This information is intended for US healthcare professionals.

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Revealing the familial thread of type 1 diabetes (T1D) by screening first- and second-degree relatives can help those who are most at risk avoid complications like DKA at Stage 3 onset. 1

Connected by T1D

Revealing the familial thread of type 1 diabetes (T1D) by screening first- and second-degree relatives can help those who are most at risk avoid complications like DKA at clinical onset. 1

Father and daughter connected by T1D

300K people are at increased risk of developing Stage 3 T1D 2

Familial history is a strong predictor for T1D; focusing on the family of patients with T1D can help identify presymptomatic (Stage 1 and 2) patients. 3,4

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Unravel the presymptomatic story behind T1D

Patients’ beta cells may be targeted for destruction before developing Stage 3 T1D. Recognition of this process and its implications can prepare families for the risks ahead of clinical onset. 1,3

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Screening can reduce DKA at onset by  ≥ 50% 5,6

Early autoantibody screening can identify those most at risk of developing Stage 3 T1D. Increased awareness and early intervention may improve outcomes at presentation and avoid significant consequences such as diabetic ketoacidosis. 1

Screening can identify T1D patients before Stage 3 onset 1

There are various organizations and resources for T1D screening and clinical trials to advance T1D care.

1.  Raab J, Haupt F, Scholz M, et al; Fr1da Study Group. Capillary blood islet autoantibody screening for identifying pre-type 1 diabetes in the general population: design and initial results of the Fr1da study. BMJ Open . 2016;6(5):1-12.

2.  Ward K, Pan C, Shinde M, Rievathavorn J, Hedge S, Gaebler JA; JDRF. Modeling the total economic value of novel type 1 diabetes (T1D) therapeutic concepts. Published January 2020. Accessed December 2, 2022. https://t1dfund.org/wp-content/uploads/2020/02/Health-Advances-T1D-Concept-Value-White-Paper-2020.pdf

3.  Insel RA, Dunne JL, Atkinson MA, et al. Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association. Diabetes Care . 2015;38(10):1964-1974.

4.  Couper JJ, Haller MJ, Greenbaum CJ, et al. ISPAD Clinical Practice Consensus Guidelines 2018: stages of type 1 diabetes in children and adolescents. Pediatr Diabetes . 2018;19(suppl 27):20-27.

5.  Barker JM, Goehrig SH, Barriga K, et al; DAISY study. Clinical characteristics of children diagnosed with type 1 diabetes through intensive screening and follow-up. Diabetes Care . 2004;27(6):1399-1404.

6.  Elding Larsson H, Vehik K, Bell R, et al. Reduced prevalence of diabetic ketoacidosis at diagnosis of type 1 diabetes in young children participating in longitudinal follow-up. Diabetes Care . 2011;34(11):2347-2353.

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