Chemical Methods of Analysis

  • First Online: 30 August 2018

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research paper on chemical analysis

  • Yury A. Zolotov 2  

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Several widely used analytical reactions were proposed in Russia, such as the reaction of phosphate with ammonium molybdate (G. V. Struve) or the reaction of nickel with dimethylglyoxime (L. A. Chugaev). N. A. Tananaev and F. Feigl simultalneously developed drop analysis. A great contribution was made to the theory of the action of complexing organic reagents on metal ions, and new such reagents were created (V. I. Kuznetsov, S. B. Savvin, etc.); particularly widespread was the reagent Arsenazo III. The kinetic method of analysis owes its generation to K. B. Yatsimirskii.

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Zolotov, Y.A. (2018). Chemical Methods of Analysis. In: Russian Contributions to Analytical Chemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-98791-0_5

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Reinventing (Bio)chemical Analysis with Paper

Affiliations.

  • 1 Pharmaceutical Analysis, Groningen Research Institute of Pharmacy , University of Groningen , Antonius Deusinglaan 1 , 9713 AV Groningen , The Netherlands.
  • 2 Laboratory of Organic Chemistry , Wageningen University and Research , Stippeneng 4 , 6708 WE Wageningen , The Netherlands.
  • PMID: 30452240
  • PMCID: PMC6282107
  • DOI: 10.1021/acs.analchem.8b04825

This paper focuses on one of the most commonly encountered materials in our society, namely paper. Paper is an inherently complex material, yet its use provides for chemical analysis approaches that are elegant in their simplicity of execution. In the first half of the previous century, paper in scientific research was used mainly for filtration and chromatographic separation. While its use decreased with the rise of modern elution chromatography, paper remains a versatile substrate for low-cost analytical tests. Recently, we have seen renewed interest to work with paper in (bio)analytical science, a result of the growing demand for inexpensive, portable analysis. Dried blood spotting, paper microfluidics, and paper spray ionization are areas in which paper is (re)establishing itself as an important material. These research areas all exploit several properties of paper, including stable sample storage, passive fluid movement and manipulation, chromatographic separation/extraction, modifiable surface and/or volume, easily altered shape, easy transport, and low cost. We propose that the real, and to date underexploited, potential of paper lies in utilizing its combined characteristics to add new dimensions to paper-based (bio)chemical analysis, expanding its applicability. This article provides the reader with a short historical perspective on the scientific use of paper and the developments that led to the establishment of the aforementioned research areas. We review important characteristics of paper and place them in a scientific context in this descriptive, yet critical, assessment of the achieved and the achievable in paper-based analysis. The ultimate goal is the exploration of integrative approaches at the interface between the different fields in which paper is or can be used.

Publication types

  • Dried Blood Spot Testing*
  • Microfluidic Analytical Techniques*

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