarizes your thesis. Writing is a thinking process. Once you have worked your way through that process by writing the body of the paper, you will have an intimate understanding of how you are supporting your thesis. After you have written the body paragraphs, go back and rewrite your thesis to make it more specific and to connect it to the topics you addressed in the body paragraph.
• Revise your introduction several times, saving each revision. Be sure your introduction previews the topics you are presenting in your paper. One way of doing this is to use keywords from the topic sentences in each paragraph to introduce, or preview, the topics in your introduction.This “preview” will give your reader a context for understanding how you will make your case.
• Experiment by taking different approaches to your thesis with every revision you make. Play with the language in the introduction. Strike a new tone. Go back and compare versions. Then pick the one that works most effectively with the body of your research paper.
• Do not try to pack everything you want to say into your introduction. Just as your introduction should not be too short, it should also not be too long. Your introduction should be about the same length as any other paragraph in your research paper. Let the content—what you have to say—dictate the length.

The first page of your research paper should draw the reader into the text. It is the paper’s most important page and, alas, often the worst written. There are two culprits here and effective ways to cope with both of them.

First, the writer is usually straining too hard to say something terribly BIG and IMPORTANT about the thesis topic. The goal is worthy, but the aim is unrealistically high. The result is often a muddle of vague platitudes rather than a crisp, compelling introduction to the thesis. Want a familiar example? Listen to most graduation speakers. Their goal couldn’t be loftier: to say what education means and to tell an entire football stadium how to live the rest of their lives. The results are usually an avalanche of clichés and sodden prose.

The second culprit is bad timing. The opening and concluding paragraphs are usually written late in the game, after the rest of the thesis is finished and polished. There’s nothing wrong with writing these sections last. It’s usually the right approach since you need to know exactly what you are saying in the substantive middle sections of the thesis before you can introduce them effectively or draw together your findings. But having waited to write the opening and closing sections, you need to review and edit them several times to catch up. Otherwise, you’ll putting the most jagged prose in the most tender spots. Edit and polish your opening paragraphs with extra care. They should draw readers into the paper.

After you’ve done some extra polishing, I suggest a simple test for the introductory section. As an experiment, chop off the first few paragraphs. Let the paper begin on, say, paragraph 2 or even page 2. If you don’t lose much, or actually gain in clarity and pace, then you’ve got a problem.

There are two solutions. One is to start at this new spot, further into the text. After all, that’s where you finally gain traction on your subject. That works best in some cases, and we occasionally suggest it. The alternative, of course, is to write a new opening that doesn’t flop around, saying nothing.

What makes a good opening? Actually, they come in several flavors. One is an intriguing story about your topic. Another is a brief, compelling quote. When you run across them during your reading, set them aside for later use. Don’t be deterred from using them because they “don’t seem academic enough.” They’re fine as long as the rest of the paper doesn’t sound like you did your research in People magazine. The third, and most common, way to begin is by stating your main questions, followed by a brief comment about why they matter.

Whichever opening you choose, it should engage your readers and coax them to continue. Having done that, you should give them a general overview of the project—the main issues you will cover, the material you will use, and your thesis statement (that is, your basic approach to the topic). Finally, at the end of the introductory section, give your readers a brief road map, showing how the paper will unfold. How you do that depends on your topic but here are some general suggestions for phrase choice that may help:

• This analysis will provide …
• This paper analyzes the relationship between …
• This paper presents an analysis of …
• This paper will argue that …
• This topic supports the argument that…
• Research supports the opinion that …
• This paper supports the opinion that …
• An interpretation of the facts indicates …
• The results of this experiment show …
• The results of this research show …

Comparisons/Contrasts

• A comparison will show that …
• By contrasting the results,we see that …
• This paper examines the advantages and disadvantages of …

Definitions/Classifications

• This paper will provide a guide for categorizing the following:…
• This paper provides a definition of …
• This paper explores the meaning of …
• This paper will discuss the implications of …
• A discussion of this topic reveals …
• The following discussion will focus on …

Description

• This report describes…
• This report will illustrate…
• This paper provides an illustration of …

Process/Experimentation

• This paper will identify the reasons behind…
• The results of the experiment show …
• The process revealed that …
• This paper theorizes…
• This paper presents the theory that …
• In theory, this indicates that …

Quotes, anecdotes, questions, examples, and broad statements—all of them can used successfully to write an introduction for a research paper. It’s instructive to see them in action, in the hands of skilled academic writers.

Let’s begin with David M. Kennedy’s superb history, Freedom from Fear: The American People in Depression and War, 1929–1945 . Kennedy begins each chapter with a quote, followed by his text. The quote above chapter 1 shows President Hoover speaking in 1928 about America’s golden future. The text below it begins with the stock market collapse of 1929. It is a riveting account of just how wrong Hoover was. The text about the Depression is stronger because it contrasts so starkly with the optimistic quotation.

“We in America today are nearer the final triumph over poverty than ever before in the history of any land.”—Herbert Hoover, August 11, 1928 Like an earthquake, the stock market crash of October 1929 cracked startlingly across the United States, the herald of a crisis that was to shake the American way of life to its foundations. The events of the ensuing decade opened a fissure across the landscape of American history no less gaping than that opened by the volley on Lexington Common in April 1775 or by the bombardment of Sumter on another April four score and six years later. The ratcheting ticker machines in the autumn of 1929 did not merely record avalanching stock prices. In time they came also to symbolize the end of an era. (David M. Kennedy, Freedom from Fear: The American People in Depression and War, 1929–1945 . New York: Oxford University Press, 1999, p. 10)

Kennedy has exciting, wrenching material to work with. John Mueller faces the exact opposite problem. In Retreat from Doomsday: The Obsolescence of Major War , he is trying to explain why Great Powers have suddenly stopped fighting each other. For centuries they made war on each other with devastating regularity, killing millions in the process. But now, Mueller thinks, they have not just paused; they have stopped permanently. He is literally trying to explain why “nothing is happening now.” That may be an exciting topic intellectually, it may have great practical significance, but “nothing happened” is not a very promising subject for an exciting opening paragraph. Mueller manages to make it exciting and, at the same time, shows why it matters so much. Here’s his opening, aptly entitled “History’s Greatest Nonevent”:

On May 15, 1984, the major countries of the developed world had managed to remain at peace with each other for the longest continuous stretch of time since the days of the Roman Empire. If a significant battle in a war had been fought on that day, the press would have bristled with it. As usual, however, a landmark crossing in the history of peace caused no stir: the most prominent story in the New York Times that day concerned the saga of a manicurist, a machinist, and a cleaning woman who had just won a big Lotto contest. This book seeks to develop an explanation for what is probably the greatest nonevent in human history. (John Mueller, Retreat from Doomsday: The Obsolescence of Major War . New York: Basic Books, 1989, p. 3)

In the space of a few sentences, Mueller sets up his puzzle and reveals its profound human significance. At the same time, he shows just how easy it is to miss this milestone in the buzz of daily events. Notice how concretely he does that. He doesn’t just say that the New York Times ignored this record setting peace. He offers telling details about what they covered instead: “a manicurist, a machinist, and a cleaning woman who had just won a big Lotto contest.” Likewise, David Kennedy immediately entangles us in concrete events: the stunning stock market crash of 1929. These are powerful openings that capture readers’ interests, establish puzzles, and launch narratives.

Sociologist James Coleman begins in a completely different way, by posing the basic questions he will study. His ambitious book, Foundations of Social Theory , develops a comprehensive theory of social life, so it is entirely appropriate for him to begin with some major questions. But he could just as easily have begun with a compelling story or anecdote. He includes many of them elsewhere in his book. His choice for the opening, though, is to state his major themes plainly and frame them as a paradox. Sociologists, he says, are interested in aggregate behavior—how people act in groups, organizations, or large numbers—yet they mostly examine individuals:

A central problem in social science is that of accounting for the function of some kind of social system. Yet in most social research, observations are not made on the system as a whole, but on some part of it. In fact, the natural unit of observation is the individual person…  This has led to a widening gap between theory and research… (James S. Coleman, Foundations of Social Theory . Cambridge, MA: Harvard University Press, 1990, pp. 1–2)

After expanding on this point, Coleman explains that he will not try to remedy the problem by looking solely at groups or aggregate-level data. That’s a false solution, he says, because aggregates don’t act; individuals do. So the real problem is to show the links between individual actions and aggregate outcomes, between the micro and the macro.

The major problem for explanations of system behavior based on actions and orientations at a level below that of the system [in this case, on individual-level actions] is that of moving from the lower level to the system level. This has been called the micro-to-macro problem, and it is pervasive throughout the social sciences. (Coleman, Foundations of Social Theory , p. 6)

Explaining how to deal with this “micro-to-macro problem” is the central issue of Coleman’s book, and he announces it at the beginning.

Coleman’s theory-driven opening stands at the opposite end of the spectrum from engaging stories or anecdotes, which are designed to lure the reader into the narrative and ease the path to a more analytic treatment later in the text. Take, for example, the opening sentences of Robert L. Herbert’s sweeping study Impressionism: Art, Leisure, and Parisian Society : “When Henry Tuckerman came to Paris in 1867, one of the thousands of Americans attracted there by the huge international exposition, he was bowled over by the extraordinary changes since his previous visit twenty years before.” (Robert L. Herbert, Impressionism: Art, Leisure, and Parisian Society . New Haven, CT: Yale University Press, 1988, p. 1.) Herbert fills in the evocative details to set the stage for his analysis of the emerging Impressionist art movement and its connection to Parisian society and leisure in this period.

David Bromwich writes about Wordsworth, a poet so familiar to students of English literature that it is hard to see him afresh, before his great achievements, when he was just a young outsider starting to write. To draw us into Wordsworth’s early work, Bromwich wants us to set aside our entrenched images of the famous mature poet and see him as he was in the 1790s, as a beginning writer on the margins of society. He accomplishes this ambitious task in the opening sentences of Disowned by Memory: Wordsworth’s Poetry of the 1790s :

Wordsworth turned to poetry after the revolution to remind himself that he was still a human being. It was a curious solution, to a difficulty many would not have felt. The whole interest of his predicament is that he did feel it. Yet Wordsworth is now so established an eminence—his name so firmly fixed with readers as a moralist of self-trust emanating from complete self-security—that it may seem perverse to imagine him as a criminal seeking expiation. Still, that is a picture we get from The Borderers and, at a longer distance, from “Tintern Abbey.” (David Bromwich, Disowned by Memory: Wordsworth’s Poetry of the 1790s . Chicago: University of Chicago Press, 1998, p. 1)

That’s a wonderful opening! Look at how much Bromwich accomplishes in just a few words. He not only prepares the way for analyzing Wordsworth’s early poetry; he juxtaposes the anguished young man who wrote it to the self-confident, distinguished figure he became—the eminent man we can’t help remembering as we read his early poetry.

Let us highlight a couple of other points in this passage because they illustrate some intelligent writing choices. First, look at the odd comma in this sentence: “It was a curious solution, to a difficulty many would not have felt.” Any standard grammar book would say that comma is wrong and should be omitted. Why did Bromwich insert it? Because he’s a fine writer, thinking of his sentence rhythm and the point he wants to make. The comma does exactly what it should. It makes us pause, breaking the sentence into two parts, each with an interesting point. One is that Wordsworth felt a difficulty others would not have; the other is that he solved it in a distinctive way. It would be easy for readers to glide over this double message, so Bromwich has inserted a speed bump to slow us down. Most of the time, you should follow grammatical rules, like those about commas, but you should bend them when it serves a good purpose. That’s what the writer does here.

The second small point is the phrase “after the revolution” in the first sentence: “Wordsworth turned to poetry after the revolution to remind himself that he was still a human being.” Why doesn’t Bromwich say “after the French Revolution”? Because he has judged his book’s audience. He is writing for specialists who already know which revolution is reverberating through English life in the 1790s. It is the French Revolution, not the earlier loss of the American colonies. If Bromwich were writing for a much broader audience—say, the New York Times Book Review—he would probably insert the extra word to avoid confusion.

The message “Know your audience” applies to all writers. Don’t talk down to them by assuming they can’t get dressed in the morning. Don’t strut around showing off your book learnin’ by tossing in arcane facts and esoteric language for its own sake. Neither will win over readers.

Bromwich, Herbert, and Coleman open their works in different ways, but their choices work well for their different texts. Your task is to decide what kind of opening will work best for yours. Don’t let that happen by default, by grabbing the first idea you happen upon. Consider a couple of different ways of opening your thesis and then choose the one you prefer. Give yourself some options, think them over, then make an informed choice.

Whether you begin with a story, puzzle, or broad statement, the next part of the introduction should pose your main questions and establish your argument. This is your thesis statement—your viewpoint along with the supporting reasons and evidence. It should be articulated plainly so readers understand full well what your paper is about and what it will argue.

After that, give your readers a road map of what’s to come. That’s normally done at the end of the introductory section (or, in a book, at the end of the introductory chapter). Here’s John J. Mearsheimer presenting such a road map in The Tragedy of Great Power Politics . He not only tells us the order of upcoming chapters, he explains why he’s chosen that order and which chapters are most important:

The Plan of the Book The rest of the chapters in this book are concerned mainly with answering the six big questions about power which I identified earlier. Chapter 2, which is probably the most important chapter in the book, lays out my theory of why states compete for power and why they pursue hegemony. In Chapters 3 and 4, I define power and explain how to measure it. I do this in order to lay the groundwork for testing my theory… (John J. Mearsheimer, The Tragedy of Great Power Politics . New York: W. W. Norton, 2001, p. 27)

As this excerpt makes clear, Mearsheimer has already laid out his “six big questions” in the introduction. Now he’s showing us the path ahead, the path to answering those questions.

At the end of the introduction, give your readers a road map of what’s to come. Tell them what the upcoming sections will be and why they are arranged in this particular order.

After having written your introduction it’s time to move to the biggest part: body of a research paper.

Back to How To Write A Research Paper .

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How to write an effective introduction for your research paper

Last updated

20 January 2024

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However, the introduction is a vital element of your research paper. It helps the reader decide whether your paper is worth their time. As such, it's worth taking your time to get it right.

In this article, we'll tell you everything you need to know about writing an effective introduction for your research paper.

• The importance of an introduction in research papers

The primary purpose of an introduction is to provide an overview of your paper. This lets readers gauge whether they want to continue reading or not. The introduction should provide a meaningful roadmap of your research to help them make this decision. It should let readers know whether the information they're interested in is likely to be found in the pages that follow.

Aside from providing readers with information about the content of your paper, the introduction also sets the tone. It shows readers the style of language they can expect, which can further help them to decide how far to read.

When you take into account both of these roles that an introduction plays, it becomes clear that crafting an engaging introduction is the best way to get your paper read more widely. First impressions count, and the introduction provides that impression to readers.

• The optimum length for a research paper introduction

While there's no magic formula to determine exactly how long a research paper introduction should be, there are a few guidelines. Some variables that impact the ideal introduction length include:

Field of study

Complexity of the topic

Specific requirements of the course or publication

A commonly recommended length of a research paper introduction is around 10% of the total paper’s length. So, a ten-page paper has a one-page introduction. If the topic is complex, it may require more background to craft a compelling intro. Humanities papers tend to have longer introductions than those of the hard sciences.

The best way to craft an introduction of the right length is to focus on clarity and conciseness. Tell the reader only what is necessary to set up your research. An introduction edited down with this goal in mind should end up at an acceptable length.

• Evaluating successful research paper introductions

A good way to gauge how to create a great introduction is by looking at examples from across your field. The most influential and well-regarded papers should provide some insights into what makes a good introduction.

Dissecting examples: what works and why

We can make some general assumptions by looking at common elements of a good introduction, regardless of the field of research.

A common structure is to start with a broad context, and then narrow that down to specific research questions or hypotheses. This creates a funnel that establishes the scope and relevance.

The most effective introductions are careful about the assumptions they make regarding reader knowledge. By clearly defining key terms and concepts instead of assuming the reader is familiar with them, these introductions set a more solid foundation for understanding.

To pull in the reader and make that all-important good first impression, excellent research paper introductions will often incorporate a compelling narrative or some striking fact that grabs the reader's attention.

Finally, good introductions provide clear citations from past research to back up the claims they're making. In the case of argumentative papers or essays (those that take a stance on a topic or issue), a strong thesis statement compels the reader to continue reading.

Common pitfalls to avoid in research paper introductions

You can also learn what not to do by looking at other research papers. Many authors have made mistakes you can learn from.

We've talked about the need to be clear and concise. Many introductions fail at this; they're verbose, vague, or otherwise fail to convey the research problem or hypothesis efficiently. This often comes in the form of an overemphasis on background information, which obscures the main research focus.

Ensure your introduction provides the proper emphasis and excitement around your research and its significance. Otherwise, fewer people will want to read more about it.

• Crafting a compelling introduction for a research paper

Let’s take a look at the steps required to craft an introduction that pulls readers in and compels them to learn more about your research.

Step 1: Capturing interest and setting the scene

To capture the reader's interest immediately, begin your introduction with a compelling question, a surprising fact, a provocative quote, or some other mechanism that will hook readers and pull them further into the paper.

As they continue reading, the introduction should contextualize your research within the current field, showing readers its relevance and importance. Clarify any essential terms that will help them better understand what you're saying. This keeps the fundamentals of your research accessible to all readers from all backgrounds.

Step 2: Building a solid foundation with background information

Including background information in your introduction serves two major purposes:

It helps to clarify the topic for the reader

It establishes the depth of your research

The approach you take when conveying this information depends on the type of paper.

For argumentative papers, you'll want to develop engaging background narratives. These should provide context for the argument you'll be presenting.

For empirical papers, highlighting past research is the key. Often, there will be some questions that weren't answered in those past papers. If your paper is focused on those areas, those papers make ideal candidates for you to discuss and critique in your introduction.

Step 3: Pinpointing the research challenge

To capture the attention of the reader, you need to explain what research challenges you'll be discussing.

For argumentative papers, this involves articulating why the argument you'll be making is important. What is its relevance to current discussions or problems? What is the potential impact of people accepting or rejecting your argument?

For empirical papers, explain how your research is addressing a gap in existing knowledge. What new insights or contributions will your research bring to your field?

Step 4: Clarifying your research aims and objectives

We mentioned earlier that the introduction to a research paper can serve as a roadmap for what's within. We've also frequently discussed the need for clarity. This step addresses both of these.

When writing an argumentative paper, craft a thesis statement with impact. Clearly articulate what your position is and the main points you intend to present. This will map out for the reader exactly what they'll get from reading the rest.

For empirical papers, focus on formulating precise research questions and hypotheses. Directly link them to the gaps or issues you've identified in existing research to show the reader the precise direction your research paper will take.

Step 5: Sketching the blueprint of your study

Continue building a roadmap for your readers by designing a structured outline for the paper. Guide the reader through your research journey, explaining what the different sections will contain and their relationship to one another.

This outline should flow seamlessly as you move from section to section. Creating this outline early can also help guide the creation of the paper itself, resulting in a final product that's better organized. In doing so, you'll craft a paper where each section flows intuitively from the next.

Step 6: Integrating your research question

To avoid letting your research question get lost in background information or clarifications, craft your introduction in such a way that the research question resonates throughout. The research question should clearly address a gap in existing knowledge or offer a new perspective on an existing problem.

Tell users your research question explicitly but also remember to frequently come back to it. When providing context or clarification, point out how it relates to the research question. This keeps your focus where it needs to be and prevents the topic of the paper from becoming under-emphasized.

Step 7: Establishing the scope and limitations

So far, we've talked mostly about what's in the paper and how to convey that information to readers. The opposite is also important. Information that's outside the scope of your paper should be made clear to the reader in the introduction so their expectations for what is to follow are set appropriately.

Similarly, be honest and upfront about the limitations of the study. Any constraints in methodology, data, or how far your findings can be generalized should be fully communicated in the introduction.

Step 8: Concluding the introduction with a promise

The final few lines of the introduction are your last chance to convince people to continue reading the rest of the paper. Here is where you should make it very clear what benefit they'll get from doing so. What topics will be covered? What questions will be answered? Make it clear what they will get for continuing.

By providing a quick recap of the key points contained in the introduction in its final lines and properly setting the stage for what follows in the rest of the paper, you refocus the reader's attention on the topic of your research and guide them to read more.

• Research paper introduction best practices

Following the steps above will give you a compelling introduction that hits on all the key points an introduction should have. Some more tips and tricks can make an introduction even more polished.

As you follow the steps above, keep the following tips in mind.

Set the right tone and style

Like every piece of writing, a research paper should be written for the audience. That is to say, it should match the tone and style that your academic discipline and target audience expect. This is typically a formal and academic tone, though the degree of formality varies by field.

Kno w the audience

The perfect introduction balances clarity with conciseness. The amount of clarification required for a given topic depends greatly on the target audience. Knowing who will be reading your paper will guide you in determining how much background information is required.

Adopt the CARS (create a research space) model

The CARS model is a helpful tool for structuring introductions. This structure has three parts. The beginning of the introduction establishes the general research area. Next, relevant literature is reviewed and critiqued. The final section outlines the purpose of your study as it relates to the previous parts.

Master the art of funneling

The CARS method is one example of a well-funneled introduction. These start broadly and then slowly narrow down to your specific research problem. It provides a nice narrative flow that provides the right information at the right time. If you stray from the CARS model, try to retain this same type of funneling.

Incorporate narrative element

People read research papers largely to be informed. But to inform the reader, you have to hold their attention. A narrative style, particularly in the introduction, is a great way to do that. This can be a compelling story, an intriguing question, or a description of a real-world problem.

Write the introduction last

By writing the introduction after the rest of the paper, you'll have a better idea of what your research entails and how the paper is structured. This prevents the common problem of writing something in the introduction and then forgetting to include it in the paper. It also means anything particularly exciting in the paper isn’t neglected in the intro.

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How to Write a Research Introduction

Last Updated: December 6, 2023 Fact Checked

This article was co-authored by Megan Morgan, PhD . Megan Morgan is a Graduate Program Academic Advisor in the School of Public & International Affairs at the University of Georgia. She earned her PhD in English from the University of Georgia in 2015. There are 7 references cited in this article, which can be found at the bottom of the page. This article has been fact-checked, ensuring the accuracy of any cited facts and confirming the authority of its sources. This article has been viewed 2,652,229 times.

The introduction to a research paper can be the most challenging part of the paper to write. The length of the introduction will vary depending on the type of research paper you are writing. An introduction should announce your topic, provide context and a rationale for your work, before stating your research questions and hypothesis. Well-written introductions set the tone for the paper, catch the reader's interest, and communicate the hypothesis or thesis statement.

Introducing the Topic of the Paper

• In scientific papers this is sometimes known as an "inverted triangle", where you start with the broadest material at the start, before zooming in on the specifics. [2] X Research source
• The sentence "Throughout the 20th century, our views of life on other planets have drastically changed" introduces a topic, but does so in broad terms.
• It provides the reader with an indication of the content of the essay and encourages them to read on.

• For example, if you were writing a paper about the behaviour of mice when exposed to a particular substance, you would include the word "mice", and the scientific name of the relevant compound in the first sentences.
• If you were writing a history paper about the impact of the First World War on gender relations in Britain, you should mention those key words in your first few lines.

• This is especially important if you are attempting to develop a new conceptualization that uses language and terminology your readers may be unfamiliar with.

• If you use an anecdote ensure that is short and highly relevant for your research. It has to function in the same way as an alternative opening, namely to announce the topic of your research paper to your reader.
• For example, if you were writing a sociology paper about re-offending rates among young offenders, you could include a brief story of one person whose story reflects and introduces your topic.
• This kind of approach is generally not appropriate for the introduction to a natural or physical sciences research paper where the writing conventions are different.

Establishing the Context for Your Paper

• It is important to be concise in the introduction, so provide an overview on recent developments in the primary research rather than a lengthy discussion.
• You can follow the "inverted triangle" principle to focus in from the broader themes to those to which you are making a direct contribution with your paper.
• A strong literature review presents important background information to your own research and indicates the importance of the field.

• By making clear reference to existing work you can demonstrate explicitly the specific contribution you are making to move the field forward.
• You can identify a gap in the existing scholarship and explain how you are addressing it and moving understanding forward.

• For example, if you are writing a scientific paper you could stress the merits of the experimental approach or models you have used.
• Stress what is novel in your research and the significance of your new approach, but don't give too much detail in the introduction.
• A stated rationale could be something like: "the study evaluates the previously unknown anti-inflammatory effects of a topical compound in order to evaluate its potential clinical uses".

Specifying Your Research Questions and Hypothesis

• The research question or questions generally come towards the end of the introduction, and should be concise and closely focused.
• The research question might recall some of the key words established in the first few sentences and the title of your paper.
• An example of a research question could be "what were the consequences of the North American Free Trade Agreement on the Mexican export economy?"
• This could be honed further to be specific by referring to a particular element of the Free Trade Agreement and the impact on a particular industry in Mexico, such as clothing manufacture.
• A good research question should shape a problem into a testable hypothesis.

• If possible try to avoid using the word "hypothesis" and rather make this implicit in your writing. This can make your writing appear less formulaic.
• In a scientific paper, giving a clear one-sentence overview of your results and their relation to your hypothesis makes the information clear and accessible. [10] X Trustworthy Source PubMed Central Journal archive from the U.S. National Institutes of Health Go to source
• An example of a hypothesis could be "mice deprived of food for the duration of the study were expected to become more lethargic than those fed normally".

• This is not always necessary and you should pay attention to the writing conventions in your discipline.
• In a natural sciences paper, for example, there is a fairly rigid structure which you will be following.
• A humanities or social science paper will most likely present more opportunities to deviate in how you structure your paper.

Research Introduction Help

Community Q&A

• Use your research papers' outline to help you decide what information to include when writing an introduction. Thanks Helpful 0 Not Helpful 1
• Consider drafting your introduction after you have already completed the rest of your research paper. Writing introductions last can help ensure that you don't leave out any major points. Thanks Helpful 0 Not Helpful 0

• Avoid emotional or sensational introductions; these can create distrust in the reader. Thanks Helpful 50 Not Helpful 12
• Generally avoid using personal pronouns in your introduction, such as "I," "me," "we," "us," "my," "mine," or "our." Thanks Helpful 31 Not Helpful 7
• Don't overwhelm the reader with an over-abundance of information. Keep the introduction as concise as possible by saving specific details for the body of your paper. Thanks Helpful 24 Not Helpful 14

You Might Also Like

• ↑ https://library.sacredheart.edu/c.php?g=29803&p=185916
• ↑ https://www.aresearchguide.com/inverted-pyramid-structure-in-writing.html
• ↑ https://libguides.usc.edu/writingguide/introduction
• ↑ https://writing.wisc.edu/Handbook/PlanResearchPaper.html
• ↑ https://dept.writing.wisc.edu/wac/writing-an-introduction-for-a-scientific-paper/
• ↑ https://writing.wisc.edu/handbook/assignments/planresearchpaper/
• ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178846/

About This Article

To introduce your research paper, use the first 1-2 sentences to describe your general topic, such as “women in World War I.” Include and define keywords, such as “gender relations,” to show your reader where you’re going. Mention previous research into the topic with a phrase like, “Others have studied…”, then transition into what your contribution will be and why it’s necessary. Finally, state the questions that your paper will address and propose your “answer” to them as your thesis statement. For more information from our English Ph.D. co-author about how to craft a strong hypothesis and thesis, keep reading! Did this summary help you? Yes No

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How to Write the Introduction to a Scientific Paper?

• Open Access
• First Online: 24 October 2021

Cite this chapter

You have full access to this open access chapter

• Samiran Nundy 4 ,
• Atul Kakar 5 &
• Zulfiqar A. Bhutta 6  

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144 Altmetric

An Introduction to a scientific paper familiarizes the reader with the background of the issue at hand. It must reflect why the issue is topical and its current importance in the vast sea of research being done globally. It lays the foundation of biomedical writing and is the first portion of an article according to the IMRAD pattern ( I ntroduction, M ethodology, R esults, a nd D iscussion) [1].

I once had a professor tell a class that he sifted through our pile of essays, glancing at the titles and introductions, looking for something that grabbed his attention. Everything else went to the bottom of the pile to be read last, when he was tired and probably grumpy from all the marking. Don’t get put at the bottom of the pile, he said. Anonymous

You have full access to this open access chapter,  Download chapter PDF

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The Introduction Section

Abstract and Keywords

Writing and publishing a scientific paper

1 what is the importance of an introduction.

An Introduction to a scientific paper familiarizes the reader with the background of the issue at hand. It must reflect why the issue is topical and its current importance in the vast sea of research being done globally. It lays the foundation of biomedical writing and is the first portion of an article according to the IMRAD pattern ( I ntroduction, M ethodology, R esults, a nd D iscussion) [ 1 ].

It provides the flavour of the article and many authors have used phrases to describe it for example—'like a gate of the city’ [ 2 ], ‘the beginning is half of the whole’ [ 3 ], ‘an introduction is not just wrestling with words to fit the facts, but it also strongly modulated by perception of the anticipated reactions of peer colleagues’, [ 4 ] and ‘an introduction is like the trailer to a movie’. A good introduction helps captivate the reader early.

2 What Are the Principles of Writing a Good Introduction?

A good introduction will ‘sell’ an article to a journal editor, reviewer, and finally to a reader [ 3 ]. It should contain the following information [ 5 , 6 ]:

The known—The background scientific data

The unknown—Gaps in the current knowledge

Research hypothesis or question

Methodologies used for the study

The known consist of citations from a review of the literature whereas the unknown is the new work to be undertaken. This part should address how your work is the required missing piece of the puzzle.

3 What Are the Models of Writing an Introduction?

The Problem-solving model

First described by Swales et al. in 1979, in this model the writer should identify the ‘problem’ in the research, address the ‘solution’ and also write about ‘the criteria for evaluating the problem’ [ 7 , 8 ].

The CARS model that stands for C reating A R esearch S pace [ 9 , 10 ].

The two important components of this model are:

Establishing a territory (situation)

Establishing a niche (problem)

Occupying a niche (the solution)

In this popular model, one can add a fourth point, i.e., a conclusion [ 10 ].

4 What Is Establishing a Territory?

This includes: [ 9 ]

Stating the general topic and providing some background about it.

Providing a brief and relevant review of the literature related to the topic.

Adding a paragraph on the scope of the topic including the need for your study.

5 What Is Establishing a Niche?

Establishing a niche includes:

Stating the importance of the problem.

Outlining the current situation regarding the problem citing both global and national data.

Evaluating the current situation (advantages/ disadvantages).

Identifying the gaps.

Emphasizing the importance of the proposed research and how the gaps will be addressed.

Stating the research problem/ questions.

Stating the hypotheses briefly.

Figure 17.1 depicts how the introduction needs to be written. A scientific paper should have an introduction in the form of an inverted pyramid. The writer should start with the general information about the topic and subsequently narrow it down to the specific topic-related introduction.

Flow of ideas from the general to the specific

6 What Does Occupying a Niche Mean?

This is the third portion of the introduction and defines the rationale of the research and states the research question. If this is missing the reviewers will not understand the logic for publication and is a common reason for rejection [ 11 , 12 ]. An example of this is given below:

Till date, no study has been done to see the effectiveness of a mesh alone or the effectiveness of double suturing along with a mesh in the closure of an umbilical hernia regarding the incidence of failure. So, the present study is aimed at comparing the effectiveness of a mesh alone versus the double suturing technique along with a mesh.

7 How Long Should the Introduction Be?

For a project protocol, the introduction should be about 1–2 pages long and for a thesis it should be 3–5 pages in a double-spaced typed setting. For a scientific paper it should be less than 10–15% of the total length of the manuscript [ 13 , 14 ].

8 How Many References Should an Introduction Have?

All sections in a scientific manuscript except the conclusion should contain references. It has been suggested that an introduction should have four or five or at the most one-third of the references in the whole paper [ 15 ].

9 What Are the Important Points Which Should be not Missed in an Introduction?

An introduction paves the way forward for the subsequent sections of the article. Frequently well-planned studies are rejected by journals during review because of the simple reason that the authors failed to clarify the data in this section to justify the study [ 16 , 17 ]. Thus, the existing gap in knowledge should be clearly brought out in this section (Fig. 17.2 ).

How should the abstract, introduction, and discussion look

The following points are important to consider:

The introduction should be written in simple sentences and in the present tense.

Many of the terms will be introduced in this section for the first time and these will require abbreviations to be used later.

The references in this section should be to papers published in quality journals (e.g., having a high impact factor).

The aims, problems, and hypotheses should be clearly mentioned.

Start with a generalization on the topic and go on to specific information relevant to your research.

10 Example of an Introduction

11 Conclusions

An Introduction is a brief account of what the study is about. It should be short, crisp, and complete.

It has to move from a general to a specific research topic and must include the need for the present study.

The Introduction should include data from a literature search, i.e., what is already known about this subject and progress to what we hope to add to this knowledge.

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Nundy, S., Kakar, A., Bhutta, Z.A. (2022). How to Write the Introduction to a Scientific Paper?. In: How to Practice Academic Medicine and Publish from Developing Countries?. Springer, Singapore. https://doi.org/10.1007/978-981-16-5248-6_17

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The Role of an Introduction

What this handout is about:.

This handout will explain the functions of introductions, offer strategies for writing effective ones, help you check your drafted introductions, and provide you with examples of introductions to be avoided.

The Role Of Introductions Introductions and conclusions can be the most difficult parts of papers to write. Usually when you sit down to respond to an assignment, you have at least some sense of what you want to say in the body of your paper. You might have chosen a few examples you want to use or have an idea that will help you answer the main question of your assignment: these sections, therefore, are not as hard to write. But these middle parts of the paper can’t just come out of thin air; they need to be introduced and concluded in a way that makes sense to your reader.

Your introduction and conclusion act as bridges that transport your readers from their own lives into the “place” of your analysis. If your readers pick up your paper about education in the autobiography of Frederick Douglass, for example, they need a transition to help them leave behind the world of Chapel Hill, television, e-mail, and the The Daily Tar Heel and to help them temporarily enter the world of nineteenth-century American slavery. By providing an introduction that helps your readers make a transition between their own world and the issues you will be writing about, you give your readers the tools they need to get into your topic and care about what you are saying. Similarly, once you’ve hooked your reader with the introduction and offered evidence to prove your thesis, your conclusion can provide a bridge to help your readers make the transition back to their daily lives. (See our handout on conclusions.)

Why Bother Writing A Good Introduction?

You never get a second chance to make a first impression.  The opening paragraph of your paper will provide your readers with their initial impressions of your argument, your writing style, and the overall quality of your work. A vague, disorganized, error-filled, off-the-wall, or boring introduction will probably create a negative impression. On the other hand, a concise, engaging, and well-written introduction will start your readers off thinking highly of you, your analytical skills, your writing, and your paper. This impression is especially important when the audience you are trying to reach (your instructor) will be grading your work.

Your introduction  is an important road map for the rest of your paper. Your introduction conveys a lot of information to your readers. You can let them know what your topic is, why it is important, and how you plan to proceed with your discussion. In most academic disciplines, your introduction should contain a thesis that will assert your main argument. It should also, ideally, give the reader a sense of the kinds of information you will use to make that argument and the general organization of the paragraphs and pages that will follow. After reading your introduction, your readers should not have any major surprises in store when they read the main body of your paper.

Ideally, your introduction will make your readers want to read your paper.  The introduction should capture your readers’ interest, making them want to read the rest of your paper. Opening with a compelling story, a fascinating quotation, an interesting question, or a stirring example can get your readers to see why this topic matters and serve as an invitation for them to join you for an interesting intellectual conversation.

Strategies For Writing An Effective Introduction

Start by thinking about the question (or questions) you are trying to answer.  Your entire essay will be a response to this question, and your introduction is the first step toward that end. Your direct answer to the assigned question will be your thesis, and your thesis will be included in your introduction, so it is a good idea to use the question as a jumping off point. Imagine that you are assigned the following question:

Education has long been considered a major force for American social change, righting the wrongs of our society. Drawing on the Narrative of the Life of Frederick Douglass, discuss the relationship between education and slavery in 19th-century America. Consider the following: How did white control of education reinforce slavery? How did Douglass and other enslaved African Americans view education while they endured slavery? And what role did education play in the acquisition of freedom? Most importantly, consider the degree to which education was or was not a major force for social change with regard to slavery.

You will probably refer back to your assignment extensively as you prepare your complete essay, and the prompt itself can also give you some clues about how to approach the introduction. Notice that it starts with a broad statement, that education has been considered a major force for social change, and then narrows to focus on specific questions from the book. One strategy might be to use a similar model in your own introduction —start off with a big picture sentence or two about the power of education as a force for change as a way of getting your reader interested and then focus in on the details of your argument about Douglass. Of course, a different approach could also be very successful, but looking at the way the professor set up the question can sometimes give you some ideas for how you might answer it.

Decide how general or broad your opening should be.  Keep in mind that even a “big picture” opening needs to be clearly related to your topic; an opening sentence that said “Human beings, more than any other creatures on earth, are capable of learning” would be too broad for our sample assignment about slavery and education. If you have ever used Google Maps or similar programs, that experience can provide a helpful way of thinking about how broad your opening should be. Imagine that you’re researching Chapel Hill. If what you want to find out is whether Chapel Hill is at roughly the same latitude as Rome, it might make sense to hit that little “minus” sign on the online map until it has zoomed all the way out and you can see the whole globe. If you’re trying to figure out how to get from Chapel Hill to Wrightsville Beach, it might make more sense to zoom in to the level where you can see most of North Carolina (but not the rest of the world, or even the rest of the United States). And if you are looking for the intersection of Ridge Road and Manning Drive so that you can find the Writing Center’s main office, you may need to zoom all the way in. The question you are asking determines how “broad” your view should be. In the sample assignment above, the questions are probably at the “state” or “city” level of generality. But the introductory sentence about human beings is mismatched—it’s definitely at the “global” level. When writing, you need to place your ideas in context—but that context doesn’t generally have to be as big as the whole galaxy! (See our handout on understanding assignments for additional information on the hidden clues in assignments.)

Try writing your introduction last.  You may think that you have to write your introduction first, but that isn’t necessarily true, and it isn’t always the most effective way to craft a good introduction. You may find that you don’t know what you are going to argue at the beginning of the writing process, and only through the experience of writing your paper do you discover your main argument. It is perfectly fine to start out thinking that you want to argue a particular point, but wind up arguing something slightly or even dramatically different by the time you’ve written most of the paper. The writing process can be an important way to organize your ideas, think through complicated issues, refine your thoughts, and develop a sophisticated argument. However, an introduction written at the beginning of that discovery process will not necessarily reflect what you wind up with at the end. You will need to revise your paper to make sure that the introduction, all of the evidence, and the conclusion reflect the argument you intend. Sometimes it’s easiest to just write up all of your evidence first and then write the introduction last—that way you can be sure that the introduction will match the body of the paper.

Don’t be afraid to write a tentative introduction first and then change it later.  Some people find that they need to write some kind of introduction in order to get the writing process started. That’s fine, but if you are one of those people, be sure to return to your initial introduction later and rewrite if necessary.

Open with an attention grabber.  Sometimes, especially if the topic of your paper is somewhat dry or technical, opening with something catchy can help. Consider these options:

• an intriguing example (for example, the mistress who initially teaches Douglass but then ceases her instruction as she learns more about slavery)
• a provocative quotation (Douglass writes that “education and slavery were incompatible with each other”)
• a puzzling scenario (Frederick Douglass says of slaves that “[N]othing has been left undone to cripple their intellects, darken their minds, debase their moral nature, obliterate all traces of their relationship to mankind; and yet how wonderfully they have sustained the mighty load of a most frightful bondage, under which they have been groaning for centuries!” Douglass clearly asserts that slave owners went to great lengths to destroy the mental capacities of slaves, yet his own life story proves that these efforts could be unsuccessful.)
• a vivid and perhaps unexpected anecdote (for example, “Learning about slavery in the American history course at Frederick Douglass High School, students studied the work slaves did, the impact of slavery on their families, and the rules that governed their lives. We didn’t discuss education, however, until one student, Mary, raised her hand and asked, ‘But when did they go to school?’ That modern high school students could not conceive of an American childhood devoid of formal education speaks volumes about the centrality of education to American youth today and also suggests the significance of the deprivation of education in past generations.”)
• a thought-provoking question (given all of the freedoms that were denied enslaved individuals in the American South, why does Frederick Douglass focus his attentions so squarely on education and literacy?)

Pay special attention to your first sentence.  Start off on the right foot with your readers by making sure that the first sentence actually says something useful and that it does so in an interesting and error-free way.

Be straightforward and confident.  Avoid statements like “In this paper, I will argue that Frederick Douglass valued education.” While this sentence points toward your main argument, it isn’t especially interesting. It might be more effective to say what you mean in a declarative sentence. It is much more convincing to tell us that “Frederick Douglass valued education” than to tell us that you are going to say that he did. Assert your main argument confidently. After all, you can’t expect your reader to believe it if it doesn’t sound like you believe it!

How To Evaluate Your Introduction Draft

Ask a friend to read it and then tell you what he or she expects the paper will discuss, what kinds of evidence the paper will use, and what the tone of the paper will be. If your friend is able to predict the rest of your paper accurately, you probably have a good introduction.

Five Kinds Of Less Effective Introductions

1. The place holder introduction.  When you don’t have much to say on a given topic, it is easy to create this kind of introduction. Essentially, this kind of weaker introduction contains several sentences that are vague and don’t really say much. They exist just to take up the “introduction space” in your paper. If you had something more effective to say, you would probably say it, but in the meantime this paragraph is just a place holder.

Example: Slavery was one of the greatest tragedies in American history. There were many different aspects of slavery. Each created different kinds of problems for enslaved people.

2. The restated question introduction.  Restating the question can sometimes be an effective strategy, but it can be easy to stop at JUST restating the question instead of offering a more specific, interesting introduction to your paper. The professor or teaching assistant wrote your questions and will be reading ten to seventy essays in response to them—he or she does not need to read a whole paragraph that simply restates the question. Try to do something more interesting.

Example: Indeed, education has long been considered a major force for American social change, righting the wrongs of our society. The Narrative of the Life of Frederick Douglass discusses the relationship between education and slavery in 19th century America, showing how white control of education reinforced slavery and how Douglass and other enslaved African Americans viewed education while they endured. Moreover, the book discusses the role that education played in the acquisition of freedom. Education was a major force for social change with regard to slavery.

3. The Webster’s Dictionary introduction.  This introduction begins by giving the dictionary definition of one or more of the words in the assigned question. This introduction strategy is on the right track—if you write one of these, you may be trying to establish the important terms of the discussion, and this move builds a bridge to the reader by offering a common, agreed-upon definition for a key idea. You may also be looking for an authority that will lend credibility to your paper. However, anyone can look a word up in the dictionary and copy down what Webster says—it may be far more interesting for you (and your reader) if you develop your own definition of the term in the specific context of your class and assignment, or if you use a definition from one of the sources you’ve been reading for class. Also recognize that the dictionary is also not a particularly authoritative work—it doesn’t take into account the context of your course and doesn’t offer particularly detailed information. If you feel that you must seek out an authority, try to find one that is very relevant and specific. Perhaps a quotation from a source reading might prove better? Dictionary introductions are also ineffective simply because they are so overused. Many graders will see twenty or more papers that begin in this way, greatly decreasing the dramatic impact that any one of those papers will have.

Example: Webster’s dictionary defines slavery as “the state of being a slave,” as “the practice of owning slaves,” and as “a condition of hard work and subjection.”

4. The “dawn of man” introduction.  This kind of introduction generally makes broad, sweeping statements about the relevance of this topic since the beginning of time. It is usually very general (similar to the place holder introduction) and fails to connect to the thesis. You may write this kind of introduction when you don’t have much to say—which is precisely why it is ineffective.

Example: Since the dawn of man, slavery has been a problem in human history.

5. The book report introduction.  This introduction is what you had to do for your elementary school book reports. It gives the name and author of the book you are writing about, tells what the book is about, and offers other basic facts about the book. You might resort to this sort of introduction when you are trying to fill space because it’s a familiar, comfortable format. It is ineffective because it offers details that your reader already knows and that are irrelevant to the thesis. Example: Frederick Douglass wrote his autobiography, Narrative of the Life of Frederick Douglass, An American Slave, in the 1840s. It was published in 1986 by Penguin Books. In it, he tells the story of his life.

Works Consulted

We consulted these works while writing the original version of this handout. This is not a comprehensive list of resources on the handout’s topic, and we encourage you to do your own research to find the latest publications on this topic. Please do not use this list as a model for the format of your own reference list, as it may not match the citation style you are using. For guidance on formatting citations, please see the UNC Libraries citation tutorial.

All quotations are from Frederick Douglass, Narrative of the Life of Frederick Douglass, An American Slave, edited and with introduction by Houston A. Baker, Jr., New York: Penguin Books, 1986.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 2.5 License. You may reproduce it for non-commercial use if you use the entire handout (just click print) and attribute the source: The Writing Center, University of North Carolina at Chapel Hill

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Introduction – Definition, Overview & Examples

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In the sphere of academic writing , the introduction holds a significant section in many types of papers ranging from academic essays to historical papers, serving as a crucial framework that provides insight into the core essence of the entire paper. An ideal introduction engages the readers, sets the tone, and includes a thesis statement , which navigates the following discourse. Crafting a compelling introductory paragraph poses an essential writing skill to improve your writing style and initial impressions of a paper.

Inhaltsverzeichnis

• 1 Introduction in a nutshell
• 2 Definition: Introduction
• 3 Contents of an introduction
• 4 Overview of structure and key aspects
• 6 Thesis introduction
• 7 Introduction vs. closing paragraph
• 8 Don’ts for writing a good introduction

Introduction in a nutshell

An introduction in academic papers is the initial section where the author provides a brief overview of the topic, outlines the main questions or issues to be addressed, and presents the thesis statement to guide readers on what to expect from the rest of the paper. It sets the stage for the discussion and helps engage the reader’s interest and understanding of the context and significance of the study.

Definition: Introduction

There are several definitions for introductions. The general one is that is at the beginning of all kinds of papers and poses an essential framework. The functions of introductions are, among others, to smoothly transition the readers into the core of the entire paper. Therefore, it forms one of the three cornerstones of many types of paper in the academic realm, next to the main body and conclusion .

A concise, engaging, and well-written introduction skillfully makes the reader excited and draws their attention to the topic by arousing interest. The introductory paragraph also needs to describe the objective of your paper and state the methods you will use to achieve your goal. It entails a sneak peek into the theoretical or empirical framework, as well as, the methodology of the paper. Moreover, it houses the rule of thumb for thesis statements, which presents a crucial role in guiding the arguments and discourse that follow. Oftentimes, the introduction includes thesis acknowledgments regarding existing literature, i.e., it provides contrasts or alignments between the study and already existing studies surrounding the same or similar topics. This plays an imperative role in contributing to the overall academic debate on the topic.

Contents of an introduction

The background for context, sentence structure , and putting ideas in context are critical aspects to consider when aiming to draw attentive readers and composing an effective introduction. Effective strategies for a good introductory paragraph are to fulfill relevance, research topic, and procedure:

• Relevance: Why is the research topic important? Hook the reader!
• Research topic: What is the research question and/or topic matter that will be covered?
• Procedure: What effective strategy should be used to answer the research question?

In short, the introductory paragraph initiates the topic matters for the area of research, as well as the research question, derived from it. A well-written introduction tells the reader why answering the research question will lead to new, important insights.

Paper outline of methods

Equally important is the essay outline of the methods used to answer the research question.

In the introductory paragraph, you need to justify how and why you have narrowed down your topic. This will be summarized by a shorter introduction and description of your line of argument and the structure of your research paper .

Tip: Make sure not to turn your introduction into a simple reproduction of your table of contents .

Like the concluding paragraph, the introductory paragraph of your bachelor’s thesis should not represent a fragment, but a constant introduction. This means that sweeping statements should be avoided so that the reader does not need to rely on insights established within the main body to understand the topic of the paper.

Overview of structure and key aspects

Find more detailed information below by clicking on the relevant aspect.

Step 1: Leading to the topic

There are numerous ways to eager readers to your research topic:

• A provocative proposition

“Sociology can no longer be dissociated from insights and findings on women’s situation in society that have been developed by feminist scientists over the last 20 years.”

• Thought-provoking questions
• What can the differences between individuals be attributed to?
• Is it genetics or environmental factors?
• What comprises the practical relevance of this question?
• An experiential report 

“Over the last few weeks I have interviewed former teachers of a primary school for girls on the immediate post-war era. Amongst other things I wanted to find out what it meant to them to have taught girls. Unanimously, the pedagogical ambition was found to be the same, regardless of the students being boys or girls.”

• A puzzling scenario

“However, while many businesses report increased visibility, there’s a surprising lack of evidence correlating social media marketing with actual sales.”

“Education and slavery were incompatible with each other.”

Note: Most of the time, well-known or famous quotes don’t work in academic papers, quote an author of a reference or source instead.

Structuring an introductory paragraph

• Introduce the general context or background: Perhaps you could explain the title in your own words or use a quotation from an author who offers a supporting or contradictory statement about your topic area.
• Definitions: Are you using any complex terminology or acronyms that need definitions ? Try to use a working definition from an expert in your subject area, rather than referring to broad statements of a dictionary.
• Introduce the ideas in context: You cannot include everything, e.g., in a 2000-word English essay introduction; select between three and five key ideas and introduce them in the order they are discussed.

Step 2: Justification of the topic’s relevance

The introductory paragraph of your thesis or research paper contextualizes your overall topic within the greater context of the area of research and establishes a connection to other studies in the general field.

The following three introduction paragraph examples are guidelines as to how you can best tie in with the most current research:

The following example illustrates how you can point the reader to your topic’s significance:

This significance of the study starts off with broad statements and gradually tapers off to a specific group or person. In essence, it delves into the general contribution of the study like the importance of this study to society as a whole, and then proceeds towards its contribution to individuals including yourself as a researcher.

Step 3: Subject of your research paper or academic essay

When writing the introduction to your research paper or your academic essay , it is crucial to touch upon what will be researched.

This can be done by addressing your research question. Keep the aspects in mind, you will be narrowing your research topic down to, and what definition of the key terms used in your research question you want to follow.

The research question is a product of your topic in research, which is why it needs to be evident and clear that there is a relationship between the question and the topic throughout your entire paper.

Step 4: Objectives of your research paper

Other vital aspects to include in the introductory paragraph are the objective you are pursuing, and the outcome you are anticipating.

The title of your research paper is not identical to your objectives. Typically, the title of your research paper or essay describes the general subject area rather than the niche you want to cover.

The introduction paragraph examples below show how to account for the objective of your paper in one sentence.

This paper reviews the problem of Pennsylvania’s dwindling landfill space, evaluates the success of recycling as a solution to this problem, and challenges the assumption that Pennsylvania will run out of landfill space by the year 2020.

As this paper will show, the fundamental problem behind the Arab-Israeli conflict is the lack of a workable solution to the third stage of partition, which greatly hinders the current

Step 5: Outline of methods

Writing an effective introduction also involves having a firm grasp of the methods you will be using to achieve your research goal. For this, you must depict the way you anticipate achieving your objectives in the introduction paragraph of your essay or research paper and how you went about to answer the research question.

Furthermore, a summary of the theoretical framework of your research paper is an essential part of the introduction, including the literature review .

In terms of empirical research like a dissertation based on empirical studies, the introduction needs to explain the methods utilized to analyze the data you gathered in your study and the proceess behind it.

Related background in the introduction paragraph, such as work experience or research stays, is a plus when it is appropriate. However, this information should only be used if relevant.

Step 6: Limitations of your research questions

Acknowledging your limitations plays a crucial factor in writing an effective introduction for your research, as they dissociate your research topic from other studies in the field.

Therefore, giving valid reasons for any limitations and restrictions makes your research unique and different from others. The introduction paragraph of your research paper clarifies why you restrict your research topic to a certain, potentially very specific research area, and why this is important to achieve the goals you set out to, whether this pertains to a bachelor’s thesis, or any other research paper.

Step 7: Differentiation and disambiguation of terms

If you use specific terminology in your research paper, it is integral to include a section explaining these fundamental terms in your introduction, so the readers can grasp a good understanding of your reseach topic.

Explanations of terms that are only relevant to individual segments of your research paper should not be part of the introduction paragraph. Focus on terms that you might use (slightly) differently than your readers might expect, and define them accordingly.

Step 8: Outline of the structure of your research paper or essay

Based on the table of contents of your paper, it is essential to provide a brief outline of the paper’s structure in the introduction. The outline should contain a clear representation of argumentative choice.

In essence, you give a short overview of how you will go about answering your research question, which is reflected in the structure of your research paper. This will also be helpful to keep the reader excited and attentive for the following discourse.

The main purposes of the investigation into children’s Internet addiction are to study the phenomenon, learn about both views, reveal the true opinion, and create a list of recommendations for parents.

I will be exploring how these POV cameras are being utilized in teaching, with a focus on science education, to gather data and provide virtual experiences – both in the lab and in the field.

Note: As a rule of thumb, the quality of the explanations depends on the length of your research paper: The shorter your research paper, the shorter your initial explanations in the introduction paragraph.

Keep in mind that the main goal is to keep the reader hooked and provide a thorough understanding of why you have chosen to proceed a certain way.

The University of Leicester gives an example of an effective essay introduction. Be aware that essays are a particular kind of research paper and differ from, e.g., articles or ‘scientific’ term papers . The example below illustrates the sections of an introduction regarding the following research question “What is the importance of imitation in early child development?”

Thesis introduction

„We want a story that starts out with an earthquake and works its way up to a climax.”

Samuel Goldwyn, film producer and publisher.

While a scientific research paper is not a film script and no professor will expect an earthquake when sitting down to read the introduction paragraph of your research paper, you still want to achieve a similar mind-blowing effect with your introduction.

Your introduction paragraph needs to captivate the reader and arouse curiosity. It is the initial impression of your paper, and therefore, should not make a negative impression. A catchy introduction guarantees that the reader will keep reading your paper with interest.

The introduction paragraph is the actual beginning of your paper, as neither the abstract, foreword, nor table of contents belong in the actual body of it.

In the introduction paragraph, you reach out to the reader for the first time, and ideally, you want to leave a good impression. Thus, the introduction poses the flagship of your research paper.

Length of the introduction paragraph

Planning your writing is quite a pragmatic endeavor. This includes deciding on how long each part of the text needs to be. The lengths of individual parts of your research paper depend on the overall length of your paper.

While the main body of your research paper should be the longest, the introduction paragraph should account for up to 15% of the scope of your text. It is advised to restrict the introduction down to only 5%, which is the equivalent of approximately one page in a 20-page research paper. Some institutional guidelines advise 10%, therefore, depending on your institution, this may vary.

In overall, the introduction paragraph of your research paper, essay, or dissertation should account for 5-15% of your paper. It is further urged to write your introduction paragraph in such a manner that it holds a sensible relation to the rest of the text. Writing an effective introduction is not an easy task just because it is comparatively short. Be brief but precise, boil everything down to its essence, and save the longer versions of explanations for the main body of the text.

Note: The introduction does not anticipate the main body. Instead, the introduction announces the content of the main body. In other words, the introduction paragraph paves the way into the main body of your paper. As an announcement, the introduction needs to be to the point by definition.

Introduction vs. closing paragraph

Where to start on that blank piece of paper in front of you? As ironic as it might sound, it is a just and well debated question. The introduction paragraph and the closing paragraph are closely linked. While the closing paragraph summarizes the main body of your research paper, the introduction paragraph prepares the reader for it. Hence, both conclusion and introduction are part of brackets that parenthesize your research paper.

Essentially, you should write the introduction paragraph at the end of your writing process. This is because you are likely to know only at the end of your work what you could actually achieve. Therefore, it is recommended to write a rough draft at first and complete the initial introduction along the way.

Writing an introduction is considered the most difficult part. Therefore, it is efficient to write a rough draft at first and finalize it once you know where you are headed. The first step of the writing process, should be the main body. This strategy can also prevent writer’s block . Adding an appropriate quote that gets the reader started and is then followed by the research discourse and a research question is an effective way of beginning your writing process.

It is also imperative that you have gained a thorough overview of your research topic prior writing your introduction, especially for more complicated topics, to captivate the reader.

Don’ts for writing a good introduction

The following table summarizes important aspects you should refrain from when writing your introduction:

The introduction does not anticipate the main body, it rather announces the content of the main body. Hence, the introduction paragraph navigates the reader to the main body of your research discourse. Based on this, the introduction needs to be short and precise by definition.

How do I start my introduction?

• Understand the purpose: Background and thesis statement
• Start with a hook: Anecdote, question, quotation, statistics , bold statement
• Tailor it to your audience: What is the target group? What do they know already?
• Revise and refine: Complete it along the way, finalize it at the end of writing

What is an introduction and example?

An introduction primarily states the purpose of an academic paper. It conveys the central or main points that will be covered. The thesis statement should be placed towards the end of the introduction, with any background information given beforehand. Introductions come right after the table of contents page, but before the body of the essay or thesis.

Click here to get to the example.

What is an introduction in simple words?

An introduction of any scientific paper represents the beginning part of the paper, where you provide basic information to transition the reader to the main discourse of the paper.

What are the contents of an introduction?

Every introduction should clearly state the purpose of your paper with a summary of the main points that will be discussed. It should be enough to give the reader an overview of what to expect in the main body of the writing. It can also include an explanation of elements that are not mentioned within the scope of the remaining writing, such as background information that may be relevant to the thesis statement. The thesis statement should always be placed towards the end of the introduction.

How do you write a good introduction?

A good introduction captures the reader’s attention immediately, which in turn makes them want to read the remaining pages of the paper. It should clearly state the main topic, provide relevant context, and explain your specific area of focus. Ultimately, it should provide the most relevant and helpful information about your research topic. The reader should be informed of any background information prior to reading the body of the thesis or essay.

What is the difference between a summary and an introduction?

The main difference between an introduction and a summary is their purpose. The introduction gives the reader a brief description of the topic and the main ideas that will be covered. A summary, on the other hand, briefly explains everything that is covered in a text in a few condensed sentences. Therefore, a summary is more general while an introduction points to the main topics and relevant ideas of the academic text.

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Organizing Academic Research Papers: 4. The Introduction

• Purpose of Guide
• Design Flaws to Avoid
• Glossary of Research Terms
• Narrowing a Topic Idea
• Broadening a Topic Idea
• Extending the Timeliness of a Topic Idea
• Academic Writing Style
• Choosing a Title
• Making an Outline
• Paragraph Development
• Executive Summary
• Background Information
• The Research Problem/Question
• Theoretical Framework
• Citation Tracking
• Content Alert Services
• Evaluating Sources
• Primary Sources
• Secondary Sources
• Tertiary Sources
• What Is Scholarly vs. Popular?
• Qualitative Methods
• Quantitative Methods
• Using Non-Textual Elements
• Limitations of the Study
• Common Grammar Mistakes
• Avoiding Plagiarism
• Footnotes or Endnotes?
• Further Readings
• Annotated Bibliography
• Dealing with Nervousness
• Using Visual Aids
• Grading Someone Else's Paper
• How to Manage Group Projects
• Multiple Book Review Essay
• Reviewing Collected Essays
• About Informed Consent
• Writing Field Notes
• Writing a Policy Memo
• Writing a Research Proposal
• Acknowledgements

The introduction serves the purpose of leading the reader from a general subject area to a particular field of research. It establishes the context of the research being conducted by summarizing current understanding and background information about the topic, stating the purpose of the work in the form of the hypothesis, question, or research problem, briefly explaining your rationale, methodological approach, highlighting the potential outcomes your study can reveal, and describing the remaining structure of the paper.

Key Elements of the Research Proposal. Prepared under the direction of the Superintendent and by the 2010 Curriculum Design and Writing Team. Baltimore County Public Schools.

Importance of a Good Introduction

Think of the introduction as a mental road map that must answer for the reader these four questions:

• What was I studying?
• Why was this topic important to investigate?
• What did we know about this topic before I did this study?
• How will this study advance our knowledge?

A well-written introduction is important because, quite simply, you never get a second chance to make a good first impression. The opening paragraph of your paper will provide your readers with their initial impressions about the logic of your argument, your writing style, the overall quality of your research, and, ultimately, the validity of your findings and conclusions. A vague, disorganized, or error-filled introduction will create a negative impression, whereas, a concise, engaging, and well-written introduction will start your readers off thinking highly of your analytical skills, your writing style, and your research approach.

Introductions . The Writing Center. University of North Carolina.

Structure and Writing Style

I. Structure and Approach

The introduction is the broad beginning of the paper that answers three important questions for the reader:

• What is this?
• Why am I reading it?
• What do you want me to think about / consider doing / react to?

Think of the structure of the introduction as an inverted triangle of information. Organize the information so as to present the more general aspects of the topic early in the introduction, then narrow toward the more specific topical information that provides context, finally arriving at your statement of purpose and rationale and, whenever possible, the potential outcomes your study can reveal.

These are general phases associated with writing an introduction:

• Highlighting the importance of the topic, and/or
• Making general statements about the topic, and/or
• Presenting an overview on current research on the subject.
• Opposing an existing assumption, and/or
• Revealing a gap in existing research, and/or
• Formulating a research question or problem, and/or
• Continuing a disciplinary tradition.
• Stating the intent of your study,
• Outlining the key characteristics of your study,
• Describing important results, and
• Giving a brief overview of the structure of the paper.

NOTE: Even though the introduction is the first main section of a research paper, it is often useful to finish the introduction very late in the writing process because the structure of the paper, the reporting and analysis of results, and the conclusion will have been completed and it ensures that your introduction matches the overall structure of your paper.

II.  Delimitations of the Study

Delimitations refer to those characteristics that limit the scope and define the conceptual boundaries of your study . This is determined by the conscious exclusionary and inclusionary decisions you make about how to investigate the research problem. In other words, not only should you tell the reader what it is you are studying and why, but you must also acknowledge why you rejected alternative approaches that could have been used to examine the research problem.

Obviously, the first limiting step was the choice of research problem itself. However, implicit are other, related problems that could have been chosen but were rejected. These should be noted in the conclusion of your introduction.

Examples of delimitating choices would be:

• The key aims and objectives of your study,
• The research questions that you address,
• The variables of interest [i.e., the various factors and features of the phenomenon being studied],
• The method(s) of investigation, and
• Any relevant alternative theoretical frameworks that could have been adopted.

Review each of these decisions. You need to not only clearly establish what you intend to accomplish, but to also include a declaration of what the study does not intend to cover. In the latter case, your exclusionary decisions should be based upon criteria stated as, "not interesting"; "not directly relevant"; “too problematic because..."; "not feasible," and the like. Make this reasoning explicit!

NOTE: Delimitations refer to the initial choices made about the broader, overall design of your study and should not be confused with documenting the limitations of your study discovered after the research has been completed.

III. The Narrative Flow

Issues to keep in mind that will help the narrative flow in your introduction :

• Your introduction should clearly identify the subject area of interest . A simple strategy to follow is to use key words from your title in the first few sentences of the introduction. This will help focus the introduction on the topic at the appropriate level and ensures that you get to the primary subject matter quickly without losing focus, or discussing information that is too general.
• Establish context by providing a brief and balanced review of the pertinent published literature that is available on the subject. The key is to summarize for the reader what is known about the specific research problem before you did your analysis. This part of your introduction should not represent a comprehensive literature review but consists of a general review of the important, foundational research literature (with citations) that lays a foundation for understanding key elements of the research problem. See the drop-down tab for "Background Information" for types of contexts.
• Clearly state the hypothesis that you investigated . When you are first learning to write in this format it is okay, and actually preferable, to use a past statement like, "The purpose of this study was to...." or "We investigated three possible mechanisms to explain the...."
• Why did you choose this kind of research study or design? Provide a clear statement of the rationale for your approach to the problem studied. This will usually follow your statement of purpose in the last paragraph of the introduction.

IV. Engaging the Reader

The overarching goal of your introduction is to make your readers want to read your paper. The introduction should grab your reader's attention. Strategies for doing this can be to:

• Open with a compelling story,
• Include a strong quotation or a vivid, perhaps unexpected anecdote,
• Pose a provocative or thought-provoking question,
• Describe a puzzling scenario or incongruity, or
• Cite a stirring example or case study that illustrates why the research problem is important.

NOTE:   Only choose one strategy for engaging your readers; avoid giving an impression that your paper is more flash than substance.

Freedman, Leora  and Jerry Plotnick. Introductions and Conclusions . University College Writing Centre. University of Toronto; Introduction . The Structure, Format, Content, and Style of a Journal-Style Scientific Paper. Department of Biology. Bates College; Introductions . The Writing Center. University of North Carolina; Introductions . The Writer’s Handbook. Writing Center. University of Wisconsin, Madison; Introductions, Body Paragraphs, and Conclusions for an Argument Paper. The Writing Lab and The OWL. Purdue University; Resources for Writers: Introduction Strategies . Program in Writing and Humanistic Studies. Massachusetts Institute of Technology; Sharpling, Gerald. Writing an Introduction . Centre for Applied Linguistics, University of Warwick; Writing Your Introduction. Department of English Writing Guide. George Mason University.

Writing Tip

Avoid the "Dictionary" Introduction

Giving the dictionary definition of words related to the research problem may appear appropriate because it is important to define specific words or phrases with which readers may be unfamiliar. However, anyone can look a word up in the dictionary and a general dictionary is not a particularly authoritative source. It doesn't take into account the context of your topic and doesn't offer particularly detailed information. Also, placed in the context of a particular discipline, a term may have a different meaning than what is found in a general dictionary. If you feel that you must seek out an authoritative definition, try to find one that is from subject specific dictionaries or encyclopedias [e.g., if you are a sociology student, search for dictionaries of sociology].

Saba, Robert. The College Research Paper . Florida International University; Introductions . The Writing Center. University of North Carolina.

Another Writing Tip

When Do I Begin?

A common question asked at the start of any paper is, "where should I begin?" An equally important question to ask yourself is, "When do I begin?" Research problems in the social sciences rarely rest in isolation from the history of the issue being investigated. It is, therefore, important to lay a foundation for understanding the historical context underpinning the research problem. However, this information should be brief and succinct and begin at a point in time that best informs the reader of study's overall importance. For example, a study about coffee cultivation and export in West Africa as a key stimulus for local economic growth needs to describe the beginning of exporting coffee in the region and establishing why economic growth is important. You do not need to give a long historical explanation about coffee exportation in Africa. If a research problem demands a substantial exploration of historical context, do this in the literature review section; note in the introduction as part of your "roadmap" [see below] that you covering this in the literature review.

Yet Another Writing Tip

Always End with a Roadmap

The final paragraph or sentences of your introduction should forecast your main arguments and conclusions and provide a description of the rest of the paper [a "roadmap"] that let's the reader know where you are going and what to expect.

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Scientific and Scholarly Writing

• Literature Searches
• Tracking and Citing References

Parts of a Scientific & Scholarly Paper

Introduction.

• Writing Effectively
• Where to Publish?
• Capstone Resources

Different sections are needed in different types of scientific papers (lab reports, literature reviews, systematic reviews, methods papers, research papers, etc.). Projects that overlap with the social sciences or humanities may have different requirements. Generally, however, you'll need to include:

INTRODUCTION (Background)

METHODS SECTION (Materials and Methods)

What is a title

Titles have two functions: to identify the main topic or the message of the paper and to attract readers.

The title will be read by many people. Only a few will read the entire paper, therefore all words in the title should be chosen with care. Too short a title is not helpful to the potential reader. Too long a title can sometimes be even less meaningful. Remember a title is not an abstract. Neither is a title a sentence.

What makes a good title?

A good title is accurate, complete, and specific. Imagine searching for your paper in PubMed. What words would you use?

• Use the fewest possible words that describe the contents of the paper.
• Avoid waste words like "Studies on", or "Investigations on".
• Use specific terms rather than general.
• Use the same key terms in the title as the paper.
• Watch your word order and syntax.

The abstract is a miniature version of your paper. It should present the main story and a few essential details of the paper for readers who only look at the abstract and should serve as a clear preview for readers who read your whole paper. They are usually short (250 words or less).

The goal is to communicate:

•  What was done?
•  Why was it done?
•  How was it done?
•  What was found?

A good abstract is specific and selective. Try summarizing each of the sections of your paper in a sentence two. Do the abstract last, so you know exactly what you want to write.

• Use 1 or more well developed paragraphs.
• Use introduction/body/conclusion structure.
• Present purpose, results, conclusions and recommendations in that order.
• Make it understandable to a wide audience.
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• Open access
• Published: 23 April 2024

Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia: a prospective, single arm, phase I trial

• Yunfei Chen   ORCID: orcid.org/0000-0001-7309-8545 1 , 2   na1 ,
• Yanmei Xu   ORCID: orcid.org/0000-0003-4607-9781 1 , 2   na1 ,
• Ying Chi 1 , 2   na1 ,
• Ting Sun 1 , 2   na1 ,
• Yuchen Gao   ORCID: orcid.org/0000-0002-0619-1595 1 , 2   na1 ,
• Xueqing Dou 3 ,
• Zhibo Han 1 , 4 ,
• Feng Xue 1 , 2 ,
• Huiyuan Li 1 , 2 ,
• Wei Liu 1 , 2 ,
• Xiaofan Liu 1 , 2 ,
• Huan Dong 1 , 2 ,
• Rongfeng Fu 1 , 2 ,
• Mankai Ju 1 , 2 ,
• Xinyue Dai 1 , 2 ,
• Wentian Wang 1 , 2 ,
• Yueshen Ma 1 , 2 ,
• Zhen Song 1 , 2 ,
• Jundong Gu 4 ,
• Wei Gong 4 ,
• Renchi Yang 1 , 2 &
• Lei Zhang   ORCID: orcid.org/0000-0001-7769-7377 1 , 2 , 5  

Signal Transduction and Targeted Therapy volume  9 , Article number:  102 ( 2024 ) Cite this article

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• Immunological disorders
• Mesenchymal stem cells

Patients with refractory immune thrombocytopenia (ITP) frequently encounter substantial bleeding risks and demonstrate limited responsiveness to existing therapies. Umbilical cord-derived mesenchymal stem cells (UC-MSCs) present a promising alternative, capitalizing on their low immunogenicity and potent immunomodulatory effects for treating diverse autoimmune disorders. This prospective phase I trial enrolled eighteen eligible patients to explore the safety and efficacy of UC-MSCs in treating refractory ITP. The research design included administering UC-MSCs at escalating doses of 0.5 × 10 6 cells/kg, 1.0 × 10 6 cells/kg, and 2.0 × 10 6 cells/kg weekly for four consecutive weeks across three cohorts during the dose-escalation phase, followed by a dose of 2.0 × 10 6 cells/kg weekly for the dose-expansion phase. Adverse events, platelet counts, and changes in peripheral blood immunity were monitored and recorded throughout the administration and follow-up period. Ultimately, 12 (with an addition of three patients in the 2.0 × 10 6 cells/kg group due to dose-limiting toxicity) and six patients were enrolled in the dose-escalation and dose-expansion phase, respectively. Thirteen patients (13/18, 72.2%) experienced one or more treatment emergent adverse events. Serious adverse events occurred in four patients (4/18, 22.2%), including gastrointestinal hemorrhage (2/4), profuse menstruation (1/4), and acute myocardial infarction (1/4). The response rates were 41.7% in the dose-escalation phase (5/12, two received 1.0 × 10 6 cells/kg per week, and three received 2.0 × 10 6 cells/kg per week) and 50.0% (3/6) in the dose-expansion phase. The overall response rate was 44.4% (8/18) among all enrolled patients. To sum up, UC-MSCs are effective and well tolerated in treating refractory ITP (ClinicalTrials.gov ID: NCT04014166).

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Introduction.

Immune thrombocytopenia (ITP) is an acquired autoimmune hemorrhagic disease characterized by isolated thrombocytopenia, resulting from an imbalance of immune tolerance that leads to accelerated platelet destruction and impaired platelet production. 1 , 2 , 3 The most common clinical manifestations of ITP include the arrest in megakaryocyte maturation and reduction in platelet count. Treatments for adult patients with ITP include glucocorticoids, intravenous immunoglobulin, TPO receptor agonist (TPO-RA), rituximab, splenectomy, and immunosuppressants. 4 , 5 Refractory ITP refers to patients who have failed multiple therapies (including TPO-RA and rituximab) and/or have not responded or relapsed after splenectomy. 6 , 7 These patients often have aggravated bleeding symptoms, a severe decline in quality of life, and increased mortality. 6 , 7 However, the regimens recommended by the current guidelines have limited effectiveness in alleviating the situation, and patients with refractory ITP are in urgent need of novel therapies to overcome this dilemma. 8 , 9

Mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells, are pluripotent progenitor cells with regenerative and immunomodulatory properties. 10 Since Hillard Lazarus’s first report in 1995 on treating hematologic malignancies with autologous bone marrow-derived progenitor stromal cells, the application of MSCs has gradually increased. 11 Many preclinical and clinical studies have confirmed that MSCs can influence both innate and adaptive immune responses through paracrine or cell-to-cell contact mechanisms. 12 , 13 Current data show that 10 mesenchymal stem cell products have been approved for marketing worldwide and are mainly used for immunoregulation and injury repair in graft-versus-host disease (GVHD), Crohn’s disease, myocardial infarction, osteoarthritis and other diseases. 14 , 15 We and other researchers have previously found that MSCs from ITP patients showed defective haematopoietic support function, impaired proliferative capacity, and reduced suppression of activated T cells. Meanwhile, we compared and analyzed the characteristics of MSCs from different tissue sources through single-cell transcriptomic and proteomic sequencing, and found that perinatal mesenchymal stem cells had stronger immunosuppressive ability than bone marrow-derived and adipose-derived MSCs. 16 Therefore, correcting the impaired autologous MSCs by drugs or infusion of exogenous umbilical cord-derived MSCs (UC-MSCs) may partly reshape the immune microenvironment in patients with ITP. 17 , 18

In the past decade, several researchers have attempted small-sample studies on the treatment of ITP using UC-MSCs and achieved the expected results. In 2012, we first reported that two patients with chronic ITP showed effective improvement in platelet count and bleeding symptoms after the administration of UC-MSCs (4.0 × 10 5 cells/kg). 19 Five years later, Wang reported that four chronic ITP patients who received UC-MSC infusion with a total cell count ranging between 5.0 × 10 7 and 1.0 × 10 8 achieved complete remission, and three relapsed within one year. 20 Although the effectiveness of UC-MSCs in treating ITP has been recognized to some extent, there is no consensus on the dosage of infusion, and there is a lack of support from standardized clinical trial research evidence. 21

Given the limited research results on the clinical efficacy, optimal treatment timing and regimen of MSCs for treating patients with refractory ITP, we conducted a prospective clinical study to evaluate the safety and efficacy of UC-MSCs for treating refractory ITP patients and explored the appropriate dose of UC-MSC therapy.

Patient characteristics

Between November 2019 and August 2022, 18 refractory ITP patients hospitalized in our center were successfully screened and enrolled in the study, including 12 patients in the dose escalation and 6 patients in the dose expansion phase (Fig. 1 ). The demographics and baseline characteristics of all eligible patients are shown in Table 1 and Supplementary Table S1 . The median age of the patients was 44 years old (range: 30–50), and 15/18 patients (83.3%) were female. All of the participants were chronic ITP patients with a median duration of 73 months (range: 15–360). A total of 15/18 patients (83.3%) had 5 or more unique prior therapies (Supplementary Table S2 ). A total of 10/18 patients (55.6%) and 13/18 patients (72.2%) had previously received splenectomy and rituximab, respectively. Platelet glycoprotein (GP) autoantibodies were detected by a commercial kit (PakAutoassay, Immucor GTI Diagnostics, USA), and 11/18 patients (61.1%) showed positive results, including anti-GP Ib/IX single positive (2/18, 11.1%), anti-GP IIb/IIIa single positive (6/18, 33.3%), and anti-GP IIb/IIIa and GP Ia/IIa double positive (3/18, 16.7%).

Flow diagram of the study. Twenty-two patients were screened for eligibility, 3 patients were excluded based on the eligibility criteria, and one patient withdrew informed consent. Finally, 18 patients were enrolled in the study. In the dose-escalation phase, 12 patients were enrolled and assigned to the 3-dose group, and 6 patients were subsequently enrolled in the dose-expansion phase

Safety and tolerability

During the dose-escalation phase, three patients were sequentially enrolled in each of the three predetermined dose groups and received UC-MSC treatment according to the protocol. Unfortunately, one patient in 2.0 × 10 6 cells/kg group experienced a grade 3 treatment-related adverse event (acute myocardial infarction) 10 days after the fourth infusion of UC-MSCs, and it was determined by experts from the academic and ethics committee as a dose-limiting toxicity event (DLT) (Supplementary Fig. S1 ). Therefore, we added three more patients to the 2.0 × 10 6 cells/kg group, and no DLT was reported in these patients. Based on this, we determined 2.0 × 10 6 cells/kg as the dosage for the subsequent dose-expansion phase.

All 18 patients enrolled in the study successfully finished the full course (four times) of UC-MSC infusion. Within the 28-week UC-MSC treatment and follow-up period, 13 patients (13/18, 72.2%) had one or more treatment emergent adverse events (TEAEs), most of which were grade 1 or 2, and all of them recovered spontaneously or after short-term intervention. The detailed adverse events (AEs) are presented in Table 2 . Briefly, the most common TEAEs were fatigue (5/18, 27.8%), blood bilirubin elevation (4/18, 22.2%) and uric acid elevation (3/18, 16.7%). Three patients reported treatment-related adverse events (TRAEs), including two cases of infusion-related reaction and one case of acute myocardial infarction that occurred ten days after the fourth infusion (with platelet count <30 × 10 9 /L at onset), which was considered possibly related to the infusion of UC-MSCs. Two patients (2/18, 11.1%) in 1.0 × 10 6 cells/kg group experienced chest tightness that was spontaneously relieved during the first UC-MSC infusion.

Serious adverse events (SAEs) occurred in four patients (4/18, 22.2%), including patient 006 in 1.0 × 10 6 cells/kg group, patients 007 and 009 in 2.0 × 10 6 cells/kg group, and patient 014 in the expansion cohort. Patients 006 and 014 experienced grade 3 gastrointestinal hemorrhage, and patient 009 had profuse menstruation during UC-MSC treatment, these were all thought to be associated with thrombocytopenia. Patient 007 experienced the DLT event mentioned above. To date, all patients enrolled and treated with UC-MSCs have not reported any AEs of malignant neoplasms.

The efficacy of UC-MSCs was analyzed separately for the dose-escalation phase and the dose-expansion phase (Supplementary Table S3 ). Excluding the influence of rescue therapy, the platelet response (R, defined as platelet count ≥30 × 10 9 /L, with at least 2-fold increase from the baseline count and the absence of bleeding) was achieved by 5 patients (41.7%, 5/12) in the dose-escalation phase, and 3 patients (50.0%, 3/6) in the dose-expansion phase. The overall response rate was 44.4% (8/18), with a median cumulative response duration of 6.5 weeks (range 3–27). The median time to the first platelet count ≥50 × 10 9 /L was 21 days (range: 7–42) (Supplementary Fig. S2 ).

Amone the 5 patients who achieved a response in the dose-escalation phase, 2 belonged to the 1.0 × 10 6 cells/kg group, and 3 belonged to the 2.0 × 10 6 cells/kg group. Therefore, the efficacy rate was 0.0% (0/3) for the 0.5 × 10 6 cells/kg group, 66.7% (2/3) for the 1.0 × 10 6 cells/kg group, and 50.0% (3/6) for the 2.0 × 10 6 cells/kg group. The median cumulative response duration among responding patients was 4.5 weeks (range: 3–6) in the 1.0 × 10 6 cells/kg group and 27 weeks (range: 7–27) in the 2.0 × 10 6 cells/kg group, respectively. The proportions of patients with platelet counts ≥50 × 10 9 /L at least once were 0.0% (0/3) in the 0.5 × 10 6 cells/kg group, 66.7% (2/3) in the 1.0 × 10 6 cells/kg group, and 50.0% (3/6) in the 2.0 × 10 6 cells/kg group. The proportions of patients with platelet counts ≥100 × 10 9 /L at least once were 0.0% (0/3), 66.7% (2/3), and 33.3% (2/6), respectively.

In the dose-expansion phase, three patients met a response, resulting in an efficacy rate of 50.0% (3/6). All three responding patients achieved platelet counts ≥50 × 10 9 /L at least once, with a median cumulative response duration of 6 weeks (range: 3–8). The proportions of patients with platelet counts ≥100 × 10 9 /L at least once was 50.0% (3/6).

After four weeks of UC-MSC treatment, patients in each group showed an improvement in the bleeding symptoms (Supplementary Table S4 ). Six patients (6/12, 50.0%) and five patients (5/6, 83.3%) were treated with rescue therapy in the dose-escalation phase and dose-expansion phase, respectively (Supplementary Table S5 ). Nine patients (9/18, 50.0%) had concomitant medications in the study (Supplementary Table S6 ). Each patient’s concomitant medications, response and rescue therapy are shown as a bar chart in Fig. 2a . The mean platelet counts with standard errors from baseline to week 28 in all patients are shown in Fig. 2b .

Treatment response, outcomes and platelet counts over time in all patients. a The best responses, concomitant medications, and rescue therapy of all 18 patients with different infusion doses (0.5 × 10 6 cells/kg, 1.0 × 10 6 cells/kg, and 2.0 × 10 6 cells/kg) are shown in the swimmer plot. GC glucocorticoids, TPO-RA thrombopoietin receptor agonist, R response. b The mean platelet counts of all enrolled patients from baseline to 24 weeks after the completion of UC-MSC administration. Data are the mean ± s.e.m., and different colors represent different infusion doses of UC-MSCs

Patient 008 relapsed 30 weeks after the first UC-MSC infusion, and patient 010 did not experience recurrence after one year of follow-up with eltrombopag 25 mg/day (the maintenance dose for three months before enrollment was 75 mg/day). Patient 007 relapsed 13 weeks after the first UC-MSC infusion, but the patient was no longer bleeding, and the platelet count was consistently >30 × 10 9 /L for 16 months of follow-up thereafter.

Compassionate use of UC-MSCs

In total, we infused 19 courses of UC-MSCs in this study. Patient 008 received another course of UC-MSC (2.0 × 10 6 cells/kg) treatment after relapse and reached treatment response again. However, the maximum platelet count after redosing was lower than that in the first course (61 × 10 9 /L vs. 89 × 10 9 /L), and the cumulative response time was also decreased (8 weeks vs. 30 weeks). TRAEs did not occur during the next 28 weeks.

Pharmacokinetics of UC-MSCs

A total of eight patients underwent pharmacokinetics assays with informed consent (Supplementary Table S7 ). The SRY gene started to be detectable in the peripheral blood of all patients at 30 min and could last for 4 h in most patients. There was no detectable human-specific sequence in the blood 8 h after injection (except patient 005). Collectively, the longest peripheral blood residence time for MSCs administered via intravenous infusion in this study was 8 h.

Humoral immunogenicity

Anti-drug antibodies (ADA) were analyzed pre-cell (−1 h ~ 0 h) and after-cell (48 h after the 4th MSC infusion) infusion in 12 patients (Supplementary Table S8 ). No ADA was detected at any time point, which demonstrated that there was no occurrence of ADA in patients after UC-MSC infusion.

Immunological changes in the peripheral blood after UC-MSC treatment

Differences in the peripheral immune environment of ITP patients before and after infusion were assessed through flow cytometry analysis (Fig. 3 and Supplementary Figs. S3 – S8 ). Due to the impact of COVID-19, some follow-up data of the enrolled patients were missing. Consequently, for the evaluation of peripheral immune alterations, we consolidated observations at 16 weeks and 24 weeks, presenting them as ≥16 weeks.

The peripheral immune monitoring plan of enrolled patients and the dynamic changes in peripheral blood immune cells after receiving UC-MSC infusion. a Blood samples were collected from all enrolled patients for platelet count and peripheral blood immune subpopulation monitoring at baseline and 2, 4, 8, 12, 16 and 24 weeks after the first infusion (peripheral blood samples at the baseline and 2 week observation points were collected within 2 h before the UC-MSC infusion). b , c Changes in the proportion of CD8+ T cells in peripheral lymphocytes after UC-MSC infusion ( n  = 8 in the response group, n  = 8 in the no response group). d , e Changes in the proportion of suppressor T cells (Tregs, CD8 + CD28 − T cells) after UC-MSC infusion ( n  = 8 in the response group, n  = 10 in the no response group). f , g Dynamic changes in the counts and percentages of CD19 + B cells in peripheral blood after UC-MSC infusion ( n  = 8 in the response group, n  = 9 in the no response group). Due to the impact of COVID-19, some follow-up data of enrolled patients were missing. Consequently, for the evaluation of peripheral immune alterations, we consolidated observations at 16 weeks and 24 weeks, presenting them as ≥16 weeks. Data are the mean ± s.e.m., and different colors represent different infusion doses of UC-MSCs in the scatterplots: purple = 0.5 × 10 6 cells/kg, green = 1.0 × 10 6 cells/kg, red = 2.0 × 10 6 cells/kg. Statistical analysis was conducted using independent samples t -tests or Wilcoxon signed-rank test, with a significance level set at p  < 0.05. W weeks, R response, NR no response

Comparing baseline immune profiles between responsive and non-responsive patients, we found that responders displayed slightly higher percentages and absolute counts of T lymphocytes, whereas B cell metrics displayed the opposite trend. However, these variances lacked statistical significance (Supplementary Fig. S3 ). The infusion period of UC-MSCs was characterized by a transient reduction in both the proportion and absolute count of peripheral T lymphocytes. In the subsequent follow-up period, these metrics exhibited a gradual upward trend, especially in the proportion of CD8 + T cells, with this increase being slightly more evident in the response group compared to the no response group, though not reaching statistical significance (Fig. 3b, c and Supplementary Fig. S4a–g ). Notably, a significant gradual increase in the proportion of CD8 + CD28 − T cells was observed in the response group. Conversely, the proportion of T regulatory cells (Tregs, CD4 + CD25 + CD127 dim/− ) significantly rose in the no response group. The absolute counts of CD8 + CD28 − T cells and Tregs demonstrated a similar pattern throughout the study period in both groups (Fig. 3d, e and Supplementary Figs. S5 and S6 ). Additionally, marginal decreases in the percentages of naïve (CD45RA + CCR7 + T cells) and central memory (CD45RA − CCR7 + T cells) T lymphocytes were observed in responsive patients (Supplementary Fig. S7 ). B cell monitoring revealed similar outcomes to T cells, though baseline B cell proportions were higher in non-responsive patients than in responsive patients (Fig. 3f, g and Supplementary Fig. S4h ), with no significant difference in the suppressor B-cell subset (CD19 + CD38 hi CD24 hi ) between two groups (Supplementary Fig. S8 ).

Quantitative analysis of plasma cytokine concentrations before and after UC-MSC infusion (0, 2, 4 weeks) in patients revealed that there were no statistically significant differences in baseline cytokine levels between the response and no response groups. However, patients in the no response group showed a significant increase in plasma levels of various inflammatory cytokines, including IL-1β, IL-2, IL-6, and IL-17, after receiving UC-MSC infusion, whereas such changes were not observed in the response group (Fig. 4 ).

Quantitative analysis of plasma cytokine concentrations before and after UC-MSC infusion. The concentrations of 12 kinds of cytokines were measured before (0), during UC-MSC infusion (2 weeks), and after UC-MSC infusion (4 weeks) in the response and no response group, respectively ( n  = 8 in the response group, n  = 10 in the no response group). The levels of plasma IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-17A, IFN-α, and TNF-α had significantly increased after the infusion of UC-MSC (all p  < 0.05). No significant changes were observed in the response group before and after the UC-MSC infusion. Data are the mean ± s.e.m., circle represents response group, square represents no response group. And different colors represent different infusion doses of UC-MSCs in the scatterplots: purple = 0.5 × 10 6 cells/kg, green = 1.0 × 10 6 cells/kg, red = 2.0 × 10 6 cells/kg. Statistical analysis was conducted using paired t -test or Wilcoxon signed-rank test, with a significance level set at p  < 0.05. W weeks, R response, NR no response

To our knowledge, this is the first prospective, open-label study that evaluated the safety and efficacy of UC-MSC infusion in refractory ITP and was first successfully documented by the China Medicinal Biotechnology Association. Although previous case reports and small sample studies have suggested that allogeneic MSC infusion may reshape immune homeostasis, improve platelet counts and alleviate bleeding symptoms in ITP patients, the sources of MSCs used in these studies vary greatly, and there are significant differences in the infusion doses used in different studies. 18 , 21 In the dose-escalation phase of this study, we compared and analyzed the safety and efficacy of UC-MSC therapy for refractory ITP under three different doses and established 2.0 × 10 6 cells/kg as the infusion dose for the dose-expansion phase.

As the most important study endpoint of this research, 72.2% of the enrolled patients experienced TEAEs after treatment, most of which were grade 1–2. Grade 3 bleeding manifestations (gastrointestinal hemorrhage, profuse menstruation) occurred in three patients, which may be attributable to the fact that all subjects in this study were refractory ITP patients with bleeding tendency and the limited efficacy of UC-MSCs. The DLT in this study was acute myocardial infarction, which was reported in one patient in the 2.0 × 10 6 cells/kg group. Although there is no previous report that MSC infusion can induce thrombotic events, the platelet count on set was low, and there was no previous history of cardiovascular disease or risk factors, so UC-MSC infusion could not be ruled out. 22 Notably, 22.2% of the subjects reported elevated liver transaminase (all incidents were Grade 1 AEs) during the observation period, which were considered related to the long-term use of concomitant drugs (danazol or TPO-RAs).

All 18 patients included in the study completed the UC-MSC treatment successfully, with an overall effective rate of 44.4% (8/18), and four patients (4/18, 22.2%) reached complete response after treatment. However, the 2.0 × 10 6 cells/kg dosage did not show the expected advantage compared to the 1.0 × 10 6 cells/kg dosage in achieving long-term remission (≥6 months, data not shown) after the infusion of UC-MSCs. Results in the dose-escalation phase reveal a dose-dependent trend in the efficacy of UC-MSCs in the dose range of 0.5–2.0 × 10 6 cells/kg, but this tendency is less pronounced when analyzing data from both phases together. UC-MSC therapy is also effective in patients who have failed or relapsed after undergoing splenectomy or rituximab. The response rates among patients who had previously undergone splenectomy or rituximab were 40.0% (4/10) and 46.2% (6/13), respectively. Patients who had received both splenectomy and rituximab previously showed a similar response rate (40.0%, 2/5). In addition, our results indicated that bleeding symptoms can be completely relieved in 60.0%–75.0% of patients after treatment, supporting the feasibility of mesenchymal stem cells as an auxiliary or emergency treatment option.

In this study, we provided some insights into the circulation dynamics of UC-MSCs by detecting the SRY gene in peripheral blood. This approach minimizes patient discomfort and is ethically acceptable. However, it cannot provide information about the distribution and metabolism of UC-MSCs in organ tissues, which is a limitation of our research. We anticipate the development of more advanced methods in the future that can simultaneously monitor the distribution and metabolism of UC-MSCs in both peripheral blood and tissues. Such advancements will contribute to a more comprehensive understanding of the potential mechanisms underlying UC-MSC treatment for refractory ITP and variations in treatment efficacy among individuals.

Previous in vitro and in vivo studies have shown that mesenchymal stem cells exert immunomodulatory effects mainly through paracrine or direct cell contact, and the main target cells are T cells. 23 , 24 In this study, we monitored peripheral blood immune cell subsets before and after UC-MSC infusion. Our findings indicate a temporary decrease in T cell percentages during the infusion of UC-MSCs, followed by a gradual increase in the proportion of CD8 + CD28 − suppressive T cell subsets. These observations would lend further support to the notion that the immunosuppressive actions of MSCs in vivo are predominantly directed at T cells, particularly in attenuating the activation of CD8 + T cells. Nonetheless, given the limited sample size and variability in dosage among patients, these results warrant confirmation through larger-scale, randomized controlled trials. In addition, we also observed a decrease in the proportion of B cells after infusion, which was considered to be associated with the inhibition of T cells by UC-MSCs indirectly affecting the activation of B cells. 25 The immunomodulatory capacity of MSCs is plastic and is believed to depend upon the kinds and concentration of inflammatory medicators as well as the intensity of the immune microenvironment activation. 26 Quantitative analysis of peripheral blood plasma cytokines revealed a predominant elevation in proinflammation cytokines in the no response group, which implied that the failure of UC-MSC treatment might be partly associated with the intricate state of the inflammation microenvironment.

This study has several limitations. Firstly, it is a single-arm, non-randomized controlled trial with a small sample size. Additionally, the total duration of follow-up was relatively short, and the COVID-19 pandemic resulted in missing data at certain follow-up points for some participants. Moreover, the limited sample size precluded the possibility of conducting subgroup analyses, including those pertinent to changes in peripheral blood immune status post-UC-MSC infusion. Therefore, the results pertaining to safety and efficacy reported in this study should be validated through future large-scale, randomized, multicentre clinical trials.

Overall, UC-MSC infusion achieved a 44.4% overall response rate in patients with refractory ITP and mild adverse events. The related mechanism may involve inhibiting T-cell activation and inducing the production of suppressor CD8+ T cells. However, given the limited sample size and expansion dosage of this study, the results need to be further verified by clinical trials with larger sample sizes and higher infusion doses.

Study design

This prospective, open-label, phase I study consisted of two parts: a dose-escalation phase for exploring the safety and efficacy of three different dosage groups according to the traditional 3 + 3 protocol and a dose-expansion phase for further verifying the optimal UC-MSC dosage (Fig. 1 ). 27 , 28 The study protocol was approved by the Ethics Committees of the Institute of Hematology and Blood Diseases Hospital, and informed consent was obtained from each participant according to the Declaration of Helsinki (ClinicalTrials.gov ID: NCT04014166).

UC-MSC product preparation

Off-the-shelf GMP-grade male infant-derived UC-MSCs were provided by Tianjin Amcellgene Co. Ltd., which has been approved by the China National Medical Products Administration (NMPA) with agreements to start clinical trials for GVHD and acute chronic liver failure (ACLF). This cryopreserved product is a mixture containing 2.0 × 10 7 UC-MSCs, 10% DMSO, and 5% human serum albumin, which needs to be thawed in a 37 °C water bath and diluted with multiple electrolyte injections (20 ml) before infusion into patients.

Patients and treatments

Patients diagnosed with refractory ITP according to the international consensus on the identifying and treating of refractory immune thrombocytopenia were screened for the study. 7 , 29 The major inclusion criteria included age 18 to 60 years, ITP duration lasting for more than 6 months, platelet count <30 × 10 9 /L and concomitant bleeding manifestations at enrollment. Patients were allowed to have concomitant treatments (TPO-RAs, glucocorticoids, danazol), but the doses must have been stable at the time of enrollment. Patients who had thrombosis, malignant tumors or severe dysfunction of vital organs (liver, kidney, lung, heart) were excluded from the study (see Supplementary Methods for details).

In the dose escalation phase, eligible patients were divided into three different dose groups sequentially. The UC-MSCs were administered once a week for a total of four times (0.5 × 10 6 cells/kg group; 1.0 × 10 6 cells/kg group; 2.0 × 10 6 cells/kg group). Subsequently, the investigator determined an optimal dose to expand the sample size by referring to the results of the dose escalation phase. In addition, during the UC-MSC infusion and follow-up period, the dosage of concomitant medications should be kept stable or gradually tapered. If the participants had sustained thrombocytopenia (platelet count <30 × 10 9 /L) or severe bleeding manifestations during the follow-up period, the investigators should propose appropriate rescue therapy or advise the patient to withdraw from the study. Moreover, if the patient did not respond well to all of the current ITP regimens and was willing to have UC-MSCs administered again, a course of UC-MSC treatment could be given again 16 weeks after the first infusion.

Patients needed to visit every week from day 1 to day 112 and every month for three months thereafter to collect data on safety and efficacy outcomes, pharmacokinetic data of UC-MSCs, incidence of UC-MSC antibodies and changes in immune status.

Pharmacokinetic study

An exploratory pharmacokinetic study was conducted to clarify the retention time of UC-MSCs in peripheral blood after injection. Briefly, the blood samples of female subjects who had never gave birth to a male infant were collected before (−1 h～0 h) and after (30 min, 1, 2, 4, 8, 16, 24, 48, 72, and 96 h) UC-MSCs infusion. Then, total DNA was extracted for PCR assays to detect the specific human DNA sequence as the SRY gene according to the manufacturer’s instructions. The operation range of the standard curve should have covered 4.00 × 10 1 –1.00 × 10 7 copies/reaction.

Anti-MSC antibody detection assay

The GMP-grade UC-MSCs were dissociated into single cells by 0.25% Trypsin-EDTA (Gibco), incubated with ADA samples for up to 30 min, and then labeled with conjugated antibodies against protein L-PE (Sino Biological) for 15 min in the dark. After washing with PBS twice, the cells were analyzed by FACS Canto II (BD Biosciences, USA) according to the instructions.

Cell staining and flow cytometry

To monitor the influence of UC-MSC infusion on peripheral immune cells, blood samples were collected from patients at various monitoring points (Fig. 3a ) and stained with antibodies (Supplementary Methods). Then, the samples were lysed with lysis buffer (BD Biosciences, USA) and washed twice with PBS. Stained cells were analyzed by FACS Canto II cytometry (BD Biosciences, USA). Quantitatively analyzed the concentrations of 12 cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-17, IFN-γ, IFN-α, and TNF-α) in peripheral blood plasma using flow cytometry bead-based assay (ABplex Human Chemokine 12-Plex Assay Kit, ABclonal).

The primary endpoints were the safety and tolerability of UC-MSCs, which were reflected by the DLT. The National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0 was used as the principle for grading and recording AEs throughout the study. The main evaluation indexes consist of physical examination, laboratory tests (liver function, renal function, electrocardiography, and virological examination) and infusion-related reactions. DLT was defined as any grade ≥3 TRAEs that occurred during the first administration to 1 month post completion of UC-MSCs and could not be relieved to grade 1 within 72 h after treatment with drugs or other interventions. The correlation between treatment and AEs was determined by the principal investigator. The secondary endpoints were the efficacy, pharmacokinetic and immunological data of UC-MSCs. Clinical response was evaluated according to the efficacy criteria of ITP, as outlined in the Supplementary Methods. 30 Response (R) was defined as platelet count ≥30 × 10 9 /L, with at least 2-fold increase from the baseline count and the absence of bleeding. No response (NR) was defined as platelet count <30 × 10 9 /L or less than 2-fold increase from the baseline platelet count or the presence of bleeding. Relapse was defined as a platelet count <30 × 10 9 /L, or less than a doubling of the baseline count, or bleeding, which occurring after the achievement of a response. The efficacy endpoint was the proportion of patients with platelet count ≥30 × 10 9 /L at least doubling of the baseline count, ≥50 × 10 9 /L, and ≥100 × 10 9 /L at least once after receiving UC-MSCs. Changes in WHO bleeding score after treatment were assessed based on the World Health Organization’s Bleeding Scale. 31

Statistical analysis

All statistical analyses were mainly descriptive and conducted using SPSS v26.0 and GraphPad Prism 9.0 software. Quantitative data are presented as medians (minimum and maximum), and qualitative data are presented as n (%). Statistical differences in the immunological changes between the effective and ineffective groups were calculated using independent sample t -test, paired t -test or Wilcoxon signed-rank test, with p values less than 0.05 considered statistically significant. Summary tables for AEs had to include all AEs that occurred in the whole period of study.

Data availability

Eligible researchers can request data sets, including unidentified individual subject data. Data may be available on request from the corresponding author from 12 to 36 months after trial completion.

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Acknowledgements

This project was supported by the CAMS Innovation Fund for Medical Sciences (CIFMS) (grant numbers 2020-I2M-C&T-B-086, 2022-I2M-2-003, and 2021-I2M-1-073), the National Key Research and Development Program of China (grant numbers 2021YFA1101603, 2023YFC2507802), and the National Natural Science Foundation of China (grant numbers 82270152, 81970121, 82070125, 82170127, and 82100151). The authors would like to acknowledge Xuan Liang from Yiducloud (Beijing) Technology Ltd. for his assistance in the data analysis. The authors appreciate all the patients for participating in this study.

Author information

These authors contributed equally: Yunfei Chen, Yanmei Xu, Ying Chi, Ting Sun, Yuchen Gao

Authors and Affiliations

State Key Laboratory of Experimental Hematology, National Clinical Research Centre for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Tianjin Key Laboratory of Gene Therapy for Blood Diseases, CAMS Key Laboratory of Gene Therapy for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China

Yunfei Chen, Yanmei Xu, Ying Chi, Ting Sun, Yuchen Gao, Zhibo Han, Feng Xue, Huiyuan Li, Wei Liu, Xiaofan Liu, Huan Dong, Rongfeng Fu, Mankai Ju, Xinyue Dai, Wentian Wang, Yueshen Ma, Zhen Song, Renchi Yang & Lei Zhang

Tianjin Institutes of Health Science, Tianjin, 301600, China

Yunfei Chen, Yanmei Xu, Ying Chi, Ting Sun, Yuchen Gao, Feng Xue, Huiyuan Li, Wei Liu, Xiaofan Liu, Huan Dong, Rongfeng Fu, Mankai Ju, Xinyue Dai, Wentian Wang, Yueshen Ma, Zhen Song, Renchi Yang & Lei Zhang

National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China

Xueqing Dou

National Engineering Research Centre of Cell Products, Tianjin Key Laboratory of Engineering Technologies for Cell Pharmaceutical, AmCellGene Engineering Co., Ltd, Tianjin, 300457, China

Zhibo Han, Jundong Gu & Wei Gong

School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730, Beijing, China

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Contributions

L. Z. designed the clinical trial. Y. C., Y. X., Y. G., Y. C., and T. S. executed the study, collected the data, and drafted the manuscript. X. D., F. X., W. L., X. L., H. D., R. F., M. J., X. D., H. L., W. W., and R. Y. contributed to the patient follow-up and data collection. Z. H., J. G., and W. G. were responsible for conducting the anti-drug antibody and pharmacokinetic assays. Y. M. and Z. S. contributed to the statistical analysis of the data and for editing the manuscript. Y. X. and Y. G. were responsible for the design of figures in manuscript and Supplementary Appendix. All authors reviewed and approved the final version of this manuscript.

Corresponding author

Correspondence to Lei Zhang .

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Chen, Y., Xu, Y., Chi, Y. et al. Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia: a prospective, single arm, phase I trial. Sig Transduct Target Ther 9 , 102 (2024). https://doi.org/10.1038/s41392-024-01793-5

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Received : 07 August 2023

Revised : 18 February 2024

Accepted : 02 March 2024

Published : 23 April 2024

DOI : https://doi.org/10.1038/s41392-024-01793-5

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