PTSD Research Paper

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PTSD Research Paper

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Get 10% off with 24start discount code, i. reactions to traumatic events, a. acute reactions, b. posttraumatic stress disorder, c. course of ptsd, ii. measures of ptsd, a. interviews, b. self-report measures, iii. prevalence of ptsd, iv. vulnerability and resiliency factors in ptsd, v. concomitant problems following trauma, vi. theories on the development and maintenance of ptsd, a. psychoanalytic theories, b. cognitive and behavioral theories, c. psychobiological approaches, vii. psychological and pharmacological interventions in ptsd, a. early interventions, b. cognitive-behavioral therapies, 1. prolonged exposure (pe), 2. stress inoculation training (sit), 3. cognitive therapy, 4. cognitive processing therapy (cpt), 5. eye movement desensitization and reprocessing (emdr), c. pharmacotherapy, d. hypnotherapy and psychodynamic psychotherapy.

VIII. Bibliography

Psychologists and physicians have long been interested in vulnerability and resilience factors in reaction to extreme stress. Earlier accounts of posttrauma reactions focused on descriptions of cases. Spurred by inclusion of Post-traumatic Stress Disorder (PTSD) in the psychiatric diagnosis nomenclature in 1980, experimental research has examined many facets of the phenomenon.

In the Diagnostic and Statistical Manual (DSM-IV) published by the American Psychiatric Association in 1994, a trauma is defined as an experienced or witnessed event that involves threat of death or serious injury, and which evokes feelings of terror, horror, or helplessness. Thus, events such as anticipated death of a loved one, job loss, or divorce would not qualify as a trauma in this formulation. The International Classification of Diseases (ICD-10), published by the World Health Organization in 1992, describes a traumatic event as having an exceptionally threatening or catastrophic nature, which would be likely to cause pervasive distress in almost anyone.

The most common traumas studied are combat, sexual assault, sexual abuse in childhood, criminal victimization, torture, accidents, and natural disasters. Larger-scale traumas, such as mass migration, refugee camp experiences, and holocausts, have not yet been thoroughly researched. Clearly, such mass traumas would be expected to have considerable impact on those individuals directly affected as well as on their children, communities, and cultures.

A number of physical and psychological symptoms are considered common reactions immediately after a traumatic experience. Many trauma victims report being disoriented and anxious after a trauma and have difficulty sleeping and concentrating. Victims are often reluctant to talk about the trauma or deliberately contemplate it; nevertheless the traumatic memory intrudes on their thoughts quite frequently. In recognition of the severe distress and psychological dysfunction that often occur immediately after a trauma, a new diagnostic classification called Acute Stress Disorder (ASD) was adopted in the DSM-IV in 1994. The focus of this disorder is on dissociative features, and, consequently, the symptom criteria include at least three of the following: a sense of numbing, detachment, or lack of emotional responsiveness, a reduction in awareness of surroundings (e.g., being in a daze), derealization, depersonalization, and dissociative amnesia. Reexperiencing of the trauma, avoidance, and arousal, as defined in the criteria for PTSD, must also exist. A diagnosis of Acute Stress Disorder is warranted when such symptoms last between 2 days and 1 month, occur within 1 month of the trauma, and interfere significantly with daily functioning.

Posttraumatic Stress Disorder, as described in DSM-IV, is a set of symptoms that begins after a trauma and persists for at least 1 month. The symptoms fall into three clusters. First, the individual must reexperience the trauma in one of the following ways: nightmares, flashbacks, or intrusive and distressing thoughts about the event; or intense emotional distress or physiological reactivity when reminded of the event. Second, the individual must have three of the following avoidance symptoms: avoidance of thoughts or feelings related to the trauma, avoidance of trauma reminders, psychogenic amnesia, emotional numbing, detachment or estrangement from others, decreased interest in leisure activities, or a sense of foreshortened future. Third, the individual must experience two of the following arousal symptoms: difficulty falling or staying asleep, difficulty concentrating, irritability or outbursts of anger, hypervigilance, or an exaggerated startle response. To meet diagnostic criteria for PTSD, the symptoms must cause significant impairment in daily functioning. These criteria provide a good operational definition of PTSD, as they describe the symptoms seen in most cases. However, the three categories of symptoms are not empirically validated as distinct symptom clusters. For instance, it is not clear that the symptoms of behavioral avoidance and emotional numbing are similar and belong in the same category.

The ICD-IO criteria for PTSD also include some reexperiencing symptoms (nightmares, flashbacks, distress on exposure to reminders), actual or preferred avoidance of trauma reminders, and either an inability to recall important aspects of the trauma or sustained psychological sensitivity and arousal (sleep disturbance, hypervigilance, difficulty concentrating). These three criteria must all be met within 6 months of the traumatic event for a diagnosis to be given.

Several differences between the two definitions can be identified. First, the DSM-IV specifies a minimal number of symptoms that need to be observed to receive the diagnosis, whereas the ICD-IO leaves more freedom for clinical judgment. The advantage of the former approach is its utility in clearly operationalizing the concept of PTSD. The disadvantage is its rigidity and the possibility that one symptom can determine diagnostic membership. Second, the ICD-IO does not recognize the numbing symptoms, which together with flashbacks and nightmares are thought to be cardinal features of PTSD. Third, arousal symptoms are optional in the ICD-IO but are required in the DSM-IE Clinical observation and theoretical accounts of PTSD support the importance of these symptoms and render the ICD-IO diagnostic criteria less satisfactory.

The course of PTSD is variable. For the majority of individuals, symptoms begin immediately after the trauma, although some appear to have a delayed reaction. During the first 3 months after the trauma, the individual is said to have acute PTSD, whereas chronic PTSD is defined as symptoms persisting beyond 3 months. Symptoms can fluctuate over time between diagnosis of PTSD, subthreshold symptoms, and few or no symptoms. Recovery is affected by a number of factors, including perception of oneself and one’s surroundings, actual social support, life stress, coping style, and personality.

A number of measures have been developed to assess PTSD, including clinical interviews and self-report instruments. These measures vary widely in terms of the target symptoms, administration time, and the samples used for ascertaining psychometric properties. Adult assessment tools are reviewed in the next section. Although some measures have also been developed for children, they are outside the scope of this paper.

The Structured Clinical Interview for DSM (SCID) is believed to be the most widely used diagnostic interview. Its major disadvantage, however, is that it does not provide a measure of symptom severity. Several other interviews that provide information of both diagnostic status and symptom severity are available. Two interviews are becoming quite widely used in PTSD research. The first is the Clinician-Administered PTSD Scale (CAPS) that yields separate scores for frequency and intensity for each symptom. Disadvantages of this interview include a long administration time and validation on military veterans only. The second interview, the PTSD Symptom Scale Interview (PSS-I), includes a combined frequency/severity rating for each of the 17 PTSD symptoms in the DSM-IV and thus yields both a diagnosis and a continuous severity rating. Unlike the CAPS, the PSS-I takes only about 15 to 20 minutes to administer and was validated on female assault victims.

Several self-report scales have been developed to assess symptoms of PTSD. The first was the Revised Impact of Events Scale (RIES), which yields two factors: intrusion and avoidance. A revised version of the RIES added hyperarousal items, but has shown mixed results in reliability studies and, like its predecessor, does not correspond fully to the DSM-IV PTSD symptoms. Two scales, the Mississippi Scale and the Penn Inventory, have excellent psychometric properties in veteran samples but do not provide information about diagnostic status because they do not fully correspond to the DSM-IV defining symptoms.

The PTSD Symptom Scale-Self-Report (PSS-SR) and its successor, the PTSD Diagnostic Scale (PDS), provide information about each of the 17 DSM-IV symptoms, yielding both diagnostic and severity information. The PDS is the only self-report instrument that assesses all DSM-IV criteria, including information about the nature of the traumatic event and the level of functional interference, in addition to information about PTSD diagnosis and symptom severity. It was validated in a sample of victims of a wide range of traumas and evidenced sound psychometric properties, and thus can be used in studies of various trauma populations.

Lifetime prevalence of PTSD in the general population is estimated at 9%, with up to a third of these cases having chronic PTSD. Among trauma victims, the rate is much higher, estimated at 24 %. However, the rates of PTSD tend to vary considerably among different types of trauma. For instance, estimates of the lifetime prevalence of PTSD in Vietnam War veterans range from 27 to 65%; in civilian populations exposed to terrorism and torture, prevalence ranges from 33 to 54%. Between 35% and 94% of victims of violent assaults manifest PTSD. In contrast, accidents and natural disasters appear to produce lower rates of PTSD, 4.6 to 59%, depending on the event studied and the degree of exposure. Even individuals with little or no direct exposure to the trauma can develop PTSD; this phenomenon has been referred to as the “ripples outward” effect. Importantly, certain occupations are at risk for PTSD by virtue of increased probability of repeated direct exposure to trauma; between 9% and 26% of professionals such as police, nurses, and firefighters develop PTSD in reaction to stressors experienced on the job.

Prevalence in certain vulnerable populations is much higher than in the general population, presumably because individuals in these groups have been exposed to more traumatic experiences. These include populations seeking outpatient psychotherapy and those in substance abuse clinics. Women appear to be somewhat more likely than men to develop PTSD after trauma, 10.4 % versus 5 %, respectively. As noted earlier, the prevalence of emotional difficulties after mass traumas, such as refugee camp experiences or holocausts, has not been systematically studied.

Factors implicated in posttrauma reactions can be divided into three categories: pretrauma variables, variables related to the trauma itself, and posttrauma variables.

Research on pretrauma demographic variables has not identified reliable predictors of who will develop chronic PTSD with one exception: women are somewhat more likely to manifest PTSD than men after experiencing a similar trauma. In contrast, it appears that poor psychological and social functioning prior to the trauma renders the individual vulnerable to developing chronic symptoms. For instance, prior hospitalization and a history of drug abuse were found to be associated with a more severe posttrauma reaction. Also, a history of traumatic events in childhood or adulthood predicts a more severe response to a new trauma.

The nature of the trauma itself also appears to affect recovery. First, traumas differ in their likelihood of producing PTSD; rape, for example, is more likely to produce persistent symptoms than a natural disaster. Second, given a specific trauma (e.g., rape), injury and perceived threat of death produce more severe and persistent reactions.

Several posttrauma factors have been found to exacerbate symptoms. It appears that dissociation (emotional numbing, amnesia, depersonalization) shortly after a trauma hinders recovery. Also, on average, assault victims who exhibit more severe initial reactions to the trauma also show more symptoms later on. Thus, individuals seem to differ in how strongly they are affected by a similar trauma, and their initial reaction is associated with later psychopathology.

Evidence on the role of social support as facilitating or hindering recovery is equivocal. It seems that negative reactions from others, such as blame, increase posttrauma psychopathology, but, unfortunately, positive reactions do not show the expected positive effects. Excessive anger or guilt after the trauma also appears to block readjustment. Additional longitudinal research on the factors that promote resilience to trauma are clearly needed.

Traumatized individuals not only exhibit ASD or PTSD symptoms, but also depression, substance abuse, anxiety, dissociation, and physical health problems.

The rate of use and abuse of drugs and alcohol, including nicotine, in traumatized individuals is higher than in the general population. There are at least two explanations for this finding. First, traumatized individuals may choose to cope with their symptoms by increasing substance use. Second, substance abuse may increase the risk of being exposed to a traumatic experience.

Many individuals report symptoms of depression after a traumatic event, such as sadness, lack of energy, diminished interest in leisure activities, hopelessness, sleeplessness, and eating disturbances. Although some of these symptoms overlap with the defining symptoms of PTSD (e.g., markedly diminished interest in activities), the two disorders are separate entities and both can develop independently as a response to a traumatic experience.

The incidence of comorbid anxiety disorders is also elevated among individuals with PTSD. For example, lifetime comorbidity of panic disorder in Vietnam veterans with PTSD was 21% in females and 8% in males, versus 1.5 to 3.5% in the general population. The lifetime prevalence of obsessive-compulsive disorder was found to be 13% in females and 10% in males, as compared with 2.5 % in the general population.

There is a greater frequency of physical health problems among trauma victims than in the general population, especially among those who develop chronic PTSD. Trauma victims have higher rates of gastrointestinal disorders and pelvic or abdominal pain, and visit the doctor more often than the general population. In the aftermath of rape and child sexual abuse, gynecological and psychosexual problems such as vaginal discharge, dysmennorhea, dyspareunia, vaginismus, and pelvic pain have also been noted.

Reactions to trauma have long captured the interest of theorists of psychopathology. Janet’s 1889 theory of reactions to trauma has influenced both early and contemporary conceptualizations. Janet proposed that when confronted with a traumatic event that besieges the victim with an overabundance of intense thoughts and feelings, too numerous or intense to integrate, some individuals selectively attend away from the trauma to trauma-irrelevant thoughts and feelings. Thus, ideas related to the trauma remain split off or dissociated from normal consciousness and become “fixed.” Although out of consciousness, these “fixed ideas” remain part of the victim’s ideational content, and therefore continue to exert influence over his or her thought, mood, and behavior in the form of fragmented reliving of the trauma such as visual images, somatic states, emotional conditions, or behavioral reenactment.

Freud wrestled with understanding the influence of traumatic experiences on the individual’s psyche. In early writings, he was influenced by Janet’s theory on the strength of the emotional reactions that are produced by a traumatic experience and that force the victim to become fixated on the trauma. Later, Freud abandoned the dissociation view and proposed that the persistence of trauma reactions reflects an association between the traumatic event and childhood repressed conflicts, ideas, or impulses, and the efforts to prevent conscious awareness of them. He also coined the concept of “repetition compulsion” to explain trauma reexperiencing, proposing that because of the need to keep it away from consciousness, the individual is forced to repeat aspects of the trauma as a contemporary experience rather than as a memory of it. Influenced by World War I experiences, Freud refocused on the external reality, and, in the spirit of Janet, viewed the emotional upheaval generated by the trauma as the source of traumatic neurosis. He suggested that the intensity of the trauma, the inability to find conscious expressions for it, and the unpreparedness of the individual cause a breach to the stimulus barrier and overwhelm the defense mechanisms. More recent theorists have proposed that the developmental level and ego resources available to the victim are central to the manner in which the trauma is experienced and to the production of symptoms. For instance, a young child, easily overwhelmed and flooded with emotion, may experience complete helplessness in the face of trauma, whereas a mature adult would be more likely to respond through emotional numbing and cognitive constriction. Psychoanalytic theorists and practitioners focus on the need to help the victim acknowledge and bear the trauma and the resulting psychic damage, and develop coping mechanisms such that the memories of the trauma are incorporated into his or her current experience.

Several schools of thought inspired cognitive-behavioral theories of PTSD. The first is learning theory, which explains PTSD symptoms in terms of instrumental and classical conditioning. The learning model that most directly influenced cognitive-behavioral treatments (CBT) aimed at anxiety reduction was Mowrer’s two-factor theory. First, Mowrer proposed that fear is acquired through classical conditioning, where a neutral stimulus comes to evoke fear through its pairing with an aversive stimulus. Applying this theory to explain PTSD symptoms, neutral stimuli (e.g., supermarket) that were present during the trauma are presumed to acquire the ability to elicit fear through their associations with the danger stimuli (e.g., gun). Through the processes of generalization and second-order conditioning, stimuli similar to those present during the trauma also come to evoke fear. For instance, the stimuli all men, being alone, and the word rape can all acquire the capacity to cause anxiety. In Mowrer’s second stage, avoidance behavior is established through the process of operant conditioning. That is, an individual learns to reduce trauma-related anxiety through avoidance of, or escape from, the feared stimuli. Escape and avoidance behaviors are negatively reinforced because avoidance diminishes the aversive fear state.

Cognitive-behavioral therapy of PTSD has also been influenced by cognitive theory. Cognitive theory assumes that the interpretation of events, rather than events themselves, underlies emotional reactions. Accordingly, an event can be interpreted in different ways and consequently can evoke different emotions. Aaron Beck and colleagues suggest that trauma victims who manifest chronic persistent anxiety are unable to discriminate between safe and unsafe signals, and consequently their thinking is dominated by the perception of danger. They also suggest that traumatic fear can be maintained through a sense of incompetence to handle stressful events.

Other cognitive theorists have postulated that cognitive schemas are disrupted after victimization. A schema is a meaning structure that guides the perception, organization, and interpretation of incoming information. Common to these theories is the supposition that a traumatic experience requires cognitive modification and that such modification is accomplished by assimilation and accommodation. Accordingly, the victim must either assimilate the traumatic experience into preexisting schemas, or, more often, change schemas to accommodate the traumatic experience. In her 1992 book, Janoff-Bulman took the position that people in general hold the assumptions: “the world is benevolent, the world is meaningful, and self is worthy,” and these assumptions are incompatible with a traumatic experience. Building on Janoff-Bulman’s ideas, other theorists suggest that the following areas are of particular relevance: safety, dependency/trust of self and others, power, esteem, intimacy, and independence.

Coming from the psychoanalytic tradition, Horowitz integrated psychoanalytical and information processing notions in his 1986 book, suggesting that people have a basic need to match trauma-related information with their “inner models based on old information.” The process of recovery entails the repeated revision of both trauma-related information and the inner models until they agree, which Horowitz referred to as the “completion tendency.”

Foa and Kozak integrated cognitive and learning theories to explain the development and maintenance of pathological anxiety in what they called emotional processing theory. In their 1986 paper, fear is conceived as a cognitive structure or a program for escaping danger which includes representations of fear stimuli, fear responses, and their meaning. Pathological fear, they suggested, is distinguished from normal fear in that it includes erroneous associations and evaluations. Emotional processing theory views anxiety disorders as representing distinctive fear structures in memory, and the persistence of anxiety symptoms is conceived as reflecting impairment in emotional processing. Accordingly, PTSD is construed as reflecting a fear memory that contains erroneous associations and evaluations, whereas a normal trauma memory reflects associations and evaluations that better match reality. First, a pathological PTSD structure contains excessive response representations that are reflected in the PTSD symptoms. Second, this structure includes erroneous stimulus-stimulus associations that do not accurately represent the world. For example, the pathological fear structure of a woman who was raped at gunpoint by a bald man would contain an association between “bald men” and “gun.” In reality, however, bald men are not more likely to carry guns or to rape than men with a full head of hair. Third, the structure also includes erroneous associations between harmless stimuli such as “bald,” “home, …. suburbs,” and the meaning of “dangerous.” Being raped one time while at home in the suburbs does not tangibly increase the chance of encountering violence in that environment. Fourth, the structure includes erroneous associations between harmless stimuli and escape or avoidance responses. For example, the victim who was raped by the bald man would tend to run away from such men. In reality, however, running away from “bald men” is not likely to enhance safety. These erroneous associations would lead to mistakenly interpreting the world as entirely dangerous.

Another set of erroneous associations and evaluations is the interpretation of the victim’s response representations. It is thought that the victim’s responses during and after the trauma, and in particular the PTSD symptoms, are interpreted to mean self-incompetence. In summary, emotional processing theory hypothesizes that two major pathological concepts underlie PTSD: the world as entirely dangerous, and the self as entirely inept.

Psychophysiological, neurohormonal, neuroanatomical, and immunological changes have been observed in animals exposed to extreme stress and in trauma victims who developed PTSD (van der Kolk, McFarlane, & Weisaeth, 1996). These changes have been hypothesized to disregulate responses to incoming information and to inhibit successful processing of traumatic memories.

The normal stress response upon exposure to a high-magnitude stressor is a complex neurohormonal response, including the release of catecholamines (e.g., epinephrine and norepinephrine), serotonin, endogenous opioids, and hormones of the hypothalamus, pituitary, or adrenal gland (e.g., cortisol, vasopressin, oxytocin). Normally, the introduction of a stressor produces intense and rapid stress responses, and these dissipate quickly after the removal of the stressor. However, after prolonged exposure to stress, the stress responses become disregulated.

Theorists propose that PTSD reflects a failure to regulate autonomic reactions to stimuli such that the individual either experiences hyperreactivity or “shutting down” and emotional numbing. Individuals with PTSD show hyperreactivity, as measured by heart rate, skin conductance, and blood pressure, in reaction to reminders of traumatic events. This disregulation of the emotional and physiological responsiveness occurs with specific reminders of the trauma as well as in reaction to intense but neutral stimuli, signifying a loss of stimulus discrimination. In addition, the individual may come to fear his or her emotional reactions because of being able to do little to control them.

Neurohormonal changes in individuals with PTSD have also been found. First, prolonged stress causes depletion of the noradrenergic system, such that receptors become hypersensitive to any new release of norepinephrine. This noradrenergic hyperreactivity is linked to the increased arousal and startle of PTSD. The high levels of norepinephrine are proposed to inhibit the release of corticotrophin-releasing hormone and thereby inhibit the entire hypothalamic-pituitaryadrenocortical axis. This inhibition, in turn, produces a deficiency in endogenous opioids. Some theories postulate that the reexperiencing symptoms of PTSD cause a burst in the release of endogenous opioids and therefore make up for this deficiency. These endogenous opioids are thought to produce an artificial numbing or calmness, another hallmark of PTSD. Additional theories propose that cortisol responses are lowered in retraumatized individuals and that serotonin levels may decrease in response to prolonged inescapable stress.

In addition to psychophysiological and neurohormonal factors, specific brain abnormalities have recently been detected in individuals with PTSD. One system that is implicated in the disorder is the limbic system, which is thought to function in memory and in emotional reactions to incoming stimuli. One area in the limbic system, the hippocampus, is presumed to record spatial and temporal aspects of experiences in memory. Researchers have noted decreased hippocampal volume in trauma victims with PTSD compared with those without PTSD. One possible explanation for this finding is that individuals with smaller hippocampuses are more likely to develop PTSD; a more likely interpretation of these results is that increased cortisol activity causes shrinkage, because cortisol is toxic to the hippocampus.

A second area in the limbic system, the amygdala, also appears to be altered in individuals with PTSD. The amygdala is thought to assign meaning to incoming stimulation by integrating memory images with emotional experiences associated with those memories, guiding emotional behavior. A single intense stimulation of the amygdala appears to alter the limbic physiology such that a “kindling” effect occurs. That is, the behavior that follows may be predominantly either “fight” or “flight,” and a pattern of conditioned behavior is set up such that there is limited processing of incoming information before the response is initiated.

Several psychological interventions have been used with trauma victims, including supportive counseling individually or in groups, brief dynamic psychotherapy, hypnotherapy, pharmacotherapy, and cognitivebehavioral therapy. As recently reviewed by Foa and Meadows, although a variety of psychological interventions are used routinely with trauma victims, controlled outcome studies have tended to focus on cognitive-behavioral treatments such as systematic desensitization, exposure, and anxiety management. Nevertheless, hypnotherapy and psychodynamic therapy have also shown promise in the few studies examining their efficacy.

The popular supposition among trauma theories is that for recovery to occur after a traumatic experience, special processing efforts should take place. This view has prompted the development of early intervention programs. These programs have focused on education, debriefing after trauma, and training professionals at risk (e.g., police). Usually, “critical incident stress debriefing” is conducted in groups, such as emergency workers, and focuses on education about common reactions to traumatic experiences, encouraging trauma victims to process their experiences in a group setting. Although such programs have become routine in many places, little is known about their efficacy. In fact, some experts have raised concerns that such programs could interfere with rather than facilitate the natural recovery process.

The recognition that victims who exhibit severe reactions immediately after the trauma are more likely to develop chronic dysfunction has prompted researchers to implement interventions that aim to prevent chronic PTSD. Foa and colleagues conducted a study to compare PTSD severity of female assault victims, who received a brief prevention program (four individual therapy sessions), to that of victims who underwent an assessment procedure. Victims who received the brief prevention program had less severe PTSD and depressive symptoms 2 months after the assault. Clearly, more studies of this type are needed before confidence in prevention efforts can be established.

Currently, five cognitive-behavioral interventions are in use for PTSD: Prolonged Exposure, cognitive therapy, Stress Inoculation Training, Cognitive Processing Therapy, and Eye Movement Desensitization and Reprocessing.

This is a set of procedures that involves confrontation with feared stimuli, either in vivo or in imagination. With PTSD, exposure therapy typically includes repeated reliving of the traumatic event in imagination and actual confrontation with feared situations and objects that have been avoided because they are reminders of the trauma but are not intrinsically dangerous.

As discussed earlier, the theoretical basis of PE lies in learning and emotional-processing theories. Foa and Kozak have proposed that successful therapy involves correcting the pathological elements of the fear structure, and that this corrective process is the essence of emotional processing. They further suggest that regardless of the type of therapeutic intervention used, two conditions are required for fear reduction. First, the fear structure must be activated through introduction of fear-relevant information. If the fear structure is not activated (fear is not evoked), the structure would not be available for modification. Second, during exposure, information that is incompatible with the existing pathological elements (e.g., fear reduction) must be provided so that the pathological fear structure can be corrected. Specifically, exposure researchers hypothesize that repeated reliving promotes several cognitive changes. First, it promotes habituation of anxiety associated with the trauma memory, and this habituation disconfirms the victim’s erroneous belief that anxiety will stay forever and therefore lead to disastrous consequences. Second, reliving promotes discrimination between “remembering” the trauma and “encountering” it again, thus reinforcing the realization that remembering itself is not dangerous. Third, repeated exposure promotes differentiation between the trauma and similar but safe situations, disconfirming the idea that the world is extremely dangerous. Fourth, it promotes the association between PTSD symptoms and a sense of mastery, rather than incompetence. Finally, repeated recounting of the trauma narrative helps to organize the narrative and thereby to facilitate the integration of the trauma memory.

Several controlled studies on exposure have shown their usefulness in treating PTSD. Whereas studies on veterans showed only modest improvement, two studies with female rape victims showed more improvement. Foa and colleagues found that exposure (imaginal and in vivo) was effective in eliminating PTSD in 55% of rape victims with chronic PTSD compared with 45% of those who received supportive counseling. Superior results were found in a second study: about 70% of victims who received Prolonged Exposure lost their PTSD diagnosis, and none of the women in a wait-list group lost their diagnosis. These treatment effects were maintained at 6-month follow-up.

This intervention consists of training victims to handle anxiety with several skills for anxiety management: relaxation, thought stopping, assertiveness, cognitive therapy, coping self-statements, and guided imagery. Although the direct goal of anxiety management techniques is to teach patients techniques to manage their anxiety, the successful acquisition of such techniques can have indirect effects on the victim’s schemas of self and the world. Specifically, the victim’s experience of being able to control the anxiety fosters a more positive self-image and thereby modifies the perception of the world as overwhelmingly dangerous. Several studies point to the efficacy of this program used alone or in combination with other techniques. For example, the two studies on rape victims reported earlier found that SIT significantly reduced PTSD, to a degree comparable to that of exposure.

Researchers believed that if PE and SIT are quite, but not completely, successful in ameliorating PTSD symptoms, a program that combined these two treatments would yield superior results. However, research does not support this view: combined programs were helpful for female assault victims, but not more than exposure or stress inoculation alone.

Cognitive techniques are often incorporated into anxiety management programs that teach patients to examine and change systematically maladaptive thoughts that can lead to negative responses. Cognitive therapy involves the use of discourse, in which the patient is taught to identify the beliefs underlying the fear, to examine whether they are distorted or accurately reflect reality, and to replace mistaken or dysfunctional beliefs with more realistic, functional ideas about the ability of the patient to cope with stress and the dangerousness of the world. One possible benefit of cognitive restructuring is that it addresses directly beliefs underlying emotions other than fear, such as anger and guilt. Early investigations of this technique revealed some promise in the use of this therapy to reduce symptoms of PTSD in rape victims.

Another cognitive-behavioral program called Cognitive Processing Therapy is described in Resick and Schnicke’s 1992 book. It involves cognitive restructuring and exposure through writing about the trauma. The cognitive therapy is geared toward correcting maladaptive cognitions associated with rape, such as power, safety, and esteem. In one study, on the average, victims who received CPT reported 40% symptom reduction, and these gains were maintained over time. More studies are needed to establish the efficacy of this relatively new treatment.

This therapy, described by Shapiro in 1995, is a form of exposure with a cognitive emphasis, accompanied by guided eye movements. The studies that have evaluated the efficacy of this treatment produced equivocal results. Some show good results, but others show no improvement. Because these studies have many methodological problems, it is difficult to determine the validity of the findings. Further well-controlled studies are needed before a definite conclusion about the value of EMDR can be made.

Many medications have been used for the treatment of PTSD, but only a few have been systematically studied. Most of these have used male combat veterans, and thus the efficacy of pharmacotherapy for other traumatized populations is largely unknown. Tricyclic antidepressants have been used in an attempt to reduce locus coeruleus overactivity and noradrenergic disregulation found in PTSD, with equivocal results. Amitriptyline and imipramine have shown modest reductions in PTSD symptoms in comparison with placebo in double-blind studies with male veterans. In contrast, desipramine failed to show efficacy. One study of fluoxetine, a selective serotonin reuptake inhibitor used to regulate serotonergic dysfunction in individuals with PTSD, found it to be effective in reducing symptoms of PTSD, especially in trauma victims other than Vietnam veterans.

Other medications that have been tested include anticonvulsants such as carbamazepine and valproic acid; but no double-blind studies have been conducted to date. Beta-adrenergic blockers such as propanolol have shown promise in reducing aggressivity and arousal symptoms in open studies, and alpha2-adrenergic agonists, such as clonidine, appear to be effective through their suppression of locus coeruleus activity.

Finally, benzodiazepines have been widely used to suppress anxiety and are believed to reduce PTSD symptoms by reducing limbic system kindling and reversing neurochemical changes in the locus coeruleus and hypothalamus. However, the rebound anxiety and withdrawal symptoms associated with benzodiazepines can be problematic.

In summary, most of our knowledge about efficacy of pharmacotherapy for PTSD is confounded by the restricted samples used in existing studies. Most were conducted on Vietnam veterans, whose symptoms are particularly resistant to all types of treatments, and therefore the present results may underestimate the efficacy of this treatment.

Hypnotherapy uses heightened concentration and focused attention to facilitate treatment related to trauma. It is based on the supposition that individuals with PTSD are unknowingly entering trance states when they reexperience the trauma and that hypnotherapy can help them learn how to control their trance states and digest the dissociated traumatic experience in a controlled manner. One study found hypnosis to be as effective as psychodynamic psychotherapy and a type of exposure called systematic desensitization. More studies of this technique are needed before conclusions can be drawn about the usefulness of hypnotherapy.

Psychodynamic psychotherapy has also been used to help individuals recover from trauma. It focuses on intrapsychic conflict about the trauma rather than on resolution of specific symptoms of PTSD. The methods used are in some respects similar to those used in cognitive-behavioral therapy, as these interventions focus on helping the victims process the traumatic experience and on teaching them how to tolerate anxiety. Both individual and group therapies have been used, and some preliminary studies suggest the utility of these interventions.

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  • Published: 28 September 2018

Posttraumatic stress disorder: from diagnosis to prevention

  • Xue-Rong Miao   ORCID: orcid.org/0000-0002-0665-8271 1 ,
  • Qian-Bo Chen 1 ,
  • Kai Wei 1 ,
  • Kun-Ming Tao 1 &
  • Zhi-Jie Lu 1  

Military Medical Research volume  5 , Article number:  32 ( 2018 ) Cite this article

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Posttraumatic stress disorder (PTSD) is a chronic impairment disorder that occurs after exposure to traumatic events. This disorder can result in a disturbance to individual and family functioning, causing significant medical, financial, and social problems. This study is a selective review of literature aiming to provide a general outlook of the current understanding of PTSD. There are several diagnostic guidelines for PTSD, with the most recent editions of the DSM-5 and ICD-11 being best accepted. Generally, PTSD is diagnosed according to several clusters of symptoms occurring after exposure to extreme stressors. Its pathogenesis is multifactorial, including the activation of the hypothalamic–pituitary–adrenal (HPA) axis, immune response, or even genetic discrepancy. The morphological alternation of subcortical brain structures may also correlate with PTSD symptoms. Prevention and treatment methods for PTSD vary from psychological interventions to pharmacological medications. Overall, the findings of pertinent studies are difficult to generalize because of heterogeneous patient groups, different traumatic events, diagnostic criteria, and study designs. Future investigations are needed to determine which guideline or inspection method is the best for early diagnosis and which strategies might prevent the development of PTSD.

Posttraumatic stress disorder (PTSD) is a recognized clinical phenomenon that often occurs as a result of exposure to severe stressors, such as combat, natural disaster, or other events [ 1 ]. The diagnosis of PTSD was first introduced in the 3rd edition of the Diagnostic and Statistical Manual (DSM) (American Psychiatric Association) in 1980 [ 2 ].

PTSD is a potentially chronic impairing disorder that is characterized by re-experience and avoidance symptoms as well as negative alternations in cognition and arousal. This disease first raised public concerns during and after the military operations of the United States in Afghanistan and Iraq, and to date, a large number of research studies report progress in this field. However, both the underlying mechanism and specific treatment for the disease remain unclear. Considering the significant medical, social and financial problems, PTSD represents both to nations and to individuals, all persons caring for patients suffering from this disease or under traumatic exposure should know about the risks of PTSD.

The aim of this review article is to present the current understanding of PTSD related to military injury to foster interdisciplinary dialog. This article is a selective review of pertinent literature retrieved by a search in PubMed, using the following keywords: “PTSD[Mesh] AND military personnel”. The search yielded 3000 publications. The ones cited here are those that, in the authors’ view, make a substantial contribution to the interdisciplinary understanding of PTSD.

Definition and differential diagnosis

Posttraumatic stress disorder is a prevalent and typically debilitating psychiatric syndrome with a significant functional disturbance in various domains. Both the manifestation and etiology of it are complex, which has caused difficulty in defining and diagnosing the condition. The 3rd edition of the DSM introduced the diagnosis of PTSD with 17 symptoms divided into three clusters in 1980. After several decades of research, this diagnosis was refined and improved several times. In the most recent version of the DSM-5 [ 3 ], PTSD is classified into 20 symptoms within four clusters: intrusion, active avoidance, negative alterations in cognitions and mood as well as marked alterations in arousal and reactivity. The diagnosis requirement can be summarized as an exposure to a stressor that is accompanied by at least one intrusion symptom, one avoidance symptom, two negative alterations in cognitions and mood symptoms, and two arousal and reactivity turbulence symptoms, persisting for at least one month, with functional impairment. Interestingly, in the DSM-5, PTSD has been moved from the anxiety disorder group to a new category of ‘trauma- and stressor-related disorders’, which reflects the cognizance alternation of PTSD. In contrast to the DSM versions, the World Health Organization’s (WHO) International Classification of Diseases (ICD) has proposed a substantially different approach to diagnosing PTSD in the most recent ICD-11 version [ 4 ], which simplified the symptoms into six under three clusters, including constant re-experiencing of the traumatic event, avoidance of traumatic reminders and a sense of threat. The diagnosis requires at least one symptom from each cluster which persists for several weeks after exposure to extreme stressors. Both diagnostic guidelines emphasize the exposure to traumatic events and time of duration, which differentiate PTSD from some diseases with similar symptoms, including adjustment disorder, anxiety disorder, obsessive-compulsive disorder, and personality disorder. Patients with the major depressive disorder (MDD) may or may not have experienced traumatic events, but generally do not have the invasive symptoms or other typical symptoms that PTSD presents. In terms of traumatic brain injury (TBI), neurocognitive responses such as persistent disorientation and confusion are more specific symptoms. It is worth mentioning that some dissociative reactions in PTSD (e.g., flashback symptoms) should be recognized separately from the delusions, hallucinations, and other perceptual impairments that appear in psychotic disorders since they are based on actual experiences. The ICD-11 also recognizes a sibling disorder, complex PTSD (CPTSD), composed of symptoms including dysregulation, negative self-concept, and difficulties in relationships based on the diagnosis of PTSD. The core CPTSD symptom is PTSD with disturbances in self-organization (DSO).

In consideration of the practical applicability of the PTSD diagnosis, Brewin et al. conducted a study to investigate the requirement differences, prevalence, comorbidity, and validity of the DSM-5 and ICD-11 for PTSD criteria. According to their study, diagnostic standards for symptoms of re-experiencing are higher in the ICD-11 than the DSM, whereas the standards for avoidance are less strict in the ICD-11 than in the DSM-IV [ 5 ]. It seems that in adult subjects, the prevalence of PTSD using the ICD-11 is considerably lower compared to the DSM-5. Notably, evidence suggested that patients identified with the ICD-11 and DSM-5 were quite different with only partially overlapping cases; this means each diagnostic system appears to find cases that would not be diagnosed using the other. In consideration of comorbidity, research comparing these two criteria show diverse outcomes, as well as equal severity and quality of life. In terms of children, only very preliminary evidence exists suggesting no significant difference between the two. Notably, the diagnosis of young children (age ≤ 6 years) depends more on the situation in consideration of their physical and psychological development according to the DSM-5.

Despite numerous investigations and multiple revisions of the diagnostic criteria for PTSD, it remains unclear which type and what extent of stress are capable of inducing PTSD. Fear responses, especially those related to combat injury, are considered to be sufficient enough to trigger symptoms of PTSD. However, a number of other types of stressors were found to correlate with PTSD, including shame and guilt, which represent moral injury resulting from transgressions during a war in military personnel with deeply held moral and ethical beliefs. In addition, military spouses and children may be as vulnerable to moral injury as military service members [ 6 ]. A research study on Canadian Armed Forces personnel showed that exposure to moral injury during deployments is common among military personnel and represents an independent risk factor for past-year PTSD and MDD [ 7 ]. Unfortunately, it seems that pre- and post-deployment mental health education was insufficient to moderate the relationship between exposure to moral injury and adverse mental health outcomes.

In general, a large number of studies are focusing on the definition and diagnostic criteria of PTSD and provide considerable indicators for understanding and verifying the disease. However, some possible limitations or discrepancies continue to exist in current research studies. One is that although the diagnostic criteria for a thorough examination of the symptoms were explicit and accessible, the formal diagnosis of PTSD using structured clinical interviews was relatively rare. In contrast, self-rating scales, such as the Posttraumatic Diagnostic Scale (PDS) [ 8 ] and the Impact of Events Scale (IES) [ 9 ], were used frequently. It is also noteworthy that focusing on PTSD explicitly could be a limitation as well. The complexity of traumatic experiences and the responses to them urge comprehensive investigations covering all aspects of physical and psychological maladaptive changes.

Prevalence and importance

Posttraumatic stress disorder generally results in poor individual-level outcomes, including co-occurring disorders such as depression and substance use, and physical health problems. According to the DSM-5 reporting, more than 80% of PTSD patients share one or more comorbidities; for instance, the morbidity of PTSD with concurrent mild TBI is 48% [ 8 ]. Moreover, cognitive impairment has been identified frequently in PTSD. The reported incidence rate for PTSD ranges from 5.4 to 16.8% in military service members and veterans [ 10 , 11 , 12 , 13 , 14 ], which is almost double those in the general population. The estimated prevalence of PTSD varies depending on the group of patients studied, the traumatic events occurred, and the measurement method used (Table  1 ). However, it still reflects the profound effect of this mental disease, especially with the rise in global terrorism and military conflict in recent years. While PTSD can arise at any life stage in any population, most research in recent decades has focused on returned veterans; this means most knowledge regarding PTSD has come from the military population. Meanwhile, the impact of this disease on children has received scant attention.

The discrepancy of PTSD prevalence in males and females is controversial. In a large study of OEF/OIF veterans, the prevalence of PTSD in males and females was similar, although statistically more prevalent in men versus women (13% vs. 11%) [ 15 ]. Another study on the Navy and Marine Corps showed a slightly higher incidence for PTSD in the women compared to men (6.6% vs. 5.3%) [ 12 ]. However, the importance of combat exposure is unclear. Despite a lower level of combat exposure than male military personnel, females generally have considerably higher rates of military sexual trauma, which is significantly associated with the development of PTSD [ 16 ].

It is reported that 44–72% of veterans suffer high levels of stress after returning to civilian life. Many returned veterans with PTSD show emotion regulation problems, including emotion identification, expression troubles and self-control issues. Nevertheless, a meta-analytic investigation of 34 studies consistently found that the severity of PTSD symptoms was significantly associated with anger, especially in military samples [ 17 ]. Not surprisingly, high levels of PTSD and emotional regulation troubles frequently lead to poor family functioning or even domestic violence in veterans. According to some reports, parenting difficulties in veteran families were associated with three PTSD symptom clusters. Evans et al. [ 18 ] conducted a survey to evaluate the impact of PTSD symptom clusters on family functioning. According to their analysis, avoidance symptoms directly affected family functioning, whereas hyperarousal symptoms had an indirect association with family functioning. Re-experience symptoms were not found to impact family functioning. Notably, recent epidemiologic studies using data from the Veterans Health Administration (VHA) reported that veterans with PTSD were linked to suicide ideations and behaviors [ 19 ] (e.g., non-suicidal self-injury, NSSI), in which depression as well as other mood disruptions, often serve as mediating factors.

Previously, there was a controversial attitude toward the vulnerability of young children to PTSD. However, growing evidence suggests that severe and persistent trauma could result in stress responses worse than expected as well as other mental and physical sequelae in child development. The most prevalent traumatic exposures for young children above the age of 1 year were interpersonal trauma, mostly related to or derived from their caregivers, including witnessing intimate partner violence (IPV) and maltreatment [ 20 ]. Unfortunately, because of the crucial role that caregivers play in early child development, these types of traumatic events are especially harmful and have been associated with developmental maladaptation in early childhood. Maladaptation commonly represents a departure from normal development and has even been linked to more severe effects and psychopathology. In addition, the presence of psychopathology may interfere with the developmental competence of young children. Research studies have also broadened the investigation to sequelae of PTSD on family relationships. It is proposed that the children of parents with symptoms of PTSD are easily deregulated or distressed and appear to face more difficulties in their psychosocial development in later times compared to children of parents without. Meanwhile, PTSD veterans described both emotional (e.g., hurt, confusion, frustration, fear) and behavioral (e.g., withdrawal, mimicking parents’ behavior) disruption in their children [ 21 ]. Despite the increasing emphasis on the effects of PTSD on young children, only a limited number of studies examined the dominant factors that influence responses to early trauma exposures, and only a few prospective research studies have observed the internal relations between early PTSD and developmental competence. Moreover, whether exposure to both trauma types in early life is associated with more severe PTSD symptoms than exposure to one type remains an outstanding question.

Molecular mechanism and predictive factors

The mechanisms leading to posttraumatic stress disorder have not yet been fully elucidated. Recent literature suggests that both the neuroendocrine and immune systems are involved in the formulation and development of PTSD [ 22 , 23 ]. After traumatic exposures, the stress response pathways of the hypothalamic–pituitary–adrenal (HPA) axis and sympathetic nervous system are activated and lead to the abnormal release of glucocorticoids (GC) and catecholamines. GCs have downstream effects on immunosuppression, metabolism enhancement, and negative feedback inhibition of the HPA axis by binding to the GC receptor (GR), thus connecting the neuroendocrine modulation with immune disturbance and inflammatory response. A recent meta-analysis of 20 studies found increased plasma levels of proinflammatory cytokines tumor necrosis factor-alpha (TNF-a), interleukin-1beta (IL-1b), and interleukin-6 (IL-6) in individuals with PTSD compared to healthy controls [ 24 ]. In addition, some other studies speculate that there is a prospective association of C-reactive protein (CRP) and mitogen with the development of PTSD [ 25 ]. These findings suggest that neuroendocrine and inflammatory changes, rather than being a consequence of PTSD, may in fact act as a biological basis and preexisting vulnerability for developing PTSD after trauma. In addition, it is reported that elevated levels of terminally differentiated T cells and an altered Th1/Th2 balance may also predispose an individual to PTSD.

Evidence indicates that the development of PTSD is also affected by genetic factors. Research has found that genetic and epigenetic factors account for up to 70% of the individual differences in PTSD development, with PTSD heritability estimated at 30% [ 26 ]. While aiming to integrate genetic studies for PTSD and build a PTSD gene database, Zhang et al. [ 27 ] summarized the landscape and new perspective of PTSD genetic studies and increased the overall candidate genes for future investigations. Generally, the polymorphisms moderating HPA-axis reactivity and catecholamines have been extensively studied, such as FKBP5 and catechol-O-methyl-transferase (COMT). Other potential candidates for PTSD such as AKT, a critical mediator of growth factor-induced neuronal survival, were also explored. Genetic research has also made progress in other fields. For example, researchers have found that DNA methylation in multiple genes is highly correlated with PTSD development. Additional studies have found that stress exposure may even affect gene expression in offspring by epigenetic mechanisms, thus causing lasting risks. However, some existing problems in the current research of this field should be noted. In PTSD genetic studies, variations in population or gender difference, a wide range of traumatic events and diversity of diagnostic criteria all may attribute to inconsistency, thus leading to a low replication rate among similar studies. Furthermore, PTSD genes may overlap with other mental disorders such as depression, schizophrenia, and bipolar disorder. All of these factors indicate an urgent need for a large-scale genome-wide study of PTSD and its underlying epidemiologic mechanisms.

It is generally acknowledged that some mental diseases, such as major depressive disorder (MDD), bipolar disorder, and schizophrenia, are associated with massive subcortical volume change. Recently, numerous studies have examined the relationship between the morphology changes of subcortical structures and PTSD. One corrected analysis revealed that patients with PTSD show a pattern of lower white matter integrity in their brains [ 28 ]. Prior studies typically found that a reduced volume of the hippocampus, amygdala, rostral ventromedial prefrontal cortex (rvPFC), dorsal anterior cingulate cortex (dACC), and the caudate nucleus may have a relationship with PTSD patients. Logue et al. [ 29 ] conducted a large neuroimaging study of PTSD that compared eight subcortical structure volumes (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle) between PTSD patients and controls. They found that smaller hippocampi were particularly associated with PTSD, while smaller amygdalae did not show a significant correlation. Overall, rigorous and longitudinal research using new technologies, such as magnetoencephalography, functional MRI, and susceptibility-weighted imaging, are needed for further investigation and identification of morphological changes in the brain after a traumatic exposure.

Psychological and pharmacological strategies for prevention and treatment

Current approaches to PTSD prevention span a variety of psychological and pharmacological categories, which can be divided into three subgroups: primary prevention (before the traumatic event, including prevention of the event itself), secondary prevention (between the traumatic event and the development of PTSD), and tertiary prevention (after the first symptoms of PTSD become apparent). The secondary and tertiary prevention of PTSD has abundant methods, including different forms of debriefing, treatments for Acute Stress Disorder (ASD) or acute PTSD, and targeted intervention strategies. Meanwhile, the process of primary prevention is still in its infancy and faces several challenges.

Based on current research on the primary prevention of post-trauma pathology, psychological and pharmacological interventions for particular groups or individuals (e.g., military personnel, firefighters, etc.) with a high risk of traumatic event exposure were applicable and acceptable for PTSD sufferers. Of the studies that reported possible psychological prevention effects, training generally included a psychoeducational component and a skills-based component relating to stress responses, anxiety reducing and relaxation techniques, coping strategies and identifying thoughts, emotion and body tension, choosing how to act, attentional control, emotion control and regulation [ 30 , 31 , 32 ]. However, efficiency for these training has not been evaluated yet due to a lack of high-level evidence-based studies. Pharmacological options have targeted the influence of stress on memory formation, including drugs relating to the hypothalamic-pituitary-adrenal (HPA) axis, the autonomic nerve system (especially the sympathetic nerve system), and opiates. Evidence has suggested that pharmacological prevention is most effective when started before and early after the traumatic event, and it seems that sympatholytic drugs (alpha and beta-blockers) have the highest potential for primary prevention of PTSD [ 33 ]. However, one main difficulty limiting the exploration in this field is related to rigorous and complex ethical issues, as the application of pre-medication for special populations and the study of such options in hazardous circumstances possibly touches upon questions of life and death. Significantly, those drugs may have potential side effects.

There are several treatment guidelines for patients with PTSD produced by different organizations, including the American Psychiatric Association (APA), the United Kingdom’s National Institute for Health and Clinical Excellence (NICE), the International Society for Traumatic Stress Studies (ISTSS), the Institute of Medicine (IOM), the Australian National Health and Medical Research Council, and the Department of Veterans Affairs and Department of Defense (VA, DoD) [ 34 , 35 , 36 , 37 , 38 ]. Additionally, a large number of research studies are aiming to evaluate an effective treatment method for PTSD. According to these guidelines and research, treatment approaches can be classified as psychological interventions and pharmacological treatments (Fig.  1 ); most of the studies provide varying degrees of improvement in individual outcomes after standard interventions, including PTSD symptom reduction or remission, loss of diagnosis, release or reduction of comorbid medical or psychiatric conditions, quality of life, disability or functional impairment, return to work or to active duty, and adverse events.

figure 1

Psychological and pharmacological strategies for treatment of PTSD. CBT. Cognitive behavioral therapy; CPT. Cognitive processing therapy; CT. Cognitive therapy; CR. Cognitive restructuring; EMDR. Eye movement desensitization and reprocessing; SSRIs. Selective serotonin reuptake inhibitors; SNRIs. Serotonin and norepinephrine reuptake inhibitors; MAO. Monoamine oxidase

Most guidelines identify trauma-focused psychological interventions as first-line treatment options [ 39 ], including cognitive behavioral therapy (CBT), cognitive processing therapy (CPT), cognitive therapy (CT), cognitive restructuring (CR), coping skills therapy (including stress inoculation therapy), exposure-based therapies, eye movement desensitization and reprocessing (EMDR), hypnosis and hypnotherapy, and brief eclectic psychotherapy. These treatments are delivered predominantly to individuals, but some can also be conducted in family or group settings. However, the recommendation of current guidelines seems to be projected empirically as research on the comparison of outcomes of different treatments is limited. Jonas et al. [ 40 ] performed a systematic review and network meta-analysis of the evidence for treatment of PTSD. The study suggested that all psychological treatments showed efficacy for improving PTSD symptoms and achieving the loss of PTSD diagnosis in the acute phase, and exposure-based treatments exhibited the strongest evidence of efficacy with high strength of evidence (SOE). Furthermore, Kline et al. [ 41 ] conducted a meta-analysis evaluating the long-term effects of in-person psychotherapy for PTSD in 32 randomized controlled trials (RCTs) including 2935 patients with long-term follow-ups of at least 6 months. The data suggested that all studied treatments led to lasting improvements in individual outcomes, and exposure therapies demonstrated a significant therapeutic effect as well with larger effect sizes compared to other treatments.

Pharmacological treatments for PTSD include antidepressants such as selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase (MAO) inhibitors, sympatholytic drugs such as alpha-blockers, antipsychotics, anticonvulsants, and benzodiazepines. Among these medications, fluoxetine, paroxetine, sertraline, topiramate, risperidone, and venlafaxine have been identified as efficacious in treatment. Moreover, in the Jonas network meta-analysis of 28 trials (4817 subjects), they found paroxetine and topiramate to be more effective for reducing PTSD symptoms than most other medications, whereas evidence was insufficient for some other medications as research was limited [ 40 ]. It is worth mentioning that in these studies, efficacy for the outcomes, unlike the studies of psychological treatments, was mostly reported as a remission in PTSD or depression symptoms; other outcomes, including loss of PTSD diagnosis, were rarely reported in studies.

As for the comparative evidence of psychological with pharmacological treatments or combinations of psychological treatments and pharmacological treatments with other treatments, evidence was insufficient to draw any firm conclusions [ 40 ]. Additionally, reports on adverse events such as mortality, suicidal behaviors, self-harmful behaviors, and withdrawal of treatment were relatively rare.

PTSD is a high-profile clinical phenomenon with a complicated psychological and physical basis. The development of PTSD is associated with various factors, such as traumatic events and their severity, gender, genetic and epigenetic factors. Pertinent studies have shown that PTSD is a chronic impairing disorder harmful to individuals both psychologically and physically. It brings individual suffering, family functioning disorders, and social hazards. The definition and diagnostic criteria for PTSD remain complex and ambiguous to some extent, which may be attributed to the complicated nature of PTSD and insufficient research on it. The underlying mechanisms of PTSD involve changes in different levels of psychological and molecular modulations. Thus, research targeting the basic mechanisms of PTSD using standard clinical guidelines and controlled interference factors is needed. In terms of treatment, psychological and pharmacological interventions could relief PTSD symptoms to different degrees. However, it is necessary to develop systemic treatment as well as symptom-specific therapeutic methods. Future research could focus on predictive factors and physiological indicators to determine effective prevention methods for PTSD, thereby reducing its prevalence and preventing more individuals and families from struggling with this disorder.

Abbreviations

American Psychiatric Association

Acute stress disorder

Cognitive behavioral therapy

Catechol-O-methyl-transferase

Cognitive processing therapy

Complex posttraumatic stress disorder

Cognitive restructuring

C-reactive protein

Cognitive therapy

Dorsal anterior cingulate cortex

Diagnostic and Statistical Manual

Disturbances in self-organization

Eye movement desensitization and reprocessing

Glucocorticoids

Glucocorticoids receptor

Hypothalamic–pituitary–adrenal axis

International classification of diseases

Impact of events scale

Interleukin-1beta

Interleukin-6

Institute of Medicine

Intimate partner violence

International Society for Traumatic Stress Studies

Monoamine oxidase

Major depressive disorder

United Kingdom’s National Institute for Health and Clinical Excellence

Non-suicidal self-injury

Posttraumatic diagnostic scale

Posttraumatic stress disorder

Randomized controlled trials

Rostral ventromedial prefrontal cortex

Serotonin and norepinephrine reuptake inhibitors;

Strength of evidence

Selective serotonin reuptake inhibitors

Tumor necrosis factor-alpha

DoD Department of Veterans Affairs and Department of Defense

Veterans Health Administration

World Health Organization

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We thank Jamie Bono for providing professional writing suggestions.

This work was supported by the National Natural Science Foundation of China (31371084 and 31171013 by ZJL), and the National Natural Science Foundation of China (81100276 by XRM).

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Miao, XR., Chen, QB., Wei, K. et al. Posttraumatic stress disorder: from diagnosis to prevention. Military Med Res 5 , 32 (2018). https://doi.org/10.1186/s40779-018-0179-0

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Received : 20 March 2018

Accepted : 10 September 2018

Published : 28 September 2018

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Psychiatry Online

  • February 01, 2024 | VOL. 181, NO. 2 CURRENT ISSUE pp.83-170
  • January 01, 2024 | VOL. 181, NO. 1 pp.1-82

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Trauma, Resilience, Anxiety Disorders, and PTSD

  • Ned H. Kalin , M.D.

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Stress and trauma are well known to be critical factors in the development and maintenance of psychopathology. In some stress-related disorders, such as anxiety and depression, stress can play an etiological role, whereas in other disorders like schizophrenia, stress can precipitate and exacerbate symptoms. Stress occurring early in life in the form of traumatic events is a transdiagnostic risk factor for developing psychopathology, whereas posttraumatic stress disorder (PTSD) is a disorder that is specifically defined as a maladaptive response to traumatic events. In the midst of the COVID-19 pandemic, and certainly to no one’s liking, we currently are involved in a naturalistic experiment linking stress to mental suffering and psychopathology.

Most of us have never experienced stressors of the magnitude and length associated with the global COVID-19 pandemic. Because the pandemic has been so prolonged, and in part as a way to cope, many of us have become inured to its catastrophic effects. It is mind boggling that we have begun to accept as commonplace the fact that 3,000 Americans per day are dying from COVID-19 or that the economic consequences are so dire that 16% of adults with children report not having sufficient food ( 1 ). Although it may be obvious, it is important to enumerate why the COVID-19 pandemic represents the perfect storm of stressors and traumatic events:

A long-term sense of uncertainty about the future coupled with a sense of uncontrollability.

Concerns about contracting COVID-19, becoming gravely ill, and dying.

Worries about losing loved ones and friends, and the grief associated with real losses.

The trauma associated with being gravely ill with COVID-19.

Prolonged physical separation and social isolation from family and friends.

Disruption of regular routines, including work and school for children.

Losses of jobs, business failures, and the profound economic consequences.

Lack of trust in leadership to effectively deal with the crisis.

As mental health care providers, we are in the uniquely challenging position of both personally experiencing the disruptive influences of chronic stress associated with the pandemic and working with patients and other vulnerable individuals to mitigate the consequences of the stress and tragedies that they are experiencing. It is critical to underscore the need to provide additional resources to underprivileged and marginalized individuals, as they are particularly vulnerable to the direct and indirect consequences of the COVID-19 pandemic. For example, Black and Latino households are twice as likely as White households to experience food insufficiency during the pandemic.

The focus of this issue of the Journal is highly relevant, as it provides new insights into the neural alterations associated with trauma, resilience, anxiety disorders, and PTSD as well as insights into new, promising treatment strategies. Dr. Yuval Neria, a PTSD expert from Columbia University, reviews neuroimaging findings in relation to PTSD and addresses how they may relate to the heterogeneity of PTSD symptom presentation and inform selective treatment approaches ( 2 ). Dr. Yair Bar-Haim from Tel Aviv University and his colleagues present a thought-provoking commentary suggesting that symptoms associated with the intrusive reexperiencing of traumatic events should be prioritized as a focus of research efforts to elaborate mechanisms underlying responses to trauma and PTSD ( 3 ). Dr. Dylan Gee and Paola Odriozola from Yale University coauthor a review that uses a translational neuroscience approach to discuss learning mechanisms relevant to the maladaptive regulation of fear and anxiety. In addition to considering conditioned fear learning and extinction, this review emphasizes the importance of safety signal learning, describes its underlying mechanisms, and speculates about the potential utility of using safety signal learning approaches in treating youths with anxiety disorders ( 4 ).

Is Inducing Anxiety in Healthy Individuals a Valid Approach for Understanding Pathophysiological Processes in Patients With Anxiety Disorder?

Numerous studies in healthy individuals have used threat-related paradigms in combination with neuroimaging to characterize the neural correlates of adaptive anxiety responses. The findings from these studies have frequently been used to draw inferences about alterations in neural activation that are associated with maladaptive anxiety responses in individuals with anxiety disorders. Chavanne and Robinson focus on determining whether studying healthy individuals under conditions of threat is a valid approach for understanding brain processes relevant to psychopathology ( 5 ). In their study, the authors first performed a meta-analysis on neuroimaging findings from studies in which patients with anxiety disorders were compared with control subjects when exposed to emotion-related paradigms. The results of this analysis were further compared with a meta-analysis of imaging findings assessing neural responses induced by unpredictable threat paradigms in healthy individuals. Across healthy individuals and those with anxiety disorders, increased activation was found in the insula, cingulate cortex, medial prefrontal cortex, and periaqueductal gray. There were also some differences between individuals with specific disorders and healthy control subjects. Similarities in neural activation between healthy individuals exposed to threat and individuals with anxiety disorders appeared to be greatest for individuals with specific phobias and were least similar for those with generalized anxiety disorder. In an editorial, Dr. Alexander Shackman from the University of Maryland and Dr. Andrew Fox from the University of California, Davis, discuss these findings in relation to the validity of using healthy subjects to understand pathophysiological processes in patients with anxiety disorders. They also point to additional work that needs to be done with animal models and humans to further develop an understanding of the mechanisms underlying pathological anxiety ( 6 ).

Using Brain Network Connectivity to Estimate the Severity of Dissociative Symptoms

Dissociative symptoms are a hallmark of PTSD and can be very disabling. The study by Lebois et al. ( 7 ) presents data demonstrating the capacity to use machine learning with functional connectivity MRI data to modestly estimate individual differences in dissociative symptoms in women with PTSD. In their study involving 65 women, the authors demonstrated that they could estimate about 24% of the variance in an individual’s dissociative symptom severity by using the functional connectivity data. Hyperconnectivity between regions of the default mode network and the frontoparietal network appeared to contribute most to this prediction. Of importance, this brain network connectivity–based estimate controlled for childhood trauma and PTSD symptom severity, suggesting that the connectivity patterns identified to be associated with dissociative symptoms involved distinct neural alterations. In addition to providing a better understanding of the neural underpinnings of dissociative symptoms, the results of this study suggest that in the future it may be plausible to use brain-based neural connectivity measurements as an objective proxy for subjective reports of dissociative symptoms. In his insightful editorial, Dr. Vinod Menon from Stanford University discusses how the functions of the default mode network and frontoparietal network, and their interactions, may relate to the subjective experience of dissociation ( 8 ). In addition, he suggests that interventions aimed at components of the salience network, such as the anterior cingulate cortex, may ameliorate dissociative symptoms by affecting interactions between the default mode and frontoparietal networks.

Patterns of Cortical Thinning Are Shared Across Individuals With Internalizing, Externalizing, and Thought Disorder–Related Symptoms

Brain structural alterations are commonly reported in patients across various psychiatric diagnoses. Romer and colleagues ( 9 ) present data demonstrating overlapping patterns of reduced cortical thickness in individuals with internalizing symptoms (e.g., depression and anxiety), externalizing symptoms (e.g., substance abuse and antisocial behavior), and thought disorder–related symptoms (e.g., delusions and hallucinations). This study used structural imaging data to assess cortical thickness and cortical surface area from 45-year-old individuals who were part of the longitudinally studied Dunedin Cohort. In addition to demonstrating cortical thinning across diagnostic domains, patterns of cortical thinning were related to the general psychopathology dimensional score known as the p factor. It is important to keep in mind that these relations do not address issues of causality. Based on these data, the authors argue that the transdiagnostic nature of pervasive cortical thinning further supports the value of a broad and general approach to study the relations between psychopathology and brain alterations.

Resilience During Pregnancy Is Associated With Increased Telomere Length in Newborns

Telomeres are strands of nucleotides at the ends of chromosomes that have various functions, including protecting the chromosome from degradation. In general, shortened telomeres have been associated with stress exposure, various illnesses, and aging. Verner and colleagues ( 10 ) studied 656 mother-infant dyad pairs and, by using multiple behavioral measures collected during pregnancy, computed factors associated with stress and positivity. Telomere length was assessed in leukocytes collected from cord blood at birth. The findings demonstrate an association between individual differences in pregnant mothers’ stress factor and shorter telomere length in newborns. In contrast, individual differences in the positivity factor during pregnancy were associated with increased telomere length. By statistically accounting for the effects of positivity on stress, the authors derived what they considered to be a measure of resilience, and by using this measure, they demonstrate that maternal resilience is associated with increased telomere length in newborns. The findings from this study are exciting as they suggest that resilience during pregnancy has important implications at the cellular and molecular level for newborns and for their development. In her editorial, Dr. Stacy Drury from Tulane University further discusses the relevance of telomere length and function in relation to health and disease. She also presents possible mechanisms by which stress during pregnancy might affect offspring telomeres ( 11 ).

Ketamine Treatment for PTSD

New and effective treatments are needed for patients with PTSD. Feder et al. ( 12 ) report findings from a randomized clinical trial examining the effects of repeated intravenous ketamine infusions on symptoms in PTSD patients. Ketamine is an N -methyl- d -aspartate receptor antagonist with effects on numerous other systems, including opiate receptors, and when administered in subanesthetic doses, it is effective in rapidly decreasing depressive symptoms. The authors of the present study previously reported that a single dose of ketamine had positive short-term effects in PTSD patients, and they now extend this work by assessing the effects of repeated ketamine administration as a means to provide longer-term efficacy. In the study, 30 chronically ill PTSD patients were randomly assigned to receive, over a 2-week period, either six infusions of ketamine (0.5 mg/kg) or midazolam (0.045 mg/kg) as an active placebo. In the 29 individuals who completed the study, 15 received ketamine. The findings demonstrated rapid responses to ketamine. When assessed at 1 and 2 weeks, ketamine was significantly and robustly more effective in reducing symptoms compared with midazolam. It is important to note that although the repeated ketamine infusions were highly effective, the median time to the loss of the ketamine response was 27.5 days. In their editorial, Dr. Murray Stein from the University of California, San Diego, and Dr. Naomi Simon from New York University emphasize the need to develop more effective treatments for PTSD. They also comment on the renewed interest in psychedelic drugs as therapeutic agents and the possible mechanisms by which ketamine may work in relation to modifying the recall of traumatic memories associated with PTSD ( 13 ).

Conclusions

The imperative to understand how stress and trauma increase the vulnerability to develop psychiatric illnesses could not be more relevant and timelier as the world’s population is experiencing unprecedented levels of stress, trauma, fear, anxiety, and grief. It is also extremely important to focus on, and understand, the factors that promote resilience, as we witness the remarkable capacities of individuals to endure, cope with, and overcome the adversity and challenges presented by the pandemic.

This issue of the Journal provides a comprehensive focus on new research findings relevant to these issues. Highlights from the reports in this issue include findings that there is evidence supporting the dimensionality of anxiety, as there is shared activation of anxiety-related neural circuitry between healthy individuals and those with anxiety disorders; that resilience during pregnancy is associated with greater “healthier” telomere length in newborns; that focusing on safety learning may be a fruitful treatment approach for anxiety disorders, especially for children; that machine learning methods can be employed with imaging data to predict the severity of dissociative symptoms in PTSD patients; and that repeated ketamine administration over a 2-week period robustly decreases PTSD symptoms.

Disclosures of Editors’ financial relationships appear in the April 2020 issue of the Journal .

1 Center on Budget and Policy Priorities: Tracking the COVID-19 recession’s effects on food, housing, and employment hardships. https://www.cbpp.org/sites/default/files/atoms/files/8-13-20pov.pdf Google Scholar

2 Neria Y : Functional neuroimaging in PTSD: from discovery of underlying mechanisms to addressing diagnostic heterogeneity . Am J Psychiatry 2021 ; 178:128–135 Abstract ,  Google Scholar

3 Bar-Haim Y, Stein MB, Bryant RA, et al. : Intrusive traumatic reexperiencing: pathognomonic of the psychological response to traumatic stress . Am J Psychiatry 2021 ; 178:119–122 Link ,  Google Scholar

4 Odriozola P, Gee DG : Learning about safety: conditioned inhibition as a novel approach to fear reduction targeting the developing brain . Am J Psychiatry 2021 ; 178:136–155 Abstract ,  Google Scholar

5 Chavanne AV, Robinson OJ : The overlapping neurobiology of induced and pathological anxiety: a meta-analysis of functional neural activation . Am J Psychiatry 2021 ; 178:156–164 Link ,  Google Scholar

6 Shackman AJ, Fox AS : Two decades of anxiety neuroimaging research: new insights and a look to the future (editorial). Am J Psychiatry 2021 ; 178:106–109 Link ,  Google Scholar

7 Lebois LAM, Li M, Baker JT, et al. : Large-scale functional brain network architecture changes associated with trauma-related dissociation . Am J Psychiatry 2021 ; 178:165–173 Link ,  Google Scholar

8 Menon V : Dissociation by network integration (editorial). Am J Psychiatry 2021 ; 178:110–112 Abstract ,  Google Scholar

9 Romer AL, Elliott ML, Knodt AR, et al. : Pervasively thinner neocortex as a transdiagnostic feature of general psychopathology . Am J Psychiatry 2021 ; 178:174–182 Abstract ,  Google Scholar

10 Verner G, Epel E, Lahti-Pulkkinen M, et al. : Maternal psychological resilience during pregnancy and newborn telomere length: a prospective study . Am J Psychiatry 2021 ; 178:183–192 Abstract ,  Google Scholar

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  • Cited by None

research essay on ptsd

  • Posttraumatic Stress Disorder (PTSD)
  • Coronavirus/COVID-19
  • Anxiety Disorders

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  • Published: 20 September 2021

Prefrontal cortex, amygdala, and threat processing: implications for PTSD

  • M. Alexandra Kredlow 1   na1 ,
  • Robert J. Fenster 2   na1 ,
  • Emma S. Laurent   ORCID: orcid.org/0000-0002-4820-8332 1 ,
  • Kerry J. Ressler   ORCID: orcid.org/0000-0002-5158-1103 2 &
  • Elizabeth A. Phelps   ORCID: orcid.org/0000-0002-6215-8159 1  

Neuropsychopharmacology volume  47 ,  pages 247–259 ( 2022 ) Cite this article

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Posttraumatic stress disorder can be viewed as a disorder of fear dysregulation. An abundance of research suggests that the prefrontal cortex is central to fear processing—that is, how fears are acquired and strategies to regulate or diminish fear responses. The current review covers foundational research on threat or fear acquisition and extinction in nonhuman animals, healthy humans, and patients with posttraumatic stress disorder, through the lens of the involvement of the prefrontal cortex in these processes. Research harnessing advances in technology to further probe the role of the prefrontal cortex in these processes, such as the use of optogenetics in rodents and brain stimulation in humans, will be highlighted, as well other fear regulation approaches that are relevant to the treatment of posttraumatic stress disorder and involve the prefrontal cortex, namely cognitive regulation and avoidance/active coping. Despite the large body of translational research, many questions remain unanswered and posttraumatic stress disorder remains difficult to treat. We conclude by outlining future research directions related to the role of the prefrontal cortex in fear processing and implications for the treatment of posttraumatic stress disorder.

Introduction

Post-traumatic stress disorder (PTSD) is a maladaptive and debilitating psychiatric disorder typically accompanied by an extreme sense of fear at the time of trauma occurrence, with characteristic re-experiencing, avoidance, and hyperarousal symptoms in the months and years following the trauma. PTSD has a prevalence of ~6% but can occur in 25–35% of individuals who have experienced severe psychological trauma, such as combat veterans, refugees, and assault victims [ 1 , 2 , 3 ]. The differential risk determining those who do versus those who do not develop PTSD is multifactorial [ 4 , 5 , 6 , 7 ]. It is in part genetic, with at least 30–40% risk heritability for PTSD following trauma [ 8 , 9 , 10 ], and in part depends on past personal history, including adult and childhood trauma and psychological factors which may differentially mediate fear and emotion regulation. Additionally, considerable evidence now supports a model in which PTSD can be viewed, in part, as a disorder of fear dysregulation. This is advantageous because the neural circuitry underlying threat and fear-related behaviors in mammals, including the amygdala–hippocampus–medial prefrontal circuit, is among the most well-understood behavioral circuits in neuroscience [ 11 , 12 , 13 , 14 ]. Further, the study of threat behavior and its underlying circuitry has led to some of the most rapid progress in understanding learning and memory processes.

Although the amygdala and other subcortical regions are perhaps best understood with relationship to threat processing across species, burgeoning evidence has provided substantial support for the role of different regions of the prefrontal cortex (PFC) in particular in regulating the encoding of threat-related behaviors across species and the emotion of fear in humans. Furthermore, the PFC has a critical role in threat inhibition and extinction, as well as in processes such as emotion regulation and avoidance.

In contrast to the promise of current scientific approaches, in the clinic PTSD remains very difficult to treat [ 15 , 16 ]. The best current treatments are in the form of exposure-based cognitive-behavioral therapies, which are thought to act on the neurocircuitry of threat extinction, in particular through the PFC. The medication treatments for PTSD are primarily limited to traditional serotonin and norepinephrine reuptake inhibitors, which are used for a broad range of depression and anxiety disorders. Advances in understanding the neural circuit of regulation of threat, fear, and PTSD symptoms may lead to novel and more robust treatment approaches.

This review aims to synthesize our current understanding of the role of the PFC in threat behaviors and threat-related emotional processing, and the role of multiple PFC subregions in PTSD. As acknowledged, this line of research is relevant to the treatment of disorders characterized by fear, such as PTSD. However, in line with the two-system view of fear and anxiety [ 17 ] and in order to not make assumptions about emotional states, the term “threat” will be used when referring to the behavioral, psychophysiological, or neural outcomes of conditioning research. The term “fear” will be reserved for describing studies in which the subjective emotion of fear was assessed or discussing the emotion more generally.

Nonhuman animal research on threat processing

The medial prefrontal cortex (mPFC) of the rodent regulates a balance between goal-oriented and habitual behaviors [ 18 , 19 ]. The mPFC receives massive inputs from subcortical structures, including the amygdala, hippocampus, ventral striatum, hypothalamus, periaqueductal gray, and cerebellum, among others, that allow it to integrate the behavioral state of the animal and adjust behavioral decisions on a moment-to-moment basis. One of the most important mPFC functions is to integrate information about potential threats in the environment with other organismal drives to determine behavioral outputs [ 20 ].

Decades of basic research on the mPFC in rodents indicate that it plays a key role in the expression and storage of the Pavlovian threat response and the establishment of threat-related extinction memories [ 21 ]. Technological advances have evolved from lesion and pharmacologic studies to experiments utilizing circuit-perturbing and single-cell approaches, which are beginning to provide data at the cell-type resolution for the role of this critical structure in the threat response. Below, we will briefly review the anatomy of the rodent mPFC, the data implicating mPFC circuitry in the threat response and in threat extinction, molecular changes in mPFC cell types with threat acquisition and extinction, and future steps in these lines of research.

Anatomy of rodent mPFC

Like most cortical regions, the mPFC is a multi-layered structure of heterogeneous cell types, composed of excitatory pyramidal neurons, inhibitory interneurons, and support cells. Beginning with Brodmann, there have been debates about the existence and location of the mPFC in rodents due to the lack of a prominent granular layer [ 22 ; see Preuss and Wise, this issue]. Cross-species comparisons can be more easily made with respect to connectivity patterns [ 23 ]. The rodent mPFC is generally considered to consist of the medial precentral area (Fr2), the dorsal anterior cingulate cortex (dACC), prelimbic cortex (PL), and infralimbic cortex (IL) [ 24 ] (see Fig.  1a ).

figure 1

a Rodent anatomy highlighting regions involved in threat learning, extinction, avoidance, and the contextual modulation of threat expression; b Human anatomy highlighting regions involved in threat learning, extinction, avoidance, cognitive regulation, and the contextual modulation of threat expression. PL = prelimbic cortex, IL = infralimbic cortex; dACC = dorsal anterior cingulate cortex, vmPFC = ventromedial prefrontal cortex, dlPFC = dorsolateral prefrontal cortex.

For the purposes of this review, we will focus on rodent PL and IL, although recent work has implicated dACC in observational threat pathways, which may be relevant to PTSD from witnessed trauma [ 25 ]. Histologically in the mouse, PL and IL differ in the thickness of layer II/III and the prominence of layer separations between superficial II/III and layer V; however, this boundary is not easily demarcated [ 26 , 27 ]. Both PL and IL receive cortical input, as well as unidirectional projections from the hippocampus, mainly CA1 and subiculum [ 24 ]. Projections to the amygdala are bidirectional, although there are differences in the projection patterns of PL and IL to the amygdaloid complex, and there is some controversy about whether PL and IL synapse onto functionally different cell types [ 28 , 29 ]. Although there is some overlap in projection patterns, IL projects most heavily to lateral septum, bed nucleus of the stria terminalis, amygdala, hypothalamus, and brainstem, while PL sends more projections to insular cortex, nucleus accumbens, thalamus, and raphe nuclei [ 29 ]. The differences in these projection patterns suggest diverging functional roles for these adjacent structures.

Evidence for PL/IL distinction

For the past 20 years, there has been an extensive, although debated, literature showing differential roles for PL and IL in threat conditioning and threat extinction [ 21 ]. The first study to demonstrate a role for the rodent ventromedial prefrontal cortex (vmPFC) came from Morgan et al., who lesioned the mPFC [ 30 ]. A follow-up study demonstrated that more dorsal areas of the mPFC affected threat learning, while more ventral mPFC was required for threat extinction [ 31 ]. Quirk et al. supported this result when they [ 32 ] performed electrolytic lesions of the rat vmPFC and assessed threat extinction memory. They found that lesions that included caudal IL ablated threat extinction memories, while those that excluded the area had no effect. Pharmacological inactivation of PL and IL with agents such as the GABA agonist muscimol further suggested opposing roles for these structures in threat conditioning and threat extinction, respectively [ 33 ]. However, these results have not been universally reproduced [ 34 , 35 ]. More recent studies from the Quirk laboratory have used optogenetics to drive or inhibit activity in excitatory IL neurons during threat extinction. These data suggest that IL neurons are necessary for encoding threat extinction memories but may not be necessary for threat extinction memory storage or retention [ 36 ]. These findings also suggest that the threat extinction memory trace may be represented by different cell populations over time. Indeed, it has been known that the threat memory is likely constituted by a distributed network of cells across a range of brain regions. Inputs to the mPFC likely help to drive evolution of the memory trace over time.

Modulation of mPFC by subcortical structures

Because the mPFC must guide behavior on a moment-to-moment basis, it needs to receive a constant stream of information from subcortical structures and send out a coordinated response. The mPFC receives dense innervation from many subcortical structures, but we will focus here upon three crucial inputs: the hippocampus, amygdala, and thalamus. The canonical role of the hippocampus in threat circuitry is to encode context-specific information of a threat trace, as it is crucial for an organism to be able to distinguish threats as belonging to a particular context. The hippocampus itself appears to have a dorsal-ventral functional gradient, with the dorsal hippocampus encoding context more specifically, while the ventral hippocampus (vHPC) includes affective information as well [ 37 ].

The vHPC sends dense direct projections to the mPFC from CA1, but also bidirectional disynaptic indirect connections to the mPFC through the reuniens nucleus of the thalamus and the perirhinal cortex [ 38 ]. Lesion studies of the hippocampus suggest a critical role in context processing [ 39 ]. Reversible inactivation of the dorsal hippocampus, through either pharmacologic or chemogenetic means, interferes with context-specific information of a threat memory [ 40 , 41 ]. Inhibition of double-projecting vHPC neurons to the mPFC and basolateral amygdala (BLA) interferes with contextual threat recall [ 42 ] and disconnection of the vHPC from the mPFC interferes with renewal of threat memories, a context-dependent process [ 43 ]. Activity-tagging coupled with optogenetic inhibition suggests that threat conditioning and extinction memories exist in separate populations of neurons within the hippocampus [ 44 ], and the hippocampus may influence mPFC activity through feed-forward inhibition mechanisms through parvalbumin interneurons [ 45 ]. In return, the mPFC appears to suppress expression of erroneous contexts in a “top-down” manner through a disynaptic pathway through the reuniens nucleus of the thalamus [ 46 ]. In addition, there may be more routes of information flow from the PFC to the hippocampus, including direct routes from the nearby anterior cingulate [ 47 ].

The amygdala communicates the salience of the threat cue to the mPFC (see Murray and Fellows, this issue, for further discussion of amygdala-PFC interactions). For thirty years, the amygdala has been implicated in both threat learning [ 48 ] and threat extinction [ 49 ] processes. The BLA sends bidirectional projections to the mPFC [ 50 ]. There is evidence to suggest that there is a dorso-ventral topographic segregation of BLA input to the mPFC; more dorsal projections (to PL) encode threat-stimulating information while more ventral projections (to IL) encode threat extinction-related information [ 51 ]. Synaptic connections between PL neurons and BLA inputs also strengthen in response to stress, in part through endocannabinoid-mediated mechanisms [ 52 ]. Projection neurons within the BLA exhibit plasticity when conditioned stimulus-unconditioned stimulus pairings occur and convey this information to the mPFC.

Finally, nuclei within the thalamus help bind threat memories to context and facilitate shifts in the mPFC threat memory trace over time. The reuniens nucleus of the thalamus coordinates oscillatory synchrony between the mPFC and the vHPC, which is necessary for proper contextual representation of threat memories [ 46 , 53 ]. The paraventricular nucleus of the thalamus plays a crucial role in the encoding of threat memories over time [ 54 ] and appears to be necessary in shifting the temporal nature of how the mPFC encodes threat memories [ 55 ].

Molecular pathways in rodent mPFC

At the molecular level, threat conditioning and extinction are associated with epigenetic, transcriptional, and translational changes that likely modify synaptic weights and cell firing properties that persistently alter circuit function. Introduction of the translational inhibitor anisomycin, either intraventricularly or into the mPFC, causes a failure to retain threat extinction memories. This suggests that translation of new protein is necessary for the formation of a novel threat extinction memory [ 56 ]. Threat conditioning and threat recall are associated with unique, cell-type-specific transcriptional changes that persist for weeks after initial training [ 57 ]. Threat extinction also requires transcriptional processes within IL: injection of an inhibitor of PARP-1, a gene involved in ADP-ribosylaton that is necessary for transcription, into mPFC impairs contextual threat extinction [ 58 ].

The BDNF-TrkB neurotrophic factor pathway has also been extensively studied with regards to mPFC and memory formation in mPFC. Expression of Bdnf in PL is necessary for consolidation of cued threat conditioning [ 59 ], while infusion of Bdnf into IL after threat acquisition is sufficient to diminish threat responses in the absence of extinction training [ 60 ]. Threat extinction is also associated with epigenetic modification. In the IL, threat extinction is associated with acetylation of histones near the Bdnf locus [ 61 ], changes to the p300/CBP complex (PCAF) [ 62 ], as well as deposition of DNA-modification marks such as 5-hydroxymethylcytosine and N6-methyl-2’deoxyadenosine (m6dA) near loci of activity-dependent genes such as Bdnf .

Additionally, inhibition of PCAF in IL was shown to interfere with threat extinction [ 62 ]. Recently, Li et al. [ 63 ], have shown that knockdown of N6amt1 , the gene responsible for m6dA deposition, within IL, blocks changes to the m6dA mark at the Bdnf promoter in vivo and impairs threat extinction retention. These findings suggest that alterations in m6dA deposition are necessary for the formation of threat extinction memories within IL [ 63 ]. These findings also strongly support the hypothesis that threat extinction memory requires epigenetic changes within IL. Our understanding of the molecular changes that occur within the mPFC during threat-related processes are still in their infancy. Gene expression changes are unique to cell type, and cell-type-specific investigations of mPFC in threat conditioning and extinction are just beginning.

Stress and threat reactions

One potential factor that alters the ability to control emotional responses via altering PFC function is stress (for review, see 64,65, Kalin and Barbas, this issue). Studies in animal models have shown that acute stress leads to changes in neuronal signaling that impair function in the dlPFC [ 64 ] and IL cortex [ 66 ]. These changes are proposed to be due to the impact of increased catecholamines, in particular noradrenergic and dopaminergic signaling, on PFC neuronal activity with even relatively mild acute stress exposure [ 64 , 65 , 67 ]. Stress also impacts signaling within the amygdala. Noradrenergic signaling from the locus coeruleus to the amygdala was recently shown to be necessary to produce the immediate extinction deficit, an impairment in extinction learning that occurs soon after fear learning and is thought to be related to the stress of the fear learning process [ 68 ]. Activity of CRF-expressing neurons within the CeA was also recently shown to contribute to this phenomenon [ 69 ]. In rodents, chronic stress also impacts neural activity in both PL and IL cortex [ 70 ] and leads to structural changes in IL cortex [ 71 ]. One consequence of stress-related PFC impairment is enhanced threat learning and impaired extinction retention in rodent models [ 66 , 70 ].

In the next section we will explore the role of PFC in human threat processing research, from acquisition and encoding of threat, to its extinction and extinction recall. We will also further integrate additional findings with regards to other threat and avoidance behaviors in response to threat stimuli and the impact of stress on the PFC. Finally, we will examine how these different brain regions and behaviors are dysregulated in threat-related disorders such as PTSD.

Preclinical human threat processing research

Threat learning.

Perhaps it is not surprising, given the extensive research with nonhuman animals, that research in humans confirms a role for the amygdala and PFC in threat learning (see Fig.  1b and Fig.  2a ). The role of the amygdala was first demonstrated in patients with amygdala damage. Relative to healthy controls, both bilateral [ 72 ] and unilateral [ 73 ] amygdala damage resulted in impaired conditioned responses, as measured by the skin conductance response (SCR). However, these patients were able to verbally report the contingency between the conditioned stimulus and shock after the procedure, which was impaired in patients with hippocampal damage whose amygdala was intact [ 72 , 74 ]. These findings suggest that the amygdala is only critical for the implicit, physiological expression of threat learning in humans, with conscious knowledge about the threatening nature of stimuli in the environment remaining intact, despite amygdala lesions. Furthermore, these findings demonstrate that there are additional brain regions that are critical for the expression of the subjective fear and threat responses, including PFC areas that are discussed in more detail below.

figure 2

a Healthy Threat Circuit. Regions involved in threat learning and the control of threat reactions via extinction, context, avoidance, or cognitive regulation. In healthy individuals the coordination of this circuit enables adaptive threat expression. b PTSD Threat Circuit. The dlPFC, vmPFC/IL, and hippocampus show impaired functioning with PTSD, whereas the amygdala and dACC/PL are enhanced. Disrupted connections between regions are indicated by dashed lines. The disrupted threat circuit with PTSD results in maladaptive threat expression. Prefrontal cortex regions are highlighted within the beige circle. Terms for animal/human homologous regions are in the same circles. PL = prelimbic cortex, IL = infralimbic cortex, dACC = dorsal anterior cingulate cortex, vmPFC = ventromedial prefrontal cortex, dlPFC = dorsolateral prefrontal cortex.

Consistent with these early patient studies, functional magnetic resonance imaging (fMRI) studies soon followed that showed increased blood oxygenation level dependent (BOLD) signal in the amygdala to a conditioned stimulus (relative to stimulus never paired with shock) [ 75 , 76 ], and the magnitude of this BOLD response was correlated with the strength of the conditioned response [ 76 ]. Interestingly, this differential amygdala BOLD response was only apparent in the early stages of threat conditioning. This finding is somewhat surprising given rodent research showing long-lasting changes in the amygdala lateral nucleus with threat learning. However, there is electrophysiological evidence in rodents showing that a subset of lateral nucleus amygdala neurons respond preferentially during initial learning [ 77 ], and there is greater responding overall at this time. It may be the case that BOLD changes in the amygdala can only be observed at time windows when there are larger populations of neurons responding, such as initial learning. One major limitation of fMRI for investigations of amygdala function in humans is that it is a relatively coarse measurement. Although the spatial resolution of standard BOLD imaging is generally 3 mm, in practice, with spatial smoothing and group averaging, the actual resolution is greater than 10 mm, which covers a substantial portion of the amygdala (which is slightly more than 1000 mm 3 in humans) and makes it very difficult to detect discrete responses in amygdala subnuclei. The challenges of using BOLD imaging to study the human amygdala is reflected in recent meta-analyses of fMRI threat learning studies, which fail to find BOLD changes in the amygdala [ 78 ], in spite of its critical role in threat learning in rodent models and patient studies.

In contrast to difficulties in detecting BOLD changes in the amygdala during threat learning, meta-analyses and individual studies reliably show activation in a number of other brain regions, including the insula cortex, which is linked to physiological arousal responses [ 79 ], the striatum, and the dACC (e.g., [ 76 , 78 , 80 ]). The dACC is a prefrontal region that is proposed to be the human homolog of the PL cortex in rodents [ 80 ]. As discussed earlier, the PL in rodents has been suggested to play a role in the expression of threat learning via projections to the basolateral amygdala, with stimulation of this region increasing conditioned freezing and inactivation reducing it.

In rodents, the PL and IL cortex are located adjacent to one another in the mPFC. In primate models, however, the PL and IL are farther apart. The primate PL cortex is thought to be divided into rostral and caudal regions with different connectivity patterns. The rostral region is thought to be more similar to the PL in rodents, with the dACC being the human homologue for that region [ 23 , 81 ]. Consistent with this suggestion, Milad et al. [ 80 ] found that both cortical thickness, and BOLD response magnitude to a conditioned stimulus in this region, were correlated with the strength of the conditioned response as measured with SCR in humans.

Although the basic circuitry of threat learning seems to be preserved across species, a primary difference between humans and other animals is that humans, more often than not, learn about threats in the environment via social interactions. For example, children learn to fear germs by being told about their existence and observing others engaging in actions attempting to avoid them. This ability is adaptive in that humans do not need to be physically harmed to learn about threats in the environment. It can also be maladaptive in that we can develop robust fears for events that are imagined and anticipated but never actually experienced, contributing greatly to human anxiety and fear-related disorders. To what extent do the brain systems involved in threat learning from direct experience, that have been investigated in rodent models, map onto socially acquired, imagined threats in humans?

To address this question, brain imaging and patient studies have examined threat learning through verbal instruction (e.g., being told a blue square predicts a shock, and then being shown a blue square) or observation (e.g., watching someone else receive a shock paired with a blue square, and then being shown a blue square). Consistent with Pavlovian threat conditioning, fMRI studies of both instructed and observational threat learning show activation in the amygdala, dACC, and insula [ 82 ]. For instructed learning, the amygdala BOLD response is left-lateralized [ 83 ], and only patients with left, but not right, amygdala damage show impaired physiological evidence of threat learning, perhaps because of the verbally mediated nature of this learning [ 84 ]. In contrast, observational learning results in increased bilateral BOLD signal in the amygdala, both when observing someone else receiving a shock paired with a conditioned stimulus (learning), and when viewing the conditioned stimulus afterwards (test). In addition, during observational learning, activation in a rostral mPFC region that has been implicated in mentalizing about others is correlated with the strength of the learned threat response as measured by SCR [ 85 ], and learning is stronger with greater empathy for the person being observed [ 86 ]. These results suggest that while the social learning of threat may engage unique neural circuitry due to the nature of the learning, it also takes advantage of the phylogenetically older mechanisms of Pavlovian threat conditioning for threat expression.

Threat extinction

Much like threat learning, neuroimaging studies of threat extinction in humans have identified brain regions that parallel those involved in extinction in rodents (see Figs.  1b and  2a ). The vmPFC is proposed to be the homologue for the IL in rodents [ 87 ] and serves to inhibit threat responses produced by the amygdala. There is consistent evidence of increases in BOLD signal in the vmPFC during extinction learning [ 88 , 89 , 90 ] and recall [ 89 , 90 , 91 , 92 ] (for review, see [ 93 , 94 , 95 ]). Further, the degree of activation of the vmPFC has been shown to be positively correlated with the degree of extinction, or extinction retention, as measured by SCR [ 89 , 90 ], consistent with the suggested role of the IL in extinction in rodent models.

Brain morphology studies also point to the human vmPFC being involved in extinction. Milad et al. [ 96 ] found vmPFC thickness to be positively correlated with extinction recall. Specifically, greater thickness was associated with smaller SCR to the conditioned stimulus during extinction recall, suggestive of better extinction recall (see also [ 97 ]). Subsequently, Winkelman et al. [ 98 ] examined the relationship between vmPFC thickness and extinction learning, rather than recall, and found similar results. Greater vmPFC thickness was associated with smaller differential SCR during early extinction learning, suggestive of better extinction learning.

Targeting extinction with neuromodulation, neuroplasticity, and context modulation

One drawback of these MRI studies, however, is that they are correlational in nature. Unlike research conducted in rodents, specific brain regions in humans cannot be lesioned or tagged, nor can regions that are not on the surface of the brain be disrupted. Researchers are able, however, to stimulate or disrupt surface frontal regions of the brain in humans using non-invasive devices. For example, transcranial direct current stimulation (tDCS) applies a low-intensity current through two electrodes attached to the scalp, and transcranial magnetic stimulation (TMS) delivers an electric current through a coiled wire placed on the scalp, creating a magnetic field across the skull. Both of these strategies are thought to modulate neuronal activity in the human brain.

Using these techniques, a few recent brain stimulation studies [ 99 , 100 , 101 , 102 , 103 ] have been conducted in humans to probe the role of the vmPFC in extinction. For example, Dittert et al. [ 100 ] administered tDCS via bitemporal electrodes aimed at the vmPFC prior to and during extinction and found that tDCS, relative to sham, stimulation resulted in faster early extinction learning. Similarly, Raij et al. [ 102 ] found that TMS, during extinction learning, to an area of the frontal cortex functionally connected to the vmPFC (i.e., the left lateral PFC), but not to an area of the frontal cortex thought to be unconnected to the vmPFC, led to enhanced extinction recall. Although these studies provide some insight into the role of the vmPFC in extinction, given the location of the vmPFC and the fact that tDCS and TMS are applied externally, it is difficult to be certain that the vmPFC in particular was stimulated in these studies.

Consistent with animal models of extinction circuitry, the vmPFC interacts with other regions such as the amygdala and hippocampus to modulate threat responses during extinction. From rodent research showing that intra-amygdala infusion of the NMDA receptor agonist d-cycloserine, which enhances NMDA-dependent plasticity, facilitates extinction learning, and successful translation of this work to humans (see [ 104 ] for review), we know that the human amygdala plays a role in extinction learning. Human imaging studies, however, have been less consistent with finding changes in BOLD signal in the amygdala during extinction [ 76 , 88 , 90 , 95 , 105 ]. Much like with threat acquisition, it may be that the involvement of the amygdala in extinction is more subtle and difficult to detect using standard fMRI techniques [ 106 ]. Nonetheless, imaging research does point to changes in the relationship between the PFC and amygdala during extinction. Connectivity analyses have demonstrated functional coupling between the mPFC and amygdala during extinction learning [ 107 ], and vmPFC and amygdala during extinction recall [ 89 , 108 ].

Also consistent with animal models (e.g., [ 40 ]), research suggests that the hippocampus is involved in contextual modulation of extinction and works in concert with the PFC during contextual extinction learning. One of the first studies demonstrating hippocampal involvement in extinction showed that patients with damage to the hippocampus failed to show contextually modulated reinstatement of conditioned responses following extinction [ 74 ]. Brain imaging studies of the contextual modulation of extinction typically manipulate the visual background during extinction and report hippocampal activation during extinction recall [ 89 , 91 , 92 ]. Importantly, functional connectivity analyses also suggest coupling of the PFC and hippocampus during contextual extinction learning [ 107 ] and recall [ 89 ].

Sleep is another factor that has been shown to modulate threat control in humans. Sleep has been shown to enhance both threat learning, and the generalization of extinction learning in humans and other animals. The documented role for sleep in memory consolidation is proposed to extend to both threat memories and extinction memories. Which of these competing memory representations is selectively strengthened depends on contextual factors such a recency of learning and replay [ 109 ]. Because of evidence for sleep’s modulation of extinction learning across species, it has been suggested that disruptions of sleep following acute trauma, or predating the traumatic experience, may contribute to the etiology or perpetuation of PTSD [ 110 ].

Avoidance/active coping

Another method of reducing conditioned threat reactions is through active avoidance or coping. Initial rodent research on the neural circuitry of active avoidance found that while the passive expression of conditioned threat responses engages a pathway from the lateral nucleus to the central nucleus, when the animal engages in an action to avoid the unconditioned stimulus, projections from the lateral nucleus to the basal nucleus to the nucleus accumbens are involved. However, in order for the animal to produce an avoidance action, conditioned freezing must be inhibited which requires the IL cortex, much like in the expression of extinction (see [ 111 ] for a review).

One benefit of avoidance learning over extinction for controlling threat reactions is that avoidance learning results in a persistent reduction in the passive conditioned response, even when the avoidance action is no longer available [ 112 ]. This is in contrast to extinction in which the conditioned response often returns through spontaneous recovery, renewal, or reinstatement. Both the acquisition of avoidance, and the reduction of the persistent conditioned threat reaction following avoidance learning, are blocked by the injection of protein synthesis inhibitors into the IL. This indicates that plasticity in the IL is critical for the persistent reduction of conditioned responses with avoidance [ 112 ]. Mirroring these findings, studies have shown that previous history with escapable shock results in a lasting reduction of the conditioned response, and this effect is eliminated with IL inactivation [ 113 ].

In humans, there is evidence that both avoidance learning and history with escapable shock can persistently reduce conditioned threat actions as measured with SCR, even when no avoidance action is available [ 114 , 115 ]. However, in order to persistently diminish threat conditioned responses in humans, avoidance actions need to be learned through trial and error and there needs to be a subjective sense of control over the unconditioned stimulus during learning [ 115 ]. Simply providing the option of an action to avoid the unconditioned stimulus yields no lasting reduction of conditioned responses when the avoidance action is no longer available, and in fact can increase them by preventing extinction learning (called “protection from extinction”, [ 116 ]). Consistent with the circuity of avoidance learning detailed in rodent models, trial-by-trial avoidance learning yields increased BOLD activation in the vmPFC and ventral striatum, relative to standard extinction [ 114 ], suggesting the brain mechanisms of active coping are preserved across species.

Emotion regulation

Although extinction and active coping can be investigated across species, humans have the unique ability to use cognitive strategies to alter emotional responses, such as responses to fear provoking stimuli (for review, [ 117 ]). One common emotion regulation strategy is cognitive reappraisal. This strategy involves reframing thoughts (also called “appraisals”) about a stimulus in order to change the emotional response that that stimulus evokes. Emotion regulation strategies can be employed with the goal of either upregulating (i.e., increasing) or downregulating (i.e., decreasing) emotions. Here, the primary focus is on data related to downregulating negative emotions, fear in particular, as these data are most relevant to PTSD and its treatment. We highlight reappraisal, which is proposed to be similar to cognitive restructuring in clinic. Neuroimaging research has provided insight into the brain regions involved in emotion regulation in humans. Studies to date suggest that emotion regulation strategies aimed at downregulating negative emotions engage cognitive control regions of the PFC, which then modulate the amygdala via various potential pathways to influence negative emotional responses.

The most recent meta-analysis of fMRI studies of emotion regulation [ 118 ] found that all strategies aimed at downregulating negative emotions were collectively associated with increased BOLD signal in the following areas: ventrolateral prefrontal cortex (vlPFC), dorsolateral prefrontal cortex (dlPFC), and dorsomedial prefrontal cortex (dmPFC). While these were the largest areas of convergence, activation was also found in other areas (i.e., the bilateral inferior parietal lobule, supplementary motor area, pre-supplementary motor area, left middle temporal gyrus, and posterior cingulate gyrus). These findings were relatively consistent with a prior meta-analysis [ 119 ], with the exception that the prior meta-analysis also found decreased BOLD signal in the amygdala and parahippocampal gyrus, consistent with the notion that cognitive control regions of the PFC modulate amygdala activity during emotion regulation. One potential reason for differing results across these two meta-analyses may be differences in the studies examined and proportions of various emotion regulation strategies included. There is some evidence that different emotion regulation strategies may recruit distinct brain regions. For example, Dörfel et al. [ 120 ] found that some emotion regulation strategies are associated with reduced activity in the amygdala, whereas others are not.

Nonetheless, the majority of imaging research to date on emotion regulation focuses on the strategy of cognitive reappraisal. Meta-analyses of cognitive reappraisal alone have consistently found increased BOLD signal in the dlPFC, vlPFC, and dmPFC [ 93 , 121 , 122 ] and decreased BOLD signal in the amygdala [ 93 , 121 ]. The dlPFC is thought to be an important driver of emotion regulation and hypothesized to be involved in the manipulation of appraisals of stimuli in working memory [ 121 , 122 , 123 ]. The vlPFC is hypothesized to support choosing and inhibiting appraisals of stimuli [ 121 , 124 , 125 ] or potentially may signal salience and the need to reappraise [ 122 ]. Finally, the dmPFC is hypothesized to support abstracting affective meaning of stimuli or the processes of self-reflecting and identifying one’s own affective reactions to stimuli [ 121 , 126 , 127 , 128 , 129 , 130 ].

Two hypotheses have been proposed for how these cognitive control regions of the PFC (i.e., the dlPFC, vlPFC, and dmPFC) influence the amygdala: (1) that they engage the vmPFC which then modulates the amygdala, similar to the neurocircuitry of extinction [ 93 , 131 , 132 ], and (2) that they modulate lateral temporal areas associated with semantic and perceptual representations, which then indirectly influence the amygdala [ 121 ].

In support of the first hypothesis, anatomical research in nonhuman primates shows that connections between the lateral PFC and amygdala are sparse relative to the vmPFC and amygdala (e.g., [ 133 , 134 ]). Additionally, a study of cognitive reappraisal of threat conditioned stimuli by Delgado et al. [ 131 ] demonstrated increased BOLD signal in the dlPFC and decreased BOLD signal in the amygdala, but also changes in vmPFC activity that mirror those that occur during extinction. Specifically, increased BOLD signal in the vmPFC after successful cognitive reappraisal was observed. Further, connectivity analyses [ 131 , 132 ], a meta-analysis conducted by Diekhof et al. in 2011, and more recent dynamic causal modeling of cognitive reappraisal data [ 135 ], also support this hypothesis.

In contrast, two more recent meta-analyses favor the second hypothesis [ 121 , 122 ]. Specifically, in addition to increased activation of the cognitive control regions of the PFC mentioned above and modulation of the amygdala, Buhle et al. [ 121 ] report increased activation of the lateral temporal cortex during cognitive reappraisal. Notably, they did not observe increased activation of the vmPFC. There are many possible reasons for these differences in findings (see [ 121 , 136 , 137 ] for discussion), however, one possibility is that it has to do with the type of cognitive reappraisal procedure used. The study by Delgado etv al. [ 131 ] involved cognitive reappraisal of threat conditioned stimuli, whereas most of the studies included in the Buhle et al. [ 121 ] meta-analysis involved cognitive reappraisal of negatively-valenced photos. It could also be that the vmPFC is involved in cognitive reappraisal for some individuals more so than others. For example, the nature of vmPFC involvement during cognitive reappraisal has been observed to vary as a function of psychiatric symptoms [ 138 , 139 ].

To date, the majority of studies on brain regions involved in emotion regulation have examined fMRI data. To our knowledge, only one study has examined brain morphometry in relation to cognitive reappraisal task performance [ 97 ] and this study did not find a relationship between success of reappraisal and dlPFC, vlPFC, or vmPFC cortical thickness. Although there do not seem to be structural changes related to the successful cognitive reappraisal, there is one lesion study [ 140 ] that supports a role of the dlPFC in cognitive reappraisal. This study examined individuals with dlPFC lesions and found that they showed impaired ability to reappraise threat conditioned stimuli as indexed by poorer subjective fear outcomes, compared to matched controls. Additionally, a few brain stimulation studies have been conducted to probe the role of the PFC in emotion regulation. In this case, given the lateral location of the cognitive control regions of the PFC implicated in emotion regulation, tDCS or TMS can be used to target these regions. However, results of these studies have been inconsistent. While some studies have found that tDCS over the dlPFC or vlPFC enhances cognitive reappraisal [ 141 , 142 , 143 ], others have not [ 143 , 144 ].

Stress and threat control

As the discussion above indicates, there are several techniques that can be used to control learned threat reactions in humans when they are no longer adaptive. However, as outlined earlier, stress, both chronic and acute, can impact the function of PFC and subcortical regions implicated in threat control. In humans, experimental studies of chronic stress are not possible due to ethical concerns; however, there is evidence that a history of childhood abuse is correlated with reduced gray matter volume in PFC regions, including the vmPFC and orbital frontal cortex [ 145 ]. In addition, mild acute stress in humans impairs the efficacy of previously acquired cognitive reappraisal strategies in reducing conditioned threat and subjective fear [ 146 ] and results in enhanced spontaneous recovery following extinction training [ 147 ]. These latter findings suggest that even when threat control techniques are successfully learned, relatively mild acute stress may impair the ability to express this learning by impacting the function of PFC inhibitory circuits.

Role of PFC in PTSD

The above evidence suggests that stress, in particular, is associated with altered PFC function and its role in regulating subcortical emotional responses. PTSD is among the most well-understood, prevalent, and medically significant stress-related disorders. A fairly large set of studies now supports a clear role for altered PFC structure and function in PTSD and related disorders (see Fig.  2b ).

Structural imaging in PFC and PTSD

Related to stress exposure, independent of PTSD, a number of studies have identified smaller volumes in PFC and decreased structural connectivity between PFC and subcortical areas as a function of violence and trauma exposure. In a prospective study of Israeli soldiers, Admon et al. [ 148 ] used diffusion tensor imaging (DTI) pre- and post-military service, reporting that soldiers with decreased hippocampal structural connectivity with the vmPFC had a more maladaptive response to stressful military service. In a small study of victims of urban violence, Rocha-Rego et al. [ 149 ] found significant reductions in gray matter volume in the ventral premotor cortex and in the pregenual ACC as a function of civilian violence. Furthermore, in a moderately large sample of post-9/11 veterans, Clausen et al. [ 150 ] found that higher combat exposure uniquely related to lower cortical thickness in the left prefrontal lobe; and that, overall, combat exposure, PTSD, and head injuries differentially relate to alterations in cortical thickness.

A number of studies have also found decreased gray matter volumes related to traumatic stress symptoms. In development, with a study of ~50 youth, Keding and Herringa [ 151 ] found that those with PTSD had reduced gray matter volume in anterior vmPFC, which inversely correlated with PTSD duration. They suggest that pediatric PTSD is associated with abnormal structure of the vmPFC, possibly related to disrupted extinction and contextual gating of fear. Similarly, in a study of over 100 participants, it was found that maltreated youth with PTSD demonstrated decreased right vmPFC volumes compared to both maltreated youth without PTSD and nonmaltreated healthy controls [ 152 ]. Similar findings have been found in adult samples. A study of 85 veterans suggested decreased structural volumes of vmPFC and ACC in those with PTSD compared to controls [ 153 ] and a smaller study of 28 veterans found smaller subgenual cingulate volumes compared to controls, in addition to a number of other limbic region structural abnormalities [ 154 ].

A number of studies have also examined structural integrity of white matter tracts, including connections to and from the PFC. Koch et al. [ 155 ] used DTI to show decreased integrity of the uncinate fasciculus tract, connecting the vmPFC to multiple subcortical, limbic regions including the amygdala, in patients with PTSD. In addition, using DTI, Fani et al. [ 156 ] found that civilians with PTSD had decreased structural connectivity via the cingulum bundle, which supports the hippocampus-dACC pathway. They suggest that altered hippocampus-ACC connectivity may represent a highly salient intermediate neural phenotype for PTSD. Further analyses of this cohort found that individuals with the “risk” allele of the FKBP5 genetic biomarker, associated with childhood maltreatment and PTSD risk, also had decreased cingulum structural integrity.

Some of these structural changes may occur quite rapidly in the aftermath of trauma—or may be preexisting and predispose some individuals to a greater risk of PTSD following trauma. Using DTI and structural imaging in the weeks following trauma exposure, research has shown that reduced fractional anisotropy of the uncinate fasciculus at around the time of trauma predicted greater PTSD symptoms (in particular posttraumatic anhedonia) at 12 months post-trauma. Furthermore, as the traumatized participants were followed over time, increased gray matter volume of the vmPFC was also associated with reduced trauma-related symptoms over the 12 months following trauma [ 157 ]. In another study recruiting patients after trauma exposure with mild traumatic brain injury, smaller cortical volumes of superior frontal cortex and rostral and caudal cingulate at 2 weeks after trauma exposure contributed to the prediction of increased likelihood of 3-month PTSD diagnosis in multivariable models incorporating other established risk factors [ 158 ].

As with many other types of human data, sample size often limits interpretation, as small sample sizes are subject to both false positive and false negative biases. Therefore, as more studies have been performed of PTSD and structural imaging, much larger analyses can be performed via meta-analyses of multiple datasets. A recent meta-analysis confirmed, using voxel-based morphometry, that there were prominent volumetric reductions in the mPFC, including the ACC, when examining over 80 different MRI studies in PTSD compared to depression [ 159 ].

In addition, one of the largest meta-analyses to date of structural cortical volumes from the ENIGMA-PGC-PTSD workgroup, compared 1379 PTSD patients to 2192 controls without PTSD. A primary finding was that volumes of left and right lateral orbitofrontal gyri were significantly smaller in PTSD patients than controls and were negatively correlated with symptom severity. Together, these findings indicate that cortical volumes in PTSD patients are smaller in prefrontal regulatory regions, consistent with preclinical work suggesting a critical role for orbital frontal PFC regions in recovery and extinction of threat behaviors [ 160 ].

Functional imaging in PFC and PTSD

It is thought that fMRI, including both emotional and cognitive task-based MRI, as well as resting state MRI may be more sensitive to pathology-related functional activity. However, it can also be criticized as there are many processing steps and the data are essentially subtractions and comparisons between different tasks, timepoints, and individuals, making interpretation often more complex than structural MRI. Nonetheless, many of the same themes with regards to the role of PFC in PTSD are found with fMRI, complementing the above structural MRI findings as well as the healthy human and preclinical data.

While many fMRI studies of PTSD have had quite limited sample sizes, some are particularly informative. Script-driven imagery with participants reading or listening to scripts of their prior trauma experiences or other stressful vignettes has been a powerful probe for determining differential brain activity in PTSD. For example, in a case-control twin study with 26 male identical twin pairs (12 PTSD; 14 non-PTSD) discordant for PTSD and combat, script-driven imagery fMRI revealed diminished activation in the mPFC during stressful versus neutral imagery in PTSD patients relative to others [ 161 ].

Another powerful method for observing brain activity is using a masked emotional probe. In this design, participants are presented with an emotional stimulus for a very brief period of time (i.e., milliseconds) and then it is replaced by a non-emotional stimulus. This minimizes explicit awareness of the emotional stimulus, while still engaging emotional perception and the associated neutral structures. For example, Killgore et al. [ 162 ] used a masked emotional probe task and compared adults with anxiety or PTSD to healthy controls. Patients (all groups combined) showed greater amygdala and reduced vmPFC activation compared to controls during the masked fearful faces. Additionally, in a prospective emergency department study following patients longitudinally, Stevens et al. [ 163 ] used an unmasked fearful faces design to demonstrate that dorsal ACC activity during presentation of fearful faces predicts ongoing symptom maintenance in the aftermath of acute trauma in civilians. These findings are consistent with some of the findings of Milad et al. [ 164 , 165 , 166 ] related to impaired extinction recall, discussed in the next section.

A number of studies have also examined the role of activity within the PFC related to prediction of treatment response. Fonzo et al. [ 167 ] reported on fMRI task-based assessment while completing three tasks assessing emotional reactivity and regulation prior to prolonged exposure psychotherapy for PTSD. At baseline, individuals with the greatest symptom improvement with therapy showed, among other findings, greater dorsal PFC and vmPFC activation during emotional conflict regulation. They interpreted these findings to suggest that participants who are most likely to benefit from exposure therapy demonstrate spontaneous activity of PFC when superficially processing threat and adapting to emotional interference. Further analysis of this study suggested that psychotherapy increased lateral frontopolar cortex activity and connectivity with the vmPFC [ 168 ]. Additionally, greater increases in frontopolar activation were associated with improvements in hyperarousal symptoms and psychological well-being. Given these findings, the authors argue that frontopolar connectivity with ventromedial regions during emotion regulation is a possible key mechanism of psychotherapeutic improvement in PTSD.

In addition, in a mindfulness-based exposure therapy intervention with a small sample size, King et al. [ 169 ] found that posterior cingulate cortex (PCC)-dlPFC functional connectivity was correlated with improvement in PTSD avoidance and hyperarousal symptoms. Overall, they surmised that increased connectivity between PCC-dlPFC brain regions could be related to attentional control and symptom improvement.

It is important to note that the “standard” observation of hyperarousal-related PTSD with increased amygdala activation and decreased mPFC activation during stressful cues seems to be reversed when subjects with PTSD have high levels of dissociative symptoms. Hooper et al. have reported increased mPFC activation in the presence of PTSD with significant dissociative symptoms (e.g., [ 170 ]). Dynamic causal modeling has been used to interpret some level of causal and temporal relationship between functionally active brain networks. Nicholson et al. [ 171 ] found that PTSD without dissociation was characterized primarily by ‘bottom-up connectivity’ from the amygdala to the vmPFC, whereas PTSD with dissociation had predominant ‘top-down connectivity’ from the vmPFC to the amygdala. The authors suggest that this provides further data supporting a model of enhanced top-down, emotional over-regulation with significant dissociation, in contrast to decreased emotion regulation in the majority of PTSD cases.

Overall, these studies suggest that, in general, decreased vmPFC and dlPFC functional activation to stressful and trauma-related cues, often accompanied by increased dACC activation to such cues, are associated with greater PTSD symptoms and decreased responses to exposure-based therapies. Successful treatment appears to be accompanied by increased activation and functional connectivity of vmPFC/dlPFC regions with other cortical and subcortical areas. Notably, PTSD with significant dissociation seems to have differential connectivity patterns, as recently further demonstrated by Jovanovic et al. [ 172 ], and may benefit from distinct approaches to treatment and recovery.

PFC, threat extinction, behavioral inhibition

Work that has done the most to connect neuroimaging findings in PTSD with both healthy human neuroimaging work and preclinical work on threat acquisition and extinction includes neuroimaging studies specifically focused on extinction of threat cues in PTSD as well as inhibitory learning processes. Milad et al. initially demonstrated some of these effects in PTSD through optimization of a within-scanner threat conditioning and extinction protocol. They found that during extinction recall there was decreased activation of vmPFC and greater activation in dACC in PTSD relative to healthy trauma-exposed participants, which was associated with impaired physiological measures of extinction recall [ 165 ]. These data suggest that impairments in PTSD recovery may result, in part, from altered PFC regulation of threat extinction recall. Increased dACC activation during threat expression and extinction and decreased vmPFC activation with extinction recall were replicated in another study by this group examining context modulation in PTSD [ 166 ]. The dACC also appears to be associated with more PTSD symptoms at rest. Marin et al. [ 164 ] found that dACC resting activity positively correlated with PTSD symptom severity and predicted increased dACC activations during extinction recall.

In addition, Helpman et al. [ 173 ] examined threat conditioning and extinction in an fMRI task before and after a course of prolonged exposure treatment for PTSD. They found that PTSD patients had pre- to post-treatment reductions in rostral ACC (rACC) activation during extinction recall, and increases in functional coherence between rACC, vmPFC, and sgACC, suggesting these circuits are modified.

In another approach to this issue, Jovanovic et al. [ 174 ] found lower vmPFC activation during a simple stop signal (or “Go/No-go”) task related to behavioral inhibition in civilians with PTSD. Inhibition in this task correlated with a physiological measure of threat extinction in a fear-potentiated startle paradigm outside of the scanner. These data suggested that the same circuits involved in behavioral inhibition appear to be involved in fear inhibition processes during differential threat conditioning and extinction. A follow-up study with a larger sample size suggested that the effects of vmPFC/rACC on behavioral inhibition are moderated by childhood maltreatment effects in participants with PTSD [ 175 ].

Conclusions and future directions

Considerable progress has been made in understanding the role that the PFC plays in rodent threat learning and threat extinction, in healthy human studies of regulation of threat and fear emotion processing, and in the ways these areas may be dysregulated in threat-related disorders such as PTSD. Still, many questions remain. Much data supports a heuristic in which PL and IL play opposing roles in the rodent threat response, the former driving threat expression, the latter threat extinction. Similarly, in human studies, the dACC and Brodmann 32-related mPFC areas appear to support threat responses and are hyperactive in PTSD associated with hyperarousal and threat emotional dysregulation. Furthermore, human data support subgenual and Brodmann 25-related mPFC areas (i.e., the vmPFC) in regulating/suppressing threat responses, supporting extinction of threat behaviors and fear emotions, and in providing top-down emotional control over amygdala and other subcortical regions.

However, there are other data to suggest that, more generally, PL encodes for the learning of rules, while IL allows for rule reversal [ 18 ]. Thus, the precise role for the mPFC is not yet entirely clear. The lens through which the “fear and threat” neuroscientists see these areas needs to become more aligned with how the “appetitive and addiction” and “cognitive control” neuroscientists view them. This will help obtain a more comprehensive overall perspective on these regions, aid in understanding their normal function, and provide better treatment approaches for a large number of disorders associated with their dysfunction. The integration of elegant and powerful circuit tools, from intersectional optogenetic and chemogenetic circuit dissection to cellular and genetically driven in vivo calcium imaging combined with behavior, are providing remarkable cell- and circuit-level appreciation of basic behavioral functions in rodents. In humans, new tools such as fMRI-guided TMS, as one example, are beginning to allow relatively rapid translation of circuit function to targeted, precision-medicine approaches for individually guided care.

Furthermore, as we have learned with subcortical structures, different cell types residing within the same brain structure may have dramatically different, sometimes opposing, functions. The mPFC has immense cellular heterogeneity, and we may expect, functional complexity. Future cell-type specific studies that dissect the circuit- and molecular-adaptations to threat learning within the mPFC will reveal additional layers of complexity to this system, and, hopefully, new therapeutic targets for PTSD. Tools, such as single cell RNA sequencing, are now being used across species from rodent to post-mortem human brain, allowing for molecular dissections to complement the above functional circuit dissections. Their translation across species will support both a scientific understanding of conservation of molecules and circuits across evolution for specific survival-related behaviors, as well as provide much more powerful targets for pharmacological and biological intervention using animal model systems targeting known conserved molecules and cell types for human therapeutic development.

In summary, while much remains to be learned, it is an extraordinarily exciting time for the field in which a great deal of convergence and replication has resulted in a fairly robust understanding of threat processing and its regulation by the PFC. How these areas encode and express threat memories over time is rapidly being dissected and integrating these data into our understanding of pathology in disorders such as PTSD is occurring. Integrating translational research in the coming years promises exciting new discoveries and approaches which may both greatly expand our knowledge of how the brain encodes behavior and also drive development of novel and robust new treatment approaches.

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KJR has received consulting income from Alkermes and Takeda, research support from NIH, Genomind, and Brainsway, and he is on scientific advisory boards for Janssen and Verily, all of which are unrelated to the present work. This work was supported by NIH (KJR: P50-MH115874, R01-MH108665; EAP: RO1- DA042855), the Frazier Institute at McLean Hospital (KJR), and the James S. McDonnell Foundation (EAP). EAP, MAK, RJF, and ESL have nothing to disclose.

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These authors contributed equally: M. Alexandra Kredlow, Robert J. Fenster.

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Department of Psychology, Harvard University, Cambridge, MA, USA

M. Alexandra Kredlow, Emma S. Laurent & Elizabeth A. Phelps

Division of Depression and Anxiety, McLean Hospital; Department of Psychiatry, Harvard Medical School, Cambridge, MA, USA

Robert J. Fenster & Kerry J. Ressler

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EAP, RJF, MAK, ESL and KJR conceptualized, wrote, and edited the manuscript. ESL made the figures.

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Correspondence to Kerry J. Ressler or Elizabeth A. Phelps .

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Alexandra Kredlow, M., Fenster, R.J., Laurent, E.S. et al. Prefrontal cortex, amygdala, and threat processing: implications for PTSD. Neuropsychopharmacol. 47 , 247–259 (2022). https://doi.org/10.1038/s41386-021-01155-7

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Published : 20 September 2021

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research essay on ptsd

105 PTSD Essay Topic Ideas & Examples

🏆 best ptsd topic ideas & essay examples, 👍 good essay topics on ptsd, ⭐ simple & easy ptsd essay titles, ❓ ptsd research questions examples.

  • How PTSD Affects Veteran Soldiers’ Families The effects are even worse to the partner who is left behind; whether wife or husband because they are required to care for the children and the thought of being the sole bread winner makes […]
  • Analysis of Posttraumatic Stress Disorder in Military Personnel The experiences that military personnel undergo determine the nature and extent of the posttraumatic stress disorder they develop during and after their deployment. However, Ramirez had resilience factors that helped him to cope and manage […] We will write a custom essay specifically for you by our professional experts 808 writers online Learn More
  • Post Traumatic Stress Disorder (PTSD) as a Health Issue in the Society The treatment is aimed at relieving the symptoms that the patient seems to be experiencing so that the individual can be able to deal with the traumatic experience.
  • Characteristics and Treatments of Post Traumatic Stress Disorder For in-depth understanding of the background of PTSD is, this paper will adopt a specific definition of abnormality that relates to the disorder itself. The category of the syndrome will also determine the type of […]
  • Post Traumatic Stress Disorder in Veterans and How Family Relationships are Affected Both qualitative and quantitative data shall be used with numbers being used to provide evidence of the occurrence and magnitude of the effects of the condition on the population.
  • The Effects of PTSD on Families of Veterans Drug abuse may result from the inadequacies in the coping abilities of family members as they try to come into terms with the suffering of their fellow family member.
  • Post Traumatic Stress Disorder: Assessment and Treatment Strategies If PTSD is ignored and fails to be treated, it can lead to disturbing consequences which widely affects not only the PTSD victim but also the relationships of the victim with his family and the […]
  • Abnormal Psychology: Posttraumatic Stress Disorder In addition, some of this research indicates that the differences in the degree of the disorder are due to the varying nature of the trauma experienced by that individual.
  • Effects of PTSD and Correlation between Diagnosis and Violence It is also worth noting that there is a correlation between PTSD and violence, though this has been cited to be of minimal significance.
  • Post Traumatic Stress Disorder Developed in Repeated War Zones Deployment Most of the combatants, usually, tailored a war awareness state to manage the consistent pressure of battle duty. Majority of the combat soldiers that were repeatedly deployed to war zones suffered post traumatic stress disorders.
  • Earthquakes as a Cause of the Post Traumatic Stress Disorder Although earthquake is a major cause of the post traumatic stress disorder, there are other factors that determine the development of the same.
  • Post Traumatic Stress Disorder: History and Symptoms This essay looks into the history, the symptoms of posttraumatic stress disorder, and the individuals who are likely to suffer from this condition, psychological problems associated with this condition and the treatment of the disorder.
  • Post-Traumatic Stress Disorder and Abused Women In most cases, these incidences of women abuse occur within the confine of a family set up or relationship where one partner tends to mistreat, mishandle, abuse and assaults the other partner and in most […]
  • Comparison of the Etiology, Diagnosis, and Treatment of DID and PTSD Individuals who were exposed to acts of violence in the past are likely to try and expose others to similar conditions. The inability to diagnose is attributed to the fact that the effects of these […]
  • Post Traumatic Stress Disorder and Its Treatment In this case a person constantly relieves the event through any of the following exposure to a situation that is similar to the event, vivid memories of the event, perceptions, and sometimes through dreams.
  • Critical Review of a Mental Disorder: The Post Traumatic Stress Disorder in DSM-IV-TR However, the risk to contracting the condition is always determined by the resilience of the personnel to these exposures, past unsettled concerns in their life history, and the quantity as well as intensity of depiction […]
  • Post-Traumatic Stress Disorder: Causes, Symptoms and Treatments One who is trying to numb and avoid remembrance of the event is likely to avoid thoughts, activities, places and even feelings that may associate with the trauma, have a feeling of detachment from others […]
  • Post-Traumatic Stress Disorder in Veterans Patient education is important in order to eradicate any form of misconception that the patients may have about PTSD, and enhance the levels of understanding of the patients, along with an improvement on their ability […]
  • Post Traumatic Stress Disorder Principles and Types The affected areas of the body include the nervous system, the brain and hormonal system. A number of issues are to be taken into consideration as for the treatment of the PDST.
  • Post-Traumatic Stress Disorder – Psychology Post-traumatic stress disorder is thought to be as a result of either corporeal disturbance or emotional disturbance, or more often a mishmash of both.
  • SNOMED-CT and PTSD Terminologies Based on the research questions described in the foregoing discussions, the researchers mapped a total of 153 PTSD-specific concepts and terms to the SNOMED-CT controlled medical terminologies and concept codes.
  • Post Traumatic Stress Disorder: Joseph Wolpe Treatment Theory This is similar to the concept of phobias wherein a person is presented with an animal that he is irrationally afraid of and the result is fear or in the case of an inanimate object […]
  • Post-Traumatic Stress Disorder: Gender Variations In this regard, the aim of the current research is to provide evidence that women have the same probability of getting PTSD as men.
  • Post-Traumatic Stress Disorder in Soldiers With the help of the course materials, I was able to understand that Huerta had a panic attack just from its description. It is critical to be honest with oneself and to accept the problem.
  • “One Family’s Fight Against PTSD” by Shawn Gourley It was a counselor, who precipitated the harmony in the family explaining both husband and spouse the fact that their life could not be the same as before.
  • Post Traumatic Stress Disorder: Caucasian Girl’ Case In Mary’s case, the medical practitioner will listen and encourage her to talk about the events when she feels ready. As a result, she will be in a better position to cope with the problem.
  • Post Traumatic Stress Disorder or Combat Fatigue According to Walser, the use of acceptance and commitment therapy is effective in treating a case of post-traumatic stress disorder, which entails the patients to experience positive and negative events without treating them as reality.
  • Post-Traumatic Stress Disorder Assets and Facilities It was easy to detect PTSD assets and facilities in the area, as the society and the government are currently establishing a vast amount of amenities for this disorder.
  • Kant’s and Mill’s Ideas for Post-Traumatic Stress Disorder From this review, the fourth section of the paper outlines the more compelling view, which is that Kant’s vision of a good life is more superior to Mill’s vision of the same.
  • PTSD as the Primary Factor Causing Infant Death The lack of studies on the issue of expecting mothers and their subgroups needs to be mentioned among the primary issues that hamper the process of addressing the problem concerning high infant death rates.
  • Emotion Regulation and Posttraumatic Stress Disorder This choice can be attributed to the positive role of the family in the emotional and cognitive function of a sufferer. The proposed intervention is to be in the form of a workshop for families […]
  • Post-Traumatic Stress Disorder and Its Theories The study by Bandelow et al.showed that the development of PTSD is associated with the dysregulation of the hypothalamic-pituitary-adrenal axis and the impaired sympathoadrenal medullary system as part of immunity.
  • Posttraumatic Stress Disorder: Modality Treatment Plan With the problem of nightmares and the related lack of sleep, the unmet need of psychological stability results in the interruption of sleep because of traumatic thoughts and nightmares.
  • Cognitive Behavioral Therapy in Treating PTSD The chosen case is the case of Ivan S, who is a war veteran who suffers from a variety of psychological symptoms that affect his relationships with his family and loved ones. Secondly, Ivan shows […]
  • Posttraumatic Stress Disorder Treatment in Soldier Within the framework of the reviewed case, one of the key needs of the soldier is to be able to cope with anger and irritation.
  • Posttraumatic Stress Disorder in Hispanic Teenager Family dynamics and social withdrawal do not seem to have affected the client’s academic history; her grades are good and she has no history of behavioral problems.
  • Racial Disparities in Posttraumatic Stress Disorder Treatment Within the framework of this submission, the author is going to discuss several components that may critically impact the complexity of psychological traumas received by African American soldiers and provide a conceptualized policy that will […]
  • Posttraumatic Stress Disorder Management in Children The purpose of this paper is to determine whether the application of the perspective of clinical psychology as the platform for treating PTSD in children will have better effects than the adoption of the methods […]
  • Post-Traumatic Stress Disorder in Missouri Veterans Unfortunately, the implemented policies have failed to meet the needs of different veterans, such as the Welcome Back Veterans, the Veterans Health Administration, and the Military Health System. Louis has several policies and programs aimed […]
  • Post-Traumatic Stress Disorder and Treatment Effectiveness In the final section, the effectiveness of all the explored interventions will be discussed to summarize the results of the present literature review.
  • “Emotional Freedom Technique and Post-Traumatic Stress Disorder” by Rebecca L. Fahey The author considers a special method of influencing military veterans who experience the effects of PTSD and feel acute bouts of depression.
  • Posttraumatic Stress Disorder in Veteran Community The creation of special programs for the rehabilitation of veterans helped alleviate the problem of PTSD during the wars in Iraq and Afghanistan and facilitated the development of a support system that is currently used.
  • Post Traumatic Stress Disorder: German Researches The other objective of the study was to identify the specific features a traumatic event could influence PTSP in the solders.
  • Post Traumatic Stress Disorder: Causes and Consequences An interesting finding from the interview is that Abby and her husband had faced the accident together, however, the reactions of the two to the accident were radically different.
  • Posttraumatic Stress Disorder After Rape Attempt During the treatment of the patient, the Target Memory is the day the girl was attacked. In her treatment, it is necessary to eliminate the feeling of guilt for the accident.
  • Living With Post Traumatic Stress Disorder This can be achieved by making efforts to keep away from the people and also the places that act as a reminder of the events.
  • Disaster Crisis: Post-Traumatic Stress Disorder Symptoms Since the account of the incidence, almost a month, she lost interest in work and concentration on activities relating to work at her place of work.
  • Client Diagnosis: Posttraumatic Stress Disorder As for the PTSD itself, the client meets criterion A because she reported car accident involving death of the other passenger.
  • Post-Traumatic Stress Disorder Treatment in Intellectually Disabled Patients: The Promise of Eye Movement Desensitization and Reprocessing Therapy The use and application of findings that shed light on current research gaps related to the effectiveness of EMDR in PTSD patients with IDs may contribute to improvements in this population’s quality of life and […]
  • Post-Traumatic Stress Disorder: Overview The overall process of evaluation and analysis of the film was done correctly and adhered to the standard principles of counseling.
  • Post-Traumatic Stress Disorder (PTSD) Among Vets One of the integral components of this concept is the problem of traumatic stressors, as is customary in international classifications, the issue of post-traumatic stress disorder.
  • Posttraumatic Stress Disorder The study seeks to find out the prevalence of TBI/PTSD and the variations in the prevalence based on the severity of TBI, as well as other related variables.
  • PTSD Mental Disorder: Triggers, Clinical Manifestations, and Treatment PTSD is normally characterized as a mental disorder that is a direct result of anxiety-related syndromes that came about as a direct result of a traumatic event.
  • Post-Traumatic Stress Disorder Diagnostics and Screening Do you observe a headache from the early morning? Do you have a headache when you sleep well?
  • Effective Use of Prazosin for Posttraumatic Stress Disorder All the traditional agents have shown to have several side effects and cannot be fully relied on in treatment of PTSD.
  • Cognitive Processing Therapy and Evidence Based Interventions for Veterans Diagnosed With PTSD According to the evidence attained, comprehensive and extensive evidence is crucial in providing a clear correlation of the benefits accrued from CPT in comparison to other forms of treatment.
  • IL-6: Predicting the Development of PTSD Therefore, it is important to understand and define the biological underpinnings of immune dysregulation in PTSD as it also plays a crucial role in helping us to understand the nature of the associations between PTSD […]
  • The Fiction Character`s PTSD Diagnosis: Rambo According to the American Psychiatric Association, experiencing traumatic events, witnessing the events, learning that a traumatic event occurred to a close person, and is exposed to aversive details of events are the triggers of PTSD.
  • Post-Traumatic Stress Disorder Pathophysiology Sakellariou and Stefanatou, further link threat responsiveness and fear regulation with the signalling of 5-HT within the amygdala; this is an area within the brain deemed essential in comprehending the reaction to fear and aetiology […]
  • “Experiences of Military Spouses of Veterans With Combat-Related PTSD” by Yambo Spouses living with PTSD veterans are unprepared and struggling to deal with issues that their husbands experience.
  • “Mindfulness Interventions in the Treatment of PTSD” by Williston The primary purpose of that article is to conduct a survey of meta-analyses related to the efficiency of cognitive behavioral therapy.
  • Substance Abuse Disorders and PTSD The concept indicates that people who have PTSD are at higher risk of substance abuse and consequently substance disorders due to the tendency to consume alcohol and use drugs to deal with stress.
  • Post-Traumatic Stress Disorder and Substance Use Disorder The hypothesis of self-medication is one of the mechanisms that can expound the comorbidity between post-traumatic stress disorder and anxiety illness.
  • PTSD Dual Representation Theory Use in Military Personnel However, it is the position of this paper that this is mere gender stereotyping and the real cause of trauma among women veterans has to do with sexual harassment.
  • PTSD in Charlie of “The Perks of Being a Wallflower” As an example of the latter, this paper focuses on the analysis of Charlie Kelmeckis, the protagonist of Stephen Chbosky’s novel The Perks of Being a Wallflower, and his PTSD.
  • 35-Year-Old Man With PTSD: Case Study In such a case, it is recommended this is precisely a recommendation, not a requirement to do an MRI, which would allow a better study of the patient’s body.
  • Psychiatry: PTSD Following Refugee Trauma The psychiatrists finally recognized PTSD in the first version of the Diagnostic and Statistical Manual of Mental Disorders after the mass occurrence of similar symptoms in Vietnam veterans.
  • Post-Traumatic Stress Disorder and Parenting Style On a scale of 1 to 10, with 1 being lowest and 10 being highest, how much do you believe that kids need to learn early who the boss is in the family?
  • Aspects of Secondary PTSD in Children They constantly contact and interact with each other, and the latter inadvertently affects the mental health of the former, which leads to the development of secondary PTSD.
  • Secondary Post Traumatic Stress Disorder in Children The relationship between parents’ experiences and interactions with the onset of PTSD in children will be explored. There is vast information on the management of treatment and prevention of PTSD in children.
  • Zaccari et al. (2020). “Yoga for Veterans With PTSD”: Content, Strength, and Weaknesses This discussion reviews the strengths and weaknesses of the method, sampling, and validity of Zaccari et al.research. The assertions reported in the article are supported by cited and referenced scientific studies, which enhances the validity […]
  • Sexual Aversion and Post-Traumatic Stress Disorder This aspect causes difficulties in prescribing therapy, since the latter requires a thorough study of the psychological nature of the problems. In the treatment of sexual aversion disorder, a doctor needs to investigate a complex […]
  • Post-Traumatic Stress Disorder Development Avoidance of objects that remind you of the traumatic incident is another symptom of PTSD. Identifying erroneous and unreasonable beliefs about the incident and replacing them with a more balanced image is also part of […]
  • Post Traumatic Stress Disorder in A Journal for Jordan Considering the loss of her husband in the war, Dana had not recovered, and the expression of irate reaction is a symptom of PTSD.
  • Post-Traumatic Stress Disorder: Case Conceptualization Samuel, an 8-year-old black male, lives in an adopted white family consisting of the father, incarcerated for domestic violence charges, the mother, the primary caretaker and the only home provider, and the older sibling.
  • Post-Traumatic Stress Disorder and Opioid Use in Veterans This study examined the proportion of United States veterans who had PTSD and engaged in the use of illegal opioids to cope with it or had done so in the past.
  • Post-Traumatic Stress Disorder Misapprehension A significant proportion of civilians are affected by post-traumatic stress but ignore the symptoms and fail to seek early interventions influenced by misconceptions about how PTSD develops and its symptoms.
  • Posttraumatic Stress Disorder Treatment Research Therefore, the advantage of qualitative research, in this case, relates to the ability to investigate patients’ PTSD treatment experiences and uncover their meanings.
  • The DSM-5 Criteria for Posttraumatic Stress Disorder The inference is backed by the fact that Victor’s traumatic situation is persistently manifesting intrusion symptoms such as nightmares, flashbacks, unwanted upsetting memories, and a lack of willingness to share previous hurtful events. Victor displays […]
  • Posttraumatic Stress Disorder: Case Presentation Report Date of initial assessment: N/A PSEUDO Name: Ana Ana is a self-referred and re-occurring client who entered counseling after the case of domestic violence. As a result, Ana expressed feelings of anxiety and fear […]
  • What Are the Signs of PTSD?
  • How Dogs Can Help Veterans Overcome PTSD?
  • What Is PTSD Usually Caused By?
  • How Do People Deal With PTSD?
  • What Are the Symptoms of PTSD?
  • What’s the Difference Between PTSD and TBI?
  • How the Cherokee Nation Can Overcome Generational PTSD?
  • Why Are People With PTSD Angry?
  • Does PTSD Change Personality?
  • What Happens if PTSD Is Untreated?
  • How Does PTSD Effect Veterans?
  • What Is the Diagnostic Criteria for Post-traumatic Stress Disorder?
  • Is PTSD a Permanent Disorder?
  • What Type of Mental Disorder Is PTSD?
  • Can PTSD Cause Mental Breakdown?
  • What Are PTSD Triggers?
  • Are People With PTSD Mentally Ill?
  • How Do Doctors Test for PTSD?
  • Can PTSD Be Mistaken for Bipolar?
  • What Are the Causes and Psychological Consequences of Post-traumatic Stress Disorder?
  • What Do PTSD Episodes Look Like?
  • What’s It Like Living With Someone With PTSD?
  • Can PTSD Cause Jealousy?
  • Does PTSD Affect Intimacy?
  • Can PTSD Cause Emotional Detachment?
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research essay on ptsd

The New Research about Complex Post-Traumatic Stress Disorder

by Shirley Davis | Jul 22, 2019 | Complex PTSD Healing , CPTSD , CPTSD Research , The Brain and CPTSD , Trauma-Informed | 12 comments

research essay on ptsd

There have been some truly remarkable research papers written about complex post-traumatic stress disorder (CPTSD) in the past few decades. Some of the research focuses exclusively on CPTSD while others can apply to any mental health disorder.

In this article, I’m going to break the ice in the series about complex post-traumatic stress disorder and new research findings.

A Definition of CPTSD

research essay on ptsd

I realize that many reading this article are familiar with the definition of CPTSD. However, for the sake of those who are not we shall examine a description of complex post-traumatic stress disorder and some older research outcomes.

CPTSD is a psychological disorder formed in response to prolonged exposure to interpersonal trauma. CPTSD forms in the minds of those who have little hope or no chance of escaping the trauma perpetrated against their person.

Used to explain complex post-traumatic stress disorder, the trauma model of mental disorders is associated with repeated sexual, psychological, physical abuse or neglect, and chronic intimate partner violence. CPTSD can form in childhood or adulthood depending on when the traumatic experiences began.

Symptoms of complex post-traumatic stress disorder vary from person to person, but a comprehensive list is below:

  • Reliving the trauma through flashbacks and nightmares
  • Avoiding situations that remind them of the trauma
  • Dizziness or nausea when remembering the trauma
  • Hyperarousal, which means being in a continual state of high alert
  • The belief that the world is a dangerous place
  • A loss of trust in the self or others
  • Difficulty sleeping or concentrating
  • Startling easy by loud noises
  • A negative self-view
  • Changes in beliefs and worldview
  • Emotional regulation difficulties
  • Problems with relationships
  • Thoughts or actions of suicide
  • Fixating on the abuser or seeking revenge

Neuroimaging of PTSD and It’s relevance to CPTSD

research essay on ptsd

A study conducted in 2013 concluded that not only were CPTSD and PTSD closely related, but there are also close similarities to borderline personality disorder (BPD) as well (Stevens,  Jovanovic, et. al. (2013) 1 . The similarities allowed researchers to conduct fMRI studies on those with PTSD and use the same data to project that the same damages were in the brains of people who live with CPTSD.

CPTSD and PTSD are not just for those who have experienced severe trauma such as rape or accidents. These two life-altering disorders affect fifty to seventy percent of the citizens of the United States and cost America over forty billion dollars per year. The suffering and impact on families and communities are profound, leaving many adults unable to cope with their lives and losing the ability to work well (Brenner, (2018) 2 .

Interestingly, some people traumatized individuals may not show symptoms for many years after the traumatic event. In fact, a paper published in the Neuroscience and Biobehavioral Review found that trauma-exposed people who presented without PTSD showed significantly smaller hippocampal volume, smaller amygdalae, and smaller cortical regions than healthy control subjects.

Not only were those brain regions affected, but regions that control intellect, such as the corpus callosum (the wiring of the brain) and smaller than average frontal lobe volume (the seat of intelligence) (Karl, Schaefer, et. al. (2006). 3       

The Findings from Neuroimaging Post-Traumatic Stress Disorder

Researchers have conducted many research projects using different modes of neuroimaging, including fMRI, PET, and newer forms of visualizing the brain come into existence every year (Bremner, Randall et. al. (1995).

What researchers looked at the brains of those who have experienced severe traumatic events, such as those returning from the war, they found damage to the amygdalae and hippocampi.

A study examined, with the then-new neuroimaging tool functional magnetic resonance imaging (fMRI) in 1980 revealed smaller than normal volumes in both the hippocampi and amygdalae of people living with the diagnosis of PTSD.

What this study shows is how two vital regions of the brain associated with emotional regulation and memory consolidation are damaged when exposed repeatedly to traumatic stress. 4, 5

Placing Complex Post-Traumatic Stress Disorder into a Spectrum

research essay on ptsd

By placing complex post-traumatic stress disorder into a spectrum means linking it to a range of conditions by similar symptoms and traits. This spectrum may represent a range of severity from “severe” to “mild nonclinical deficits.”

While classifying trauma disorders into a spectrum may seem to lessen the impact of complex post-traumatic stress disorder, it does not. By putting CPTSD into a spectrum, it will finally receive recognition in the next Diagnostic and Statistical Manual of Mental Disorders.

What Neuroimaging is Teaching Us

Neuroimaging has become a powerful tool in recognizing and treating complex post-traumatic stress disorder. However, studies on CPTSD directly are nearly non-existent. By using neuroimaging techniques and tools such as fMRI, scientists are getting closer to understating how badly trauma impacts both children and adults.

Children who grow up under stress from living in a dysfunctional family where they experienced some type of abuse or neglect, grow up with significant changes in their brains. Since they have damage to their hippocampi and amygdalae, they have problems regulating their emotions and overreacting to triggers in their adult environment that cause conflict in forming adult relationships.

Since the hippocampus and amygdala are vital for memory formation, survivors of childhood neglect and abuse have problems remembering events or even suffer from dissociative amnesia. Dissociative amnesia includes forgetting having said or done something or losing time for short periods without having alters like with dissociative identity disorder.

Clearly, complex post-traumatic stress disorder is highly disruptive to the lives of those living under its influence. However, new and exciting research about not just CPTSD but other mental health disorders as well shine a new light of hope for future treatments.

A Hint of Things to Come  

research essay on ptsd

Be sure to watch for the next installment in this two-part series because the next article will not only blow your mind but also give you hope and encouragement.

  References

  • Stevens, J. S., Jovanovic, T., Fani, N., Ely, T. D., Glover, E. M., Bradley, B., & Ressler, K. J. (2013). Disrupted amygdala-prefrontal functional connectivity in civilian women with posttraumatic stress disorder.  Journal of psychiatric research ,  47 (10), 1469-1478.
  • Brenner, G.H, (2018). New Study Shows Brain Change After Psychological Trauma. P sychology Today. Retrieved from: https://www.psychologytoday.com/us/blog/experimentations/201812/new-study-shows-brain-change-after-psychological-trauma
  • Karl, A., Schaefer, M., Malta, L. S., Dörfel, D., Rohleder, N., & Werner, A. (2006). A meta-analysis of structural brain abnormalities in PTSD. Neuroscience & Biobehavioral Reviews , 30(7), 1004-1031. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/16730374/
  • Bremner, J. D., Randall, P., Scott, T. M., Bronen, R. A., Seibyl, J. P., Southwick, S. M., … & Innis, R. B. (1995). MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder.  The American journal of psychiatry , 152(7), 973.
  • Pitman, R. K., Rasmusson, A. M., Koenen, K. C., Shin, L. M., Orr, S. P., Gilbertson, M. W., … & Liberzon, I. (2012). Biological studies of post-traumatic stress disorder. Nature Reviews Neuroscience , 13(11), 769.

research essay on ptsd

My name is Shirley Davis and I am a freelance writer with over 40-years- experience writing short stories and poetry. Living as I do among the corn and bean fields of Illinois (USA), working from home using the Internet has become the best way to communicate with the world. My interests are wide and varied. I love any kind of science and read several research papers per week to satisfy my curiosity. I have earned an Associate Degree in Psychology and enjoy writing books on the subjects that most interest me.

12 Comments

Samantha Ballew

Thank you! I have always been “forgetful”. I forget specifics of conversations and can’t remember previous things that I said. It has always made me feel crazy and i receive a lot of backlash because of how much i forget. Now I know I am not crazy and being forgetful is no fault of my own. Now I just have to figure out how to fix that.

Shirley Davis

I’m so glad you found my article helpful. Keep us posted on how you are doing. Shirley J. Davis

Jessica

Are there any studies being done? I have a PTSD diagnosis and when I brought this up to my therapist she had never heard of it. I really think that this fits my experiences a lot more. I would absolutely love to allow someone to pick my brain if it improves the quality of knowledge and care for future patients. The more we know the better the chance of finding the most successful treatment and getting the best help.

Yes, there are plenty of studies. You can find them on Google scholar. However, I don’t know if there are studies going on right now. Try Googling it. Sorry I can’t be of more help. Shirley

Alex

I have just been diagnosed with C-PTSD. They thought it was Ptsd at first but my symptoms have affected me my whole life it seems.

There doesn’t seem to be much info here in the uk. Is there any articles you can suggest on the above please? I’m trying to understand who i am at the moment if you can understand my logic. Thank you

Robert Courtnallfakelastname

I respectfully think that complex PTSD, is far more complicated, I suffer from it and want to interact with researchers, professionals and reach out to those suffering. I have all the symptoms, everyone, of CPTSD, it is too easily dismissed, as a personality disorder, but I believe, no. My mother had post-partum depression, badly, so I didn’t exist. This frustrated my father, who came emotionally/verbally abusive. My mother, against medical advice, went offer birth control and had a daughter, that she always wanted, growing up with all sisters, figuring, what do I have to live for anyway and that was her emotional rock. Obviously, now, my father saw that as betrayal, emotional/verbal abuse escalated, he called my sister, the amazing accident, I got sick of it and after saying it one too many times, I asked him to stop, flapped, hard enough for a room to hear it, not hurt, but a mental wound, his ego, challenged. He apologized, fine, but that fixes nothing. He then left, when I was 10, moving us to a crappy area, having to fit in, in fear of getting bullied, beat up, asked to man up and look after my mother, on disability for mental health, did not know how to drive and a sister, 6 years younger. He returns, lonely, this happened 4 times and I could not express myself at home, so it caused problems at school. It got worse, in other ways, he wanted me to take over a family business, I did not want to, I tried University, did well, but many abused student loans, parental signing of loans, so parents knew coverage mandatory, he wouldn’t sign it, the first time, it seems sunny outside, like a future, that would be mine, denied. Our city had the largest mental health hospital in the country, shut down, for the wrong reason, so I cashed in an insurance policy, with extra equity, asked a student counselor, how to get qualified for something and a community college, counseling course, added suicide prevention/interaction, but also, psychological testing and evaluation, in cooperation, with a large university, some long-distance courses, but my tutor, a professor, taught psychiatry. I was all in, went way above course requirements, ready every book on counseling, ran out, then psychiatric nursing books, ran out, then psychiatric manuals, mastered the DSM 4, interpretive guide, then medical accompaniment guide, less noted, then upgraded to the DSM 5, really, an amendment. I did terrible in grade school, hell at school, hell at home, a 51 to pass, then finished that course, with a 96, dropped to a 94, because, learning psychological testing and analysis, I overqualified for OCD, PTSD, Anxiety disorder, histrionic personality disorder, Major Depression and my assessment was correct, but I didn’t want to accept it, dropped 2 points. That is not brilliance, but the effort and desire to learn. I did my practicum at an addiction clinic, did testing, to help prepared psychiatrists, for consultations, asking for feedback, and usually, they said it was so spot on, the diagnosis, prognosis, tests used, scores, interpretation, medication I would use, they astounded, but it really wasn’t. Hard work, but this might sound selfish, I needed to help myself and in doing so, help others. * It doesn’t explain biological, or genetic disposition, it doesn’t explain happening so young, and emotional, cognitive cancer, if you will, I dropped my position, to the dismay of my clinic, citing, being an impaired professional, keeping my qualification, but this emotional cancer, was eating me alive and if I couldn’t give 100% to others, I was stepped down, hoped to get back, but took something simpler, but that became hard. ** To think about: how, after a family history of mental health, regardless of a living hell childhood? That is not a borderline personality disorder, I helped with that. I taught CBT and this was way beyond that, but helped, more minor cases, none good, but not this bad. I interacted with the U of Penn, looking at the FDA and drugs. How does it work? A drug company makes a drug, picks from, then, 30 researchers, paid $500,00 USD for their time, each tested 3 times and if failed, it failed, but too many passed and could not be repeated, by independent researchers and theirs, was to teach and findings were not good. It was found, that drug companies shared, who was passing drugs, with no chance to pass, in agreement, marketing would be competition, with billions at stake. One researcher, from an iconic university, had an income of $837,00 USD, but only $237,000 from the university, passing everything, to be picked again, put on lifetime suspension, “whoop de doo”! How many did he pass, wrongfully? There were 30 on suspension, from a year, 6 years, or life, it was predicted by them, it would rise, now 6 years, for bad, life for profound, now 130 lifetimes suspension. Example: Citalopram (Celexa), went generic, you get 7 years, then shareholders want a replacement, there is none, so they looked at, what entered the body, Escitalopram (Lexapro), mild filtering by the liver, more the casing, but it is the same drug, new name and it passed? How? Then Prozac (Fluoxetine) went generic, so did Zyprexa, an atypical antipsychotic (Olanzapine), both now generic, atypicals boost SSRIs (antidepressants), in small doses, so they were combined, called Symbyax and it passed, as new, when both could be combined generic and that is the relationship, between Imipramine (Elavil) and Desipramine (Norpramin), older, Tricyclic Antidepressants, meaning they affect Serotonin, Norepinephrine, and Dopamine, but with side-effects, they all do, underrated by all, but the move to SSRIs, was not better, just less lethal, if downing a whole bottle, if all effected, no kidding and the truth, is these are all stabs in the dark, with acknowledgment, that they have no clue how they work, guessing, fine, better than nothing, but this leads to treatment-resistant depression diagnoses, a number of failed antidepressants, but you may try six, but really, you tried 2 of each version, really 3, not 6. Paxil failed, really, Luvox was taken off the market, basically, I have seen, persons supported, off brutal street drugs, a former addictions counselor and nothing compared to weaning off of Effexor, I did and it was absolutely worse than what I saw, helping others come off of cocaine, heroin, or ecstasy. How could that go unnoticed and true? Why and how are atypicals passing so fast, new antidepressants passing so fast, they should be, better than nothing, some, but this broken system hurts those that are hurting, which is us. I used to be on the other side of the table, so I can see from both sides. It is alarming, that I often know more about medications, than doctors and pharmacists, not being smart, I learned, to be good at my job and I still look at my studies and it is brutal. One company noted, that it was 10% better than another, I wanted to know, what that meant and it meant, it was 1.9% effective, over 0.9% effective, so stats, are worse, than lies and mistruths. Celexa did show good efficacy (it works better than placebo (fake)), so that means Lexapro, has to be the same. Pdocs, look at a number of failed meds, then right them off, but most shouldn’t have passed in the first place, so giving up, is never good. Professional arrogance, is real, thankfully, my co-workers, were great. It really means, not keeping up with the times, or stubborn, or, both. * The seeming, good approach, I say seeming, is CBT, or DBT, (cognitive behavioral therapy and dialectic), needed, but not loving meds, it has to be in combination, but it sucks, for me, to have to find what I need to know out, that skill, not lost, but my pdoc, a good guy, seems to see that, as he knows better, how dare I suggest trying something and that is professional arrogance, even a good person. ** The takeaway and I want to talk to those, that are really looking at this, is CPTSD, is not the same as PTSD, with genetic predisposition a factor, it is not a borderline personality disorder, very responsive to CBT, or DBT, not the same. I remember feeling this, as early as 3 years of age, way before this could happen, not joking and it never stopped and you cannot develop, fully personality disorder, that young, without a genetic predisposition. This belongs, separate, in the DSM, as it is different. For those that don’t know, the DSM is like a maze. If this shows, move to here, if this symptom is there, but not this, move here, if both, move here and that is how it goes, so one symptom, changes everything and it takes communication, experience, an open mind, and cooperation. I do NOT know it all, I work hard to know, ask those that know more, know where to look, ask for validity and it is hard work, to help myself and I want to help others and work with professionals, so things change and their hard work, is not discounted. One form, of professional arrogance, is publication. If published, then shown wrong, that is not good for income, or reputation, but it is alright, to readdress it, being human, in a follow-up. I was asked to work on a manual and procedure guide, thinking, my boss if curious, I rewrote it, with experience learned, I got called into an office, I didn’t know, what I did wrong, but I was told, they wanted that, as the new policy manual and training manual, not just for them, but colleges and universities wanted it, for teaching and I was asked, if I would be willing to hand over copyright, or trademark rights and I said, of course. The goal is to help and that is not bragging, it happened and from hard work. If I screwed up, I would go back and note it, without hesitation, or arrogance. ** This is real, the symptoms are real, examining and listening to experts, not me, it seems, CBT, or DBT, similar, plus an antidepressant, that offer efficacy, it works, with least side effects, the goal, plus not eliminating benzodiazepines, for anxiety, wrongly hated, the stop panic attacks and it is not mental, for severe, but found, by accident and body overreaction, to high CO2 levels, but not abnormal, like an allergic reaction, which is an overreaction, to something harmless, by our own immune system and that changed the game, when psychopharmacological researchers found, they could induce them in themselves (accident), but only benzodiazepines would stop them, why, who know, but not and ADs, a game-changers. There is some hate, for good reason, but note this. If anyone is started on an AD, the dose is low, increased slowly, to minimize side-effects, biological adjustment, find a therapeutic dose, considered appropriate, but if the same is done, with a benzodiazepine, people scream tolerance, danger, narcotic, but anything, mixed with alcohol, or a street drug, to enhance the effect, is a narcotic, including, many anti-seizure medications. Lorazepam acts fast, with a shorter half-life (time for half to leave the body, metabolize), but clonazepam, has a slow onset and long half-life, so it feels more natural, not like being on an anxiety roller coaster. If Tylenol, enhanced the effects of street drugs, or alcohol, it would be a narcotic. *** This may sound like pushing meds, I hate them, but the information helps, you can dispute it, or look it up, stopping trying is stupid, it is all trial and error right now, but complex post-traumatic stress disorder is unique, it has to have a genetic predisposition, to happen to many so young, or at least, not discounted, not throwing everything under personality disorders, but there is validity when it makes sense, but in my opinion, suffering and those friends I ask, former co-workers, a team, agree, it is nothing, to help myself, others and want to cooperate with those, my educated, more experienced, to help all and they, not discounted. It sucks, to be honest, but giving up, is just dumb. Once something enters the Cochrane manual, the Cochrane Institute, in Scotland, my heredity, invite the best of the best specialists, but when someone challenges the status quo, they are often in a war against a decision, which does not make them wrong, but they face, wrongly, ridiculous and unprofessional hurdles, again, professional arrogance and that is among all professional, not picking on mental health professionals. *** This is for all, but if a professional reads this, I would love to interact with them, why this is so long, also valid, they will no true and cooperation moves forward. All the best, be well and I will use a fake name, with hackers everywhere, but can be contacted, easily. Be well to all and don’t give up, plus, don’t give up, advocating for yourself, or, not being a hater, find a doctor, that is a teammate, mandatory. * Important* I am not asking anyone to agree, mindlessly. I don’t know it all. If any helps, good. If wrong, fine. The goal, is to help everyone and that means helping professionals, hopefully taking note and I respect all other opinions, because you may be right, fine, me wrong, but ego is not in the way. Take care!

Erika

I was put on Effexor very high dose for a psychotic depression from Cptsd My second round after Cptsd all childhood from a malignant narcasstic mother This time it’s 9 years on and it permanent nothing touches it and I developed a host of severe chronic health conditions and told I have brain damage My psychiatrist tried everything over 8 years then said nothing more he could do. I’m still on the Effexor that’s 9 years. Do you think beneficial to come off it. I don’t know if it’s doing anything or just making me numb I think my Cptsd is permanent 3 rounds of it thanks to my evil mum

Mercedes Clampitt

I would like to be notified when new article is released.

I’m not sure how we would do that, but you can ask about it using the contact us at https://cptsdfoundation.org/contact-us/ Thank you for reading my articles, it means a lot to me. Shirley

Aaron Billings

This is new to me. Why is it new to me? I am reading and the challenges of my life suddenly make sense. Other people have similar symptoms. I don’t think this information is taught to people training to be therapists.

Joel theriot

Interested Joel Theriot

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  • Open access
  • Published: 21 February 2024

Challenges of living with veterans with post-traumatic stress disorder from the perspective of spouses: a qualitative content analysis study

  • Zahra Maddah   ORCID: orcid.org/0000-0003-3826-7205 1 ,
  • Reza Negarandeh   ORCID: orcid.org/0000-0002-7597-5094 2 ,
  • Soheil Rahimi   ORCID: orcid.org/0000-0003-0806-2823 1 &
  • Shahzad Pashaeypoor   ORCID: orcid.org/0000-0002-2012-3783 3 , 4  

BMC Psychiatry volume  24 , Article number:  151 ( 2024 ) Cite this article

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Background and objective

The needs and characteristics of veterans with post-traumatic stress disorder (PTSD) create significant challenges in family life, particularly for spouses. Identifying the nature of these challenges from the perspective of spouses leads to a more comprehensive and profound understanding of their existing problems and can be used for targeted interventions. Therefore, this research was conducted to explore the challenges of living with veterans suffering from PTSD from the perspective of their spouses.

This qualitative study used conventional content analysis to explore Challenges of spouses of veterans with post-traumatic stress disorder. Fifteen spouses of veterans with PTSD from the Veterans Affairs Center in Iran between June 2022 and January 2023, were purposively selected to participate in the study. Semi-structured in-depth interviews were conducted to collect data. The interviews were audio-recorded and transcribed verbatim. The data were analyzed using the method proposed by Graneheim and Lundman content analysis method with the support of MAXQDA 2020 software.

The mean age of the participants was 56.74 ± 6.43 years. Through data analysis, seven main categories and sixteen subcategories were identified. These categories included burnout (sleep disturbances, feelings of exhaustion), apathy towards self-care and caring for the veteran (neglecting self-care, lack of interest in continuing care), depression (feelings of hopelessness and being at the end of the line, decreased self-confidence ( Crushed and ignored (being mistreated, having multiple roles), relationship disturbances (Dissatisfaction with marital relationship,isolation and limited social interactions, disconnection from God), financial burden (heavy costs of care, lack of insurance support), and declining social status (negative attitude of the society, suffering from discrimination and inequality).

The consequences of PTSD-related injuries in veterans directly and indirectly affect the overall living conditions of their spouses. These spouses experience emotional detachment and constant rejection, leading to a decrease in their resilience against existing stressors and exposing them to disruptive and challenging issues in individual, family, and social dimensions of life that affect their physical and mental well-being. Therefore, these spouses require empowerment and access to social support in dimensions of educational, caregiving, therapeutic, and supportive. It is recommended that health policymakers pay special attention to designing up-to-date interventions to enhance the health of these spouses in physical, mental, spiritual, and social dimensions.

Peer Review reports

Introduction

Post-traumatic stress disorder (PTSD) is the occurrence of specific symptoms after experiencing or witnessing one or more very severe or unfortunate stressful events with the possibility of real death or the threat of death and severe injury [ 1 ]. It is a chronic mental disorder that may cause a person to feel fear, disorder or panic after seeing or experiencing a traumatic event [ 2 , 3 ]. According to the DSM-5, people may encounter such stressful events in one of the following ways: experiencing the event directly, witnessing the event for others, learning that an unfortunate event has happened to a loved one or close friend. War, physical attack, terrorist attacks, and natural disasters are all examples of traumatic events [ 2 ]. four specific symptoms of this disorder are: intrusions, avoidance, negative alterations in mood and cognition, and alterations in arousal or reactivity. These symptoms must persist for more than 1 month and cause functional impairment to be diagnosed with PTSD [ 2 , 3 ]. PTSD is the most common mental disorder among veterans returning from war [ 4 ]. This disorder occurs mainly in the first two years after experiencing trauma [ 5 ] in 9–25% of war casualties [ 6 ], and its prevalence in Vietnamese soldiers is 30%, in women [ 7 ] and men who served in Iraq [ 8 ], 14%, and the prevalence of this disorder has been reported as 14.9% in the Iranian military personnel [ 9 ]. According to available medical records, more than 80% of Iranian veterans have been diagnosed with PTSD [ 10 ].The most mental problems are reported among people who were often present on the front lines of war [ 11 ].

According to conducted studies, this disorder can have unpredictable, destructive, and irreparable consequences and outcomes for veterans, their family members, and the community [ 12 , 13 ]. These, in turn, result in significant indirect costs in terms of physical, mental, and social damages for both veterans and their family members, especially their spouses [ 14 , 15 ]. The spouses of these veteran’s act as like a refuge against these issues and are actually a way for the family to connect with the society [ 16 , 17 ].

Evidence shows that PTSD veterans often have problems such as anger, aggression and lack of intimacy between spouses. Lifelong contact with these veterans, having the roles of caregiver, wife, mother at the same time attending to the needs of children, taking care of other family members, being in charge of all the duties and responsibilities of life alone, they face problems in their daily life that lead to these people not having a normal routine in life like other members of the society. As a result, these individuals, unlike other members of the society, do not have a typical routine in their lives [ 18 , 19 , 20 ]. In fact, these spouses have a unique position because, despite having conditions similar to other individuals in society, they are particularly involved in dealing with the consequences of physical and mental disabilities endured by the veteran. This, in turn, threatens the well-being of these spouses and results in a decrease in their quality of life [ 19 , 21 ]. The results of a study conducted by Ghahramani et al. in Iran in 2022 revealed that spouses of veterans experience a low quality of life, particularly in terms of their mental well-being compared to other dimensions. Thus, it is crucial to pay attention to the families of veterans, especially their spouses [ 22 ]. Similarly, the findings of a study by Mousavi and colleagues in 2021 in Iran indicate that spouses of veterans with psychiatric disorders and PTSD obtained significantly lower scores on various subscales of the quality of life [ 19 , 23 , 24 ]. Moreover, a study by Allen et al. in Croatia in 2018 demonstrated the detrimental impact of chronic PTSD in veterans on the physical and mental health, social relationships, and overall quality of life of their spouses [ 25 ].

The spouses of veterans with PTSD, as indirect victims of war and the closest individuals to these patients, play a vital and key role in the lives of these veterans [ 26 ]. They face numerous unavoidable challenges in their social, professional, and family lives, and neglecting these challenges and problems can have detrimental effects on their well-being and functioning [ 18 ].

One of the important factors that play a role in the interactions of family members is family dynamics. Family dynamics are defined as unique methods used by each family member to interact within the family [ 27 ].

This theory holds that family interactions are interconnected like the links of a chain, it is not possible for one family member to experience difficulties without affecting other family members [ 28 ]. Furthermore, the family is the primary source of emotional support during psychological and social pressures. When this source encounters problems, each family member becomes exposed to considerable psychological and social pressures. Therefore, these pressures can have a negative impact on the function of family members and cause a crisis in the family [ 29 ].

Since the mental effects caused by war are chronic and progressive and continuously affect the quality of life of the affected person, family members, especially their spouses who try to support the veteran [ 30 , 31 ].

Previous research indicates that the challenges faced by spouses of veterans with PTSD have not been directly studied as a distinct topic until now. Considering that these spouses are among the most influential individuals in promoting the health and improving the quality of life of family members, and considering that most studies conducted in Iran have primarily focused on veterans and fewer studies have specifically targeted the spouses who are often the forgotten victims of war, it is essential to address their specific challenges [ 32 , 33 ]. Wives are an integral part of veterans’ lives, unfortunately, as a result of living with the injured person for a long time, signs and symptoms of post-traumatic stress disorder are observed in them [ 34 ]. Also, considering the cultural and religious differences of the Iranian society, especially in this group of people, and the existence of a gap between theoretical and practical knowledge among the life experiences of the veterans’ caregivers, these experiences can be obtained with the help of a qualitative study [ 35 ]. This study was conducted to answer the question, “What are the challenges of living with a veteran diagnosed with PTSD and what effect does it have on their personal, family and social life? " In other words, the research team intended to elucidate the challenges faced by spouses of veterans with PTSD in order to design targeted interventions to improve their mental well-being. Therefore, it is necessary to deeply explore these challenges through a qualitative study. Qualitative research data are of a subjective nature, derived from the perceptions and beliefs of the study participants. As a result, these studies provide a valuable approach to describe lived experiences and contribute to understanding human experiences [ 36 , 37 ]. By explaining the challenges faced by the wives of PTSD veterans, a more comprehensive view and knowledge can be obtained on the problems of this group of women, who have received less attention, also the identification of these challenges can be the basis for further studies for effective planning to improve the performance of these women, because these women are close The most important people are considered to be veterans, and by improving the performance of these women. Regarding the above mentioned issues, we designed this qualitative study with the aim of exploring the challenges of living with a veteran diagnosed with PTSD from the perspective of their spouses.

Materials and methods

Type of study.

A qualitative study with a conventional content analysis approach was conducted from June 2022 to January 2023. In this method, information is directly obtained from the participants without preconceived ideas, imposed opinions, or predetermined theoretical perspectives. The knowledge generated through this approach is based on the perspectives of the participants and obtained from the data derived from the interview transcripts [ 38 ].

Participants and research setting

The research population consisted of the spouses of veterans with PTSD. The inclusion criteria for participants in this study were women whose spouses were veterans diagnosed with PTSD by a psychiatrist, who were in a current marital relationship at the time of the study, were able to communicate in Persian, had no hearing problems, and had at least basic literacy skills in reading and writing. The exclusion criteria were severe mental disorders and receiving psychiatric treatments, an obvious physical disorder that leads to the creation of limitations and challenges in the individual, so that due to this disorder, the veteran does not have the necessary ability to seek care, for example, paralysis., and withdrawal from the study at any time of the study. In this study, 15 spouses of veterans who spoke Farsi were selected. The research was conducted at the Veterans Affairs Center in Iran. This center serves as the main source of information and services for veterans returning from war in Saveh County. Due to easy access to the research population and the participants being covered by this center, it was selected as the research setting.

The process of selecting the participants was such that the researcher was present at the Department of Veterans and after obtaining permission from the head of the center to study the files of the veterans, she first identified the veterans suffering from post-traumatic stress disorder and then made a phone call to their spouses, and receiving information from them, if they met the entry criteria and were willing to participate in the study, while explaining the objectives of the research, he invited them to an interview to get their experiences. The average duration of each interview ranged from 30 to 45 min Three interviewees were re-interviewed.

Data collection method

In order to collect the data, semi-structured, in-depth, face-to-face interviews were conducted in a quiet room without any environmental distractions at the Veterans Affairs Center. The interviews commenced with open-ended questions and were purposefully guided to explore the challenges of living with a veteran diagnosed with PTSD. The interview method was flexible, allowing the researcher to gather more detailed information compared to other methods. The interviews were conducted based on an interview guide developed by the research team, which included questions such as: “please describe your experiences of living with your veteran’s husband” and “please explain your difficulties and challenges in your life” and “How has your husband’s condition affected your family life? ”and “How has living with this person affected you socially?” Probing questions were also used during the interviews to ensure the researcher’s understanding of the participants’ statements, encourage further elaboration, and explore emerging topics. Unlike the main study questions, probing questions were not predetermined [ 39 ]. Probing questions were asked for further clarification (e.g. “What do you mean?”, “Will you elaborate further?”). Silent probes allowed participants to reflect on descriptions Towards the end of each interview, participants were invited to share any additional thoughts, and the possibility of future interviews with them was discussed. All the interviews were conducted in Persian by the first author, a doctoral student trained in healthcare qualitative research. Data collection and analysis were simultaneous and during this process the topic guide was modified to explore emerging areas of interest. The participants were also asked for their permission to be contacted if the researcher had any further questions. Data collection continued until data saturation was reached, meaning that in the last two interviews, participants reiterated ideas similar to the information obtained from previous interviews, and no new concepts or categories emerged. Data saturation occurs when no new information can be extracted from the data, and the categories have reached their maximum possible development [ 40 ]. The participants’ interviews were recorded using an audio recording device with their full awareness and consent. Subsequently, the participants’ conversations were transcribed verbatim as soon as possible after each interview.

Data analysis

The data were analyzed using the conventional content analysis approach. Content analysis is a qualitative data analysis method used to categorize sentences. It is a research method to describe the content derived from communication systematically and objectively [ 41 ]. In this study, data analysis was performed using the Graneheim and Lundman’s approach, which involves five steps for analyzing qualitative data: (1) transcribing the interview completely immediately after each interview, (2) multiple readings of the entire transcripts to gain a general understanding of the content, (3) Identifying meaning units and basic codes, (4) categorizing initial codes into broader categories, (5) determining the main theme of the categories [ 42 ]. To understand and immerse in the data, the transcripts were read multiple times to develop a comprehensive understanding. Each section of the text was then assigned a name or code, and notes were made in the margin. The codes were then compared for similarities and differences, and codes that were similar or had similar meanings and concepts were grouped together. Based on this process, initial categories of codes were developed, and all categories were compared and classified. The classification process continued, and in the end, subcategories and main categories were derived. The coding and categorization process of categories and subcategories was reviewed and revised in multiple research group sessions. This process continued until the group reached agreement on coding and categories, and ultimately, by repeated examination of the categories and contemplation of the overall concept derived from each of them, the underlying meaning of the text and the main category were extracted. we used MAXQDA 2020 for managing codes, themes and memos. Memos were written throughout the analysis process to capture thoughts and reflections of the spouses of veterans with PTSD statements.

Trustworthiness of data

In this study, the four criteria of Lincoln and Guba including credibility, transferability, confirmability, and dependability were used to check the validity of the data [ 43 ]. To ensure the credibility of the findings, we used debriefing by peer and member check methods. In the case of peer debriefing, we had a request to peers who were not researchers on the study but had critique expertise in the field of Veterans PTSD including Psychiatrist and psychiatric nurse. The research team committed themselves to adhere to the topics of the peers and take their opinions into account in the final conclusions. In order to member check, a summary of the interview was returned to the participants to confirm or refute the accuracy of the researcher’s perception. In cases of disagreement between the perception of researchers and the opinion of the participant, we tried to reach a common understanding about the subject through interaction with participants. To improve the transferability of the findings, purposeful and heterogeneous sampling was used in terms of Age, education, Employment status, Income. Audit trial and peer review were used to control the dependability of data. Our research team with different expertise reviewed, revised, and confirmed all encoded data and determined subcategories and categories to confirm the confirmability of the data.

Initially, the study objectives were explained to the participants, and written informed consent was obtained from those who were willing to participate in the study. Additionally, permission was obtained to record the interviews using an audio recording device. Furthermore, the participants were assured of the principles of confidentiality, anonymity, voluntary participation in the study, and the freedom to withdraw at any time without any consequences. The participants were actively involved in determining the time and location of the interviews, ensuring a collaborative approach.

Based on the findings, the mean age of the participants in the study was 56.72 ± 6.34 years. Furthermore, 33.33% of the individuals had a primary education, 60.00% were housewives, and 66.66% had 1 to 3 children. Additionally, 53.33% of the participants expressed that their income was not sufficient for a decent life. More details are presented in Table  1 .

The analysis of the interviews led to the extraction of 721 initial codes, which were further reduced to 172 codes through repeated reviews of the codes and comparison of their differences and similarities. Finally, these codes were categorized into sixteen sub-categories and seven main categories related to the spouses’ perspectives on the challenges of living with a veteran diagnosed with PTSD. These categories included burnout, apathy towards self-care and caring for the veteran, depression, Crushed and ignored, relationship disturbances, financial burden, and declining social status, as shown in Table  2 .

Given that the spouses of veterans are constantly in the role of caregivers and repeatedly face the challenges associated with the veterans, and considering the significant responsibilities they have within the veterans’ families, caring for these individuals can lead to burnout over the years, both physically and mentally.

In this study, the burnout category included two subcategories: sleep disturbances and feelings of exhaustion.

Sleep Disturbances The spouses of the veterans stated that due to the sleep disorder, which is one of the common problems in the veterans suffering from post-traumatic stress disorder, they also experienced sleep problems such as low-quality sleep, difficulty falling asleep, chronic insomnia, and a sense of insecurity.

The participants expressed their experiences in this regard, “I can’t sleep due to the intensity of stress. I may sleep for about 4 to 5 hours during the whole day, but I never have a deep sleep within that duration.” (P. 5)
I wake up at the slightest sound during sleep. Sometimes, I wake up multiple times during the night and go back to sleep. When I wake up in the morning, it feels like I haven’t slept all night. (P. 7)

Feelings of exhaustion A number of participants stated that they have experienced constant feeling of tiredness, inability to do household chores, lack of strength and energy, aggravation of physical problems caused by the maintenance and care of veterans.

One of the participants expressed it as follows, “I constantly have headaches, back pain, and leg pain all the time. My lower back bones have deteriorated, and I have taken many medications, but I don’t get better. Even though I’m not really old, because I have been doing heavy work since a young age and taking care of my spouse, I have ended up like this. I’m always tired, I have no motivation or energy for anything.” (P. 2)
I feel that in recent years, I have become very incapable. It’s not that I’m being lazy, no, I just don’t have enough energy and strength to get up and do my work. Most of the time, my tasks remain unfinished, and it frustrates me. (P. 13)

Apathy towards self-care and caring for the veteran

In addition to caring for their husbands, the spouses of veterans with PTSD are also responsible for raising children and attending to all daily life tasks and responsibilities. These responsibilities signify the challenging roles these spouses have in their lives. Over time, these factors can lead to indifference and neglect towards self-care and the care of the veteran.

This category contained two subcategories: neglecting self-care and lack of interest in continuing care.

Neglecting self-care The spouses of veterans with PTSD, due to their continuous engagement in caring for their spouse and fulfilling multiple responsibilities, often neglect their own health, both physical and mental. This self-neglect can put these spouses at risk of developing physical and mental illnesses. Ignoring physical problems, disregarding their own mental well-being, lack of self-care, lack of motivation for self-care, and neglecting oneself were other challenges of living with a veteran diagnosed with PTSD. In this study, the participants believed that they lacked sufficient time, motivation, and conviction for self-care.

They expressed their experiences as follows, “…… I went to several doctors, and most of them said I needed surgery. But I wonder, if I undergo surgery, I’ll have to spend some time in bed. Then who will take care of this life and the children? Who will do my tasks? My husband is also unwell so I can’t expect him to help.” (P. 4)
I’ve given up on myself, may God protect me. Just being able to manage the issues and problems of my life is a lot. I don’t have time for myself anymore.” (P. 5)

Lack of interest in continuing care Feeling annoyed with the veteran and children, lack of appreciation from the veteran, and experiencing a sense of indifference towards continuing caring for the veteran were among the challenges of living with veterans suffering from PTSD. In this study, some of the participants believed that they had become disinterested in continuing to take care of the veteran, which could be attributed to emotional detachment and the veteran’s lack of appreciation for their efforts and sacrifices.

The participants expressed their experiences as follows, “I try my best to take good care of him, show him love, and give him his medications on time. But who appreciates it? Who knows the value of these hands that are worn out?” (P. 14)
I have always sacrificed so much to take care of him, neglecting my own needs and interests, just to ensure I can take good care of my husband. But it’s a shame that he doesn’t even recognize my love and care. There have been times when, due to his aggressive behavior that threatened my life, I had to leave home, but my heart couldn’t stay away, and I came back.” (P. 9)

Since veterans with PTSD themselves face significant psychological and social challenges, it is highly likely that their family members are also at risk of experiencing psychological harm [ 44 ]. Among them, the spouse of the veteran is the primary emotional and psychological support for the veteran and is the first person directly exposed to secondary trauma and cognitive difficulties [ 45 ] According to the interviews, the spouses of veterans with PTSD have been involved in some psychological problems due to the problems and hardships of their husbands.

This category included two subcategories: feelings of hopelessness and being at the end of the line, decreased self-confidence,

Feelings of hopelessness (being at the end of the line) Lack of enjoyment in life, improper mental state, boredom, suicidal thoughts, death wishes, meaninglessness of life, decreased motivation, and insufficient emotional connection were among the challenges experienced by most participants in living with veterans suffering from PTSD.

Also The participants stated that they experienced a lack of hope in life, a sense of being defeated, and a lack of purpose. They argued that due to long-term exposure to the challenges of living with a veteran suffering from PTSD, they had lost their hope.

The participants expressed their experiences in this regard, “I ask my spouse if he mistreats me because he thinks I am his prisoner. Sometimes, I pray to God for death to find peace.” (P. 4)
To be honest, life has no meaning for me anymore. I have no motivation to continue living. Sometimes I ask myself how I’m still alive with all these problems. I should have died a hundred times by now, but…” (P. 15)
The participants shared their experiences in this regard, “I feel like a lifeless being. I just go through the days without any meaning. There is no joy, no purpose, no aspiration. I simply have nothing anymore.” (P. 8)

Decreased self-confidence The loss of self-confidence means lack of trust in one’s abilities and difficulty expressing opinions, which were among the challenges of living with a veteran suffering from PTSD, as expressed by some of the spouses in this study.

In this regard, one of the participants stated, “He made me stay at home all the time. I had become so secluded and my self-confidence had deteriorated to the point that I couldn’t even utter a single word outside or in family gatherings.“(P. 1)

Crushed and ignored

Despite their significant efforts to meet the needs of the veterans with PTSD and their families and juggling multiple roles simultaneously such as being a spouse and a mother, these spouses are unfortunately often overlooked and not given the appreciation they deserve. Not only are their efforts unacknowledged by the family members and the veterans themselves, but also they are mistreated and beaten by the veterans in many cases. This leads to a feeling of being alongside a sense of being overlooked.

In this study, this category had three subcategories: being mistreated, having multiple roles and having a sense of self-sacrifice.

Being mistreated Veterans suffering from PTSD are more sensitive than ordinary individuals due to the chronic nature of the illness and their mental engagement with traumatic war memories and psychological challenges. They are quick-tempered people who react very quickly to environmental stimuli and become aggressive [ 46 ]. Violent behavior is one of the consequences of veterans being placed in complex situations, which makes family members, especially their spouses, experience physical violence and psychological insecurity [ 47 ]. In this study, being mistreated refers to physical assault by the veteran, lack of physical safety, and fear and anxiety, with the spouses of veterans being the primary victims.

In this regard, the participants shared their experiences as follows, “My husband once physically assaulted me over a trivial matter. He hit me so hard that two of my teeth broke. Since then, I’m afraid to argue with him because when he gets angry, he loses control over his behavior.” (P. 12)

Having multiple roles , the participants stated that due to their spouse’s problems, they play multiple roles that sometimes conflict with each other.

In this regard, one of the participants said, “I’m exhausted from doing everything myself. Most household responsibilities, such as grocery shopping, clothing, etc. are on my shoulders. Although I make a great effort to manage everything well, sometimes I feel overwhelmed and on the verge of collapse.” (P. 6)
I was both the homemaker and the breadwinner. I had to carry the entire burden of life on my shoulders and handle both household and external tasks alone. Moreover, my spouse required constant care, and I had to take care of many personal matters on his behalf. (P. 4)

Having a sense of self-sacrifice One of the forms of emotional support that the spouses of veterans offered to them was self-sacrifice in various ways. They selflessly dedicated themselves physically, emotionally, and mentally to their spouses. However, due to the lack of recognition and understanding of their sacrifices and selflessness, these spouses developed a sense of self-neglect in their own lives. Their comprehensive caregiving, enduring suffering, self-sacrifice, concealing their pains, maintaining appearances, disregarding their own interests, sacrificing to preserve the family’s life, and letting go of the arguments were among the experiences shared by the participants.

In this regard, one of the participants said, “With all his anger and our arguments, I sacrificed myself for this life.” (P. 12)
Many people tell me that I have dedicated myself to my husband and children, that I am a generous and compassionate person who has managed to live all these years in such circumstances. (P. 3)

Relationship disturbances

Given the hardships that spouses of veterans with PTSD endure and the neglect they face from both family and society, Especially the veteran, they gradually experience disruptions in their intrapersonal and interpersonal relationships(including husband and wife relationships), as well as in their relationship with God [ 48 ].

This category had three subcategories, including Dissatisfaction with marital relationship, Isolation and limited social interactions and disconnection from God.

Dissatisfaction with marital relationship in a healthy marriage, the presence of a satisfying sexual relationship plays a significant role in maintaining the stability of the family unit. In veterans, sexual relationships and functioning may vary depending on the type and severity of their trauma [ 49 ]. Some spouses experienced a lack of desire for sexual intimacy and a decrease in the quantity and quality of their marital relationship, which, in turn, resulted in marital dissatisfaction and a growing distance between the husband and wife.

The Participants in this study expressed their experiences in this regard, “The mental condition of my spouse has also affected our intimate relationship to the point that I have no desire or patience for sexual intercourse.” (P. 14)
My spouse and I haven’t had any sexual relationship for about 5 years or more, and it all goes back to the psychiatric medications that he takes. (P. 8)

Isolation and limited social interactions Isolation and relationship disturbances were among the challenges mentioned by the majority of participants. In fact, one of the problems and hardships that spouses of veterans with PTSD endure is a sense of loneliness, which leads to a lack of connections with others.

In this regard, one of the participants said, “My interactions with relatives and friends have become limited. Relatives don’t drop by because of my spouse’s bad behavior, and I and my children are hesitant to visit relatives because he might suddenly cause a scene there.” (P. 6)
For several years, I have lost interest in socializing and connecting with others. This man has taken away all my motivation. (P. 11)

Disconnection from God based on the interview findings, the spouses, due to living with a veteran suffering from PTSD for a long time, experience a disconnection from God in various forms. Feelings of being abandoned, lack of peace, and anger towards God were expressed by the participants. This disconnection from God is experienced as a sense of unrest in these individuals.

In this regard, one of the participants said, “Every day I pray and ask God to help this man get on the right path, to bring his senses back so that our life can improve. But when I realized that God didn’t listen to my voice, I became very angry with Him, and I kept asking why He treated me this way, as I haven’t been a bad servant.” (P. 7)”

Financial burden

The participants stated that the absence or lack of money caused them to experience many financial problems. Veterans suffering from PTSD who are unable to work and have high medical expenses because the families of these veterans experience many financial problems in addition to physical illness due to the veteran’s mental illness. In this study, financial burden was classified into two subcategories, including heavy costs of care and lack of insurance support.

Heavy costs of care Many participants complained about the high cost of treatment and counseling fees as well as inadequate income. Veterans suffering from PTSD not only experience the physical and psychological effects of the illness but also suffer from the financial burden of their care. Their families are also concerned about the high medical expenses in addition to the challenges of caring for the veteran.

In this regard, one of the participants said, “Our income is meager, and it all goes for medication and treatment for my spouse. There’s nothing left for us.” (P. 13)
These veterans are in great need of counseling services. For each half-hour session my spouse attended, we had to pay 70,000 tomans. We had to go at least twice a week. I took my spouse for a few sessions, but I couldn’t afford to continue the treatment. My spouse only has a retirement pension, which barely covers our living expenses amidst these high costs. (P. 8)

Lack of insurance support Insufficient insurance support was among the issues mentioned by the majority of participants. According to the data, insurance only covers limited services such as occupational therapy, physiotherapy, and physician visits. However, it does not fully cover many services needed by these veterans, including medication costs. The participants stated, this issue has made their life situation worse. One of the participants said,

It’s true that my spouse has supplementary insurance, but most of the time, when we take my spouse for treatment, either it’s not covered by the supplementary insurance, or we have to pay out of pocket and then submit the invoices to receive a small percentage of the expenses several months later. It’s very difficult for us in this situation. (P. 13)

Declining social status

This category refers to how the valor and sacrifices of veterans were initially valued while the values have diminished over time.

This category encompassed two subcategories, namely negative attitude of the society, and suffering from discrimination and inequality.

Negative attitude of the society The reduction in the social status, unfair judgments, and negative attitude of the society were among the experiences reported by the majority of participants. They believed that Veterans suffering from PTSD due to many psychological problems and their families are considered as distinct social groups whose social status and respect are not adequately by some individuals. They had experienced negative treatment from some people towards veterans and their families.

In this regard, one of the participants said, “People keep their distance and say, ‘You’re lucky, the government takes care of everything for you. What worries do you have?’ But they don’t know that we are burning from within ourselves, regardless of how others perceive us…” (P. 3)
People don’t know how much we struggle. They think we have no worries or problems in our lives. They say, ‘You went to the frontlines once in your life, so what? It’s nothing now.’ But it lasts a lifetime. They think being a veteran is a ladder to your own and your children’s progress. (P. 1)

Suffering from discrimination and inequality The sense of discrimination among Families of veterans suffering from PTSD disorder refers to the feeling of injustice and in receiving privileges related to these people and their families, as well as the lack of proper access to resources and services in the society.

One of the participants said, “Because my spouse’s disability rating is below 25%, we don’t qualify for many benefits and resources, neither for us nor for our children. We don’t even have the right to object. It sometimes feels like we are being insulted.” (P. 14)
I strongly disagree with these percentage-based classifications. I know people whose situations are much better than my spouse’s, but they managed to get a higher rating through favoritism. It’s okay. I always tell my spouse that you went to war for the sake of God, entrust everything to Him. (P. 9)

The purpose of this study was to explore the challenges of living with a veteran suffering from PTSD from the perspective of their spouses. The identified challenges were categorized into seven categories, burnout, apathy towards self-care and caring for the veteran, depression, Crushed and ignored, relationship disturbances, financial burden, and declining social status.

After the war and the return of veterans to their families, the stressors arising from the war and their negative impact on the physical and mental well-being of the veterans and the family members, especially the spouses who repeatedly experience the turmoil of the afflicted person, persist [ 50 ]. These experiences lead to a reduction in the quality of life of the family members, particularly the spouses of these veterans [ 51 ]. The family acts like a system because the behavior of the members of a family is a function of the behavior of other family members, and if there is a problem in the behavior and states of one of the members, the balance of the family is disrupted. The influence of one member of the family on another member is obvious and clear, so that it is not possible for a person to have a problem in a family and this problem does not affect other family members [ 52 ]. Therefore, the families of PTSD patients are in a more difficult and unstable situation emotionally, which leads to burnout in the functioning of the family and presents challenges and crises over time [ 4 ]. These challenges were clearly observed in the findings of the present study, which were based on the interviews with participants (spouses of veterans with PTSD).

Sleep disturbance is one of the primary and most common complaints among spouses of veterans PTSD. Because veterans have behaviors such as nightmares, frequent waking up, severe insomnia, etc., they cause suffering and discomfort to their spouses and as a result, sleep disorders in them [ 53 ]. According to the findings of a study by Hojjati et al. in Iran (2017),the lived experiences of the spouses of veterans indicate a decrease in their sleep quality. These spouses, due to marital commitment, are concerned about the condition of their spouse even during sleep and unconsciously wake up at night to be present beside them [ 51 ]. These findings are consistent with the results of the present study, as the participants expressed that due to the unique and specific circumstances of their spouses, they were lacking sufficient, suitable, and quality sleep for a long time and suffered from chronic insomnia. This sleep disturbance, in turn, exacerbates the challenges they face in various aspects of their lives, including physical dimensions.

Nursing and caring for disabled people such as veterans, especially veterans suffering from post-traumatic stress disorder, causes the caregiver, who in most cases is the spouse of a veteran, to suffer from many physical problems. Some of these physical problems have psychological roots and others are caused directly by the patient [ 54 ]. The results of the present study revealed that the Conditions of veterans with PTSD veterans with PTSD had an impact on the physical and psychological well-being of family members, especially their spouses, who have continuous and long-term contact with these stressors, leading to feelings of fatigue, inability to perform household tasks, lack of capacity and energy to engage in activities, and consequently, exacerbation of physical problems. Polenick et al.in United States (2017) showed that living with physically and mentally disabled people causes physical problems in the spouse [ 55 ] and Akhoondzadeh et al.in Iran (2017) showed that the spouses of veterans with PTSD experienced significant physical, emotional, and psychological challenges due to their continuous and repeated interaction with the veterans [ 56 ]. These results are in line with the results of the present study.

Furthermore, Braš et al.in Croatia (2019) found that the spouses of veterans were significantly affected by the physical disabilities and psychological consequences experienced by the veterans [ 57 ]. These challenges, over the long term, disrupt family functioning and give rise to common issues such as shame, guilt, mistrust, and reduced intimacy within the family [ 19 ]. The enduring nature of these challenges can not only give rise to physical problems but also have an impact on the mental well-being of spouses, resulting in distress and the development of psychological disorders [ 58 ] The results of a study by Owens-King et al. (2019) revealed that the spouses of these veterans can be considered among the at-risk groups in terms of mental health [ 59 ]. The highest prevalence of psychological problems among these spouses is related to depression and anxiety [ 60 ]. Additionally, the findings of a study by Heydari et al.in Iran (2022) showed that the spouses of veterans with PTSD experienced more psychological consequences of post-traumatic events compared to other family members, since the hyperarousal symptoms of veterans contribute to serious impairments, such as stress and depression, in their spouses, leading to high levels of distress [ 61 ]. These findings are consistent with the results of the present study, highlighting that these spouses experience challenges such as hopelessness, reduced self-confidence, and a sense of sacrifice, which they struggle to cope with.

Beks et al.in Canada (2018) found that the level of violence and aggression, particularly domestic violence towards spouses, was significantly higher in families of veterans with psychological injuries compared to other families, which could be attributed to the heightened irritability of the veterans [ 62 ]. These findings are in line with the results of the present study, where the spouses expressed that despite their significant sacrifices in caring for the veterans, accepting additional caregiving roles alongside other heavy responsibilities, financial concerns, reduced social support, adaptation to adverse life circumstances, they experienced repeated physical abuse and violence from the veterans. They added that these experiences not only created feelings of insecurity, fear, and anxiety but also contributed to a sense of being sacrificed in life and ultimately led to disinterest in self-care and caring for the veteran. The persistence of these issues and challenges results in a sense of neglect and feeling overwhelmed, leading to impaired functioning of these spouses within the family. These findings are consistent with a study by Borjali et al. in Iran (2021) in this regard [ 63 ].

One of the challenges expressed by these spouses was that the veteran’s condition had affected intimate relationships within the extended family. These spouses must constantly play the role of a mediator between the veteran and the children and always maintain a support role for both parties, which creates additional pressure. Moreover, these veterans exhibit behaviors such as lack of interest and motivation in socializing with others, and they also face difficulties in their communication with others. As a result, the spouses of these veteran’s experience limitations in their interactions with others and subsequently become isolated. These findings are consistent with the results of a study by Khodabakhshi et al. in Iran (2019), which indicate that the pressures arising from providing psychological and physical care to the veteran also have negative effects on the relationship between the mother or spouse as the primary caregiver and the children and acquaintances [ 64 ].

Post-traumatic stress disorder may cause a veteran to be unable to perform his marital duties and tasks, and on the other hand, due to inefficient behaviors, may create conditions that cause problems in married life [ 65 ]. Allen et al. in United States (2018) found that the spouses of elderly veterans with PTSD had lower marital intimacy compared to other couples [ 25 ],which is consistent with the findings of the present study. The majority of participants expressed dissatisfaction with their marital relationship, which led to reduced life satisfaction, loss of hope in life, and decreased individual, psychological, and social functioning of the spouses over time. However, it should be noted that not all participants mentioned this issue; they neither explicitly reported a lack of satisfaction with their marital relationship, nor did they highlight a decrease in emotional and psychological intimacy between them and their veteran spouses.

The majority of the participants stated that when they faced challenges in life, they found solace in their spiritual and religious beliefs, which in turn created motivation and hope for them. They believed that the spiritual rewards of such practices were significant to them, rather than worldly rewards. As a result, they never surrendered to difficulties. However, some others expressed that sometimes the problems and issues were greater than what could be solely addressed by these religious beliefs. Consequently, it can be argued that individuals may exhibit different reactions. Some may resort to spirituality and seek help from God, accepting these challenges as divine tests, while others may reduce or sever their connection with God. These findings were evident in the results of the present study and are consistent with the findings of a study by Yahyazadeh et al. in Iran (2016) [ 18 ].

One of the challenges found in the present study was the financial burden, which is in line with the results of the study by Mitter et al. (2017), which showed that living with a disabled adult imposes additional costs on the family [ 66 ]. Evans et al. (2019) concluded that homelessness among combat soldiers and veterans has increased and needs a plan to improve [ 67 ]. Although veteran’s affairs covers some of the expenses of these people, many veterans do not use these privileges and medical expenses Excess creates problems for them. The results of the present study showed that one of the bothersome challenges for the veterans’ spouses was that the support available in the society for veterans and their families, in addition to being inadequate, also created an inappropriate psychological atmosphere and even led to social exclusion for these families. The attitude of the society and even some governmental institutions towards the phenomenon of veteran and being subjected to unjust judgments constantly offended these families. This, in turn, has caused suffering for the veterans and their children. These findings are consistent with the results of a study by Shafiei et al.in Iran (2022), which indicated that the general public’s stereotypical view towards the financial benefits and social privileges of veterans was often accompanied by bias due to their lack of awareness of the deeper realities. Sometimes, these issues become so intense that these families prefer not to mention their “father being a veteran” because they are faced with unrealistic and unjust judgments from others [ 68 ].

The overall belief was that the social status of these veterans has declined, which is consistent with the findings of a study by Khalili et al. in Iran (2018), who stated that the literature on veterans has undergone changes, and in many cases, the sanctity and social status of being a veteran have been diminished to a set of compliments as well as advertising and media discourse [ 69 ]. According to the findings of Khodabakhshi et al.in Iran (2019), there have been transformations in the values and perceptions associated with being a veteran and self-sacrifice, leading to a materialistic and livelihood-oriented approach to the extent that, in the overall societal perspective, the material and economic outlook has prevailed over the cultural outlook [ 64 ]. This is in line with the findings of the present study and reflects the complaints of the spouses, indicating that despite the limited and insufficient benefits and allocations considered for veterans and the heavy costs of their care, the negative attitudes of individuals in the society persist, leading to a sense of discrimination, humiliation, and deprivation of respect.

Furthermore, feelings of alienation and lack of organizational belonging towards service-providing institutions have led to a sense of deprivation of organizational identity. This dissatisfaction with service-providing institutions is consistent with the results of a study by Shariati et al.in Iran [ 70 ], indicating that veterans have gone to war and accepted its consequences due to their special values and beliefs. In other words, the value of self-sacrifice accompanies the insignificance of material rewards for them. This transformation has also added to the cultural concerns and the scope of separation and social isolation among veterans and some family members, especially their spouses and children [ 71 ]. Overall, the above factors indicate that the psychological and physical condition of veterans with PTSD casts a shadow over their entire lives, particularly their family life, has led to dissatisfaction among family members, especially the spouses of these veterans, and has created deep wounds in the economic, social, and cultural dimensions of their lives.

Limitations

The present study, similar to other studies, has limitations. One of the limitations was the trust of the participants, the spouses of the veterans did not have enough trust to express their challenges at first. The researcher tried to control this limitation by interacting with the spouses for a long time and gaining their trust so that they can express their behavior freely. Furthermore, another limitation of this study due to the nature of qualitative studies is that the generalization of the results cannot be considered with certainty.

The results of the present study demonstrated that the consequences of PTSD-related injuries in veterans directly and indirectly affect the overall living conditions of their spouses. These spouses experience emotional detachment and constant rejection, leading to a decrease in their resilience against existing stressors and exposing them to disruptive and challenging issues in physical, psychological, and social dimensions of life. The spouses of these veterans are at the center of the family and serve as a refuge in the face of life difficulties. In addition to fulfilling their spousal duties, they shoulder the responsibilities of motherhood and other roles, often prioritizing the needs of others over their own physical and mental well-being, in order to regulate the relationships within the family and with the community. Therefore, the identification of these life challenges is considered essential because it enables the implementation of beneficial and constructive measures to empower them in psychological, emotional, and physical aspects. It also allows them to benefit from social support in educational, caregiving, therapeutic, and supportive dimensions, such as counseling and providing appropriate information.

Since the spouses of veterans with PTSD have an important role in maintaining and maintaining the cohesion of the family environment, and with their flexibility and adaptability, they can play an important role in finding family balance and reducing stress and tensions in life. Therefore, support systems such as counseling and providing appropriate information can improve the quality of life of veterans’ spouses and subsequently improve the quality of life of veterans. In the meantime, teaching life skills and communication skills and stress management methods and increasing understanding and social support can be helpful ultimately leading to positive impacts on the society. it is essential to develop precise plans to address and facilitate the challenges faced by these spouses and to empower family members, especially the spouse directly involved in dealing with the difficulties arising from the veteran’s injury. Additionally, it creates the necessary environment and motivation for further research in this field for researchers.

Data availability

The datasets used and analyzed during the current study available from the corresponding author on reasonable request.

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Acknowledgements

This study was part of a PhD thesis approved by Tehran University of Medical Sciences, Tehran, Iran. We would like to thank the Research Administration of this university (Code: 63051), Community Based Participatory Research Center, Tehran University of Medical Sciences, Tehran, Iran and authorities of Veterans Affairs Center and all the spouses of veterans with PTSD who assist us in this study.

This study was funded and supported Tehran University of Medical Sciences and Health Services, Iran. The funding source had no role in the design of the study, the collection, analysis and interpretation of the data, and the writing of the manuscript.

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Zahra Maddah & Soheil Rahimi

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Reza Negarandeh

Department of Community Health and Geriatric Nursing, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran

Shahzad Pashaeypoor

Community Based Participatory Research Center, Tehran University of Medical Sciences, Tehran, Iran

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ZM and ShP: design of study and acquisition of data; ZM, RN, SR and ShP: drafting the manuscript. ZM, RN, ShP: data analysis; All authors assisted in revising the text and approved the final manuscript.

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The study was carried out in accordance with the Declaration of Helsinki. Study was approved by the Ethics Committee of Tehran University of Medical Sciences with the ethical code.IR.TUMS.FNM.REC.1400.225. Initially, the study objectives were explained to the participants, and written informed consent was obtained from those who were willing to participate in the study.

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Maddah, Z., Negarandeh, R., Rahimi, S. et al. Challenges of living with veterans with post-traumatic stress disorder from the perspective of spouses: a qualitative content analysis study. BMC Psychiatry 24 , 151 (2024). https://doi.org/10.1186/s12888-024-05572-y

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DOI : https://doi.org/10.1186/s12888-024-05572-y

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research essay on ptsd

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Post Traumatic Stress Disorder Essay Examples

Ptsd essay topics and outline examples, essay title 1: understanding ptsd: causes, symptoms, and treatment.

Thesis Statement: This essay explores Post-Traumatic Stress Disorder (PTSD) by examining its root causes, the range of symptoms experienced by those affected, and various therapeutic approaches and treatment options available to individuals struggling with PTSD.

  • Introduction
  • Defining PTSD and Its Diagnostic Criteria
  • Common Causes and Triggers of PTSD
  • Symptoms and Psychological Effects on Individuals
  • Treatment Modalities: Therapy, Medications, and Alternative Approaches

Essay Title 2: The Impact of PTSD on Veterans: Addressing the Mental Health Crisis

Thesis Statement: This essay focuses on the prevalence of PTSD among military veterans, the unique challenges they face, and the importance of providing comprehensive mental health support, including therapy, peer counseling, and community resources.

  • PTSD in Military Context: Causes and Traumatic Experiences
  • Challenges Faced by Veterans: Reintegration and Mental Health Stigma
  • Promoting Veteran Well-Being: Accessible Mental Health Services
  • Community and Government Initiatives to Support Veterans with PTSD

Essay Title 3: PTSD in Children and Adolescents: Recognizing and Healing Childhood Trauma

Thesis Statement: This essay sheds light on the prevalence of PTSD in children and adolescents exposed to trauma, emphasizing the importance of early intervention, trauma-informed care, and support systems for young individuals experiencing post-traumatic stress.

  • Childhood Trauma and Its Impact on Mental Health
  • Signs and Symptoms of PTSD in Children and Adolescents
  • Treatment Approaches: Play Therapy, Counseling, and Family Support
  • Educational and Community Resources to Address Childhood PTSD

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Benefits of Exersize in Reducing The Effects of Post-traumatic Stress

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Increased Violence in Toronto and The Prevention of Post Traumatic Stress Disorder

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PTSD Essay Topic Ideas & Examples

  • How PTSD Affects the Families of Veteran Soldiers
  • Analysis of Military Personnel with Post-Traumatic Stress Disorder
  • Post-Traumatic Stress Disorder (PTSD) as a Health Issue in Society
  • Post-Traumatic Stress Disorder Characteristics and Treatments
  • The Impact of Post-Traumatic Stress Disorder on Veterans Family Relationships
  • The Impact of PTSD on Veteran Families
  • Post-Traumatic Stress Disorder: Evaluation and Management Techniques
  • Post-Traumatic Stress Disorder is an Example of Abnormal Psychology.
  • PTSD Effects and the Link Between Violence and Diagnosis
  • Repeated Deployments to War Zones Led to the Development of Posttraumatic Stress Disorder
  • The Role of Earthquakes in Post-Traumatic Stress Disorder
  • The History and Signs of Post-Traumatic Stress Disorder
  • Comparison of the Etiology, Diagnosis, and Treatment of DID and PTSD
  • Post-Traumatic Stress Disorder and Abused Women
  • Treatment for Post-Traumatic Stress Disorder
  • Post-Traumatic Stress Disorder: Causes, Symptoms, and Treatments
  • Critical Review of a Mental Disorder: The Post-Traumatic Stress Disorder in DSM-IV-TR
  • Veterans with Post-Traumatic Stress Disorder
  • Principles and Types of Post-Traumatic Stress Disorder
  • Psychology of Post-Traumatic Stress Disorder
  • Terminologies for PTSD and SNOMED-CT
  • Joseph Wolpe Treatment Theory for Post-Traumatic Stress Disorder
  • Gender differences in Post-Traumatic Stress Disorder (PTSD)
  • Soldiers’ Post-Traumatic Stress Disorder
  • Shawn Gourley’s “One Family’s Fight Against PTSD”
  • Caucasian Girl’s Case: Post-Traumatic Stress Disorder
  • Combat Fatigue or Post-Traumatic Stress Disorder
  • Post-Traumatic Stress Disorder Resources and Assets
  • Concepts for Post-Traumatic Stress Disorder from Kant and Mill
  • PTSD is the Leading Cause of Infant Death

Good Essay Topics on PTSD

  • Posttraumatic Stress Disorder and Emotional Control
  • Theories of Post-Traumatic Stress Disorder
  • Treatment Strategy for Post-Traumatic Stress Disorder
  • Cognitive Behaviour Therapy for Post-Traumatic Stress Disorder
  • Military Post-Traumatic Stress Disorder Treatment
  • Post-Traumatic Stress Disorder in Latino Adolescents
  • Racial Disparities in the Treatment of Post-Traumatic Stress Disorder
  • Post-Traumatic Stress Disorder in Missouri Veterans
  • Post-Traumatic Stress Disorder Management in Children
  • Treatment Success for Post-Traumatic Stress Disorder
  • Rebecca L. Fahey’s “Emotional Freedom Technique and Post-Traumatic Stress Disorder.”
  • Veterans and Posttraumatic Stress Disorder
  • German Studies on Post-Traumatic Stress Disorder
  • Post-Traumatic Stress Disorder: Factors Affecting Its Development
  • Living with Post-Traumatic Stress Disorder
  • Post-Traumatic Stress Disorder After a Rape Attempt
  • Disaster Crisis: Symptoms of Post-Traumatic Stress Disorder
  • Post-Traumatic Stress Disorder is the client’s diagnosis
  • Eye Movement Desensitization and Reprocessing Therapy for Post-Traumatic Stress Disorder in Intellectually Handicapped Patients
  • Overview of Post-Traumatic Stress Disorder
  • Veterans’ Post-Traumatic Stress Disorder (PTSD)
  • Post-Traumatic Stress Disorder
  • Mental Disorder of PTSD: Risk Factors, Clinical Symptoms, and Treatment
  • Diagnostics and Screening for Post-Traumatic Stress Disorder
  • Effective Treatment for Post-Traumatic Stress Disorder with Prazosin
  • Evidence-based Interventions and Cognitive Processing Therapy for PTSD in Veterans
  • IL-6: Predictors of PTSD Development

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Posttraumatic Stress Disorder: Overview of Evidence-Based Assessment and Treatment

Cynthia l. lancaster.

1 Ralph H. Johnson Veterans Affairs Medical Center, 109 Bee Street, Charleston, SC 29401, USA; ude.csum@ycsacnal (C.L.L.); ude.csum@sreteet (J.B.T.); ude.csum@dsorg (D.F.G.)

2 Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 5 Charleston Center Drive, Suite 151, Charleston, SC 29401, USA

Jenni B. Teeters

Daniel f. gros, sudie e. back.

Posttraumatic stress disorder (PTSD) is a chronic psychological disorder that can develop after exposure to a traumatic event. This review summarizes the literature on the epidemiology, assessment, and treatment of PTSD. We provide a review of the characteristics of PTSD along with associated risk factors, and describe brief, evidence-based measures that can be used to screen for PTSD and monitor symptom changes over time. In regard to treatment, we highlight commonly used, evidence-based psychotherapies and pharmacotherapies for PTSD. Among psychotherapeutic approaches, evidence-based approaches include cognitive-behavioral therapies (e.g., Prolonged Exposure and Cognitive Processing Therapy) and Eye Movement Desensitization and Reprocessing. A wide variety of pharmacotherapies have received some level of research support for PTSD symptom alleviation, although selective serotonin reuptake inhibitors have the largest evidence base to date. However, relapse may occur after the discontinuation of pharmacotherapy, whereas PTSD symptoms typically remain stable or continue to improve after completion of evidence-based psychotherapy. After reviewing treatment recommendations, we conclude by describing critical areas for future research.

1. Introduction

Posttraumatic stress disorder (PTSD) is among the most common mental health disorders in the United States [ 1 ]. PTSD is associated with a chronic course and debilitating symptoms. This manuscript reviews the epidemiology and clinical characteristics of PTSD, current options for screening and treatment, and describes more recent directions in treatment research.

1.1. Epidemiology

PTSD develops after exposure to a potentially traumatic event. According to the Diagnostic and Statistical Manual of Mental Disorders (DSM; [ 2 ]), the traumatic event must involve exposure to actual or threatened death, serious injury, or sexual violence. Exposure is defined as directly experiencing or witnessing a traumatic event, or learning that a trauma occurred to a close family member or friend. PTSD can also develop from repeated or extreme exposure to aversive details of traumatic events, such as military photographers whose job it is to photograph the details of wartime atrocities, first responders who are charged with collecting human remains, and police officers who are repeatedly exposed to details of child abuse. The fifth edition of the diagnostic manual explicitly excludes exposure to traumas via television, movies, pictures, or electronic mediums, possibly due to concerns that the definition of trauma was enlarging to a construct too broad to be useful [ 2 ]. Even so, nearly 90% of the general population endorses experiencing one or more traumatic events (with the modal number of trauma exposures being three), such as sexual or physical assault, combat, motor vehicle accidents, and natural disasters [ 3 ].

Although most individuals experience a traumatic event during their lifetime, the majority of trauma-exposed individuals do not develop PTSD. The lifetime prevalence of PTSD is estimated at 8.3% [ 3 ]. During the weeks following a traumatic event, the vast majority of individuals exhibit normative acute reactions, such as intrusive thoughts or dreams about the event, hyper-alertness, irritability, and problems with sleep, memory, and/or concentration [ 4 , 5 , 6 , 7 , 8 ]. For approximately two-thirds of individuals exposed to a traumatic event, these symptoms resolve on their own with time [ 7 , 9 , 10 ]. PTSD thus is characterized by a failure to follow the normative trajectory of recovery after exposure to a traumatic event. A key to understanding this disorder is therefore investigating predictors of the trajectory of recovery or non-recovery.

Researchers have identified a dose-response relation between exposure to traumatic events and the subsequent development of PTSD, such that the prevalence of PTSD increases as the number of traumatic events increase [ 3 , 11 , 12 ]. PTSD is also more likely to occur after more severe types of trauma, such as rape, childhood sexual abuse, or military combat [ 13 ]. Furthermore, the population trajectory seems to differ by trauma type. In comparing intentional to non-intentional traumas (as distinguished by whether harm was inflicted deliberately), Santiago and colleagues [ 10 ] found that PTSD prevalence increases over time among survivors of intentional trauma, whereas the opposite is true among survivors of non-intentional traumas.

Higher risk for PTSD has also been associated with numerous pre-trauma variables, including female gender, disadvantaged social, intellectual, and educational status, history of trauma exposure prior to the index event, negative emotional attentional bias, anxiety sensitivity, genetic subtypes implicated in serotonin or cortisol regulation, as well as personal and family history of psychopathology [ 11 , 12 , 14 , 15 , 16 , 17 ]. PTSD risk factors related to peri-traumatic and post-traumatic variables include perceived life threat during the trauma, more intense negative emotions during or after the trauma (e.g., fear, helplessness, shame, guilt, and horror), dissociation during or after the trauma, lower levels of social support after the trauma, and generally more severe symptoms during the first week following the traumatic event [ 12 , 18 ].

1.2. Clinical Characteristics

In addition to a history of trauma exposure, PTSD is characterized by four clusters of symptoms: (1) re-experiencing symptoms (e.g., recurrent intrusive memories, traumatic nightmares, and flashbacks); (2) avoidance symptoms (e.g., avoiding trauma-related thoughts and feelings and/or objects, people, or places associated with the trauma); (3) negative changes in cognitions and mood (e.g., distorted beliefs about oneself or the world, persistent shame or guilt, emotional numbing, feelings of alienation, inability to recall key details of the trauma); and (4) alterations in arousal or reactivity symptoms (e.g., irritability, hypervigilance, reckless behavior, sleep disturbance, difficulty concentrating). In order to qualify for a diagnosis of PTSD, these symptoms must be present for more than one month, lead to significant distress or functional impairment, and must not be due to medications, substance use, or a medical condition.

2. Assessment of PTSD

The thorough assessment of symptoms is an essential component in the effective treatment of PTSD. The primary goals of assessment include the detection of trauma exposure, evaluation of DSM-5 PTSD criteria, and ongoing assessment of symptom severity during treatment [ 19 ]. Assessment procedures may involve several steps, ranging from the initial screening typically conducted in non-specialty clinics (e.g., primary care offices) to lengthy diagnostic interviews, and self-report symptom questionnaires. Together, the data gathered through these various methods provides invaluable information that can be used to inform treatment planning and monitor treatment progress. Numerous assessment tools have been developed and investigated for PTSD. The following sections focus on the most common and empirically supported measures relevant to diagnostics, treatment planning, and treatment monitoring for PTSD (see Table 1 for overview).

Commonly used screening and self-report measures for trauma exposure and PTSD symptom severity.

2.1. Initial Screening

Several brief tools have been developed to screen for exposure to a Criterion A traumatic event, which allows for rapid identification of persons at-risk for PTSD. These screening tools are especially relevant to busy settings that necessitate that a large amount of data be collected in a short period of time, such as primary care clinics [ 20 ]. Although there is no gold-standard trauma-exposure screener [ 19 ], several options with growing support in the literature exist [ 21 , 22 ]. Questionnaires such as the Trauma Assessment of Adults [ 21 ], the Brief Trauma Questionnaire [ 23 ], the Life Events Checklist [ 24 ], and the Trauma Life Events Questionnaire [ 22 ] all have psychometric support for evaluating exposure to potentiality traumatic events. In addition to trauma exposure screeners, abbreviated PTSD symptom screeners are frequently used to determine the need for more in depth clinical interviews. These include the Primary Care PTSD Screen (PC-PTSD; [ 25 ]), the Short Form of the PTSD Checklist-Civilian Version [ 26 ], the Trauma Screening Questionnaire (TSQ [ 11 ]), and the Short Post-Traumatic Stress Disorder Rating Interview (SPRINT [ 27 ]).

2.2. Diagnosis

After initial screening, more advanced assessment procedures should be conducted to establish clinical diagnosis of PTSD based on the DSM-5 diagnostic criteria. In general, these diagnostic assessments can take up to several hours to complete and require significant training to administer. Although excellent disorder-specific interviews exist for PTSD (Clinician Administered PTSD Scale [ 28 ], PTSD Symptom Scale—Interview Version [ 29 ]), interviews designed to assess the full spectrum of psychiatric disorders may be better suited for treatment planning due to high rates of psychiatric comorbidity among PTSD patients (e.g., major depressive disorder, substance use disorders, etc.). One of the best examples of this is the Structured Clinical Interview of DSM-5 Disorders (SCID [ 30 ]). The SCID has been shown to provide valid and reliable diagnostics for PTSD as well as most other psychiatric disorders. Additional structured clinical interviews include the Anxiety Disorder Interview Schedule for DSM-5 [ 31 ], which, unlike the SCID, provides an index to quantify symptom severity, and the Mini International Neuropsychiatric Interview [ 32 ], which also provides the DSM diagnoses but takes approximately half the time to administer relative to the SCID.

2.3. Symptom Severity and Treatment Tracking

Once a PTSD diagnosis has been established, symptom frequency and severity are the next essential components to treatment planning and monitoring. A number of measures have been developed for monitoring PTSD symptoms. These measures are generally brief, self-report assessments of the 20 symptoms associated with PTSD. Some of the most widely used measures include the PTSD Checklist for DSM-5 [ 28 ] and the Posttraumatic Diagnostic Scale for DSM-5 [ 29 ]. These provide quick feedback regarding symptom severity and include cutoff scores to inform diagnostic status [ 19 , 29 , 33 ]. Separate trauma-specific versions of symptom severity measures have also been developed (e.g., military vs. civilian [ 33 ]). In addition, more brief versions have been proposed to further reduce the time demands, but not the accuracy, of symptom severity questionnaires such as the Primary Care PTSD screen (PC-PTSD [ 25 , 34 ]).

3. Evidence-Based Treatments

Is PTSD primarily a biological or psychological phenomenon, and relatedly, are psychosocial or pharmacological treatments more appropriate? This question sets up a false dichotomy, as PTSD is rooted in both biological and psychological factors with regard to onset of symptoms, development of PTSD diagnosis, and maintenance of the disorder. Studies demonstrate that biological differences [ 36 ] and psychosocial differences [ 14 , 37 ] contribute to the risk for developing PTSD. Experimental research additionally provides evidence that both biological and psychological interventions delivered relatively soon after trauma exposure have the potential to mitigate or even prevent (in the case of psychotherapy for Acute Stress Disorder) the development of PTSD [ 38 , 39 ]. Furthermore, across several controlled clinical trials, both pharmacological [ 40 ] and psychological [ 41 ] interventions have been shown to significantly reduce PTSD symptoms. Altogether, the extant literature provides a strong case that PTSD is rooted in both biological and psychological underpinnings. The more pressing question, then, is which intervention pathway provides the most potent and persistent symptom reduction, and for which patients? The following section reviews evidence-based psychological and pharmacological treatments.

3.1. Psychosocial Interventions for PTSD

Exposure-Based Interventions. Exposure-based interventions are the most empirically supported treatment modalities for PTSD [ 41 , 42 ]. The early roots of exposure-based therapies rest in the development of behaviorism in the 1920s, when Pavlov [ 42 ] demonstrated that fear could be both conditioned and extinguished through learning experiences. For example, repeatedly pairing the presentation of a tone with an uncomfortable shock eventually led to an automatic fear response to the tone (even in the absence of a shock). Furthermore, repeatedly playing the same feared tone without the shock eventually reduced (or extinguished) the fear response to the tone. Exposure-based behavioral therapies for PTSD are rooted in these same straightforward principles. The therapist helps the patient to systematically approach, instead of avoid, safe but feared stimuli (e.g., the memory of the trauma or situations that remind the patient of the traumatic event) in the absence of the feared consequences (such as bodily harm or unending anxiety), until the feared consequences are disconfirmed and the automatic fear response to trauma-related stimuli subsides. Though this basic principle is common to all exposure-based therapies across anxiety disorders, the necessity of defining the therapy provided in the context of clinical trials led to the development of specific, session-by-session exposure therapy protocols for the treatment for PTSD.

One of the most commonly investigated and empirically-supported exposure-based protocols for PTSD is Prolonged Exposure therapy (PE; [ 41 , 43 ]). PE is an 8-to-15-session protocol, typically provided in weekly or bi-weekly, 60-to-90 minute sessions [ 43 , 44 ]. The majority of patients who complete PE evidence significant and reliable reductions in PTSD symptoms [ 45 ]. In the beginning of PE, patients are taught a brief relaxation breathing exercise, and they receive psycho-education about PTSD symptoms and factors that contribute to the maintenance of PTSD (e.g., avoidance of the memory and related reminders). Over the next several sessions, the patient revisits and describes the trauma memory aloud for a prolonged time (e.g., 30–45 min) in order to extinguish the fear response associated with the memory. This is called imaginal exposure. In addition, the patient is taught to approach safe, trauma-related situations that have been avoided because they remind the patient of the trauma. This is called in vivo exposure. As “homework” between sessions, patients listen to recordings of the therapy sessions and practice the in vivo exposures.

In randomized clinical trials, dropout rates from PE have ranged from 10%–38% [ 44 ]. Notably, researchers have found that dropout can be higher in community settings ([ 46 , 47 ] although dropout rates do not differ between exposure and non-exposure therapies for PTSD [ 47 ]. A meta-analysis pooled across 13 studies found large effect sizes of PE relative to control groups at post-treatment, and medium to large effects at follow up time points [ 41 ]. Evidence also suggests that PE can produce further symptom reduction among patients with only partial response to pharmacotherapy [ 48 ].

3.2. Cognitive-Based Therapies

Over time, the field of psychotherapy has expanded to include cognitive-based treatment techniques in addition to exposure-based techniques. Though PE is categorized as a cognitive-behavioral therapy, and its exposure-based protocol does produce changes in negative thinking patterns associated with PTSD [ 49 ], the intervention strategies themselves are primarily behavioral rather than cognitive. Cognitive Processing Therapy (CPT; [ 50 , 51 ]) on the other hand, relies more heavily on interventions that directly target maladaptive thinking patterns. CPT, alongside other cognitive-based therapies for PTSD, emphasizes the role that maladaptive or inaccurate interpretation of a situation plays in maintaining disorders such as PTSD, and intervenes directly with the thoughts rather than the resulting behaviors.

Similar to PE, the initial sessions of CPT include psycho-education about PTSD symptomatology and the role of avoidance in maintaining PTSD, but CPT provides much stronger emphasis on the role of maladaptive thinking patterns in maintaining PTSD symptoms. Early in therapy, the patient writes a statement of impact that the traumatic event had on their life, specifically including details about how the trauma affected the patient’s beliefs about self, others, and the world. This is read aloud and discussed with the therapist. The therapist begins to gently question any potential maladaptive thinking patterns, thereby helping the patient discover over-generalized or unhelpful automatic thoughts. Over time, the therapist works with the patient to develop strategies for generating more useful or accurate thinking patterns. In the standard CPT protocol, the patient additionally writes one to two detailed accounts of the trauma and reads this account aloud in session. The last several sessions focus on specific areas of one’s life that are likely affected by maladaptive trauma-related thought patterns, including the areas of safety, trust, power/control, esteem, and intimacy. At the end of treatment, the patient re-writes the impact statement, which is used to evaluate treatment gains.

The 12-session CPT protocol can be disseminated effectively in either a group or individual format [ 51 ]. Elements of CPT have also been disseminated effectively in a dyadic format in the context of Cognitive Behavioral Conjoint Therapy (CBCT) for PTSD [ 52 ]. Dropout rates are approximately 20% in CPT [ 53 ] and no different than other active psychotherapies for PTSD [ 54 , 55 ]. Numerous trials have found CPT to be superior to a wait-list control group [ 53 , 55 , 56 ] and one study has demonstrated its equivalence to PE [ 55 ]. One dismantling study suggests that CPT may be equally efficacious with and without the written account of the trauma [ 57 ]. Subsequent analyses of this data qualified these results, demonstrating that those with higher levels of dissociation (especially depersonalization) responded best to the full protocol, and those with lower dissociation responded more rapidly to CPT without the trauma account [ 58 ]. Of note, other cognitive therapy protocols [ 59 , 60 , 61 , 62 ] or combined exposure and cognitive therapy protocols [ 63 , 64 ] have shown promising results [ 41 ].

3.3. Eye Movement Desensitization and Reprocessing.

Eye movement desensitization and reprocessing (EMDR) therapy had also received empirical support for the treatment of PTSD [ 65 , 66 ]. The model used to explain PTSD in EMDR is similar to cognitive-behavioral therapies in that PTSD is viewed as a result of insufficient processing of the traumatic memory. EMDR hypothesizes that the trauma memory, if not fully processed, is stored in its initial state, preserving any misperceptions or distorted thinking patterns that occurred at the time of the trauma.

At the outset of EMDR, patients are trained in strategies for managing negative emotions. The length of this treatment phase varies in accordance with the patient’s skill level in this area. To prepare for “reprocessing,” patients generate a list of traumatic (or other emotionally significant) experiences, along with distorted beliefs related to the experience (e.g., “I am a failure”) and desired beliefs (e.g., “I can handle tough situations”). During the reprocessing phase, the therapist asks the patient to bring to mind a vivid visual representation of the traumatic memory, along with the distorted belief (i.e., cognitive exposure), and to focus on the physical sensations related to the traumatic memory (i.e., interoceptive/visceral exposure). The patient is then instructed to engage in bilateral/saccadic eye movements, following the clinician’s finger from left to right for several repetitions. The patient visualizes the memory while continuing to engage in the bilateral stimulation. The patient is asked what experiences emerge next (e.g., thoughts, images, emotions, or sensations), and the cycle is repeated. The patient later practices thinking the desired thought (e.g., “I can handle tough situations”) with the visual image of the trauma brought to mind.

The bilateral eye movements in EMDR are somewhat controversial. In support of the use of this strategy, van den Hout and colleagues [ 67 ] found that bilateral eye movements during autobiographical memory recall reduce vividness and emotions attached to the memory (though their research was conducted in healthy controls rather than in PTSD patients). Developers of EMDR hypothesize that bilateral eye movements therefore reduce distress attached to the trauma memory, thereby reducing avoidance, and allowing for increased attention to more adaptive thinking patterns that are then attached to the traumatic memory [ 65 ]. A recent meta-analysis further supports that bilateral stimulation (eye movements are not the only potential form of bilateral stimulation used in EMDR) impacts memory in ways that might facilitate PTSD treatment [ 68 ]. Other researchers have hypothesized, however, that the exposure-based components of EMDR are all that is required, and a review of dismantling studies has demonstrated that the EMDR protocol works just as well without the bilateral stimulation component [ 69 ]. Regardless of the validity of its theoretical underpinnings, EMDR has empirical support in that it consistently outperforms no-treatment controls and demonstrates similar outcomes to exposure- and cognitive-based psychotherapies for PTSD [ 41 , 70 ].

3.4. Relaxation-Based Psychotherapies

Although less frequently studied and supported in the more recent literature, relaxation-based psychotherapies are another type of psychotherapy for PTSD. One of the most commonly investigated relaxation-based therapies for PTSD is Stress Inoculation Training (SIT; [ 71 , 72 ]). The treatment model is based on Lazarus & Folkman’s [ 73 ] conceptualization of stress resulting from perceived situational demands outweighing perceived resources to meet demands [ 74 ]. In this model, PTSD and other anxiety/stress disorders are maintained by ongoing perceptions of situational demands outweighing the available coping resources. The primary goal in SIT is to increase the patient’s sense of mastery over their anxiety, and to “inoculate” patients against future episodes of pervasive anxiety and stress. Treatment therefore focuses primarily on skills training in a vast array of anxiety-management strategies such as breathing retraining, muscle relaxation, negative-thought stopping, and restructuring/challenging maladaptive cognitions. Relaxation skills are trained and practiced in sessions using techniques such as behavioral rehearsal and imagery, modeling, and role-play. As treatment progresses, anxiety management strategies are practiced in the context of increasingly challenging and anxiety-provoking situations, including during graduated in vivo/situational exposures. Mastering the use of anxiety management skills in stressful situations is viewed as producing “inoculation” against future problems.

In clinical trials for PTSD treatment, SIT outperforms wait-list and supportive counseling [ 75 , 76 ]. However, evidence suggests that PE is superior to both SIT and SIT combined with exposure [ 75 ]. The reduced efficacy of PE+SIT in comparison to PE could be due to the reduced dosage of therapeutic exposure to feared situations in the combined treatment, or perhaps could be due to a “kitchen sink” effect (i.e., rapid training in too many strategies rather than focused mastery of one strategy).

4. Evidence-Based Pharmacological Treatments

Although psychotherapeutic interventions are the first and most supported option for the treatment of PTSD, there are several evidence-based pharmacological treatments available. In contrast to psychological interventions, pharmacotherapies can be provided in most clinical settings and require much less time and effort on the part of the patient (e.g., fewer and shorter appointments, no homework between visits). The foundation of pharmacological treatments is supported by a growing literature for the association between PTSD and dysregulations in neurotransmitter and neuroendocrine systems [ 77 , 78 , 79 , 80 ]. For the purposes of this review, we have focused on the current medication options with the most evidence, and therefore omitted older (e.g., monoamine oxidase inhibitors) and less studied options (e.g., mood stabilizers).

4.1. Selective Serotonin Reuptake Inhibitors

Most of the current research on pharmacotherapy for PTSD is focused on the selective serotonin reuptake inhibitors (SSRIs) to treat PTSD [ 40 ]. SSRIs have a broad effect on PTSD symptoms, including improvements in re-experiencing, avoidance, numbing, and hyper-arousal symptoms, and related quality of life improvements associated with the symptom reductions [ 81 ]. In terms of specific SSRIs, both sertraline and paroxetine have received FDA support for PTSD treatment and were superior to placebo in multisite clinical trials [ 81 , 82 , 83 , 84 , 85 ]. Other agents, such as fluvoxamine and citalopram, also have received support for the treatment of PTSD [ 86 , 87 ]. Interestingly, paroxetine also has been shown to potentially address cognitive deficits associated with PTSD, in addition to the clinical symptoms [ 88 ]. Longer trials of SSRIs (36 weeks) have been associated with a higher percentage of treatment response compared to the standard 12-week trials [ 89 ]. Unfortunately, independent of the duration of the trial, the discontinuation of SSRIs is associated with the relapse of PTSD symptoms [ 81 , 83 , 90 ]. In contrast, symptoms typically remain stable or continue to improve after completion of evidence-based psychotherapy for PTSD [ 91 ].

4.2. Other Promising Agents

There are several other agents that have received support in the pharmacological treatment of PTSD. These agents tend to effect specific sets of symptoms within PTSD, and are often studied in conjunction with an SSRI [ 81 ]. Two common examples are trazadone, an antidepressant serotonergic agent with a sedating side effect, and prazosin, an antiadrenergic agent that has been studied in the treatment of sleep and nightmares in PTSD. Prazosin has received increased attention as of late after randomized clinical trials demonstrating its effectiveness for PTSD-related sleep disruptions and nightmares, as well as global functioning and PTSD symptoms [ 92 ]. While these medications have shown some promise in reducing PTSD symptoms, they are not FDA approved for the treatment of PTSD and further research on their efficacy for PTSD is needed.

5. Summary and Future Directions

In summary, PTSD is a relatively common and highly debilitating psychiatric disorder affecting approximately 8% of the U.S. population [ 2 ]. Potent evidence-based psychosocial interventions are available, and several medications have FDA approval for the treatment of PTSD. While pharmacological treatments have shown some promise, more investigation and advancement in this area is needed. One of the most important concerns with the sole use of pharmacotherapy for PTSD treatment is the evidence that discontinuing treatment can be associated with relapse [ 81 , 83 , 90 ]. Although relapse is relatively infrequent after one responds to an evidence-based psychotherapy for PTSD [ 91 ], a proportion of patients either drop out of therapy prematurely or do not respond to therapy [ 46 , 47 , 54 ]. It is therefore critical to continue to investigate new strategies to improve upon the available treatments for PTSD.

One novel line of research has investigated the potential to enhance mechanisms of learning during cognitive behavioral therapies (such as those used for PTSD) by administering medications that could facilitate fear extinction, for example, d -cycloserine, yohimbine, methylene blue, MDMA, and oxytocin [ 93 , 94 ]. However, pharmacological augmentation of learning mechanisms is still in its infancy and will require much further exploration before these strategies can be recommended as standard treatment techniques for PTSD. Another line of cutting edge research involves priming the trauma memory through a reminder, and then preventing reconsolidation of the primed memory through pharmacological blockade [ 95 ]. Although some evidence suggests that this technique reduces emotional reactivity to the trauma memory [ 95 ], findings in this newer area of research are very preliminary and somewhat conflicted [ 39 ]. Innovative treatments outside the realms of psychotherapy and pharmacotherapy, such as neuronal feedback and brain stimulation techniques [ 96 ], are also being explored and may help reduce PTSD symptoms, particularly in treatment-resistant patients.

Acknowledgments

This research was supported by NIDA grant R01 DA030143 (PI: Back), NIDA grant K02 DA039229 (PI: Back), and Department of Veteran Affairs CSR&D Career Development Award CX000845 (PI: Gros). The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of NIDA, Department of Veterans Affairs, or the United States government.

Conflicts of Interest

There are no conflicts of interest to disclose.

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